Regulation of P2X(7) nucleotide receptor function in human monocytes by extracellular ions and receptor density.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2001-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPCELL.2001.280.4.C943PMID 11245611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors.

  2000cited by this paper
• Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors

  2000influential reference
• P2Z/P2X7receptor-dependent apoptosis of dendritic cells.

  1999cited by this paper
• Maitotoxin activates a nonselective cation channel and a P2Z/P2X7-like cytolytic pore in human skin fibroblasts.

  1999cited by this paper
• Pore dilation of neuronal P2X receptor channels

  1999cited by this paper
• Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds

  1999cited by this paper
• Maitotoxin and P2Z/P2X7purinergic receptor stimulation activate a common cytolytic pore.

  1999cited by this paper
• Dynamic selectivity filters in ion channels.

  1999cited by this paper
• Hetero-oligomeric Assembly of P2X Receptor Subunits

  1999cited by this paper
• Ionic effects on human recombinant P2X7 receptor function

  1999cited by this paper
• Extracellular sodium regulates airway ciliary motility by inhibiting a P2X receptor

  1999cited by this paper
• Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues.

  1998cited by this paper
• Blockade of human P2X7 receptor function with a monoclonal antibody.

  1998cited by this paper
• Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7channel.

  1998cited by this paper
• Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases.

  1998cited by this paper
• Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel.

  1998cited by this paper
• Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor.

  1997cited by this paper
• Spontaneous Cell Fusion in Macrophage Cultures Expressing High Levels of the P2Z/P2X7 Receptor

  1997cited by this paper
• Purinoceptor‐operated cationic channels in human B lymphocytes.

  1997cited by this paper
• The Permeabilizing ATP Receptor, P2X7

  1997cited by this paper
• Nucleotide receptors.

  1997cited by this paper
• In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor‐α release by PDE inhibitors

  1997cited by this paper
• ATP, a partial agonist for the P2Z receptor of human lymphocytes

  1997cited by this paper
• Human Monocyte Interleukin-1β Posttranslational Processing

  1996cited by this paper
• The Cytolytic P2Z Receptor for Extracellular ATP Identified as a P2X Receptor (P2X7)

  1996cited by this paper
• Extracellular ATP causes loss of L‐selectin from human lymphocytes via occupancy of P2Z purinoceptors

  1996cited by this paper
• Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response.

  1996cited by this paper
• Induction of the P2z/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-gamma in the human THP-1 monocytic cell line.

  1996cited by this paper
• RSR13: Effects on tumor oxygenation and response to therapy

  1996cited by this paper
• Expression of multiple ATP receptor subtypes during the differentiation and inflammatory activation of myeloid leukocytes

  1996cited by this paper
• ATP induces the release of IL-1 from LPS-primed cells in vivo.

  1995cited by this paper
• The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role.

  1995influential reference
• Variation of LPS-binding capacity, epitope expression, and shedding of membrane-bound CD14 during differentiation of human monocytes.

  1995cited by this paper
• Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

  1994cited by this paper
• Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes.

  1994cited by this paper
• P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages.

  1994cited by this paper
• The ATP4- receptor-operated ion channel of human lymphocytes: inhibition of ion fluxes by amiloride analogs and by extracellular sodium ions.

  1992cited by this paper
• The Effects of Interferon-γ and Bacterial Lipopolysaccharide on CD14 Expression in Human Monocytes

  1992cited by this paper
• Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes.

  1991cited by this paper
• Extracellular adenosine triphosphate increases cation permeability of chronic lymphocytic leukemic lymphocytes.

  1989influential reference
• ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

  1987cited by this paper
• Properties of the Fc receptor on macrophages.

  1976cited by this paper

• Purinergic Signaling in Non-Parenchymal Liver Cells

  2024cites this paper
• Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R

  2024cites this paper
• Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy

  2022cites this paper
• Preparation of the Murine Anti-Human P2X7 Receptor Monoclonal Antibody (Clone L4).

  2022cites this paper
• Physiologic roles of P2 receptors in leukocytes

  2022cites this paper
• Extracellular ATP: A powerful inflammatory mediator in the central nervous system.

  2022cites this paper
• Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases

  2021cites this paper
• Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology

  2021cites this paper
• Role of P2X7 Receptors in Immune Responses During Neurodegeneration

  2021cites this paper
• Macrophage Response Driven by Extracellular ATP.

  2021cites this paper
• P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

  2020cites this paper
• Functional expression of P2X1, P2X4 and P2X7 purinergic receptors in human monocyte-derived macrophages.

  2020cites this paper
• Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor

  2020cites this paper
• Flow cytometry: An accurate tool for screening P2RX7 modulators

  2020cites this paper
• Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?

  2019cites this paper
• The role of vitamin D and P2X7R in multiple sclerosis.

  2019cites this paper
• P2X7 receptor in cardiovascular disease: The heart side

  2019cites this paper
• The Elusive P2X7 Macropore.

  2018cites this paper
• Calibration-FreeQuantitative Immunoassay by Flow Cytometry : Theoretical Consideration and Practical Implementation for IgGAntibodyBinding to CD 14 Receptors onHuman Leukocytes

  2018cites this paper
• Calibration‐free quantitative immunoassay by flow cytometry: Theoretical consideration and practical implementation for IgG antibody binding to CD14 receptors on human leukocytes

  2018cites this paper
• Regulation of P2X Purinergic Receptor Signaling by Cholesterol.

  2017cites this paper
• The P2X7 Receptor.

  2017cites this paper
• Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts

  2017cites this paper
• Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner

  2017cites this paper
• Novel therapeutic targets in uveitis

  2017cites this paper
• Defective phagocytic clearance of apoptotic cells and macrophages as such are involved in the development of the aterosclerotic lesions that initiate acute thrombotic and vascular diseases , including myocardial infarction and stroke

  2017cites this paper
• Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain

  2016cites this paper
• Personalized management of asthma exacerbations: lessons from genetic studies

  2016cites this paper
• Inhibition of P2X Receptors Protects Human Monocytes against Damage by Leukotoxin from Aggregatibacter actinomycetemcomitans and α-Hemolysin from Escherichia coli

  2016cites this paper
• Expression density of receptors to IL-1β in atopic dermatitis.

  2016cites this paper
• Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes.

  2016cites this paper
• Human β Defensin-3 Increases CD86 Expression on Monocytes by Activating the ATP-Gated Channel P2X7

  2015cites this paper
• Pathogen Clearance Macrophages That Promotes Intracellular Antimicrobial Peptide LL-37 by Human Receptor Regulates Internalization of 7 P 2 X and

  2015cites this paper
• Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis

  2015cites this paper
• P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance

  2015cites this paper
• Using fruit fly eyes as membrane protein factories: Expression of rat P2X2 and pannexin-1 in Drosophila melanogaster

  2015cites this paper
• Tanshinone II A Sulfonate, but Not Tanshinone II A, Acts as Potent Negative Allosteric Modulator of the Human Purinergic Receptor P2X7

  2014cites this paper
• The purinergic P2×7 receptor is expressed on monocytes in Behçet's disease and is modulated by TNF‐α

  2014cites this paper
• Purinergic and Calcium Signaling in Macrophage Function and Plasticity

  2014cites this paper
• The P2X7 Receptor in AMD

  2014cites this paper
• Die Rolle der Ekto-5´-Nukleotidase (CD73) bei der Entzündungsreaktion nach Herzinfarkt in der Maus

  2014cites this paper
• Tanshinone II A sulfonate but not tanshinone II A acts as potent negative allosteric modulator of the human purinergic receptor P2X7

  2014cites this paper
• Optimized flow cytometry protocol for analysis of surface expression of interleukin-1 receptor types I and II

  2013cites this paper
• Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia

  2013cites this paper
• P2X7R-driven IL-1 responses in differentiated murine Dendritic Cells; comparison with Macrophages.

  2013cites this paper
• The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation

  2013cites this paper
• Hypoxia Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia

  2013cites this paper
• The Effect of Anions on the Human P2X7 Receptor

  2012cites this paper
• Expression and function of the P2X7 receptor in monocytes from patients with Behçet’s disease

  2012influential citation
• Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion

  2012cites this paper
• Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking

  2012cites this paper
• Intracellular Signaling Pathways Integrating the Pore Associated with P2X7R Receptor with Other Large Pores

  2012cites this paper
• Molecular and functional properties of P2X receptors—recent progress and persisting challenges

  2012cites this paper
• P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

  2012cites this paper
• Biomedicine and Immunological Science Section of Clinical Pharmacology XXIV Cycle

  2012cites this paper
• Cholesterol-Binding Peptides and Phagocytosis

  2012cites this paper
• Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions.

  2011cites this paper
• Activation and Regulation of Purinergic P2X Receptor Channels

  2011cites this paper
• The effect of anions on the human P2X7 receptor.

  2011cites this paper
• The Role of the P2X7 Receptor in Infectious Diseases

  2011cites this paper
• Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function

  2010cites this paper
• TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.

  2010cites this paper
• Characterisation of expression and functional properties of P2Xz receptors

  2010cites this paper
• Expression and function of the P2X7 receptor on human malignant cell lines

  2010influential citation
• Inhibition of neuronal cell death after retinoic acid-induced down-regulation of P2X7 nucleotide receptor expression

  2010influential citation
• Preservation of Differentiation and Clonogenic Potential of Human Hematopoietic Stem and Progenitor Cells during Lyophilization and Ambient Storage

  2010cites this paper
• Involvement of P2X receptors in the NAD+-induced rise in [Ca2+]i in human monocytes

  2009cites this paper
• P2X7 receptor and macrophage function

  2009cites this paper
• Predictions suggesting a participation of beta-sheet configuration in the M2 domain of the P2X(7) receptor: a novel conformation?

  2009cites this paper
• The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types

  2009cites this paper
• The P2X7 receptor–pannexin connection to dye uptake and IL-1β release

  2009cites this paper
• Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control.

  2009cites this paper
• Ecto-ADP-Ribosyltransferases in Murine Adenine Dinucleotide and Activation by Extracellular Nicotinamide Receptor 7 Differential Regulation of P 2 X Schilling and

  2009cites this paper
• Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells

  2009cites this paper
• Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells.

  2009cites this paper
• Expression, signaling, and function of P2X7 receptors in bone

  2009cites this paper
• Expression and Function of ART2.1 ecto-ADP-ribosyltransferase in Inflammatory Effector Cells

  2009cites this paper
• Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells : characterization and inhibition by low molecular weight antagonists

  2009cites this paper
• Human rheumatoid synoviocytes express functional P2X7 receptors

  2008cites this paper
• The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions

  2008cites this paper
• Assembly and trafficking of P2X purinergic receptors (Review)

  2008cites this paper
• Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor

  2008cites this paper
• Standardized method to minimize variability in a functional P2X7 flow cytometric assay for a multi‐center clinical trial

  2008cites this paper
• The nucleotide receptor P2RX7 mediates ATP‐induced CREB activation in human and murine monocytic cells

  2008cites this paper
• Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7‐sensitive pathway independent of formyl peptide receptor‐like 1

  2008cites this paper
• Extracellular ATP Is Cytotoxic to Mononuclear Phagocytes but Does Not Induce Killing of Intracellular Mycobacterium avium subsp. paratuberculosis

  2007cites this paper
• Changes in expression of P2X7 receptors in NOD mouse pancreas during the development of diabetes

  2007cites this paper
• P2 purinergic receptor modulation of cytokine production

  2007cites this paper
• Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease.

  2006cites this paper
• Trehalose uptake through P2X7 purinergic channels provides dehydration protection.

  2006cites this paper
• Pharmacology of P2X channels

  2006cites this paper
• A Thr357 to Ser Polymorphism in Homozygous and Compound Heterozygous Subjects Causes Absent or Reduced P2X7 Function and Impairs ATP-induced Mycobacterial Killing by Macrophages*

  2006cites this paper
• Human P2X7 pore function predicts allele linkage disequilibrium.

  2006cites this paper
• The cytokine IL‐1β transiently enhances P2X7 receptor expression and function in human astrocytes

  2005influential citation
• N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X7 receptors

  2005cites this paper
• CD 39-associated high ATPase activity contribute to the loss of P 2 X 7-mediated calcium response in LCL cells.

  2005cites this paper
• Detection of Human P2X7 Nucleotide Receptor Polymorphisms by a Novel Monocyte Pore Assay Predictive of Alterations in Lipopolysaccharide-Induced Cytokine Production1

  2005cites this paper
• N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P 2 X 7 receptors

  2005cites this paper
• Cytokine Production Alterations in Lipopolysaccharide-Induced Monocyte Pore Assay Predictive of Receptor Polymorphisms by a Novel Nucleotide 7 Detection of Human P 2 X

  2005cites this paper
• Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor1

  2005cites this paper