Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Chemico-Biological Interactions

• Publication date

  1997-10-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0009-2797(97)00068-9PMID 9413544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structure, function, and regulation of cytochrome P450 2A enzymes.

  1997cited by this paper
• Alanine-scanning Mutagenesis of a Putative Substrate Recognition Site in Human Cytochrome P450 3A4

  1997cited by this paper
• Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity.

  1997cited by this paper
• Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver.

  1997cited by this paper
• A hypothetical model for the active site of human cytochrome P4502E1.

  1997cited by this paper
• Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase.

  1997cited by this paper
• Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

  1997cited by this paper
• Some DNA targets of the yeast CYP1 transcriptional activator are functionally asymmetric--evidence of two half-sites with different affinities.

  1997cited by this paper
• Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes.

  1997cited by this paper
• Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

  1997cited by this paper
• Drug metabolism by Escherichia coli expressing human cytochromes P450

  1997cited by this paper
• Human P450 metabolism of warfarin.

  1997cited by this paper
• Heterologous expression of human drug-metabolizing enzymes.

  1997cited by this paper
• Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

  1997cited by this paper
• 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

  1996cited by this paper
• Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes.

  1996cited by this paper
• Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4

  1996cited by this paper
• Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.

  1996cited by this paper
• P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

  1996cited by this paper
• Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity (*)

  1996cited by this paper
• Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli

  1996cited by this paper
• Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.

  1996cited by this paper
• Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

  1996cited by this paper
• Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.

  1996cited by this paper
• Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

  1996cited by this paper
• Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.

  1996cited by this paper
• Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.

  1996cited by this paper
• The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

  1995cited by this paper
• Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids

  1995cited by this paper
• Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein.

  1995cited by this paper
• Interpretations of cytochrome P450 mechanisms from kinetic studies.

  1995cited by this paper
• Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.

  1995cited by this paper
• Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.

  1995cited by this paper
• Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice.

  1995cited by this paper
• Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.

  1995cited by this paper
• Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.

  1995cited by this paper
• Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes.

  1995cited by this paper
• A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization.

  1995cited by this paper
• Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481.

  1995cited by this paper
• Validation of the (ω-l)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1

  1995cited by this paper
• Evidence That Aspartic Acid 301 Is a Critical Substrate-Contact Residue in the Active Site of Cytochrome P450 2D6 (*)

  1995cited by this paper
• The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein.

  1995cited by this paper
• Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes.

  1995cited by this paper
• Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1.

  1995cited by this paper
• Role of Residue 363 and 206 in Conversion of Cytochrome P450 2B1 from a Steroid 16-Hydroxylase to a 15α-Hydroxylase

  1994cited by this paper
• Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9.

  1994cited by this paper
• Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties.

  1994cited by this paper
• Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

  1994cited by this paper
• Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes.

  1994cited by this paper
• Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism.

  1994cited by this paper
• Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.

  1994cited by this paper
• Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

  1994cited by this paper
• Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.

  1994cited by this paper
• Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.

  1994cited by this paper
• Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

  1994cited by this paper
• Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.

  1993cited by this paper
• Engineering mouse P450coh to a novel corticosterone 15 alpha-hydroxylase and modeling steroid-binding orientation in the substrate pocket.

  1993cited by this paper
• Studies on the mutagenic activation of heterocyclic amines by cynomolgus monkey, rat and human microsomes show that cynomolgus monkeys have a low capacity to N-oxidize the quinoxaline-type heterocyclic amines.

  1993cited by this paper
• Purification from liver microsomes from untreated cynomolgus monkeys of cytochrome P450 closely related to human cytochrome P450 2B6.

  1993cited by this paper
• A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3.

  1993cited by this paper
• Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11.

  1993cited by this paper
• Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity.

  1993cited by this paper
• Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.

  1993cited by this paper
• Expression of rabbit cytochromes P4504A which catalyze the omega-hydroxylation of arachidonic acid, fatty acids, and prostaglandins.

  1993cited by this paper
• Regulation of steroid hydroxylase gene expression: importance to physiology and disease.

  1993cited by this paper
• Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.

  1993cited by this paper
• The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

  1993cited by this paper
• Cytochrome P450 4A4: expression in Escherichia coli, purification, and characterization of catalytic properties.

  1993cited by this paper
• Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.

  1993cited by this paper
• Characterization of cytochrome P-450 2B6 in human liver microsomes.

  1993cited by this paper
• Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

  1993cited by this paper
• Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1.

  1992cited by this paper
• Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

  1992cited by this paper
• Nicotine metabolism by cDNA-expressed human cytochrome P-450s

  1992cited by this paper
• Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP).

  1992cited by this paper
• Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity.

  1992cited by this paper
• Further studies on chimeric P450 2C2/2C14 having testosterone 16 beta-hydroxylase activity which is absent in the parental P450s.

  1992cited by this paper
• Human cytochrome P-450 enzymes.

  1992cited by this paper
• Catalytic and immunologic similarities between monkey and human liver cytochrome P-450db1 (human cytochrome P-450 2D6).

  1992cited by this paper
• Analysis of the catalytic specificity of cytochrome P450 enzymes through site‐directed mutagenesis

  1992cited by this paper
• High‐level expression of functional human cytochrome P450 1A2 in Escherichia coli

  1992cited by this paper
• Constitutive expression and hormonal regulation of male sexually differentiated cytochromes P450 in primary cultured rat hepatocytes.

  1992cited by this paper
• Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

  1992cited by this paper
• Role of Glu318 at the putative distal site in the catalytic function of cytochrome P450d.

  1992cited by this paper
• Role of Glu318 and Thr319 in the catalytic function of cytochrome P450d (P4501A2): effects of mutations on the methanol hydroxylation

  1992cited by this paper
• Molecular basis for a functionally unique cytochrome P450IIB1 variant.

  1991cited by this paper
• A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.

  1991cited by this paper
• CO binding studies of engineered cytochrome P-450ds: effects of mutations at putative distal sites in the presence of polycyclic hydrocarbons.

  1991cited by this paper
• Cytochrome P450IID subfamily in non-human primates. Catalytical and immunological characterization.

  1991cited by this paper
• Nomenclature of electron‐transfer proteins

  1991cited by this paper
• Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase.

  1991cited by this paper
• Effects of individual mutations in the P-450(C21) pseudogene on the P-450(C21) activity and their distribution in the patient genomes of congenital steroid 21-hydroxylase deficiency.

  1991cited by this paper
• Ligand binding studies of engineered cytochrome P-450d wild type, proximal mutants, and distal mutants.

  1991cited by this paper
• Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.

  1991cited by this paper
• Absorption spectral study of cytochrome P450d-phenyl isocyanide complexes: effects of mutations at the putative distal site on the conformational stability.

  1991cited by this paper
• Purification and characterization of cytochrome P450 2E2 from hepatic microsomes of neonatal rabbits.

  1991cited by this paper
• Dissociation of hydroxylase and lyase activities by site-directed mutagenesis of the rat P45017 alpha.

  1991cited by this paper
• The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

  1991cited by this paper
• Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation.

  1990cited by this paper
• Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms.

  1990cited by this paper

• Computerized predictive approaches of genotoxicity and mutagenesis in 3D Hepoid of normal and transformed human hepatocytes.

  2025cites this paper
• Identifying metabolites of new psychoactive substances using in silico prediction tools

  2025cites this paper
• Dose-dependent modulation of hepatic cytochrome P450 enzymes by tenvermectin: implications for medication safety and combination therapy

  2025cites this paper
• Interest of molecular networking in fundamental, clinical and forensic toxicology: A state-of-the-art review

  2024cites this paper
• In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis.

  2023cites this paper
• Effects of acaricides on the activities of monooxygenases in bovine liver microsomes.

  2023cites this paper
• Preclinical Pharmacokinetics and in vitro Metabolism of FHND5071, a Novel Selective RET Kinase Inhibitor

  2023cites this paper
• Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain

  2023cites this paper
• Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate.

  2022cites this paper
• A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline

  2022cites this paper
• Demethylnobiletin and its major metabolites: Efficient preparation and mechanism of their anti-proliferation activity in HepG2 cells

  2022cites this paper
• Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine

  2022cites this paper
• Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

  2022cites this paper
• Phase I Metabolism of Pterostilbene, a Dietary Resveratrol Derivative: Metabolite Identification, Species Differences, Isozyme Contribution, and Further Bioactivation.

  2022cites this paper
• Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes.

  2021cites this paper
• The steroid metabolome of pregnancy, insights into the maintenance of pregnancy and evolution of reproductive traits.

  2021cites this paper
• DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies

  2021cites this paper
• Enabling comprehensive assessments of drug–drug interaction risks

  2020cites this paper
• Cytochrome P450 2E1 and its roles in disease.

  2020cites this paper
• New insights in equine steroidogenesis: an in-depth look at steroid signaling in the placenta.

  2020cites this paper
• Enterococcus faecium HDRsEf1 Represses CYP3A29 Expression in the Intestine through the TLR1/2-induced A20 to attenuate the NF-κB/RXR-α Signaling

  2020cites this paper
• Predicting the transfer of contaminants in ruminants by models - potentials and challenges.

  2020cites this paper
• Characterization of CYP2D protein from human brain cerebellum

  2020cites this paper
• Research trends in chemico-biological interactions: The golden jubilee (1969-2019).

  2020cites this paper
• In vivo testing of orally delivered nanoparticles

  2020cites this paper
• In Vivo Assessment of the Efficiency of Systemic Delivery

  2020cites this paper
• Oral Controlled Release Systems: Current Strategies and Challenges

  2019cites this paper
• Genetic diversity of cytochrome P450 1A2 with different metabolic activities in domestic cats

  2019cites this paper
• Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats

  2019cites this paper
• Drug-induced liver injury

  2019cites this paper
• Nutritional conditioning : The effect of a short-term high fat diet on hepatic drug metabolism

  2019cites this paper
• Impact of Xenobiotics Under a Changing Climate Scenario

  2019cites this paper
• Pharmacokinetics behaviors of l-menthol after inhalation and intravenous injection in rats and its inhibition effects on CYP450 enzymes in rat liver microsomes

  2019cites this paper
• Strain and sex differences in drug hydrolase activities in rodent livers.

  2019cites this paper
• Medications in Space: In Search of a Pharmacologist’s Guide to the Galaxy

  2019cites this paper
• Effects of formaldehyde on detoxification and immune responses in silver pomfret (Pampus argenteus)

  2019cites this paper
• A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism

  2019cites this paper
• Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes

  2018cites this paper
• Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges.

  2018cites this paper
• Exploring the human intestine in a dish: From physiology to disease

  2018cites this paper
• Formalin-Fixed Paraffin-Embedded Tissues—An Untapped Biospecimen for Biomonitoring DNA Adducts by Mass Spectrometry

  2018cites this paper
• Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ

  2018cites this paper
• In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity

  2018cites this paper
• The safety evaluation of food flavouring substances: the role of metabolic studies.

  2018cites this paper
• Predikering av interaksjonen mellom atorvastatin og ciklosporin (CsA) ved bruk av en PBPK-modell (Simcyp)

  2018cites this paper
• Assessing the value of enrofloxacin and carprofen combination treatment in southern white rhinoceros (Ceratotherium simum) through the use of pharmacokinetic modelling

  2018cites this paper
• Phylogenetic analysis of the cytochrome P450 (CYP450) nucleotide sequences of the horse and predicted CYP450s of the white rhinoceros (Ceratotherium simum) and other mammalian species

  2018cites this paper
• Xanthates As Useful Probes for Testing the Active Sites of Cytochromes P450 4A11 and 2E1

  2017cites this paper
• Distinct urinary metabolite profiles of two pharmacologically active N-methylanthranilates: Three approaches to xenobiotic metabolite identification.

  2017cites this paper
• Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450.

  2017cites this paper
• Porcine Cytochrome P 450 and Metabolism

  2017cites this paper
• Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions

  2017cites this paper
• Instructions for use Title High expression of the mRNA of cytochrome P 450 and phaseII enzymes in the lung and kidney tissues of cattle

  2017cites this paper
• GIT Anatomy and Physiology and Drug Oral Bioavailability: Impact of Species Differences

  2017cites this paper
• Evaluation of the Ecstasy influence on tramadol and its main metabolite plasma concentration in rats

  2017cites this paper
• Interspecies Variation of In Vitro Stability and Metabolic Diversity of YZG-331, a Promising Sedative-Hypnotic Compound

  2017cites this paper
• Instructions for use Title High expression of the mRNA of cytochrome P 450 and phase II enzymes in the lung and kidney tissuesof cattle

  2017cites this paper
• Metabolism of okadaic acid by NADPH-dependent enzymes present in human or rat liver S9 fractions results in different toxic effects.

  2017cites this paper
• Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis.

  2017cites this paper
• Effets du diabète de type 2 sur l’expression et l’activité des cytochromes P450 hépatiques et extra-hépatiques chez la souris C57BL/6 sous une diète riche en gras

  2017influential citation
• In vivo Studies for Drug Development via Oral Delivery: Challenges,Animal Models and Techniques

  2017cites this paper
• Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections

  2016cites this paper
• Improving bioaccumulation assessment: Relationship between in vitro and in vivo biotransformation rates of hydrophobic organic chemicals in mammals

  2016cites this paper
• The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) for in vitro genetic toxicity assessment.

  2016cites this paper
• The identification of functional mutations affecting boar taint

  2016cites this paper
• Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats

  2016cites this paper
• Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases

  2016influential citation
• Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs

  2016cites this paper
• The Use of Genetically Modified Animals in Discovery Toxicology

  2016cites this paper
• Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human diseases.

  2016cites this paper
• Network analysis and cross species comparison of protein-protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics.

  2016cites this paper
• Mathematical and Experimental Model of Oxygen Diffusion for HepaRG Cell Spheroids

  2016cites this paper
• Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.

  2016cites this paper
• In vitro inhibition of CYP1A and CYP3A by phenolic compounds from bilberry (Vaccinium myrtillus), in male and female porcine liver microsomes

  2015influential citation
• PHARMACOGENETICS AND CANINE CYTOCHROME P450 POLYMORPHISMS

  2015cites this paper
• Pharmacokinetic aspects of meloxicam in koalas: including its hepatic microsomal metabolism compared with other selected species

  2015influential citation
• Identification and characterization of in vitro and in vivo metabolites of steroidal alkaloid veratramine

  2015cites this paper
• Species Differences in the Pharmacokinetic Parameters of Cytochrome P450 Probe Substrates between Experimental Animals, such as Mice, Rats, Dogs, Monkeys, and Microminipigs, and Humans

  2015cites this paper
• Identification and functional characterization of novel feline cytochrome P450 2A

  2015cites this paper
• Mitigating role of baicalein on lysosomal enzymes and xenobiotic metabolizing enzyme status during lung carcinogenesis of Swiss albino mice induced by benzo(a)pyrene

  2014cites this paper
• Heterologous Expression of Equine CYP3A94 and Investigation of a Tunable System to Regulate Co-Expressed NADPH P450 Oxidoreductase Levels

  2014cites this paper
• Effetto della disfunzione epatica sull’induzione enzimatica: valutazione dell’inducibilità dei CYP1A e CYP3A in ratti con cirrosi sperimentalmente indotta

  2014cites this paper
• Potential drug interactions with melatonin.

  2014cites this paper
• Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System

  2014cites this paper
• Up-regulation on cytochromes P450 in rat mediated by total alkaloid extract from Corydalis yanhusuo

  2014cites this paper
• Determination of rhynchophylline and hirsutine in rat plasma by UPLC-MS/MS after oral administration of Uncaria rhynchophylla extract.

  2014cites this paper
• In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris).

  2014cites this paper
• Molecular cloning and cDNA characterization of Camelus dromedarius putative cytochrome P 450 s 1 A , 2 C , and 3 A

  2014cites this paper
• Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism.

  2014cites this paper
• Monkey-based Research on Human Disease: The Implications of Genetic Differences

  2014cites this paper
• An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety

  2014cites this paper
• Pathophysiology and Toxicology of the Heart

  2014cites this paper
• Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms

  2014cites this paper
• Molecular cloning and cDNA characterization of Camelus dromedarius putative cytochrome P450s 1A, 2C, and 3A.

  2014cites this paper
• Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes.

  2013cites this paper
• Cytochrome P450 Activation of Toxins and Hepatotoxicity

  2013cites this paper
• Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine.

  2013cites this paper
• Nicotine addictions: Neurobiological circuits and pharmacological targets

  2013cites this paper
• L’inhibition des cytochromes P450 dans les cas d’insuffisance rénale chronique : rôle de l’hormone parathyroïdienne

  2013cites this paper
• Clinically Relevant Drug-Drug and Drug-Food Interactions

  2013influential citation