Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2002-10-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0303-7207(02)00227-7PMID 12385827
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor.

  2002cited by this paper
• Production and purification of recombinant human inhibin and activin.

  2002cited by this paper
• The distribution of betaglycan protein and mRNA in rat brain, pituitary, and gonads: implications for a role for betaglycan in inhibin-mediated reproductive functions.

  2002cited by this paper
• Inhibin binding sites and proteins in pituitary, gonadal, adrenal and bone cells.

  2001cited by this paper
• Ligand Binding and Functional Properties of Betaglycan, a Co-receptor of the Transforming Growth Factor-β Superfamily

  2001cited by this paper
• Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).

  2001cited by this paper
• Importance of inhibin B in the regulation of FSH secretion in the human male.

  2001cited by this paper
• Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle.

  2001cited by this paper
• Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A.

  2001cited by this paper
• Identification of specific inhibin A-binding proteins on mouse Leydig (TM3) and sertoli (TM4) cell lines.

  2001cited by this paper
• Dynamics of the Follicle-Stimulating Hormone (FSH)-Inhibin B Feedback Loop and Its Role in Regulating Spermatogenesis in the Adult Male Rhesus Monkey (Macaca mulatta) as Revealed by Unilateral Orchidectomy1.

  2000cited by this paper
• Structure and expression of a membrane component of the inhibin receptor system.

  2000cited by this paper
• Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

  2000cited by this paper
• Transcriptional control by the TGF‐β/Smad signaling system

  2000cited by this paper
• Identification of a Binding Site on the Type II Activin Receptor for Activin and Inhibin*

  2000cited by this paper
• Dynamics of the follicle-stimulating hormone (FSH)-inhibin B feedback loop and its role in regulating spermatogenesis in the adult male rhesus monkey (Macaca mulatta) as revealed by unilateral orchidectomy.

  2000cited by this paper
• Activin signal transduction pathways.

  2000cited by this paper
• Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

  2000cited by this paper
• Activin and inhibin binding to the soluble extracellular domain of activin receptor II.

  1999cited by this paper
• Identification of high affinity binding sites for inhibin on ovine pituitary cells in culture.

  1999cited by this paper
• Identification of an Inhibin Receptor in Gonadal Tumors from Inhibin α-Subunit Knockout Mice*

  1998cited by this paper
• The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors.

  1998cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• Activin subunit, follistatin, and activin receptor gene expression in the prepubertal female rat pituitary.

  1998cited by this paper
• Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells.

  1997cited by this paper
• Circulating concentrations of dimeric inhibin A and B in the male rhesus monkey (Macaca mulatta).

  1997cited by this paper
• Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

  1997cited by this paper
• Modulation of granulosa cell deoxyribonucleic acid synthesis and differentiation by activin.

  1996cited by this paper
• Formation and activation by phosphorylation of activin receptor complexes.

  1996cited by this paper
• Inhibin A and inhibin B are inversely correlated to follicle-stimulating hormone, yet are discordant during the follicular phase of the rat estrous cycle, and inhibin A is expressed in a sexually dimorphic manner.

  1996cited by this paper
• Measurement of dimeric inhibin B throughout the human menstrual cycle.

  1996cited by this paper
• Inhibin-B: a likely candidate for the physiologically important form of inhibin in men.

  1996cited by this paper
• Anti-activin A Antibody (IgY) Specifically Neutralizes Various Activin A Activities

  1996cited by this paper
• Activation of signalling by the activin receptor complex

  1996cited by this paper
• Inhibin Antagonizes Inhibition of Liver Cell Growth by Activin by a Dominant-negative Mechanism (*)

  1995cited by this paper
• Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2 (*)

  1995cited by this paper
• Hybridization histochemical localization of activin receptor subtypes in rat brain, pituitary, ovary, and testis.

  1994cited by this paper
• Characterization of type I receptors for transforming growth factor-beta and activin.

  1994cited by this paper
• Perifusion of rat pituitary cells with gonadotropin-releasing hormone, activin, and inhibin reveals distinct effects on gonadotropin gene expression and secretion.

  1993cited by this paper
• Betaglycan presents ligand to the TGF beta signaling receptor.

  1993cited by this paper
• Expression of type II activin receptor genes in the male and female reproductive tissues of the rat.

  1993cited by this paper
• Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle.

  1993cited by this paper
• Localization of activin receptor (ActR-IIB2) mRNA in the rat seminiferous epithelium.

  1993cited by this paper
• Betaglycan presents ligand to the TGFβ signaling receptor

  1993cited by this paper
• Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.

  1992cited by this paper
• Activin-A inhibits proopiomelanocortin messenger RNA accumulation and adrenocorticotropin secretion of AtT20 cells.

  1991cited by this paper
• Expression cloning of an activin receptor, a predicted transmembrane serine kinase.

  1991cited by this paper
• Expression cloning and characterization of the TGF-beta type III receptor.

  1991cited by this paper
• Effect of recombinant activin-A on gonadotropin secretion in the female rat.

  1991cited by this paper
• Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

  1991cited by this paper
• Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors.

  1991cited by this paper
• Differential Binding of Transforming Growth Factor-β1, -β2, and -β3 by Fibroblasts and Epithelial Cells Measured by Affinity Cross-Linking of Cell Surface Receptors

  1991cited by this paper
• Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms.

  1990cited by this paper
• Localization of inhibin/activin subunit mRNAs within the primate ovary.

  1990cited by this paper
• Binding of transforming growth factor-beta to cell surface proteins varies with cell type.

  1989cited by this paper
• Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels.

  1989cited by this paper
• Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle.

  1988cited by this paper
• Chemical and biological characterization of the inhibin family of protein hormones.

  1988cited by this paper
• Comparison of the biological actions of TGF beta‐1 and TGF beta‐2: Differential activity in endothelial cells

  1988cited by this paper
• Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

  1987cited by this paper
• Inhibin-mediated feedback control of follicle-stimulating hormone secretion in the female rat.

  1986cited by this paper
• A homodimer of the β-subunits of inhibin a stimulates the secretion of pituitary follicle stimulating hormone

  1986cited by this paper
• A homodimer of the beta-subunits of inhibin A stimulates the secretion of pituitary follicle stimulating hormone.

  1986cited by this paper

• Targeting CD44 and other pleiotropic co-receptors as a means for broad inhibition of tumor growth and metastasis

  2024cites this paper
• Activins and Inhibins in Cardiovascular Pathophysiology

  2024cites this paper
• Biomarkers of Reproductive Health in Wildlife and Techniques for Their Assessment

  2023cites this paper
• Evolving roles of activins and inhibins in ovarian cancer pathophysiology.

  2023cites this paper
• Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss

  2022cites this paper
• Impairment of ovarian follicular development caused by titanium dioxide nanoparticles exposure involved in the TGF‐β/BMP/Smad pathway

  2022cites this paper
• TGFBR3L is an inhibin B co-receptor that regulates female fertility

  2021cites this paper
• Cellular Processes in Human Ovarian Follicles Are Regulated by Expression Profile of New Gene Markers—Clinical Approach

  2021cites this paper
• IGSF1 Does Not Regulate Spermatogenesis or Modify FSH Synthesis in Response to Inhibins or Activins

  2021cites this paper
• TGF‐β superfamily co‐receptors in cancer

  2021cites this paper
• A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors

  2021cites this paper
• A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor.

  2020cites this paper
• Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B.

  2020cites this paper
• A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors

  2020cites this paper
• Follistatin expressed in mechanically-damaged salivary glands of male mice induces proliferation of CD49f+ cells

  2020cites this paper
• Expression of TGFBR1, TGFBR2, TGFBR3, ACVR1B and ACVR2B is altered in ovaries of cows with cystic ovarian disease

  2019cites this paper
• From Consternation to Revelation: Discovery of a Role for IGSF1 in Pituitary Control of Thyroid Function

  2018cites this paper
• Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice.

  2018cites this paper
• TGF-&bgr; family co-receptor function and signaling

  2018cites this paper
• Implantation Failure Is Associated With Increased α-Inhibin and β-Glycan Gene Expression in Secretory Phase Endometrium: Nested Case–Control Study of Infertile Women Undergoing IVF/Fresh Embryo Transfer

  2017cites this paper
• Dually modified transmembrane proteoglycans in development and disease.

  2017cites this paper
• The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways

  2017cites this paper
• An investigation of the role of the TGFbeta-TAZ signaling crosstalk in canine osteosarcoma metastasis

  2016cites this paper
• Mouse Models for the Study of Synthesis, Secretion, and Action of Pituitary Gonadotropins.

  2016cites this paper
• Pituitary disorders and their extra-pituitary implications : observations in patients with nonfunctioning pituitary macroadenoma and the IGSF1 deficiency syndrome

  2016cites this paper
• Pituitary disorders and their extra-pituitary implications

  2016cites this paper
• Normal gonadotropin production and fertility in gonadotrope-specific Bmpr1a knockout mice.

  2016cites this paper
• Chapter 116 – Gonadotropins: Regulation of Synthesis and Secretion

  2016cites this paper
• Chapter 117 – Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone)

  2016cites this paper
• Recent advances in central congenital hypothyroidism

  2015cites this paper
• Neonatal screening and a new cause of congenital central hypothyroidism

  2014cites this paper
• Activin A, B, and AB increase human trophoblast cell invasion by up-regulating N-cadherin.

  2014cites this paper
• Inhibin at 90: from discovery to clinical application, a historical review.

  2014cites this paper
• Evolution of the TGF-beta superfamily with emphasis on Nodal

  2014cites this paper
• Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis.

  2014cites this paper
• Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells.

  2013cites this paper
• Ovarian Hormones: Structure, Biosynthesis, Function, Mechanism of Action, and Laboratory Diagnosis

  2013cites this paper
• Studies on enhancing embryo quantity and quality by immunization against inhibin in repeatedly superovulated Holstein heifers and the associated endocrine mechanisms.

  2013cites this paper
• IGSF1 deficiency syndrome

  2013cites this paper
• Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling*

  2012cites this paper
• Betaglycan (TβRIII) Is Expressed in the Thymus and Regulates T Cell Development by Protecting Thymocytes from Apoptosis

  2012cites this paper
• Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

  2012cites this paper
• Expression of Inhibin/Activin Proteins and Receptors in the Human Hypothalamus and Basal Forebrain

  2012cites this paper
• Comprehensive analysis of TGF-β and BMP receptor interactomes.

  2012cites this paper
• When versatility matters: activins/inhibins as key regulators of immunity

  2012cites this paper
• The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase.

  2011cites this paper
• Aberrantly increased mRNA expression of betaglycan, an inhibin co‐receptor in the ovarian tissues in women with polycystic ovary syndrome

  2010cites this paper
• Reviews: Activins and Related Proteins in the Establishment of Pregnancy

  2010cites this paper
• Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production.

  2010cites this paper
• The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

  2009cites this paper
• Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes.

  2009cites this paper
• Inhibin A and B in vitro bioactivities are modified by their degree of glycosylation and their affinities to betaglycan.

  2007cites this paper
• Gonadotrophins modulate hormone secretion and steady-state mRNA levels for activin receptors (type I, IIA, IIB) and inhibin co-receptor (betaglycan) in granulosa and theca cells from chicken prehierarchical and preovulatory follicles.

  2007cites this paper
• Paracrinicity: The Story of 30 Years of Cellular Pituitary Crosstalk

  2007cites this paper
• Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription.

  2007cites this paper
• The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.

  2007cites this paper
• GROWTH DIFFERENTIATION FACTOR 9 SIGNALLING IN THE OVARY

  2007cites this paper
• Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone b subunit transcription

  2007cites this paper
• GROWTH DIFFERENTIATION FACTOR 9 SIGNALLING IN THE OVARY

  2007cites this paper
• Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone β subunit transcription

  2007cites this paper
• CHAPTER 10 – Follicular Development: Mouse, Sheep, and Human Models

  2006cites this paper
• Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins.

  2006cites this paper
• The activin axis in liver biology and disease.

  2006cites this paper
• Expression of inhibin-activin subunits, follistatin and smads in granulosa-luteal cells collected at oocyte retrieval

  2006cites this paper
• Identification of gene networks modulated by activin in LbetaT2 cells using DNA microarray analysis.

  2006influential citation
• Structural Basis for a Functional Antagonist in the Transforming Growth Factor β Superfamily*

  2005cites this paper
• Growth Factor Expression Associated With Regulation of Olfactory Neurogenesis

  2005cites this paper
• Tgf-beta superfamily and mouse craniofacial development: interplay of morphogenetic proteins and receptor signaling controls normal formation of the face.

  2005cites this paper
• Pattern of secretion of immunoreactive inhibin/activin subunits by avian granulosa cells.

  2005cites this paper
• Activins and inhibins: Physiological roles, signaling mechanisms and regulation

  2005cites this paper
• Molecular biology of inhibin action.

  2004cites this paper
• The Shedding of Betaglycan Is Regulated by Pervanadate and Mediated by Membrane Type Matrix Metalloprotease-1*

  2004cites this paper
• The transforming growth factor-beta superfamily of receptors.

  2004influential citation
• REVIEW Regulation of gonadotropin subunit gene transcription

  2004cites this paper
• Activin and inhibin receptor gene expression in the ewe pituitary throughout the oestrous cycle.

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Regulation of gonadotropins by inhibin and activin.

  2004cites this paper
• Regulation of gonadotropin subunit gene transcription.

  2004cites this paper
• Inhibin: Actions and Signalling

  2004cites this paper
• Regulation of Gonadotropins by Inhibin and Activin

  2004cites this paper
• Molecular Biology of Inhibin Action

  2004cites this paper
• Inhibins, activins, and follistatin in the aging female and male.

  2004cites this paper
• Inhibins, Activins, and Follistatin in the Aging Female and Male

  2004cites this paper
• Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells.

  2003cites this paper
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  2003cites this paper
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  2003cites this paper
• Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin.

  2003cites this paper
• Normal Reproductive Function in InhBP/p120-Deficient Mice

  2003influential citation
• Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF‐β ligand:receptor interactions

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