Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone β subunit transcription

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Molecular Endocrinology

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1677/JME.1.02196
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004influential reference
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  1996cited by this paper
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  1996cited by this paper
• MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

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  1995cited by this paper
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