BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2009-07-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0903854106PMID 19549844PMCID PMC2708681
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diagnosing and exploiting cancer's addiction to blocks in apoptosis

  2008influential reference
• BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells.

  2008cited by this paper
• Germinal centres: role in B-cell physiology and malignancy

  2008cited by this paper
• Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas

  2007cited by this paper
• BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis*

  2007cited by this paper
• Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells

  2007cited by this paper
• Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR

  2007cited by this paper
• A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

  2007cited by this paper
• BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma.

  2006cited by this paper
• Reverse engineering of regulatory networks in human B cells

  2005cited by this paper
• Reverse Engineering of Regulatory Networks

  2005cited by this paper
• BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

  2005cited by this paper
• Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice.

  2005cited by this paper
• The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

  2004cited by this paper
• Tracking CD40 signaling during germinal center development.

  2004cited by this paper
• Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells

  2004influential reference
• Direct Repression of prdm1 by Bcl-6 Inhibits Plasmacytic Differentiation1

  2004cited by this paper
• MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

  2004cited by this paper
• BCL6 Controls the Expression of the B7-1/CD80 Costimulatory Receptor in Germinal Center B Cells

  2003cited by this paper
• Transcriptional analysis of the B cell germinal center reaction

  2003cited by this paper
• Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

  2003cited by this paper
• Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene1

  2002cited by this paper
• Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas

  2002cited by this paper
• Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

  2001cited by this paper
• BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

  2000cited by this paper
• Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.

  1998cited by this paper
• BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.

  1998cited by this paper
• Monitoring and interpreting the intrinsic features of somatic hypermutation

  1998cited by this paper
• Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

  1998cited by this paper
• The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

  1997cited by this paper
• Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

  1997cited by this paper
• Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein.

  1997cited by this paper
• Control of inflammation, cytokine expression, and germinal center formation by BCL-6.

  1997cited by this paper
• Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene.

  1996cited by this paper
• Transcriptional repression by the proto-oncogene BCL-6.

  1996cited by this paper
• BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

  1996cited by this paper
• Clonal selection and learning in the antibody system

  1996cited by this paper
• BCL-6 expression during B-cell activation.

  1996cited by this paper
• BCL-6 protein is expressed in germinal-center B cells.

  1995cited by this paper
• Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

  1995cited by this paper
• Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

  1995cited by this paper
• Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.

  1993cited by this paper
• Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

  1993cited by this paper
• LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

  1993influential reference
• Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.

  1992cited by this paper
• Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

  1990cited by this paper
• Alternative promoters and exons, somatic mutation and deregulation of the Bcl‐2‐Ig fusion gene in lymphoma.

  1988cited by this paper
• Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas.

  1987cited by this paper
• Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.

  1986cited by this paper
• Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.

  1984cited by this paper

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• B cell development and longevity of IgE plasma cells.

  2026cites this paper
• B-cell lymphoma: Advances in pathogenesis, diagnosis, and targeted therapies.

  2025cites this paper
• Reactive Bcl2‐positive germinal centres in paediatric tonsils: expanding the spectrum of lymphoma mimickers in children and adolescents

  2025cites this paper
• Diffuse large B cell lymphoma (DLBCL): epidemiology, pathophysiology, risk stratification, advancement in diagnostic approaches and prospects: narrative review

  2025cites this paper
• BCL6 is required for the thymic development of TCRαβ+CD8αα+ intraepithelial lymphocyte lineage

  2024cites this paper
• Suppression of interferon α and γ response by Huwe1-mediated Miz1 degradation promotes SARS-CoV-2 replication

  2024cites this paper
• YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.

  2024cites this paper
• The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6

  2024cites this paper
• Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells

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  2024cites this paper
• BCL2 Protein Progressively Declines during Robust CLL Clonal Expansion: Potential Impact on Venetoclax Clinical Efficacy and Insights on Mechanism

  2024cites this paper
• B cell memory: from generation to reactivation: a multipronged defense wall against pathogens

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  2024cites this paper
• CD62L expression marks a functionally distinct subset of memory B cells

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• High BECN1 Expression Negatively Correlates with BCL2 Expression and Predicts Better Prognosis in Diffuse Large B-Cell Lymphoma: Role of Autophagy

  2023cites this paper
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• The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma

  2023cites this paper
• FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins

  2023cites this paper
• TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses

  2023cites this paper
• Memory B cell differentiation from germinal centers.

  2023cites this paper
• The germinal center in the pathogenesis of B cell lymphomas

  2023cites this paper
• Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib.

  2023cites this paper
• Distinct B-Cell Specific Transcriptional Contexts of the BCL2 Oncogene Impact Pre-Malignant Development in Mouse Models

  2022cites this paper
• Germinal Centers.

  2022cites this paper
• Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.

  2022cites this paper
• BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer

  2022cites this paper
• Investigating the Mechanism of Germinal Center Shutdown

  2022cites this paper
• Super-enhancer hypermutation alters oncogene expression in B cell lymphoma

  2022cites this paper
• Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells

  2022influential citation
• Making Sense of Antisense Oligonucleotide Therapeutics Targeting Bcl-2

  2022cites this paper
• Generation of High Quality Memory B Cells

  2022cites this paper
• Emerging insights into origin and pathobiology of primary central nervous system lymphoma.

  2021cites this paper
• CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer

  2021cites this paper
• Structural basis of Apt48 inhibition of the BCL6 BTB domain.

  2021cites this paper
• Diverse B-cell specific transcriptional contexts of the BCL2 oncogene in mouse models impacts pre-malignant development

  2021cites this paper
• BH3 Mimetics in Hematologic Malignancies

  2021cites this paper
• Die genetische Evolution der in situ follikulären Neoplasie zum t(14;18)-positiven aggressiven B‑Zell-Lymphom

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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.

  2021cites this paper
• Impact of Genetic Polymorphism of Myeloid Differentiation Primary Response Gene 88, Enhancer of Zeste Homolog 2, and B-cell Lymphoma 2 like 11 in Patients with Diffuse Large B Cell Lymphoma Treated with Rituximab, Cyclophosphamide, Doxorubicin, Vincristin

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  2018cites this paper
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  2018cites this paper
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