The role of prostanoids in urinary bladder physiology

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature reviews. Urology

• Publication date

  2012-03-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/nrurol.2012.33PMID 22410675
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiology and pathophysiology

  2013cited by this paper
• Re: Detrusor underactivity: a plea for new approaches to a common bladder dysfunction.

  2012cited by this paper
• Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves

  2012cited by this paper
• Interactions between cholinergic and prostaglandin signaling elements in the urothelium: role for muscarinic type 2 receptors.

  2012cited by this paper
• Modulation of stretch evoked adenosine triphosphate release from bladder epithelium by prostaglandin E₂.

  2011cited by this paper
• Bladder outlet obstruction induced expression of prostaglandin E2 receptor subtype EP4 in the rat bladder: a possible counteractive mechanism against detrusor overactivity.

  2011cited by this paper
• Detrusor underactivity: A plea for new approaches to a common bladder dysfunction

  2011cited by this paper
• The effect of intravesical acetylsalicylic acid instillation on tissue prostaglandin levels after partial bladder outlet obstruction in rabbits

  2011cited by this paper
• The relationship between prostaglandin E receptor 1 and cyclooxygenase I expression in guinea pig bladder interstitial cells: proposition of a signal propagation system.

  2011cited by this paper
• Prostaglandin E₂mediates spontaneous rhythmic contraction in rabbit detrusor muscle.

  2011cited by this paper
• Antimuscarinics suppress adenosine triphosphate and prostaglandin E2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction.

  2011cited by this paper
• Prostaglandin receptor EP1 and EP2 site in guinea pig bladder urothelium and lamina propria.

  2010cited by this paper
• Stretch independent regulation of prostaglandin E2 production within the isolated guinea‐pig lamina propria

  2010cited by this paper
• Urinary nerve growth factor but not prostaglandin E2 increases in patients with interstitial cystitis/bladder pain syndrome and detrusor overactivity

  2010cited by this paper
• Drugs for treatment of urinary retention after surgery in adults.

  2010cited by this paper
• Expression of E‐series prostaglandin (EP) receptors and urodynamic effects of an EP4 receptor antagonist on cyclophosphamide‐induced overactive bladder in rats

  2010cited by this paper
• 777 SAFETY, TOLERABILITYAND PHARMACOKINETIC OF MULTIPLE ASCENDING DOSES OF THE EP-1 RECEPTOR ANTAGONIST ONO-8539, A POTENTIAL NEW AND NOVEL THERAPY TO OVERACTIVE BLADDER IN HEALTHY YOUNG AND ELDERLY SUBJECTS

  2010cited by this paper
• Potential for control of detrusor smooth muscle spontaneous rhythmic contraction by cyclooxygenase products released by interstitial cells of Cajal

  2009cited by this paper
• Cyclooxygenases: structural and functional insights Research on COX structure and function in the authors' laboratory is supported by grants from the National Institutes of Health (CA-89450 and GM-15431). Published, JLR Papers in Press, October 23, 2008.

  2009cited by this paper
• Exenatide efficacy and safety: a systematic review

  2009cited by this paper
• THEMED ISSUE: GPCR RESEARCH PAPER Dual modulation of urinary bladder activity and urine flow by prostanoid EP3 receptors in the conscious rat

  2009cited by this paper
• Intravesical botulinum toxin A administration inhibits COX-2 and EP4 expression and suppresses bladder hyperactivity in cyclophosphamide-induced cystitis in rats.

  2009cited by this paper
• Effects of prostaglandins on the smooth muscle of the urinary tract.

  2009cited by this paper
• Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence

  2009cited by this paper
• Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice.

  2008cited by this paper
• Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species.

  2008cited by this paper
• Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: role of mucosal muscarinic receptors.

  2008cited by this paper
• Guide to Receptors and Channels (GRAC), 3rd edition

  2008cited by this paper
• The localization of cyclo-oxygenase immuno-reactivity (COX I-IR) to the urothelium and to interstitial cells in the bladder wall

  2008cited by this paper
• Prostaglandin E Receptors*

  2007cited by this paper
• The effects of exogenous prostaglandins and the identification of constitutive cyclooxygenase I and II immunoreactivity in the normal guinea pig bladder

  2007cited by this paper
• The role of the prostacyclin receptor antagonist RO3244019 in treating neurogenic detrusor overactivity after spinal cord injury in rats

  2007cited by this paper
• Mechanisms of Disease: involvement of the urothelium in bladder dysfunction

  2007cited by this paper
• Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists.

  2007cited by this paper
• Urodynamic effects of a novel EP(1) receptor antagonist in normal rats and rats with bladder outlet obstruction.

  2007cited by this paper
• Prostaglandin E2 release from isolated bladder strips in rats with spinal cord injury

  2006cited by this paper
• Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists.

  2006cited by this paper
• Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats.

  2006cited by this paper
• The role of COX-2 inhibitors in the perioperative setting: efficacy and safety--a systematic review.

  2006cited by this paper
• Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder.

  2006cited by this paper
• Effect of cyclooxygenase inhibitors on the micturition reflex in rats: correlation with inhibition of cyclooxygenase isozymes

  2006cited by this paper
• Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom

  2005cited by this paper
• Prostaglandin E2 and bethanechol in combination for treating detrusor underactivity

  2004cited by this paper
• Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice.

  2004cited by this paper
• Role of the urothelium in bladder function

  2004cited by this paper
• Prostaglandin E2 and bethanechol in combination for treating detrusor underactivity

  2004cited by this paper
• Urinary bladder contraction and relaxation: physiology and pathophysiology.

  2004cited by this paper
• COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat.

  2003cited by this paper
• Overactive Bladder--Pharmacological Aspects

  2002cited by this paper
• Prostaglandin H2 (PGH2) accelerates formation of amyloid β1−42 oligomers

  2002cited by this paper
• COMMUNICATION Prostaglandin H 2 (PGH 2 ) accelerates formation of amyloid b 1)42 oligomers

  2002cited by this paper
• Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

  2001cited by this paper
• Intravesically administered ketoprofen in treatment of detrusor instability: cross-over study.

  2000cited by this paper
• Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats

  2000cited by this paper
• Obstruction stimulates COX-2 expression in bladder smooth muscle cells via increased mechanical stretch.

  1999cited by this paper
• Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder

  1998cited by this paper
• Cyclooxygenases 1 and 2.

  1998cited by this paper
• Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction.

  1997cited by this paper
• Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction.

  1997cited by this paper
• Prostaglandin E receptors.

  1995cited by this paper
• Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involvement of tachykinins?

  1995cited by this paper
• VIII. International union of pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes

  1994cited by this paper
• International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

  1994cited by this paper
• Prostaglandin prophylaxis and bladder function after vaginal hysterectomy: a prospective randomised study

  1993cited by this paper
• Prostanoids as local modulators of reflex micturition.

  1992cited by this paper
• Actions of two novel prostaglandin analogs, SC-29169 and SC-31391, on guinea pig and human isolated urinary bladder.

  1992cited by this paper
• Prostaglandin for enhancing bladder function after vaginal surgery. Does it work?

  1992cited by this paper
• Bladder contributes to eicosanoids excreted in urine.

  1990cited by this paper
• Prostaglandins for enhancing detrusor function after surgery for stress incontinence in women.

  1990cited by this paper
• Detrusor hyperreflexia induced by intravesical instillation of xylene in conscious rats.

  1990cited by this paper
• Comparison of the mode of action of prostaglandin E2 (PGE2) and sulprostone, a PGE2-derivative, on the lower urinary tract in healthy women

  1990cited by this paper
• Prostanoids modulate reflex micturition by acting through capsaicin-sensitive afferents.

  1988cited by this paper
• Influence of prostaglandins and ketoprofen on contractile responses of human and pig detrusor and trigone muscles in vitro.

  1987cited by this paper
• Eicosanoid synthesis by human urinary bladder mucosa: pathological implications.

  1987cited by this paper
• The Mode of Action of Prostaglandin E2, F2α and Prostacyclin on Vesicourethral Smooth Muscle

  1986cited by this paper
• The mode of action of prostaglandin E2, F2 alpha and prostacyclin on vesicourethral smooth muscle.

  1986cited by this paper
• The rat urinary bladder produces prostacyclin as well as other prostaglandins.

  1984cited by this paper
• Release of arachidonate cascade products by the rabbit bladder; neurophysiological significance?

  1984cited by this paper
• Mechanical trauma to bladder epithelium liberates prostanoids which modulate neurotransmission in rabbit detrusor muscle.

  1984cited by this paper
• Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary bladder.

  1984cited by this paper
• The rat urinaryprostacyclin as well as other

  1984cited by this paper
• α1- and α2-adrenoceptors in the smooth muscle of isolated rabbit urinary bladder and urethra

  1984cited by this paper
• Solvent-induced fragmentation of prostaglandin endoperoxides. New aldehyde products from PGH2 and a novel intramolecular 1,2-hydride shift during endoperoxide fragmentation in aqueous solution

  1984cited by this paper
• Alpha 1- and alpha 2-adrenoceptors in the smooth muscle of isolated rabbit urinary bladder and urethra.

  1984cited by this paper
• Prostaglandin type E activity dominates in urinary tract smooth muscle in vitro.

  1983cited by this paper
• Evidence for a prostaglandin link in the purinergic activation of rabbit bladder smooth muscle.

  1982cited by this paper
• The value of intravesical prostaglandin E2 and F2 alpha in women with abnormalities of bladder emptying.

  1981cited by this paper
• The Value of lntravesical Prostaglandin E2and F2αin Women with Abnormalities of Bladder Emptying

  1981cited by this paper
• Prostaglandin involvement in contractions evoked in rabbit detrusor by field stimulation and by adenosine 5'-triphosphate.

  1981cited by this paper
• The effect of exogenous prostaglandins F2 alpha and E2 and indomethacin on micturition.

  1981cited by this paper
• The role of prostaglandins in the maintenance of the tone of the rabbit urinary bladder.

  1980cited by this paper
• Role of prostaglandins in the responses of rabbit detrusor to non-cholinergic, non-adrenergic nerve stimulation and to ATP.

  1980cited by this paper
• Intravesical prostaglandin: release and effect of bladder instillation on some micturition parameters.

  1980cited by this paper
• Prostaglandin E2 production by rabbit urinary bladder.

  1980cited by this paper
• A comparison between bromocriptine and indomethacin in the treatment of detrusor instability.

  1980cited by this paper
• Production and effects of prostaglandins in the detrusor from homo, cat, rabbit, and rat.

  1980cited by this paper
• Evaluation of flurbiprofen in detrusor instability.

  1980cited by this paper
• The synthesis and release of prostaglandins by human urinary bladder muscle in vitro.

  1979cited by this paper
• Release of prostaglandins into the pelvic venous blood of dogs in response to vesical distension and pelvic nerve stimulation.

  1979cited by this paper
• The synthesis and release of prostaglandins by human urinary bladder muscle in vitro.

  1979cited by this paper

• Effect of some prostanoid receptor modulators on cholinergic and purinergic pathways in rat model of hemorrhagic cystitis: potential beneficial action of selexipag and alprostadil.

  2025cites this paper
• Prostaglandins Regulate Urinary Purines by Modulating Soluble Nucleotidase Release in the Bladder Lumen

  2025cites this paper
• Prostaglandins Differentially Regulate the Constitutive and Mechanosensitive Release of Soluble Nucleotidases in the Urinary Bladder Mucosa

  2024cites this paper
• The future of neuromodulation

  2024cites this paper
• Recent advances in the diagnosis of bladder outlet obstruction in men

  2024cites this paper
• Investigating Urine Biomarkers in Detrusor Underactivity and Detrusor Overactivity with Detrusor Underactivity Patients

  2023cites this paper
• Uroprotective Potential of Campesterol in Cyclophosphamide Induced Interstitial Cystitis; Molecular Docking Studies

  2023cites this paper
• Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction

  2023cites this paper
• Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors

  2022cites this paper
• Change of Urinary Nitrite Excretion in Primary Enuresis after Indomethacin Treatment

  2021cites this paper
• Isoprostanes evoke contraction of the murine and human detrusor muscle via activation of the thromboxane prostanoid TP receptor and Rho-kinase.

  2021cites this paper
• Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

  2021cites this paper
• Potential urine biomarkers in bladder outlet obstruction-related detrusor underactivity

  2021cites this paper
• The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor

  2020cites this paper
• Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766

  2020cites this paper
• PGE2 receptors in detrusor muscle: Drugging the undruggable for urgency.

  2020cites this paper
• EP2 and EP3 receptors as therapeutic targets for underactive bladder/detrusor underactivity due to diabetic cystopathy in a type 1 diabetic rat model

  2020cites this paper
• Female underactive bladder – Current status and management

  2019influential citation
• Treatment of Voiding LUTS

  2019cites this paper
• Sildenafil corrects the increased contractility of rat detrusor muscle induced by alprostadil in vitro

  2019cites this paper
• Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP1 receptor antagonist

  2018cites this paper
• High luteinizing hormone weakens urinary continence mechanisms in association with prostaglandin E2 elevation in a postmenopausal rat model

  2018cites this paper
• Are There Pharmacotherapeutic Options for Underactive Bladder?

  2018cites this paper
• Urinary bladder hypertrophy characteristic of male ROMK Bartter's mice does not occur in female mice.

  2018cites this paper
• Inhibitory Effects of Urothelium‐related Factors

  2017cites this paper
• OAB without an overactive bladder in the acute prostaglandin E2 rat model.

  2017cites this paper
• Combination treatment of nocturnal enuresis with desmopressin and indomethacin

  2017cites this paper
• Review of underactive bladder.

  2017cites this paper
• SN003, a CRF1 receptor antagonist, attenuates depressive‐like behavior and detrusor overactivity symptoms induced by 13‐cis‐retinoic acid in rats

  2017cites this paper
• Promising Effects of a Novel EP2 and EP3 Receptor Dual Agonist, ONO-8055, on Neurogenic Underactive Bladder in a Rat Lumbar Canal Stenosis Model.

  2016cites this paper
• THE INFLUENCE OF MONTELUKAST ON THE ACTIVITY OF THE AUTONOMIC NERVOUS SYSTEM ESTIMATED BY HEART RATE VARIABILITY IN EXPERIMENTAL PARTIAL BLADDER OUTLET OBSTRUCTION IN RATS.

  2016cites this paper
• Updates of underactive bladder: a review of the recent literature

  2016cites this paper
• Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.

  2016cites this paper
• Effect of Selective Prostaglandin E2 EP2 Receptor Agonist CP‐533,536 on Voiding Efficiency in Rats with Midodrine‐Induced Functional Urethral Obstruction

  2016cites this paper
• Prostaglandin-targeting agents and spectral heart rate variability in experimental partial bladder outlet obstruction in rats.

  2016cites this paper
• Potential Future Pharmacological Treatment of Bladder Dysfunction.

  2016cites this paper
• Pharmacological Modulation of Mucosa-Related Impairment of β-Adrenoceptor-Mediated Relaxation in Human Detrusor

  2015cites this paper
• Drug therapy of overactive bladder - What is coming next?

  2015influential citation
• The cardiovascular and gastrointestinal adverse effects of cyclooxygenase inhibitors seems to be a major concern that restricts their use in the treatment of urinary bladder dysfunction

  2015cites this paper
• Research Findings on Overactive Bladder

  2015cites this paper
• Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2

  2015cites this paper
• The role of prostanoids in the urinary bladder function and a potential use of prostanoid-targeting pharmacological agents in bladder overactivity treatment.

  2015cites this paper
• Spectral heart rate variability in rats with cyclophosphamide-induced hemorrhagic cystitis treated with cyclooxygenase inhibitors.

  2015cites this paper
• Promising experimental drugs and drug targets

  2015cites this paper
• Cytotoxic drugs and their effects on bladder function

  2015cites this paper
• The applicability of the "read-across hypothesis" for assessing the effects of human pharmaceuticals on fish

  2014cites this paper
• Regulation of vascular COX-2, NOX-1 and NOX-4 expression by angiotensin II and interleukin 1β: role of HuR and implication in cell migration

  2014cites this paper
• Pathophysiology and animal modeling of underactive bladder

  2014cites this paper
• Release and inhibitory effects of prostaglandin D2 in guinea pig urinary bladder and the role of urothelium.

  2014cites this paper
• Prostaglandin E2 excitatory effects on guinea pig urinary bladder smooth muscle: a novel regulatory mechanism mediated by large-conductance voltage- and Ca2+-activated K+ channels.

  2014cites this paper
• Studies on inhibitory modulation of urinary tract motility

  2014cites this paper
• Advanced therapeutic directions to treat the underactive bladder

  2014cites this paper
• Prostaglandins and Phosphodiesterases in the urinary bladder wall

  2013cites this paper
• The effect of indomethacin on the muscarinic induced contractions in the isolated normal guinea pig urinary bladder

  2013cites this paper
• Rationale for the Use of Prostaglandins and Phosphodiesterase Inhibitors in the Treatment of Functional Bladder Disorders

  2013cites this paper