A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Developmental Cell

• Publication date

  2004-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1534-5807(04)00065-6PMID 15068795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.

  2003cited by this paper
• The uric-86 Gene Product Couples Cell Lineage and Cell Identity in C . elegans

  2003cited by this paper
• MYC recruits the TIP60 histone acetyltransferase complex to chromatin

  2003cited by this paper
• ATP-dependent nucleosome remodeling.

  2002cited by this paper
• Functional organization of the yeast proteome by systematic analysis of protein complexes

  2002cited by this paper
• Malignant Worms: What Cancer Research Can Learn from C. elegans

  2002cited by this paper
• dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.

  2001influential reference
• The Yeast NuA4 and Drosophila MSL Complexes Contain Homologous Subunits Important for Transcription Regulation*

  2001influential reference
• LG II balancer chromosomes in Caenorhabditis elegans: mT1(II;III) and the mIn1 set of dominantly and recessively marked inversions

  2001cited by this paper
• E2F Transcriptional Activation Requires TRRAP and GCN5 Cofactors*

  2001cited by this paper
• Histone acetyltransferases.

  2001cited by this paper
• C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity.

  2001cited by this paper
• The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.

  2001cited by this paper
• The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1.

  2001cited by this paper
• The p400 complex is an essential E1A transformation target.

  2001cited by this paper
• Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit

  2001cited by this paper
• Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.

  2000cited by this paper
• NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans.

  2000cited by this paper
• The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination.

  2000cited by this paper
• Three Yeast Proteins Related to the Human Candidate Tumor Suppressor p33ING1 Are Associated with Histone Acetyltransferase Activities

  2000cited by this paper
• The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

  2000cited by this paper
• The many HATs of transcription coactivators.

  2000cited by this paper
• Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.

  2000influential reference
• The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.

  1999cited by this paper
• Molecular analyses of the class B synthetic multivulva genes of Caenorhabditis elegans

  1999cited by this paper
• The rde-1 gene, RNA interference, and transposon silencing in C. elegans.

  1999cited by this paper
• NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM‐related cofactor Tra1p

  1999cited by this paper
• Genetics of RAS signaling in C. elegans.

  1998cited by this paper
• The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.

  1998cited by this paper
• MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.

  1998cited by this paper
• lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

  1998cited by this paper
• Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.

  1998cited by this paper
• Tra1p Is a Component of the Yeast Ada·Spt Transcriptional Regulatory Complexes*

  1998cited by this paper
• C. Elegans II

  1998cited by this paper
• Erratum: Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases

  1997cited by this paper
• The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.

  1997cited by this paper
• EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.

  1996cited by this paper
• Yeast SAS silencing genes and human genes associated with AML and HIV–1 Tat interactions are homologous with acetyltransferases

  1996cited by this paper
• The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

  1995cited by this paper
• When is a lipid kinase not a lipid kinase? When it is a protein kinase.

  1995cited by this paper
• lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.

  1993cited by this paper
• The gene lin-3 encodes an inductive signal for vulval development in C. elegans

  1992cited by this paper
• Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

  1991cited by this paper
• Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

  1990cited by this paper
• let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein.

  1990cited by this paper
• The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

  1989cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989cited by this paper
• Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

  1988cited by this paper
• Pattern formation during vulval development in C. elegans.

  1986influential reference
• Caenorhabditis elegans deficiency mapping.

  1984cited by this paper
• Homoeosis in Drosophila: a new enhancer of polycomb and related homoeotic mutations.

  1983cited by this paper
• Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans.

  1981cited by this paper
• Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans.

  1981cited by this paper
• Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans.

  1980cited by this paper
• Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.

  1977cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper

• The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms

  2026cites this paper
• Mechanisms of lineage specification in Caenorhabditis elegans.

  2023cites this paper
• Large‐scale genetic screens identify BET‐1 as a cytoskeleton regulator promoting actin function and life span

  2022cites this paper
• Function of lipid binding proteins of parasitic helminths: still a long road

  2022cites this paper
• Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan

  2022cites this paper
• Disruption of the DREAM Complex Results in Cell Cycle Deregulation

  2020cites this paper
• Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability.

  2019cites this paper
• Identification of Essential Genes in Hepatocellular Carcinomas using CRISPR Screening

  2019cites this paper
• The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning

  2018cites this paper
• Critical genomic regulation mediated by Enhancer of Polycomb

  2018cites this paper
• Systematic characterisation of temporal and fate asymmetries and its regulation during Caenorhabditis elegans Embryogensis /Ho Vincy Wing Sze.

  2017influential citation
• The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF‐16/FOXO transcription factors

  2017cites this paper
• Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes

  2017cites this paper
• Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development

  2017cites this paper
• An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in C. elegans males

  2016cites this paper
• Roles for the Histone Modifying and Exchange Complex NuA4 in Cell Cycle Progression in Drosophila melanogaster

  2016cites this paper
• GENETIC DISSECTION OF FACTORS THAT PROMOTE GENOME STABILITY IN THE CAENORHABDITIS ELEGANS GERM LINE

  2016cites this paper
• Cell fate determination

  2016cites this paper
• X Chromosome Crossover Formation and Genome Stability in Caenorhabditis elegans Are Independently Regulated by xnd-1

  2016cites this paper
• Condensin and Chromatin Mediated X Chromosome Architecture in Caenorhabditis elegans.

  2016cites this paper
• MOLECULAR GENETIC STUDY OF REPRODUCTIVE SYSTEM DEVELOPMENT IN THE NEMATODE CAENORHABDITIS BRIGGSAE

  2016cites this paper
• Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry

  2015cites this paper
• The DREAM complex promotes gene body H2A.Z for target repression

  2015cites this paper
• Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation

  2014cites this paper
• Characterizing the Role of Gds1p in the Saccharomyces cerevisiae Environmental Stress Response

  2014influential citation
• HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans

  2014cites this paper
• SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.

  2014cites this paper
• Dependence of the Sperm/Oocyte Decision on the Nucleosome Remodeling Factor Complex Was Acquired during Recent Caenorhabditis briggsae Evolution

  2014cites this paper
• during Wing Development Has Multiple Roles in Notch Signaling SAGA and Tip60 Complexes, Drosophilathe Tra1/TRRAP Subunit of the

  2014cites this paper
• Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

  2013cites this paper
• Development-Specific Differences in the Proteomics of Angiostrongylus cantonensis

  2013cites this paper
• Canonical RTK-Ras-ERK signaling and related alternative pathways

  2013cites this paper
• through modulation of pRB/E2F cell cycle target genes The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation

  2013cites this paper
• Transcriptional regulation of gene expression in C. elegans.

  2013cites this paper
• Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi

  2013cites this paper
• Enzymatic Mechanisms and Chemical Probes of the Myst Family of Histone Acetyltransferases

  2013cites this paper
• Evolutionary Change within a Bipotential Switch Shaped the Sperm/Oocyte Decision in Hermaphroditic Nematodes

  2013influential citation
• Biology and Mechanisms of Short RNAs in Caenorhabditis elegans.

  2013cites this paper
• Tip 60 and p 400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression

  2013cites this paper
• The DREAM complex: master coordinator of cell cycle-dependent gene expression

  2013cites this paper
• Role of Pleiotropy in the Evolution of a Cryptic Developmental Variation in Caenorhabditis elegans

  2012cites this paper
• Function of the Active Site Lysine Autoacetylation in Tip60 Catalysis

  2012cites this paper
• A Network of Genes Antagonistic to the LIN-35 Retinoblastoma Protein of Caenorhabditis elegans

  2012cites this paper
• Developmental Biology: Frontiers for Clinical Genetics

  2012cites this paper
• Kinetic mechanism and inhibitory study of protein arginine methyltransferase 1

  2012cites this paper
• New insights into the SAGA complex from studies of the Tra1 subunit in budding and fission yeast

  2012cites this paper
• The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

  2011cites this paper
• DNA damage during meiosis induces chromatin remodeling and synaptonemal complex disassembly.

  2011cites this paper
• Opposing oncogenic activities of small DNA tumor virus transforming proteins.

  2011cites this paper
• The multifaceted proteins Reptin and Pontin as major players in cancer.

  2011cites this paper
• SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria.

  2011cites this paper
• The LIN-15A and LIN-56 Transcriptional Regulators Interact to Negatively Regulate EGF/Ras Signaling in Caenorhabditis elegans Vulval Cell-Fate Determination

  2011cites this paper
• Histone H4 Acetylation Differentially Modulates Arginine Methylation by an in Cis Mechanism*

  2011cites this paper
• Development of Inhibitors and Assay Methods for Histone Acetyltransferases

  2011cites this paper
• Epigenetics in C. elegans: Facts and challenges

  2011cites this paper
• xnd-1 Regulates the Global Recombination Landscape in C. elegans

  2010cites this paper
• The E1A-Associated p400 Protein Modulates Cell Fate Decisions by the Regulation of ROS Homeostasis

  2010cites this paper
• Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans

  2010cites this paper
• Rôle de l'histone acétyltransférase Tip60 et son partenaire, l'ATPase p400, dans la tumorigénèse colorectale et le contrôle du devenir cellulaire

  2010cites this paper
• Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling.

  2010cites this paper
• The histone demethylase UTX enables RB-dependent cell fate control.

  2010cites this paper
• Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60

  2010influential citation
• Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity

  2010cites this paper
• Maintenance of Neuronal Laterality in Caenorhabditis elegans Through MYST Histone Acetyltransferase Complex Components LSY-12, LSY-13 and LIN-49

  2010cites this paper
• Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.

  2009cites this paper
• A Mechanistic Basis for the Coordinated Regulation of Pharyngeal Morphogenesis in Caenorhabditis elegans by LIN-35/Rb and UBC-18–ARI-1

  2009cites this paper
• MYST family histone acetyltransferases take center stage in stem cells and development

  2009cites this paper
• HPL-2/HP1 Prevents Inappropriate Vulval Induction in Caenorhabditis elegans by Acting in Both HYP7 and Vulval Precursor Cells

  2009cites this paper
• NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components.

  2009cites this paper
• The genetics of the sexually dimorphic deaths of the C. elegans CEM neutrons

  2009cites this paper
• Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.

  2009cites this paper
• TRA-1/GLI controls the expression of the Hox gene lin-39 during C. elegans vulval development.

  2009cites this paper
• Structure-Function Analysis of the THAP Zinc Finger of THAP1, a Large C2CH DNA-binding Module Linked to Rb/E2F Pathways*

  2008cites this paper
• The Caenorhabditis elegans ekl (Enhancer of ksr-1 Lethality) Genes Include Putative Components of a Germline Small RNA Pathway

  2008cites this paper
• Eaf1 Is the Platform for NuA4 Molecular Assembly That Evolutionarily Links Chromatin Acetylation to ATP-Dependent Exchange of Histone H2A Variants

  2008influential citation
• Conserved functions of the pRB and E2F families

  2008cites this paper
• Multiple Levels of Redundant Processes Inhibit Caenorhabditis elegans Vulval Cell Fates

  2008cites this paper
• Histone acetylation and chromatin signature in stem cell identity and cancer.

  2008cites this paper
• Coordinated Regulation of Intestinal Functions in C. elegans by LIN-35/Rb and SLR-2

  2008cites this paper
• The Genomic Distribution and Function of Histone Variant HTZ-1 during C. elegans Embryogenesis

  2008cites this paper
• TOWARDS UNDERSTANDING THE MECHANISMS OF EPIGENETIC REGULATION: PART 1. AN EVOLUTIONAL INSIGHT INTO PCG-MEDIATED GENE REPRESSION

  2008cites this paper
• The conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana.

  2007influential citation
• The Cloning and Characterization of the Histone Acetyltransferase Human Homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 Is Essential for Multicellular Development

  2007cites this paper
• Orchestration of chromatin-based processes: mind the TRRAP

  2007cites this paper
• Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with Always early

  2007cites this paper
• MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

  2007cites this paper
• The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes.

  2007cites this paper
• The genes coding for the MYST family histone acetyltransferases, Tip60 and Mof, are expressed at high levels during sperm development.

  2007cites this paper
• C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions

  2007cites this paper
• Critical role of the p400/mDomino chromatin‐remodeling ATPase in embryonic hematopoiesis

  2007cites this paper
• The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.

  2007cites this paper
• Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation.

  2007cites this paper
• The SynMuv genes of Caenorhabditis elegans in vulval development and beyond.

  2007influential citation
• Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

  2007cites this paper
• LIN-61, One of Two Caenorhabditis elegans Malignant-Brain-Tumor-Repeat-Containing Proteins, Acts With the DRM and NuRD-Like Protein Complexes in Vulval Development but Not in Certain Other Biological Processes

  2007cites this paper
• THAP1, un régulateur clé de la prolifération des cellules endothéliales : relations structure/fonction et gènes ciblés

  2007cites this paper
• Metabolism, cytoskeleton and cellular signalling in the grip of protein Nϵ ‐ and O‐acetylation

  2007cites this paper
• Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development

  2007cites this paper
• The meiotic pattern and chromatin structure in Caenorhabditis elegans

  2007cites this paper
• DPL-1 DP, LIN-35 Rb and EFL-1 E2F Act With the MCD-1 Zinc-Finger Protein to Promote Programmed Cell Death in Caenorhabditis elegans

  2007cites this paper