The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular and Cellular Biology

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.23.22.8306-8315.2003PMID 14585987PMCID PMC262371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The mismatch repair system is required for S-phase checkpoint activation

  2003cited by this paper
• Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity.

  2003cited by this paper
• Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific.

  2002cited by this paper
• Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-κB through an AKT/P70S6K/p38-MAPK pathway

  2002cited by this paper
• ATM Is Activated in Response toN-Methyl-N′-nitro- N-nitrosoguanidine-induced DNA Alkylation*

  2002cited by this paper
• Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38

  2002cited by this paper
• DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes

  2002cited by this paper
• Activation of Akt/Protein Kinase B Overcomes a G2/M Cell Cycle Checkpoint Induced by DNA Damage

  2002cited by this paper
• Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

  2001cited by this paper
• Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

  2001cited by this paper
• Functional interactions and signaling properties of mammalian DNA mismatch repair proteins

  2001cited by this paper
• p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

  2001cited by this paper
• Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.

  2001influential reference
• Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest

  2000cited by this paper
• Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents.

  2000cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors

  2000cited by this paper
• Temozolomide in malignant gliomas.

  2000cited by this paper
• Future directions in the treatment of malignant gliomas with temozolomide.

  2000cited by this paper
• Cell cycle regulation by the Cdc25 phosphatase family.

  2000influential reference
• Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

  2000cited by this paper
• Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene

  2000cited by this paper
• The Pyridinyl Imidazole Inhibitor SB203580 Blocks Phosphoinositide-dependent Protein Kinase Activity, Protein Kinase B Phosphorylation, and Retinoblastoma Hyperphosphorylation in Interleukin-2-stimulated T Cells Independently of p38 Mitogen-activated Protein Kinase*

  2000cited by this paper
• The p38 signal transduction pathway: activation and function.

  2000cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  2000influential reference
• Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

  1999cited by this paper
• 14-3-3σ is required to prevent mitotic catastrophe after DNA damage

  1999cited by this paper
• Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

  1999cited by this paper
• 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.

  1999cited by this paper
• p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials.

  1999influential reference
• Tetrazepinones Are Equally Cytotoxic to Mer 1 and Mer 2 Human Tumor Cell Lines

  1999cited by this paper
• O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics.

  1998cited by this paper
• Involvement of the mismatch repair system in temozolomide-induced apoptosis.

  1998cited by this paper
• Microsatellite instability and mutation of DNA mismatch repair genes in gliomas.

  1998cited by this paper
• Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6*

  1998cited by this paper
• Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

  1997influential reference
• Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells.

  1997cited by this paper
• Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

  1997influential reference
• Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

  1996cited by this paper
• Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase (*)

  1996cited by this paper
• Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

  1995cited by this paper
• DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

  1995cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.

  1995cited by this paper
• Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

  1995cited by this paper
• Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients.

  1995cited by this paper
• NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.

  1994cited by this paper
• Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

  1994cited by this paper
• Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

  1993cited by this paper
• An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

  1993cited by this paper
• Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.

  1992influential reference
• Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

  1990cited by this paper
• Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

  1987cited by this paper
• Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

  1986influential reference
• Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

  1983cited by this paper
• Mismatch correction at O6-methylguanine residues in E. coli DNA

  1982cited by this paper
• HARD AND SOFT ACIDS AND BASES

  1963cited by this paper
• For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group. Review Temozolomide for Brain Tumours Current and Future Developments in the Use of Temozolomide for the Treatment of Brain Tumours

  year unknowncited by this paper

• The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G2-Checkpoint Activation in Cells Exposed to Ionizing Radiation

  2023influential citation
• Review: therapeutic approaches for circadian modulation of the glioma microenvironment

  2023cites this paper
• Role of p38 MAP kinase in cancer stem cells and metastasis

  2022cites this paper
• ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer.

  2022cites this paper
• Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways

  2021cites this paper
• ROS and oncogenesis with special reference to EMT and stemness.

  2020cites this paper
• Withdrawn: In vitro single‐strand DNA damage and cancer cell cytotoxicity of temozolomide

  2019cites this paper
• Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant p53 Glioblastoma Cells

  2019cites this paper
• Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa

  2019cites this paper
• Aberrant Transcriptional Regulation of Super-enhancers by RET Finger Protein-histone Deacetylase 1 Complex in Glioblastoma: Chemoresistance to Temozolomide

  2019cites this paper
• Role of Metformin and AKT Axis Modulation in the Reversion of Hypoxia Induced TMZ-Resistance in Glioma Cells

  2019cites this paper
• The G2 phase arrest induced by sterigmatocystin is dependent on hMLH1- ERK/p38-p53 pathway in human esophageal epithelium cells in vitro.

  2018cites this paper
• Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots.

  2018cites this paper
• In vitro single-strand DNA damage and cancer cell cytotoxicity effects of Temozolomide

  2017cites this paper
• High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response

  2017cites this paper
• Three Combined Treatments, a Novel HDAC Inhibitor OBP-801/YM753, 5-Fluorouracil, and Paclitaxel, Induce G₂ Phase Arrest Through the p38 Pathway in Human Ovarian Cancer Cells.

  2017cites this paper
• Cell cycle arrest of glioma cells in response to temozolomide

  2017cites this paper
• Synthesis and biological evaluation of glycosides containing triazene-chalcones

  2017cites this paper
• Title MGMT promoter methylation and temozolomide response in choroidplexus carcinoma

  2017cites this paper
• Mismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells

  2017cites this paper
• Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas

  2016cites this paper
• PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud

  2016cites this paper
• Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.

  2016cites this paper
• Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM

  2015cites this paper
• Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.

  2015cites this paper
• Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data

  2015cites this paper
• Targeting glioblastoma cancer stem cells: the next great hope?

  2014cites this paper
• Inhibition of JNK potentiates temozolomide-induced cytotoxicity in U87MG glioblastoma cells via suppression of Akt phosphorylation.

  2014cites this paper
• The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses

  2014cites this paper
• Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

  2014cites this paper
• High expression of the mismatch repair protein MSH6 is associated with poor patient survival in melanoma.

  2014cites this paper
• Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation, and Cell Cycle: Role and Targeting

  2014cites this paper
• Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and mitochondrial dysfunction in hepatoblastoma cancer (HepG2) cells

  2014cites this paper
• Interleukins in glioblastoma pathophysiology: implications for therapy

  2013cites this paper
• Influence of DNA Repair on Nonlinear Dose-Responses for Mutation

  2013cites this paper
• Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

  2013cites this paper
• Triazene compounds in the treatment of acute myeloid leukemia: a short review and a case report.

  2013cites this paper
• Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage

  2013cites this paper
• Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival

  2013cites this paper
• Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation

  2012cites this paper
• NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

  2012cites this paper
• Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy.

  2012cites this paper
• Defective DNA Mismatch Repair-dependent c-Abl-p73-GADD45α Expression Confers Cancer Chemoresistance

  2012cites this paper
• Polyphenolic extract isolated from Korean Lonicera japonica Thunb. induce G2/M cell cycle arrest and apoptosis in HepG2 cells: involvements of PI3K/Akt and MAPKs.

  2012cites this paper
• Assessment of Missense Alterations in MLH1 and their Pathogenic Significance

  2012cites this paper
• Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells

  2011cites this paper
• Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

  2011cites this paper
• The combi-targeting concept: mechanism of action of the pleiotropic combi-molecule RB24 and discovery of a novel cell signaling-based combination principle.

  2011cites this paper
• A Novel Function of p38-Regulated/Activated Kinase in Endothelial Cell Migration and Tumor Angiogenesis

  2011cites this paper
• Morphological Analysis of CDC2 and Glycogen Synthase Kinase 3β Phosphorylation as Markers of G2 → M Transition in Glioma

  2011cites this paper
• Prognostic value of H-MLH1 after adjusting for RPA class in GBM patients.

  2011cites this paper
• Implication de la voie ERK3/4-MK5 dans la phase G2/M du cycle cellulaire

  2011cites this paper
• Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution

  2011cites this paper
• Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells

  2011cites this paper
• Involvement of mismatch repair proteins in adaptive responses induced by N-methyl-N'-nitro-N-nitrosoguanidine against γ-induced genotoxicity in human cells.

  2011cites this paper
• Evaluation of Mismatch Repair Gene Polymorphisms and their Contribution to Colorectal Cancer and its Subsets

  2011cites this paper
• Biological Responses of Glioma Cell to Chemotherapeutic Agents

  2011cites this paper
• MGMT promoter methylation and temozolomide response in choroid plexus carcinoma

  2011cites this paper
• Clinically Relevant Doses of Chemotherapy Drugs Selectively and Reversibly Block Glioblastoma Neurosphere Proliferation in vitro: A Dissertation

  2010cites this paper
• Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta.

  2010cites this paper
• DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data.

  2010cites this paper
• DNA mismatch repair and the transition to hormone independence in breast and prostate cancer.

  2010cites this paper
• Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells.

  2010cites this paper
• Influence of Cell Cycle Checkpoints and p53 Function on the Toxicity of Temozolomide in Human Pancreatic Cancer Cells

  2010cites this paper
• Development of lentiviral vectors targeted to P38MAPK inhibition and Akt activation in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

  2010cites this paper
• The potential and limitations of p38MAPK as a drug target for the treatment of hematological malignancies.

  2010cites this paper
• p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage

  2010cites this paper
• Activin A induction of erythroid differentiation through MKK6‐p38α/p38β pathway is inhibited by follistatin

  2010cites this paper
• Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells

  2009influential citation
• Recognition of O6MeG Lesions by MGMT and Mismatch Repair Proficiency may be a Prerequisite for Low-Dose Radiation Hypersensitivity

  2009cites this paper
• Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry

  2009cites this paper
• A New Isoquinolinium Derivative, Cadein1, Preferentially Induces Apoptosis in p53-defective Cancer Cells with Functional Mismatch Repair via a p38-dependent Pathway*

  2009cites this paper
• Recent approaches to improve the antitumor efficacy of temozolomide.

  2009cites this paper
• DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment.

  2009cites this paper
• Cell Cycle Effects and Increased Adduct Formation by Temozolomide Enhance the Effect of Cytotoxic and Targeted Agents in Lung Cancer Cell Lines

  2009cites this paper
• Mechanism of 2‐methoxyestradiol‐induced apoptosis and growth arrest in human breast cancer cells

  2009cites this paper
• A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest.

  2009cites this paper
• Mismatch Repair Protein Deficiency Compromises Cisplatin-induced Apoptotic Signaling*

  2009cites this paper
• Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

  2009cites this paper
• Mismatch repair protein-dependent cytotoxic signaling in cells treated with the cancer chemotherapeutic cisplatin

  2009influential citation
• Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy

  2009cites this paper
• Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them

  2008cites this paper
• The p38 MAPK stress pathway as a tumor suppressor or more?

  2008cites this paper
• Implicaciones de los genes reparadores hMLH1 y hMSH2 en el carcinoma de células renales esporádico

  2008cites this paper
• Characterization of a side population of astrocytoma cells in response to temozolomide.

  2008cites this paper
• DNA Mismatch Repair-dependent Activation of c-Abl/p73α/GADD45α-mediated Apoptosis*

  2008cites this paper
• Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.

  2008cites this paper
• AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition

  2008cites this paper
• Role of c-Abl Kinase in DNA Mismatch Repair-dependent G2 Cell Cycle Checkpoint Arrest Responses*

  2008cites this paper
• TMZ-BioShuttle – a reformulated Temozolomide

  2008cites this paper
• Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

  2008cites this paper
• [Molecular pharmacology on DNA methylating agent temozolomide].

  2007cites this paper
• Triazene compounds: mechanism of action and related DNA repair systems.

  2007cites this paper
• Mismatch repair (MMR) efficiency and MSH2 gene mutation in human colorectal carcinoma cell line COLO320HSR

  2007cites this paper
• Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.

  2007cites this paper
• MLH1- and ATM-dependent MAPK Signaling Is Activated through c-Abl in Response to the Alkylator N-Methyl-N′-nitro-N′-nitrosoguanidine*

  2007cites this paper
• Contribution of Notch signaling activation to human glioblastoma multiforme.

  2007cites this paper
• Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite

  2007cites this paper
• The pathways to tumor suppression via route p38.

  2007cites this paper
• Non-tumor cells from an MSH2-null individual show altered cell cycle effects post-UVB.

  2007cites this paper