Epigenetic modifications of caveolae associated proteins in health and disease

Caveolae are small, “omega-shaped” invaginations at the plasma membrane of the cell which are involved in a variety of processes including cholesterol transport, potocytosis and cell signalling. Within caveolae there are caveolae-associated proteins, and changes in expression of these molecules have been described to play a role in the pathophysiology of various diseases including cancer and cardiovascular disease. Evidence is beginning to accumulate that epigenetic processes may regulate the expression of these caveolae related genes, and hence contribute to disease progression. Here, we summarize the current knowledge of the role of epigenetic modification in regulating the expression of these caveolae related genes and how this relates to changes in cellular physiology and in health and disease.

• Publication year

  2015

• Venue

  BMC Genetics

• Publication date

  2015-06-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s12863-015-0231-yPMID 26112043PMCID 4482180
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers

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• Emerging role of polymerase-1 and transcript release factor (PTRF/ Cavin-1) in health and disease

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• Arterial Dysfunction but Maintained Systemic Blood Pressure in Cavin-1-Deficient Mice

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• MicroRNA-199a-5p Affects Porcine Preadipocyte Proliferation and Differentiation

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  2013cited by this paper
• MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway.

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• MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidney epithelial PK15 cells

  2013influential reference
• Cavin1; a Regulator of Lung Function and Macrophage Phenotype

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• Caveolae as plasma membrane sensors, protectors and organizers

  2013cited by this paper
• Methylation profiling defines an extensive field defect in histologically normal prostate tissues associated with prostate cancer.

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• miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

  2013influential reference
• Intestinal Salmonella typhimurium Infection Leads to miR-29a Induced Caveolin 2 Regulation

  2013influential reference
• Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription.

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• CpG island shore methylation regulates caveolin-1 expression in breast cancer

  2012cited by this paper
• Hepatitis B virus X protein suppresses caveolin-1 expression in hepatocellular carcinoma by regulating DNA methylation

  2012cited by this paper
• 5'-CpG island promoter hypermethylation of the CAV-1 gene in breast cancer patients of Kashmir.

  2012cited by this paper
• Down‐regulation of the cavin family proteins in breast cancer

  2012cited by this paper
• Cavin proteins: New players in the caveolae field.

  2011cited by this paper
• MicroRNAs 103 and 107 regulate insulin sensitivity

  2011influential reference
• MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1.

  2011influential reference
• MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2

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• Epigenetics: methylation‐associated repression of heparan sulfate 3‐O‐sulfotransferase gene expression contributes to the invasive phenotype of H‐EMC‐SS chondrosarcoma cells

  2010cited by this paper
• DNA methylation and cellular reprogramming.

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• Changes in caveolae, caveolin, and polymerase 1 and transcript release factor (PTRF) expression in prostate cancer progression

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• DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker

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• SRBC/cavin‐3 is a caveolin adapter protein that regulates caveolae function

  2009influential reference
• SDPR induces membrane curvature and functions in the formation of caveolae

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• DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker.

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• Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.

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• The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members

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• MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.

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• PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function.

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• Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

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• Caveolin-1 in tumor progression: the good, the bad and the ugly

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• A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization*

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• Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.

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• Expression changes of CAV1 and EZH2, located on 7q31 approximately q36, are rarely related to genomic alterations in primary prostate carcinoma.

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• Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

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• Methylation Status of Genes Upregulated by Demethylating Agent 5-aza-2′-Deoxycytidine in Hepatocellular Carcinoma

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• Lipid rafts in health and disease

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• The multiple faces of caveolae

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• Mechanisms of microRNA‐mediated gene regulation

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• High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.

  2007cited by this paper
• Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements.

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• Hepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53.

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• Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer

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• Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells.

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• Diagnostic and therapeutic applications of epigenetics.

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• MicroRNA gene expression deregulation in human breast cancer.

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• Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle.

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• Getting rid of caveolins: phenotypes of caveolin-deficient animals.

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• Combinatorial microRNA target predictions

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• CpG island methylator phenotype in cancer

  2004cited by this paper
• Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers.

  2004cited by this paper
• Galectin-3 and metastasis

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• Role of caveolae and caveolins in health and disease.

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• Different Roles for Caveolin-1 in the Development of Non-Small Cell Lung Cancer versus Small Cell Lung Cancer

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• Caveolin-1 deficiency stimulates neointima formation during vascular injury.

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• Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy

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  2003cited by this paper
• Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3.

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• Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms.

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• Histone deacetylases: silencers for hire.

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• Sequence and detailed organization of the human caveolin‐1 and ‐2 genes located near the D7S522 locus (7q31.1)

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• Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse

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• Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells.

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• Mutational analysis of caveolin‐induced vesicle formation

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• Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes

  1998cited by this paper
• Targeting of Protein Kinase Cα to Caveolae

  1998cited by this paper
• Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

  1996cited by this paper
• Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle (*)

  1996influential reference
• Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

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• Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

  1995influential reference
• De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

  1995cited by this paper

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• Pervasive role of the long noncoding RNA DNM3OS in development and diseases

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• Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

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• Progress and prospects of mechanotransducers in shear stress-sensitive signaling pathways in association with arteriovenous malformation.

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• Role of caveolin-1 in human organ function and disease: friend or foe?

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• Altered protein profile of plasma extracellular vesicles in oral squamous cell carcinoma development.

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• Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer

  2020cites this paper
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  2017cites this paper
• A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal

  2017cites this paper
• Versatile Functions of Caveolin-1 in Aging-related Diseases

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• Caveolin proteins: a molecular insight into disease

  2016cites this paper
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  2016cites this paper