Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites

Cortical computations are critically dependent on interactions between pyramidal neurons (PNs) and a menagerie of inhibitory interneuron types. A key feature distinguishing interneuron types is the spatial distribution of their synaptic contacts onto PNs, but the location-dependent effects of inhibition are mostly unknown, especially under conditions involving active dendritic responses. We studied the effect of somatic vs. dendritic inhibition on local spike generation in basal dendrites of layer 5 PNs both in neocortical slices and in simple and detailed compartmental models, with equivalent results: somatic inhibition divisively suppressed the amplitude of dendritic spikes recorded at the soma while minimally affecting dendritic spike thresholds. In contrast, distal dendritic inhibition raised dendritic spike thresholds while minimally affecting their amplitudes. On-the-path dendritic inhibition modulated both the gain and threshold of dendritic spikes depending on its distance from the spike initiation zone. Our findings suggest that cortical circuits could assign different mixtures of gain vs. threshold inhibition to different neural pathways, and thus tailor their local computations, by managing their relative activation of soma- vs. dendrite-targeting interneurons.

• Publication year

  2012

• Venue

  PLoS Comput. Biol.

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1371/journal.pcbi.1002550PMID 22719240PMCID 3375251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• The reported effects were reproduced in neocortical slice experiments and in both simple and detailed compartmental models.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• On-the-path dendritic inhibition modulated both dendritic-spike gain and threshold depending on its distance from the spike initiation zone.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• Distal dendritic inhibition raised dendritic spike thresholds while minimally affecting their amplitudes.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• Somatic inhibition divisively suppressed the amplitude of dendritic spikes recorded at the soma while minimally affecting dendritic spike thresholds.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review

• compartmental models

  modeling approach

  Multi-compartment neuron models used to simulate dendritic and somatic electrical behavior.

  Aliases: simple compartmental model, detailed compartmental model

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• dendritic spikes

  neural event

  Local regenerative electrical events that originate in a neuron’s dendrites.

  Aliases: dendritic spike

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• distal dendritic inhibition

  synaptic input

  Inhibitory synaptic input delivered to a dendritic location far from the soma.

  Aliases: distal dendritic input

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• neocortical slices

  experimental preparation

  Ex vivo cortical tissue preparations used for electrophysiological experiments.

  Aliases: cortical slices

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• on-the-path dendritic inhibition

  synaptic input

  Inhibitory input placed along the dendritic route between a spike initiation site and the soma.

  Aliases: intervening dendritic inhibition

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• somatic inhibition

  synaptic input

  Inhibitory synaptic input directed to the soma of a pyramidal neuron.

  Aliases: soma-targeting inhibition

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review
• spike initiation zone

  cellular structure

  The dendritic location where a local spike is first generated before propagating.

  Aliases: initiation zone

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewAnonymous (b2adb6bfad) review

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