Pharmacotherapeutic targets in Alzheimer's disease

Yif'at Biran,C. Masters,K. Barnham,A. Bush,P. Adlard

Published 2008 in Journal of Cellular and Molecular Medicine

ABSTRACT

•  Current pharmacotherapies for the treatment of AD •  AD pharmacotherapies targeting τ ‐  Modulators of – kinases or phosphatases ‐  τ aggregation inhibitors (TAIs) •  AD pharmacotherapies targeting Aβ ‐  Inhibitors and/or modulators of the secretases ‐  Aβ aggregation inhibitors ‐  Passive or active immunization •  The metal hypothesis of AD •  AD pharmacotherapies targeting metal ions ‐  Antioxidants ‐  Metal chelators ‐  Metal complexes ‐  Metal‐protein attenuating compounds

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