Studying signal transduction in neuronal cells: the Trk/NGF system.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Progress in Brain Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0079-6123(08)64005-4PMID 9932398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain-Derived Neurotrophic Factor and Neurotrophin-3 in Cultures of Embryonic Rat Cortical Neurons

  2006cited by this paper
• The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death

  1998cited by this paper
• NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis

  1997cited by this paper
• Signal transduction by the neutrophin receptors

  1997cited by this paper
• Signal transduction by the neurotrophin receptors.

  1997cited by this paper
• Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor*

  1997cited by this paper
• p53 associates with trk tyrosine kinase

  1997cited by this paper
• Signalling through the neurotrophin receptor p75NTR.

  1997cited by this paper
• Neurotrophins live or let die: does p75NTR decide?

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns.

  1997cited by this paper
• Viral vectors for modulating gene expression in neurons.

  1996cited by this paper
• Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells

  1996cited by this paper
• Differential Utilization of Trk Autophosphorylation Sites*

  1996cited by this paper
• Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

  1996cited by this paper
• Intracellular signaling pathways activated by neurotrophic factors.

  1996cited by this paper
• Raf, but Not MEK or ERK, Is Sufficient for Differentiation of Hippocampal Neuronal Cells

  1996cited by this paper
• Developmental and mature expression of full‐length and truncated TrkB, receptors in the rat forebrain

  1996cited by this paper
• Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity.

  1996cited by this paper
• Neurotrophins Induce Sphingomyelin Hydrolysis

  1995cited by this paper
• Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation

  1995cited by this paper
• Neutralizing Anti‐p21ras Fabs Suppress Rat Sympathetic Neuron Survival Induced by NGF, LIF, CNTF and cAMP

  1995cited by this paper
• Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

  1995cited by this paper
• Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.

  1995cited by this paper
• p75 and Trk: a two-receptor system.

  1995cited by this paper
• Constitutive Overexpression of CDK2 Inhibits Neuronal Differentiation of Rat Pheochromocytoma PC12 Cells (*)

  1995cited by this paper
• NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

  1995cited by this paper
• Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor (*)

  1995cited by this paper
• TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells

  1995cited by this paper
• Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*)

  1995cited by this paper
• Protein modules and signalling networks

  1995cited by this paper
• Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis.

  1995cited by this paper
• Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

  1995cited by this paper
• Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells (*)

  1995cited by this paper
• Early events in neurotrophin signalling via Trk and p75 receptors.

  1995cited by this paper
• A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.

  1995cited by this paper
• NGF-stimulated retrograde transport of trkA in the mammalian nervous system

  1995cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells.

  1995cited by this paper
• Induction of neurite outgrowth by MAP kinase in PC12 cells.

  1995cited by this paper
• Calcium influx induces neurite growth through a Src-Ras signaling cassette.

  1995cited by this paper
• Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.

  1994cited by this paper
• Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.

  1994cited by this paper
• Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

  1994cited by this paper
• Neurotrophin signal transduction by the Trk receptor.

  1994cited by this paper
• Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

  1994cited by this paper
• Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.

  1994cited by this paper
• Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

  1994cited by this paper
• Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

  1994cited by this paper
• Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.

  1994cited by this paper
• Expression and function of TRK-B and BDNF in human neuroblastomas

  1994cited by this paper
• Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo

  1993cited by this paper
• Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

  1993cited by this paper
• The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

  1993cited by this paper
• Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Eukaryotic Signal Transduction Group.

  1993cited by this paper
• Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma.

  1993cited by this paper
• Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture

  1993cited by this paper
• A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions

  1993cited by this paper
• Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation.

  1992cited by this paper
• Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases.

  1992cited by this paper
• ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK.

  1992cited by this paper
• Nerve growth factor mediates signal transduction through trk homodimer receptors.

  1992cited by this paper
• Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.

  1992cited by this paper
• Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions

  1991cited by this paper
• The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.

  1991cited by this paper
• Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

  1991cited by this paper
• The trk proto-oncogene encodes a receptor for nerve growth factor.

  1991cited by this paper
• A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

  1986cited by this paper
• PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor

  1986cited by this paper
• Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

  1986cited by this paper
• Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

  1985cited by this paper
• Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation.

  1985cited by this paper
• Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

  1976cited by this paper

• SIK2: A novel negative feedback regulator of FGF signaling

  2023cites this paper
• Disentangling the signaling complexity of nerve growth factor receptors by CRISPR/Cas9

  2022cites this paper
• Anti-apoptotic effects of BDNF-TrkB signaling in the treatment of hemorrhagic stroke

  2020cites this paper
• Conductive polymer scaffolds to improve neural recovery

  2017cites this paper
• Mechanisms of cellular adaptation to quantum dots – the role of glutathione and transcription factor EB

  2012cites this paper
• Estudio del papel de las palmitoil-proteínas en la regeneración del sistema nervioso, la importancia de la palmitoilación y la ubicación en dominios lipídicos de la membrana en su función

  2011cites this paper
• Effect of NGF on the Subcellular Localization of Group IIA Secretory Phospholipase A2 (GIIA) in PC12 Cells: Role in Neuritogenesis

  2010cites this paper
• Transglutaminase 2 and NF-kappaB interplay during NGF-induced differentiation of neuroblastoma cells.

  2008cites this paper
• Characterization and use of the NSC‐34 cell line for study of neurotrophin receptor trafficking

  2008cites this paper
• Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones

  2007cites this paper
• A multiplexed proteomics approach to differentiate neurite outgrowth patterns.

  2006cites this paper
• Null mutations for exon III and exon IV of the p75 neurotrophin receptor gene enhance sympathetic sprouting in response to elevated levels of nerve growth factor in transgenic mice.

  2006cites this paper
• Comparison of target innervation by sympathetic axons in adult wild type and heterozygous mice for nerve growth factor or its receptor trkA

  2004cites this paper
• The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation

  2004cites this paper
• NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch.

  2004cites this paper
• Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP

  2003cites this paper
• Activation of the mitogen‐activated protein kinase pathway through p75NTR: A common mechanism for the neurotrophin family

  2003cites this paper
• Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor-induced neurite outgrowth in rats.

  2003cites this paper
• Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway.

  2002cites this paper
• Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells

  2002cites this paper
• Inosine stimulates axon growth in vitro and in the adult CNS.

  2002cites this paper
• Intrathecal administration of nerve growth factor delays GAP 43 expression and early phase regeneration of adult rat peripheral nerve.

  2002cites this paper
• Two separate domains in the golli myelin basic proteins are responsible for nuclear targeting and process extension in transfected cells

  2002cites this paper
• Islet-neogenesis-associated protein enhances neurite outgrowth from DRG neurons.

  2002cites this paper
• The Tyrosine Kinase GTK Signal Transduction and Biological Function BY

  2001cites this paper
• A purine-sensitive mechanism regulates the molecular program for axon growth

  2001cites this paper
• The Atypical Protein Kinase C-interacting Protein p62 Is a Scaffold for NF-κB Activation by Nerve Growth Factor*

  2001cites this paper
• Regulation of neurotrophin‐induced axonal responses via Rho GTPases

  2001cites this paper
• Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways.

  2001cites this paper
• Genetics of central nervous system developmental disorders.

  2001cites this paper
• Emerging roles for telomerase in neuronal development and apoptosis

  2001cites this paper
• The non‐peptidyl fungal metabolite L‐783,281 activates TRK neurotrophin receptors

  2001cites this paper
• Modulation of cholinergic marker expression by nerve growth factor in dorsal root ganglia

  2000cites this paper
• Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells

  2000cites this paper
• Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)

  2000cites this paper
• Activation of the Stat3 Signaling Pathway Is Required for Differentiation by Interleukin-6 in PC12-E2 Cells*

  2000cites this paper
• Detection of Protein Phosphorylation in Tissues and Cells

  2000cites this paper
• Region- and peptide-specific regulation of the neurotrophins by estrogen.

  2000cites this paper
• Signaling pathways mediating anti-apoptotic action of neurotrophins.

  2000influential citation
• Neurotrophine und aktivitätsabhängige synaptische Plastizität: Untersuchungen zum Ort und Mechanismus der regulierten Neurotrophin-Freisetzung in adenoviral transduzierten hippokampalen Primärkulturen

  2000cites this paper
• Regulation of Inner Ear Innervation by Neurotrophins

  1999cites this paper
• The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.

  1999cites this paper
• Neurotrophin signaling via Trks and p75.

  1999cites this paper