Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Journal of Cell Science

• Publication date

  1992-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 1506423
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Poleward microtubule flux mitotic spindles assembled in vitro

  1991cited by this paper
• Mitotic spindle assembly by two different pathways in vitro

  1991cited by this paper
• Two different microtubule-based motor activities with opposite polarities in kinetochores

  1991cited by this paper
• Mechanism of inhibition of cell proliferation by Vinca alkaloids.

  1991cited by this paper
• Quantitation of cellular tubulin in microtubules and tubulin pools by a competitive ELISA.

  1991influential reference
• Localization of cytoplasmic dynein to mitotic spindles and kinetochores

  1990cited by this paper
• Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

  1990cited by this paper
• Cytoplasmic dynein is localized to kinetochores during mitosis

  1990cited by this paper
• Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells

  1990cited by this paper
• Cell line-specific differences in the control of cell cycle progression in the absence of mitosis.

  1990cited by this paper
• Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.

  1990influential reference
• Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells

  1990cited by this paper
• Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly.

  1989cited by this paper
• p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

  1989cited by this paper
• Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence

  1989cited by this paper
• Dominoes and clocks: the union of two views of the cell cycle.

  1989cited by this paper
• The effect of podophyllotoxin on microtubule dynamics.

  1989cited by this paper
• The forces that move chromosomes in mitosis.

  1988cited by this paper
• Distribution of pericentriolar material in multipolar spindles induced by colcemid treatment in Chinese hamster ovary cells.

  1988cited by this paper
• Phase dynamics at microtubule ends: the coexistence of microtubule length changes and treadmilling

  1987cited by this paper
• Chinese hamster ovary cells.

  1987cited by this paper
• Redistribution of fluorescently labeled tubulin in the mitotic apparatus of sand dollar eggs and the effects of taxol.

  1987cited by this paper
• Kinetics and Steady State Dynamics of Tubulin Addition and Loss at Opposite Microtubule Ends: The Mechanism of Action of Colchicine a

  1986cited by this paper
• A radiolabeled monoclonal antibody binding assay for cytoskeletal tubulin in cultured cells

  1986influential reference
• Mitotic inhibition and aneuploidy induction by naturally occurring and synthetic estrogens in Chinese hamster cells in vitro.

  1986cited by this paper
• Sites of microtubule assembly and disassembly in the mitotic spindle.

  1986cited by this paper
• Taxol stabilization of microtubules in vitro: dynamics of tubulin addition and loss at opposite microtubule ends.

  1985cited by this paper
• Diethylstilboestrol: the binding and effects of diethylstilboestrol upon the polymerisation and depolymerisation of purified microtubule protein in vitro.

  1985cited by this paper
• Mitosis in eukaryotic cells: an overview of chromosome distribution.

  1985cited by this paper
• Tubulin dynamics in cultured mammalian cells

  1984cited by this paper
• Spindle microtubule dynamics in sea urchin embryos: analysis using a fluorescein-labeled tubulin and measurements of fluorescence redistribution after laser photobleaching

  1984cited by this paper
• Differential radiolabeling of opposite microtubule ends: methodology, equilibrium exchange-flux analysis, and drug poisoning.

  1983cited by this paper
• Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material.

  1983cited by this paper
• Interaction of vinblastine with steady-state microtubules in vitro.

  1982cited by this paper
• Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle

  1981cited by this paper
• Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor nocodazole. Nocodazole accumulated mitotic cells.

  1980cited by this paper
• Test of four possible mechanisms for the temporal control of spindle and cytoplasmic microtubule assembly in HeLa cells.

  1980cited by this paper
• Taxol stabilizes microtubules in mouse fibroblast cells.

  1980cited by this paper
• Role of spindle microtubules in the control of cell cycle timing

  1979cited by this paper
• Promotion of microtubule assembly in vitro by taxol

  1979cited by this paper
• Letters to the EditorMICROTUBULES

  1978cited by this paper
• Interaction of oncodazole (R 17934), a new antitumoral drug, with rat brain tubulin.

  1976cited by this paper
• The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro.

  1976cited by this paper
• [Effects of temperature].

  1973cited by this paper
• Nondisjunction of chromosomes in a synchronized cell population initiated by reversal of Colcemid inhibition.

  1970cited by this paper
• MICROTUBULAR CRYSTALS IN MAMMALIAN CELLS

  1969cited by this paper
• Vinblastine and Griseofulvin Reversibly Disrupt the Living Mitotic Spindle

  1968cited by this paper
• THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS

  1968cited by this paper
• CHAPTER 18 – Some Macromolecular Characteristics of Synchronized HeLa Cells

  1966cited by this paper
• CHAPTER 17 – Effects of Temperature on the Mitotic Cycle of Normal and Synchronized Mammalian Cells

  1966cited by this paper

• WDR62 and CEP170 recruit MAPKBP1 for pericentriolar material cohesion and mitotic spindle formation

  2026cites this paper
• Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment

  2026cites this paper
• In Silico Study of Analysing the Capability of Vinblastine and Vincristine as Inhibitory Agents for Targeting the Cathepsin B Enzyme by Molecular Docking

  2025cites this paper
• Dynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression

  2025cites this paper
• Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans

  2025cites this paper
• Suspected vinca alkaloid toxicosis in a 9‐week‐old dachshund puppy due to ingestion of periwinkle bush ( Catharanthus spp., formerly Vinca spp.)

  2025cites this paper
• Sophoraflavanone G from Phit-Sanat (Sophora Exigua Craib) inhibits WT1 protein expression and induces cell cycle arrest and apoptosis in acute myeloid leukemia

  2025cites this paper
• Unveiling the anticancer power of vinca rosea leaves: A pharmacognostical and phytochemical approach

  2025cites this paper
• ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression.

  2025cites this paper
• Antitumor and immunomodulatory activities of diphyllin and its derivatives.

  2025cites this paper
• Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly

  2024cites this paper
• Knockdown of TFAP2E results in rapid G2/M transition in oral squamous cell carcinoma cells

  2024cites this paper
• The severity of meiotic aneuploidy is associated with altered morphokinetic variables of mouse oocyte maturation

  2024cites this paper
• Distinct Sub- to Superdiffuse Insulin Granule Transport Behaviors in β-Cells Are Strongly Affected by Granule Age.

  2024cites this paper
• Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

  2024cites this paper
• Ovatodiolide Regulating Hepatocellular Carcinoma Stemness Through SP1/MTDH/STAT3 Signaling Pathway.

  2024cites this paper
• Dual inhibition of topoisomerase II and microtubule of podophyllotoxin derivative 5p overcomes cancer multidrug resistance.

  2024cites this paper
• Environmentally dependent and independent control of 3D cell shape.

  2024cites this paper
• The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells

  2024cites this paper
• Vinorelbine Alters lncRNA Expression in Association with EGFR Mutational Status and Potentiates Tumor Progression Depending on NSCLC Cell Lines’ Genetic Profile

  2023cites this paper
• Quantitative analysis of peroxisome tracks using a Hidden Markov Model

  2023cites this paper
• Improving homology‐directed repair by small molecule agents for genetic engineering in unconventional yeast?—Learning from the engineering of mammalian systems

  2023cites this paper
• Cell-cycle arrest at the G1/S boundary enhances transient voltage-gated ion channel expression in human and insect cells

  2023cites this paper
• Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes†

  2023cites this paper
• Mitosis exit followed by death in interphase prevents the development of polyploid giant cancer cells

  2023cites this paper
• Biosynthesis, extraction, detection and pharmacological attributes of vinblastine and vincristine, two important chemotherapeutic alkaloids of Catharanthus roseus (L.) G. Don: A review

  2023cites this paper
• The medicinal panorama of benzimidazoles and their scaffolds as anticancer and antithrombotic agents: A review

  2023cites this paper
• An improved multicellular human organoid model for the study of chemical effects on palatal fusion

  2023cites this paper
• Orchestration of pluripotent stem cell genome reactivation during mitotic exit

  2023cites this paper
• Photodynamic therapy induced cell cycle arrest and cancer cell synchronization: review

  2023cites this paper
• Common Markers and Small Molecule Inhibitors in Golgi Studies.

  2023cites this paper
• Measuring the linear viscoelastic regime of MCF-7 cells with a monolayer rheometer in the presence of microtubule-active anti-cancer drugs at high concentrations

  2022cites this paper
• Anti-tumor pharmacology of natural products targeting mitosis

  2022cites this paper
• Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

  2022cites this paper
• Synchronizing Mammalian Cells for Mitotic Analysis of the Localization of Survivin.

  2022cites this paper
• Radiotherapy transiently reduces the sensitivity of cancer cells to lymphocyte cytotoxicity

  2022cites this paper
• The effect of cytoskeleton inhibitors on coccolith morphology in Coccolithus braarudii and Scyphosphaera apsteinii

  2022cites this paper
• Double cytoplast embryonic cloning improves in vitro but not in vivo development from mitotic pluripotent cells in cattle

  2022cites this paper
• O Risco Genético das Terapias do Câncer

  2022cites this paper
• Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

  2022cites this paper
• Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins

  2022cites this paper
• Saffron nephroprotective effects against medications and toxins: A review of preclinical data

  2022cites this paper
• Bcl-xL activity influences outcome of the mitotic arrest

  2022influential citation
• TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle

  2021cites this paper
• Self-Targeting of Carbon Dots into the Cell Nucleus: Diverse Mechanisms of Toxicity in NIH/3T3 and L929 Cells

  2021cites this paper
• Anti-Tumoral Effects of a (1H-Pyrrol-1-yl)Methyl-1H-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines

  2021cites this paper
• Anti-Tumoral Effects of A Benzimidazolyl Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines

  2021cites this paper
• Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells

  2021cites this paper
• LMBD1 protein participates in cell mitosis by regulating microtubule assembly.

  2021cites this paper
• Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB

  2021cites this paper
• Influenza A Viruses Enter Host Cells via Extracellular Ca2+ Influx-Involved Clathrin-Mediated Endocytosis.

  2021cites this paper
• Benzimidazole based hybrids against complex diseases: a catalogue of the SAR profile.

  2021cites this paper
• Understanding the Mechanistic Functioning of Bioactive Compounds in Medicinal Plants

  2021cites this paper
• Quantifying 3D cell-matrix interactions during mitosis and the effect of anticancer drugs on the interactions

  2021influential citation
• In Silico Drug Design and Molecular Docking Study of Some Related Structural Isomers of Nocodazole Analogues as Tubulin-Polymerization Inhibitors

  2020cites this paper
• Molecular determinants for α-tubulin methylation by SETD2

  2020cites this paper
• Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle

  2020cites this paper
• A combined prophylactic modality of podophyllotoxin and rutin alleviates radiation induced injuries to the lymphohematopoietic system of mice by modulating cytokines, cell cycle progression, and apoptosis

  2020cites this paper
• Rapid profiling of G2 phase to mitosis progression by flow cytometry in asynchronous cells

  2020cites this paper
• Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm.

  2020cites this paper
• Genetically encoded live-cell sensor for tyrosinated microtubules

  2020cites this paper
• A novel compound that disrupts mitotic spindle poles in human cells

  2020cites this paper
• Mouse Models and Tools for the in vivo Study of Neutrophils

  2020cites this paper
• Microtubule-targeting agents and their impact on cancer treatment.

  2020cites this paper
• Precision genetic cellular models identify therapies protective against endoplasmic reticulum stress

  2020cites this paper
• Genetically encoded live cell sensor for tyrosinated microtubules

  2020cites this paper
• Podophyllotoxin affects porcine oocyte maturation by inducing oxidative stress-mediated early apoptosis.

  2020cites this paper
• Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

  2020cites this paper
• Astral microtubules determine the final division axis of cells confined on anisotropic surface topography

  2020cites this paper
• A comparative analysis of methods to measure kinetochore-microtubule attachment stability.

  2020cites this paper
• Chromosomally unstable tumor cells specifically require KIF18A for proliferation

  2020cites this paper
• HSV-1 Infection in Keratinocyte Cell Lines Treated with Mitotic HSV-1 Infection in Keratinocyte Cell Lines Treated with Mitotic Inhibitors Inhibitors

  2020cites this paper
• A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

  2020cites this paper
• Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

  2019cites this paper
• CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis

  2019cites this paper
• Vitamin E-conjugated phosphopeptide inhibitor of the polo-box domain of polo-like kinase 1.

  2019cites this paper
• Upconverting Nanorockers for Intracellular Viscosity Measurements During Chemotherapy

  2019cites this paper
• The protective effects of saffron stigma alcoholic extract against vincristine sulfate drug-induced renal toxicity in rat

  2019cites this paper
• CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells

  2019cites this paper
• Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase

  2019cites this paper
• Inclusion of an extended treatment with recovery improves the results for the human peripheral blood lymphocyte micronucleus assay.

  2019cites this paper
• The mechanisms of the spindle assembly checkpoint and the mitotic cell death

  2019cites this paper
• The hepatoprotective and antioxidative effect of saffron stigma alcoholic extract against vincristine sulfate induced toxicity in rats

  2019cites this paper
• Tau Modulates VGluT1 Expression.

  2019cites this paper
• Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.

  2019cites this paper
• Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines.

  2019cites this paper
• Molecular design and anticancer activities of small-molecule monopolar spindle 1 inhibitors: A Medicinal chemistry perspective.

  2019cites this paper
• Investigating the effect of poly‐l‐lactic acid nanoparticles carrying hypericin on the flow‐biased diffusive motion of HeLa cell organelles

  2019cites this paper
• Naked Liquid Marbles: A Robust Three-Dimensional Low-Volume Cell-Culturing System.

  2019cites this paper
• The Evolution of Modern Medicine: Garden to Pill Box

  2019cites this paper
• Cytotoxic and genotoxic action of Tagetes patula flower methanol extract and patuletin using the Allium test

  2019cites this paper
• Intracellular localisation of platelet-activating factor during mammalian embryo development in vitro: a comparison of cattle, mouse and human.

  2019cites this paper
• AFM study: Cell cycle and probe geometry influences nanomechanical characterization of Panc1 cells.

  2019cites this paper
• Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration

  2019cites this paper
• Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents

  2019cites this paper
• Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore–microtubule dynamics

  2018cites this paper
• Exposure to podophyllotoxin inhibits oocyte meiosis by disturbing meiotic spindle formation

  2018cites this paper
• Plant-Derived Extracts and Compounds: An Alternative Therapy Against Breast Cancer

  2018cites this paper
• LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains

  2018cites this paper
• Large-Scale Analysis of Microtubule Pharmacology via Phosphoproteomics and High-Content Imaging

  2018cites this paper