Functional Analysis of the Mouse Scn8a Sodium Channel

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Neuroscience

• Publication date

  1998-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.18-16-06093.1998PMID 9698304PMCID PMC6793187
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional Analysis of the Rat I Sodium Channel inXenopus Oocytes

  1998influential reference
• The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons

  1998cited by this paper
• Functional Analysis of a Voltage‐Gated Sodium Channel and Its Splice Variant from Rat Dorsal Root Ganglia

  1998cited by this paper
• Sodium Channel Activation Gating Is Affected by Substitutions of Voltage Sensor Positive Charges in All Four Domains

  1997influential reference
• Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells.

  1997cited by this paper
• Ion channel mutations in mouse models of inherited neurological disease.

  1997cited by this paper
• Alternative Splicing of the Sodium Channel SCN8A Predicts a Truncated Two-domain Protein in Fetal Brain and Non-neuronal Cells*

  1997cited by this paper
• Persistent sodium currents through brain sodium channels induced by G protein betagamma subunits.

  1997cited by this paper
• Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

  1997influential reference
• Persistent Sodium Currents through Brain Sodium Channels Induced by G Protein βγ Subunits

  1997cited by this paper
• Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice.

  1997influential reference
• Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): Different expression patterns in developing rat nervous system

  1997cited by this paper
• Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.

  1997cited by this paper
• A Missense Mutation in the Sodium Channel Scn8a Is Responsible for Cerebellar Ataxia in the Mouse Mutant jolting

  1996cited by this paper
• Mutation Detection in the med and medJ Alleles of the Sodium Channel Scn8a

  1996cited by this paper
• A novel, abundant sodium channel expressed in neurons and glia

  1995cited by this paper
• Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

  1995cited by this paper
• Expression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat

  1995cited by this paper
• Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15.

  1995cited by this paper
• Sodium channel mRNAs I, II and III in the CNS: cell-specific expression.

  1994cited by this paper
• Distribution of I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain.

  1993cited by this paper
• Primary Structure and Functional Expression of the β 1 Subunit of the Rat Brain Sodium Channel

  1992cited by this paper
• Cellular and molecular biology of voltage-gated sodium channels.

  1992cited by this paper
• Novel voltage clamp to record small, fast currents from ion channels expressed in Xenopus oocytes.

  1992influential reference
• Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.

  1992cited by this paper
• Physiological and biochemical studies on the cerebellar cortex of the murine mutants "jolting" and "motor end-plate disease".

  1992cited by this paper
• Alternatively spliced sodium channel transcripts in brain and muscle

  1992cited by this paper
• A voltage-dependent gating transition induces use-dependent block by tetrodotoxin of rat IIA sodium channels expressed in Xenopus oocytes.

  1991cited by this paper
• Expression of ion channels by injection of mRNA into Xenopus oocytes.

  1991cited by this paper
• Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.

  1990cited by this paper
• Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

  1989cited by this paper
• Primary structure of rat brain sodium channel III deduced from the cDNA sequence

  1988cited by this paper
• A rat brain Na+ channel alpha subunit with novel gating properties.

  1988cited by this paper
• A rat brain na + channel α subunit with novel gating properties

  1988cited by this paper
• Tissue-specific expression of the RI and RII sodium channel subtypes.

  1987cited by this paper
• Existence of distinct sodium channel messenger RNAs in rat brain

  1986cited by this paper
• A CEREBELLAR ABNORMALITY IN THE MOUSE WITH MOTOR END‐PLATE DISEASE

  1985cited by this paper
• Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.

  1980cited by this paper
• Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.

  1980cited by this paper

• Astrocyte-induced firing in primary afferent axons

  2025cites this paper
• Persistent Na+ and M-type K+ currents opposingly control spike gain in CA3 pyramidal cells.

  2025cites this paper
• Voltage-gated sodium channels (NaV) in GtoPdb v.2025.3

  2025cites this paper
• Automated Patch Clamp for the Detection of Tetrodotoxin in Pufferfish Samples

  2024influential citation
• Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

  2023cites this paper
• Voltage-gated sodium channels (NaV) in GtoPdb v.2023.1

  2023cites this paper
• The Hodgkin‐Huxley‐Katz Prize Lecture: A Markov model with permeation‐dependent gating that accounts for resurgent current of voltage‐gated Na channels

  2023cites this paper
• Resurgent current in context: Insights from the structure and function of Na and K channels

  2023influential citation
• Early Fluid and Nutritional Management of Extremely Preterm Newborns During the Fetal-To-Neonatal Transition.

  2023cites this paper
• Persistent sodium current (INaP) in the spinal locomotor network promotes two distinct nonlinear firing patterns: a self-sustained spiking triggered by a brief excitation in bistable motoneurons and bursting oscillations in interneurons of the central pattern

  2023cites this paper
• Role of NaV1.6-mediated persistent sodium current and bursting-pacemaker properties in breathing rhythm generation

  2023influential citation
• Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

  2023cites this paper
• Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins

  2022cites this paper
• CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav1.6 Channels and Reduces Neuronal Excitability

  2022cites this paper
• SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons

  2022cites this paper
• De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy

  2021cites this paper
• Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types

  2021cites this paper
• Sodium channelopathies in neurodevelopmental disorders

  2021cites this paper
• Slow recovery from the inactivation of voltage-gated sodium channel Nav1.3 in mouse taste receptor cells

  2021cites this paper
• Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control

  2021cites this paper
• Distinctive Properties and Powerful Neuromodulation of Nav1.6 Sodium Channels Regulates Neuronal Excitability

  2021cites this paper
• Changes of the biophysical properties of voltage-gated Na+ currents during maturation of the sodium-taste cells in rat fungiform papillae

  2021influential citation
• The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

  2020cites this paper
• S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability

  2020cites this paper
• Small and large cutaneous fibers display different excitability properties to slowly increasing ramp pulses.

  2020cites this paper
• Low-Resistance silver bromide electrodes for recording fast ion channel kinetics under voltage clamp conditions.

  2020cites this paper
• Distinct functional alterations in SCN8A epilepsy mutant channels

  2019cites this paper
• Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

  2019cites this paper
• Trafficking mechanisms underlying Nav channel subcellular localization in neurons

  2019cites this paper
• SiRNA-mediated ankyrin-G silence modulates the expression of voltage-gated Na channels in murine hippocampal HT22 cells

  2019cites this paper
• M-current downregulation leads to stellate ganglia sympathetic hyperactivity associated with hypertension

  2019cites this paper
• Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Effects of FGF14 and NaVβ4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons

  2019cites this paper
• Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage-gated sodium channels.

  2019cites this paper
• SCN8A (NaV1.6): Gate to Chronic Pain

  2018cites this paper
• Regional and Developmental Differences in Na+ Currents in Vestibular Primary Afferent Neurons

  2018cites this paper
• Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons

  2018cites this paper
• A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy

  2018cites this paper
• Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons

  2018cites this paper
• Action potential propagation recorded from single axonal arbors using multielectrode arrays.

  2018cites this paper
• Response Characteristics and Retinal Origin of the Photopic Negative Response of the Electroretinogram in Dogs

  2017cites this paper
• Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.

  2017cites this paper
• Loss of Nav b 4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance Graphical Abstract Highlights

  2017cites this paper
• Recording action potential propagation in single axons using multi-electrode arrays

  2017cites this paper
• Functional properties of action potential propagation in sensory neuron cultures: an in vitro microfluidic investigation

  2017cites this paper
• Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.

  2017cites this paper
• T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

  2017cites this paper
• Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes.

  2017cites this paper
• Biophysical Mechanisms of Rhythm Generation in the Pre-Bötzinger Complex

  2017cites this paper
• Contribution of Nav1.8 sodium channels to retinal function.

  2017cites this paper
• Membrane state diagrams make electrophysiological models simple

  2016cites this paper
• Ionic mechanisms maintaining action potential conduction velocity at high firing frequencies in an unmyelinated axon

  2016influential citation
• A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia

  2016cites this paper
• The investigation of axonal pathology in the cerebellum of patients with mitochondrial disease

  2016cites this paper
• Physiology and Pathophysiology of Sodium Channel Inactivation.

  2016cites this paper
• SCN8A encephalopathy: Research progress and prospects

  2016cites this paper
• Myelin damage and repair in pathologic CNS: challenges and prospects

  2015cites this paper
• Locomotor Pattern Generation in Neonatal Rats Contribution of Persistent Sodium Current to

  2015cites this paper
• Cav1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells

  2015cites this paper
• Adult Rat CA1 Pyramidal Cells Differentially Regulate the Intrinsic Excitability of Axo-Somatic and Apical Dendritic Kv7/M Channels

  2015cites this paper
• Sodium Currents in Utricular Hair Cells Developmental Changes in Two Voltage-Dependent

  2015cites this paper
• Characterization of Specific Roles of Sodium Channel Subtypes in Regional Anesthesia

  2015cites this paper
• Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells

  2015cites this paper
• Cell-attached single-channel recordings in intact prefrontal cortex pyramidal neurons reveal compartmentalized D1/D5 receptor modulation of the persistent sodium current

  2015influential citation
• mRNA Variants of a Neuronal Sodium Channel in Rat Cardiac Myocytes

  2015cites this paper
• Predicting Cell-Type Specific Active Properties by Developing Multi-Compartment Models Using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus

  2015cites this paper
• Preferential Targeting of Nav1.6 Voltage-Gated Na+ Channels to the Axon Initial Segment during Development

  2015cites this paper
• Reduced availability of voltage‐gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells

  2015cites this paper
• Biosynthetic studies of tetrodotoxin and its anticancer activities assessment in vitro

  2014cites this paper
• Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents.

  2014cites this paper
• Cerebellar Purkinje Neurons and Granule Cells 1.6) in V (Na Scn8a Knockout of Sodium Channel Impaired Motor Function in Mice With Cell-Specific

  2014cites this paper
• A Genetic Interaction Network Model of a Complex Neurological Disease

  2014cites this paper
• A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy.

  2014cites this paper
• Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.

  2014influential citation
• Resurgent current of voltage‐gated Na+ channels

  2014cites this paper
• Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.

  2013cites this paper
• Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability

  2013cites this paper
• Influence of Afterpotentials on the Recovery Cycle Modeling the Excitability of Mammalian Nerve Fibers

  2013cites this paper
• Discovery and characterization of NaV modulatory venom peptides

  2013cites this paper
• Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.

  2013cites this paper
• Motor unit.

  2012cites this paper
• Pharmacological kinetics of BmK AS, a sodium channel site 4-specific modulator on Nav1.3

  2012cites this paper
• Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials

  2012cites this paper
• Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies

  2012cites this paper
• Voltage‐Gated Sodium Channels as Therapeutic Targets

  2012cites this paper
• Increased resurgent sodium currents (INaR) in inherited and acquired disorders of excitability

  2012cites this paper
• Pathogenesis of multiple sclerosis : understanding role of axonal damage

  2012cites this paper
• Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels

  2012influential citation
• Sodium channels and microglial function.

  2012cites this paper
• Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by µO‐conotoxin MrVIB

  2012cites this paper
• Biophysical characterization of neuronal and skeletal muscle sodium channels, and their regulation by auxiliary beta subunits

  2012cites this paper
• Differential effects of Zn2+ on activation, deactivation, and inactivation kinetics in neuronal voltage-gated Na+ channels

  2011cites this paper
• Resurgent Na+ current: a new avenue to neuronal excitability control.

  2011cites this paper
• Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis.

  2011cites this paper
• Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.

  2011cites this paper
• Voltage-gated sodium channels: mutations, channelopathies and targets.

  2011cites this paper
• Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits.

  2011cites this paper
• Neurofilament Changes in Multiple Sclerosis

  2011cites this paper
• Molecular and functional differences in voltage-activated sodium currents between GABA projection neurons and dopamine neurons in the substantia nigra.

  2011cites this paper
• Independent and joint modulation of rat Nav1.6 voltage-gated sodium channels by coexpression with the auxiliary β1 and β2 subunits.

  2011cites this paper