Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing neural contributions resulting from neural adaptation to high stimulus repetition rates. To allow for the analysis of the complex ECochG responses to high rates, we deconvolved responses using the Continuous Loop Averaging Deconvolution (CLAD) technique. We examined the effect of high stimulus repetition rate and stimulus duration on SP amplitude measurements made with extratympanic ECochG to tone bursts in 20 adult females with normal hearing. We used 500 and 2,000 Hz tone bursts of various stimulus durations (12, 6, 3 ms) and repetition rates (five rates ranging from 7.1 to 234.38/s). A within-subject repeated measures (rate x duration) analysis of variance was conducted. We found that, for both 500 and 2,000 Hz stimuli, the mean deconvolved SP amplitudes were larger at faster repetition rates (58.59 and 97.66/s) compared to slower repetition rates (7.1 and 19.53/s), and larger at shorter stimulus duration compared longer stimulus duration. Our concluding hypothesis is that large SP amplitude to short duration stimuli may originate primarily from neural excitation, and large SP amplitudes to long duration, fast repetition rate stimuli may originate from hair cell responses. While the hair cell or neural origins of the SP to various stimulus parameters remains to be validated, our results nevertheless provide normative data as a step toward applying the CLAD technique to understanding diseased ears.
Human Summating Potential Using Continuous Loop Averaging Deconvolution: Response Amplitudes Vary with Tone Burst Repetition Rate and Duration
A. E. Kennedy,W. Kaf,J. Ferraro,R. Delgado,J. Lichtenhan
Published 2017 in Frontiers in Neuroscience
ABSTRACT
PUBLICATION RECORD
- Publication year
2017
- Venue
Frontiers in Neuroscience
- Publication date
2017-07-27
- Fields of study
Medicine, Psychology
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- continuous loop averaging deconvolution (clad) technique
A deconvolution method used to separate overlapping electrocochleography responses recorded at high stimulus repetition rates.
Aliases: CLAD
- extratympanic electrocochleography
A noninvasive electrocochleography recording approach used here to measure cochlear potentials from outside the tympanic membrane.
Aliases: extratympanic ECochG, ECochG
- hair cell response
Cochlear hair-cell activity proposed as another possible source contributing to the measured summating potential under some stimulus conditions.
Aliases: hair cell responses
- neural excitation
Neural activity proposed as one possible source contributing to the measured summating potential under some stimulus conditions.
Aliases: neural contributions
- stimulus duration
The length of each tone-burst stimulus, varied here across 12, 6, and 3 ms.
Aliases: duration
- stimulus repetition rate
The rate at which tone-burst stimuli were presented, varied across five rates from 7.1 to 234.38 per second.
Aliases: repetition rate, high repetition rate
- summating potential (sp) amplitude
The amplitude of the summating potential component measured from the electrocochleography response.
Aliases: SP amplitude, summating potential
- tone burst stimulus
Auditory tone-burst stimuli presented at 500 Hz and 2,000 Hz with different durations in this experiment.
Aliases: tone bursts
REFERENCES
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