Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

No abstract is available for this paper.

• Publication year

  2016

• Venue

  EMBO Journal

• Publication date

  2016-06-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.15252/embj.201593084PMID 27334614PMCID PMC4969577
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

  2016cited by this paper
• Autophagy: a druggable process that is deregulated in aging and human disease.

  2015cited by this paper
• Mitofusin 2-Deficiency Suppresses Cell Proliferation through Disturbance of Autophagy

  2015cited by this paper
• Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan

  2015cited by this paper
• Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts.

  2015cited by this paper
• Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

  2015cited by this paper
• Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

  2015cited by this paper
• Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats.

  2014cited by this paper
• Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.

  2014cited by this paper
• The search for antiaging interventions: from elixirs to fasting regimens.

  2014cited by this paper
• Sarcopenia and Physical Frailty: Two Sides of the Same Coin

  2014cited by this paper
• The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease

  2014cited by this paper
• Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy

  2014cited by this paper
• Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

  2014cited by this paper
• Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

  2013cited by this paper
• The role of mitochondria in aging.

  2013cited by this paper
• PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

  2013cited by this paper
• Mfn2 modulates the UPR and mitochondrial function via repression of PERK

  2013cited by this paper
• A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells.

  2013cited by this paper
• Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials.

  2013cited by this paper
• Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.

  2013cited by this paper
• Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress*

  2012cited by this paper
• Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

  2012cited by this paper
• Ageing as a risk factor for disease.

  2012cited by this paper
• Genome-wide analysis and expression profiling of the DREB transcription factor gene family in Malus under abiotic stress

  2012cited by this paper
• Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry.

  2011cited by this paper
• The dynamin‐related protein DRP‐1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity

  2011cited by this paper
• Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

  2011cited by this paper
• Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles

  2010cited by this paper
• Mitochondria supply membranes for autophagosome biogenesis during starvation.

  2010cited by this paper
• Mitochondrial fission and remodelling contributes to muscle atrophy

  2010cited by this paper
• Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

  2010cited by this paper
• Proteasomal activity in skeletal muscle: a matter of assay design, muscle type, and age.

  2010cited by this paper
• The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure.

  2010cited by this paper
• Mitochondrial function as a determinant of life span

  2009cited by this paper
• Autophagy is required to maintain muscle mass.

  2009cited by this paper
• Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

  2009cited by this paper
• Regulation of the aging process by autophagy.

  2009cited by this paper
• Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

  2009cited by this paper
• Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

  2009cited by this paper
• Mitochondrial dynamics in mammalian health and disease.

  2009cited by this paper
• GAGA: A PARSIMONIOUS AND FLEXIBLE MODEL FOR DIFFERENTIAL EXPRESSION ANALYSIS

  2009cited by this paper
• Effects of Habitat Conversion on Temporal Activity Patterns of Phyllostomid Bats in Lowland Amazonian Rain Forest

  2009cited by this paper
• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  2008cited by this paper
• Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart.

  2008cited by this paper
• Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia*

  2008cited by this paper
• Gene Expression Omnibus ( GEO ) : Microarray data storage , submission , retrieval , and analysis

  2008cited by this paper
• Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells

  2007cited by this paper
• Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum

  2007cited by this paper
• Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models

  2007cited by this paper
• Resistance training, insulin sensitivity and muscle function in the elderly.

  2006cited by this paper
• Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle

  2006cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005influential reference
• Transgenic mice that express Cre recombinase under control of a skeletal muscle‐specific promoter from mef2c

  2005cited by this paper
• Decline in skeletal muscle mitochondrial function with aging in humans.

  2005cited by this paper
• Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.

  2005influential reference
• About the authors

  2004cited by this paper
• Dysregulation of HSG triggers vascular proliferative disorders

  2004cited by this paper
• Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

  2003cited by this paper
• Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth

  2001cited by this paper
• Mitochondrial respiratory chain activity in the human brain as a function of age.

  1999cited by this paper
• Cellular energy utilization and molecular origin of standard metabolic rate in mammals.

  1997cited by this paper
• Oxidative damage and mitochondrial decay in aging.

  1994cited by this paper
• The histochemical profiles of fast fiber types IIB, IID, and IIA in skeletal muscles of mouse, rat, and rabbit.

  1993cited by this paper
• Contractile properties of skeletal muscles from young, adult and aged mice.

  1988cited by this paper
• The effect of ageing and exercise on skeletal muscle function.

  1984cited by this paper
• Physiological changes in ageing muscles

  1973cited by this paper

• Role of mitochondrial dysfunction in muscle wasting in cancer cachexia: a narrative review.

  2026cites this paper
• The Role of Fibro/adipogenic Progenitors (FAPs) in Sarcopenia: Mechanisms and Potential Therapeutic Strategies

  2026cites this paper
• Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice.

  2026cites this paper
• ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis

  2026cites this paper
• Markers of clinical and mitochondrial adaptation in response to moderate intensity continuous training: A systematic review and meta-analysis

  2026cites this paper
• Beyond muscle weakness: pathogenesis of sepsis-induced myopathy and its management

  2026cites this paper
• Critical roles of m6A demethylase FTO in ovarian aging

  2026cites this paper
• Structural and mitochondrial dendritic degenerations in old hypoglossal motor neurons.

  2026cites this paper
• Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis

  2025cites this paper
• Advancing muscle aging and sarcopenia research through spatial transcriptomics

  2025cites this paper
• Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis

  2025cites this paper
• Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse.

  2025cites this paper
• Previous short‐term disuse dictates muscle gene expression and physiological adaptations to subsequent resistance exercise

  2025cites this paper
• Oxidative Stress in Neurodegenerative Disorders: A Key Driver in Impairing Skeletal Muscle Health

  2025cites this paper
• The role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism.

  2025cites this paper
• NAD+ Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1‐Mediated Mitochondrial Function via NAMPT

  2025cites this paper
• HSALR Mice Exhibit Co-Expression of Proteostasis Genes Prior to Development of Muscle Weakness

  2025cites this paper
• The Evolving Landscape of Analytical Mitochondrial Research: Mass Spectrometry, Its Proteomic and Lipidomic Insights.

  2025cites this paper
• NIPSNAP1 and NIPSNAP2 facilitate healthy aging independent of mitophagy.

  2025cites this paper
• Canonical and non-canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology.

  2025cites this paper
• The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors

  2025cites this paper
• Epimedii Folium and Ligustri Lucidi Fructus synergistically delay renal aging through AMPK/ULK1/Bcl2L13-mediated mitophagy.

  2025cites this paper
• Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study

  2025cites this paper
• Exploring the role of traditional Chinese medicine in sarcopenia: mechanisms and therapeutic advances

  2025cites this paper
• PRMT1 (protein arginine methyltransferase 1) is essential for neuromuscular junction and mitochondrial homeostasis via mitophagy regulation

  2025cites this paper
• Rutin as a Circadian Modulator Preserves Skeletal Muscle Mitochondrial Function and Reduces Oxidative Stress to Protect Against D-Galactose-Induced Aging In Vitro and In Vivo

  2025cites this paper
• Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.

  2025cites this paper
• Implantable electrical stimulation device enhances pelvic floor tissue repair and reduces collagen over-degradation in rats with stress urinary incontinence

  2025cites this paper
• Aptamer‐Conjugated Exosomes Ameliorate Diabetes‐Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a‐Mediated Mitochondrial Function

  2025cites this paper
• Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control

  2025cites this paper
• Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

  2025cites this paper
• Prolonged sepsis triggers abnormal mitochondrial dynamics in the limb muscles and diaphragm

  2025cites this paper
• Molecular constraints of sarcopenia in the ageing muscle

  2025cites this paper
• The structure and function of mitofusin 2 and its role in cardiovascular disease through mediating mitochondria-associated endoplasmic reticulum membranes

  2025cites this paper
• Molecular Framework of the Onset and Progression of Skeletal Muscle Aging

  2025cites this paper
• HMGB1 and mitochondrial dysfunction: a double-edged sword in ageing

  2025cites this paper
• Peri-mitochondrial actin filaments inhibit Parkin assembly by disrupting ER-mitochondria contacts

  2025cites this paper
• Leveraging mitochondrial stress to improve healthy aging.

  2025cites this paper
• Mitochondrial Dynamics in Aging Heart

  2025cites this paper
• α-Ketoglutarate Ameliorates Sarcopenia in D-Galactose-Induced Aging Mice by Modulating Protein Homeostasis and Optimizing Mitochondrial Function

  2025cites this paper
• Age and sex-specific changes in mitochondrial quality control in skeletal and cardiac muscle

  2025cites this paper
• Engineering healthy aging: A review of biomedical platforms for mechanistic intervention in geriatric decline

  2025cites this paper
• Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity.

  2025cites this paper
• Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model

  2025cites this paper
• Cannabinol (CBN) alleviates age-related cognitive decline by improving synaptic and mitochondrial health

  2025cites this paper
• 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes

  2025cites this paper
• cAMP-MFN2 signaling suppresses cochlear cell senescence and age-related hearing loss

  2025cites this paper
• Activation of Sirtuin3 by 6,4′-Dihydroxy-7-methoxyflavanone Against Myoblasts Senescence by Attenuating D-Galactose-Induced Oxidative Stress and Inflammation

  2025cites this paper
• EPA-enriched phospholipids and DHA-enriched phospholipids prevent dexamethasone-induced skeletal muscle atrophy via regulating protein turnover and mitochondrial quality.

  2025cites this paper
• The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation

  2025cites this paper
• A multimodal exercise countermeasure prevents the negative impact of head‐down tilt bed rest on muscle volume and mitochondrial health in older adults

  2024cites this paper
• Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds

  2024cites this paper
• Does Autophagy have a Role in the Pathogenesis of Pediatric Hepatic Steatosis?

  2024cites this paper
• Bacteria–organelle communication in physiology and disease

  2024cites this paper
• The Changes of Mitochondria during Aging and Regeneration

  2024cites this paper
• Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy

  2024cites this paper
• Age‐related muscle atrophy? Mitofusin 2 the rescue

  2024influential citation
• The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

  2024cites this paper
• The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology.

  2024cites this paper
• Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases

  2024cites this paper
• TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging

  2024influential citation
• MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission

  2024influential citation
• The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle

  2024cites this paper
• Mitochondrial Adaptations in Aging Skeletal Muscle: Implications for Resistance Exercise Training to Treat Sarcopenia

  2024cites this paper
• Differential effects of EPA and DHA on aging-related sarcopenia in mice and possible mechanisms involved.

  2024cites this paper
• Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy

  2024cites this paper
• Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease

  2024cites this paper
• ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis in Fuchs’ dystrophy

  2024cites this paper
• The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders.

  2024cites this paper
• Oxidative phosphorylation decline and mitochondrial dynamics disequilibrium are involved in chicken large white follicle atresia.

  2024cites this paper
• Tat-Beclin-1 Ameliorates Memory by Improving Neuronal Cytoarchitecture and Mitigating Mitochondrial Dysfunction in Scopolamine-Induced Amnesic Male Mice.

  2024cites this paper
• Mitochondria in skeletal system-related diseases.

  2024cites this paper
• Harnessing Mitophagy for Therapeutic Advances in Aging and Chronic Neurodegenerative Diseases

  2024cites this paper
• The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart

  2024cites this paper
• Hydrogen sulfide mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications.

  2024cites this paper
• Heme deficiency in skeletal muscle exacerbates sarcopenia and impairs autophagy by reducing AMPK signaling

  2024cites this paper
• Prospective Intervention Strategies Between Skeletal Muscle Health and Mitochondrial Changes During Aging

  2024cites this paper
• Regulation of mitochondria-lysosome interactions in skeletal muscle during exercise, disuse, and aging.

  2024cites this paper
• Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

  2024cites this paper
• Metformin restores autophagic flux and mitochondrial function in late passage myoblast to impede age-related muscle loss.

  2024cites this paper
• Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets.

  2024cites this paper
• BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia

  2024cites this paper
• 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

  2023cites this paper
• Using mass spectrometry imaging to visualize age-related subcellular disruption

  2023cites this paper
• The syndromic triad of COVID-19, type 2 diabetes, and malnutrition

  2023cites this paper
• The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases

  2023cites this paper
• Identification of mitochondria-related key gene and association with immune cells infiltration in intervertebral disc degeneration

  2023cites this paper
• The mediating role of inflammaging between mitochondrial dysfunction and sarcopenia in aging: a review.

  2023cites this paper
• Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

  2023cites this paper
• The contribution of mitochondria to age-related skeletal muscle wasting: A sex-specific perspective.

  2023cites this paper
• Extensive accumulation of misfolded protein aggregates during natural aging and senescence

  2023cites this paper
• Mitofusin-2: Functional Switch Between Mitochondrial Function And Neurodegeneration.

  2023cites this paper
• Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

  2023cites this paper
• The effect of caloric restriction on genetical pathways

  2023cites this paper
• Changes in Pancreatic Senescence Mediate Pancreatic Diseases

  2023cites this paper
• The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4

  2023cites this paper
• Mitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases

  2023cites this paper
• Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics

  2023cites this paper
• Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

  2023cites this paper
• Sex Differences in the Skeletal Muscle Response to a High Fat, High Sucrose Diet in Rats

  2023cites this paper