Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Molecular and Cellular Biology

• Publication date

  1996-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/MCB.16.9.4700PMID 8756627PMCID PMC231470
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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  1992influential reference
• Studies on the yeast α‐mating factor: A model for mammalian peptide hormones

  1992cited by this paper
• 12 Pheromone Response and Signal Transduction during the Mating Process of Saccharomyces cerevisiae

  1992cited by this paper
• Multifunctional yeast high-copy-number shuttle vectors.

  1992cited by this paper
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  1992influential reference
• Getting started with yeast.

  1991cited by this paper
• High-efficiency transformation of yeast by electroporation.

  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1984cited by this paper
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  1983cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1979cited by this paper
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