Adenosine A1 receptor: Functional receptor-receptor interactions in the brain

Over the past decade, many lines of investigation have shown that receptor-mediated signaling exhibits greater diversity than previously appreciated. Signal diversity arises from numerous factors, which include the formation of receptor dimers and interplay between different receptors. Using adenosine A1 receptors as a paradigm of G protein-coupled receptors, this review focuses on how receptor-receptor interactions may contribute to regulation of the synaptic transmission within the central nervous system. The interactions with metabotropic dopamine, adenosine A2A, A3, neuropeptide Y, and purinergic P2Y1 receptors will be described in the first part. The second part deals with interactions between A1Rs and ionotropic receptors, especially GABAA, NMDA, and P2X receptors as well as ATP-sensitive K+ channels. Finally, the review will discuss new approaches towards treating neurological disorders.

• Publication year

  2007

• Venue

  Purinergic Signalling Purinergic Signalling

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11302-007-9065-zPMID 18404442PMCID 2072922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.

  2007influential reference
• Partners for adenosine A1 receptors

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• Functions of heteromeric association between adenosine and P2Y receptors

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• Region specific galanin receptor/neuropeptide Y Y1 receptor interactions in the tel- and diencephalon of the rat. Relevance for food consumption.

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• Purine and pyrimidine receptors

  2007influential reference
• Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels

  2007cited by this paper
• Physiology and pathophysiology of purinergic neurotransmission.

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• Adenosine Receptor Heteromers and their Integrative Role in Striatal Function

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• A1 adenosine receptor-mediated modulation of neuronal ATP-sensitive K channels in rat substantia nigra.

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• G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways.

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• The 7 TM G‐Protein‐Coupled Receptor Target Family

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• Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus.

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• NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice.

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• Modulatory role of adenosine and its receptors in epilepsy: possible therapeutic approaches.

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• A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro

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• Heterodimeric adenosine receptors: a device to regulate neurotransmitter release

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• ATP-sensitive potassium channels.

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• Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus.

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