Ileal losses of nitrogen and amino acids in humans and their importance to the assessment of amino acid requirements.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Gastroenterology

• Publication date

  2002-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1053/GAST.2002.34233PMID 12105833
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isotopic studies of protein and amino acid requirements.

  2002cited by this paper
• Energy nutrients modulate the splanchnic sequestration of dietary nitrogen in humans: a compartmental analysis.

  2001cited by this paper
• Characterization of a mouse colonic system B(0+) amino acid transporter related to amino acid absorption in colon.

  2001cited by this paper
• Whole-body nitrogen and splanchnic amino acid metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture.

  2001cited by this paper
• The effect of dietary peptide concentration on endogenous ileal amino acid loss in the growing pig

  2000cited by this paper
• Human adult amino acid requirements: [1-13C]leucine balance evaluation of the efficiency of utilization and apparent requirements for wheat protein and lysine compared with those for milk protein in healthy adults.

  2000cited by this paper
• Criteria and Significance of Dietary Protein Sources in Humans Contribution of Microbial Amino Acids to Amino Acid Homeostasis of the Host

  2000cited by this paper
• A high-protein meal exceeds anabolic and catabolic capacities in rats adapted to a normal protein diet.

  2000cited by this paper
• Criteria and Significance of Dietary Protein Sources in Humans Nitrogen and Amino Acid Requirements: The Massachusetts Institute of Technology Amino Acid Requirement Pattern 1,2

  2000cited by this paper
• Comparison of the isotope dilution method for determination of the ileal endogenous amino acid losses with labelled diet and labelled pigs.

  2000cited by this paper
• Dispensable and indispensable amino acids for humans.

  2000cited by this paper
• Incorporation of urea and ammonia nitrogen into ileal and fecal microbial proteins and plasma free amino acids in normal men and ileostomates.

  1999cited by this paper
• Nutritional value of [15N]-soy protein isolate assessed from ileal digestibility and postprandial protein utilization in humans.

  1999cited by this paper
• Assessment of net postprandial protein utilization of 15N-labelled milk nitrogen in human subjects

  1999cited by this paper
• Net postprandial utilization of [15N]-labeled milk protein nitrogen is influenced by diet composition in humans.

  1999cited by this paper
• Nitrogen cycling in the gut.

  1998cited by this paper
• Infusion of soy and casein protein meals affects interorgan amino acid metabolism and urea kinetics differently in pigs.

  1998cited by this paper
• Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets.

  1998cited by this paper
• Dietary amino acids are the preferential source of hepatic protein synthesis in piglets.

  1998cited by this paper
• The 15N amino acid dilution method allows the determination of the real digestibility and of the ileal endogenous losses of the respective amino acid in pigs.

  1998cited by this paper
• The current 15N-leucine infusion technique is not suitable for quantitative measurements of ileal endogenous amino acid flows in pigs.

  1998cited by this paper
• Nutrient Requirements and Interactions Feeding Diets Containing High Levels of Milk Products or Cellulose Decrease Urease Activity and Ammonia Production in Rat Intestine

  1998cited by this paper
• Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications.

  1998cited by this paper
• [15N]-labeled pea flour protein nitrogen exhibits good ileal digestibility and postprandial retention in humans.

  1997cited by this paper
• Evaluation of the 15N-isotope dilution technique for determining the recovery of endogenous protein in ileal digestion of pigs: effect of dilution in the precursor pool for endogenous nitrogen secretion.

  1997cited by this paper
• Gastrojejunal kinetics and the digestion of [15N]beta-lactoglobulin and casein in humans: the influence of the nature and quantity of the protein.

  1996cited by this paper
• The use of 15N-labeled dietary proteins for determining true ileal amino acid digestibilities is limited by their rapid recycling in the endogenous secretions of pigs.

  1996cited by this paper
• Lysine requirement of adult males is not affected by decreasing dietary protein.

  1996cited by this paper
• A 15N-leucine-dilution method to measure endogenous contribution to luminal nitrogen in the human upper jejunum.

  1996cited by this paper
• Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N-acetyl- and N-pivaloyl amino acid esters to measure 15N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastro-intestinal tract of minipigs.

  1996cited by this paper
• The gastro-ileal digestion of 15N-labelled pea nitrogen in adult humans

  1996cited by this paper
• Can amino acid requirements for nutritional maintenance in adult humans be approximated from the amino acid composition of body mixed proteins?

  1995cited by this paper
• Digestion patterns of endogenous and different exogenous proteins affect the composition of intestinal effluents in humans.

  1995cited by this paper
• Recent advances in methods of assessing dietary amino acid requirements for adult humans.

  1995cited by this paper
• The 24-h pattern and rate of leucine oxidation, with particular reference to tracer estimates of leucine requirements in healthy adults.

  1994cited by this paper
• Human amino acid requirements: can the controversy be resolved?

  1994cited by this paper
• Amino acid losses in ileostomy fluid on a protein-free diet.

  1994cited by this paper
• Gastroileal nitrogen and electrolyte movements after bovine milk ingestion in humans.

  1992cited by this paper
• Meal stimulation of albumin synthesis: a significant contributor to whole body protein synthesis in humans.

  1992cited by this paper
• The effects of intravenous urea infusions on portal and arterial plasma ammonia and urea enrichment of jejunal and colonic infusions. Acute experiments with growing pigs.

  1992cited by this paper
• The effect of source of fiber on ileal and fecal amino acid digestibility and bacterial nitrogen excretion in growing pigs.

  1991cited by this paper
• The effect of protein status of the pig on the recovery and amino acid composition of endogenous protein in digesta collected from the distal ileum.

  1989cited by this paper
• A theoretical basis for increasing current estimates of the amino acid requirements in adult man, with experimental support.

  1989cited by this paper
• Nitrogen losses from the human small bowel: obligatory losses and the effect of physical form of food.

  1988cited by this paper
• Studies on the secretion of amino acids and of urea into the gastrointestinal tract of pigs. 3. Secretion of urea determined by continuous intravenous infusion of 15N-urea.

  1986cited by this paper
• Studies on the secretion of amino acids and of urea into the gastro intestinal tract of pigs. 1. Secretion of leucine into the stomach and upper part of the duodenum during continuous intravenous infusion of 14C-leucine.

  1986cited by this paper
• Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation.

  1985cited by this paper
• Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals.

  1973cited by this paper
• AMINO acid requirements of adult man.

  1957cited by this paper
• The amino acid requirements of adult man.

  1957cited by this paper

• Grazing intensity versus stocking methods: implications for greenhouse gas emissions in integrated crop-livestock systems

  2026cites this paper
• Nutritional quality of proteins from major oilseeds – a review

  2026cites this paper
• From Production to Food Systems: A Systems-Level Review of Drivers, Requirements, and Integration for Lunar and Martian Food Systems

  2026cites this paper
• Plant proteins for human and environmental health: knowledge, barriers, and levers for their development, a case study in France. A review

  2025cites this paper
• Digestion, Metabolism, and Health Effects of Plant Proteins and Their Food Formulations: A Systematic Scoping Review of Clinical Postprandial Studies and in vitro Methods

  2025cites this paper
• Rapeseed protein as a sustainable source of protein in humans: modification of rapeseed meal by physical and chemical methods

  2025influential citation
• How stable isotopes can advance nutrition assessments to inform sustainable food systems

  2025cites this paper
• Food microstructure and protein digestion in the human gastrointestinal tract: an ileostomy study focusing on interindividual variability in gluten digestibility.

  2025cites this paper
• True ileal amino acid digestibility and digestible amino acid scores (DIAASs) of the cruciferin and napin fractions of rapeseed: Impact of processing.

  2025cites this paper
• Comparison of the dual isotope tracer approach with oro-ileal balance method for determination of amino acid digestibility in cannulated pigs.

  2025cites this paper
• Recycling of Undigested Proteins Provided by the Host to the Large Intestine Microbiota: Implication for Intestinal Bacterial Anabolism, Growth, and Physiology

  2025cites this paper
• Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels

  2025cites this paper
• Comparative analysis of the nutritional composition, digestibility, metabolomics profiles and growth influence of cow, goat and sheep milk powder diets in rat models

  2024cites this paper
• Potential impact of climate change on dietary grain protein content and its bioavailability-a mini review

  2024cites this paper
• Protein quality, nutrition and health

  2024cites this paper
• Digestive and metabolic bioavailability in healthy humans of 15N-labeled rapeseed and flaxseed protein incorporated in biscuits.

  2023cites this paper
• Values for the digestibility of pea protein isolate or casein amino acids determined using the dual isotope method are not similar to those derived with the standard ileal balance method in healthy volunteers.

  2023cites this paper
• Metabolism of alimentary compounds by the intestinal microbiota and consequences for gut health

  2023cites this paper
• Resistant Maltodextrin Suppresses Intestinal Phenols Production by Modifying the Intestinal Environment.

  2023cites this paper
• Role of Hydrogen Sulfide in Inflammatory Bowel Disease

  2023cites this paper
• Métodos para evaluar la biodisponibilidad, la bioaccesibilidad y el valor nutricional de suplementos alimenticios

  2023cites this paper
• Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth

  2023cites this paper
• Use of isotope-labeled body or dietary proteins to determine dietary amino acid digestibility.

  2023cites this paper
• Differential effects of milk proteins on amino acid digestibility, post-prandial nitrogen utilization and intestinal peptide profiles in rats.

  2023cites this paper
• Measurement of True Indispensable Amino Acid Digestibility by the Dual Isotope Tracer Technique: A Methodological Review.

  2022cites this paper
• Low-Protein Infant Formula and Obesity Risk

  2022cites this paper
• Production of Indole and Indole-Related Compounds by the Intestinal Microbiota and Consequences for the Host: The Good, the Bad, and the Ugly

  2022cites this paper
• Amino Acids in Foods, Feeds, and Nutrition

  2021cites this paper
• In Vitro Protein Digestibility of Selected Plant and Animal Foods by Multi-Enzyme Assay

  2021cites this paper
• Protein digestion and bioavailability

  2021cites this paper
• Protein quality and sources

  2021cites this paper
• The true amino acid digestibility of 15N-labelled sunflower biscuits determined with ileal balance and dual isotope methods in healthy humans.

  2021cites this paper
• Evaluation of Protein Quality in Humans and Insights on Stable Isotope Approaches to Measure Digestibility – A Review

  2021influential citation
• Real ileal amino acid digestibility of pea protein compared to casein in healthy humans, a randomized trial.

  2021cites this paper
• A controlled human intervention trial to study protein quality by amino acid uptake kinetics with the novel Lemna protein concentrate as case study

  2021cites this paper
• Paternal high protein diet modulates body composition, insulin sensitivity, epigenetics, and gut microbiota intergenerationally in rats

  2021cites this paper
• Using naso- and oro-intestinal catheters in physiological research for intestinal delivery and sampling in vivo: practical and technical aspects to be considered.

  2021cites this paper
• Les « dessous » du PD-CAAS et du DIAAS, deux critères en apparence simples de qualité nutritionnelle des protéines

  2021cites this paper
• Goat milk protein digestibility in relation to intestinal function

  2021cites this paper
• Nutritional Quality of Milk Proteins

  2021cites this paper
• Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy

  2020cites this paper
• Metabolic Availability of Lysine in Milk and a Vegetarian Cereal-Legume Meal Determined by the Indicator Amino Acid Oxidation Method in Indian Men.

  2020cites this paper
• Blood 15N:13C Enrichment Ratios Are Proportional to the Ingested Quantity of Protein with the Dual-Tracer Approach for Determining Amino Acid Bioavailability in Humans

  2020cites this paper
• Very low ileal nitrogen and amino acid digestibility of zein compared to whey protein isolate in healthy volunteers.

  2020cites this paper
• Protein Digestion and Absorption

  2020cites this paper
• Milk proteins: A rich source of bioactives for developing functional foods

  2020cites this paper
• Effect of different pre-boiling treatment on in vitro protein and amino acid digestibility of mung beans [Vigna radiata (L.) Wilczek]

  2020cites this paper
• Milk proteins: Digestion and absorption in the gastrointestinal tract

  2020cites this paper
• True ileal amino acid digestibility and digestible indispensable amino acid scores (DIAASs) of plant-based protein foods.

  2020cites this paper
• Bioactive peptides originating from gastrointestinal endogenous proteins in the growing pig: In vivo identification.

  2020cites this paper
• Les critères de qualité des protéines ont-ils évolué ?

  2019cites this paper
• The Effect of Eight-Week Total Body Resistance Exercise on Liver Functional Parameters in Patients with Non-Alcoholic Fatty Liver Disease

  2019cites this paper
• 15N and ²H Intrinsic Labeling Demonstrate That Real Digestibility in Rats of Proteins and Amino Acids from Sunflower Protein Isolate Is Almost as High as That of Goat Whey.

  2019cites this paper
• Intact and hydrolyzed casein lead to similar ileal endogenous protein and amino acid flows in adult humans.

  2019cites this paper
• Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota

  2019cites this paper
• Integrated Nutraceutical – Nutritional Approaches to Address Equine Leaky Gut Syndrome

  2019cites this paper
• Quantifying the contribution of dietary protein to whole body protein kinetics: examination of the intrinsically labeled proteins method.

  2019cites this paper
• Gastro-intestinal Digestibility of Processed Forms of Cow’s Milk Proteins under Simulated Infant and Adult Conditions Characterised by in vitro Methods

  2019cites this paper
• High-protein diets for weight management: Interactions with the intestinal microbiota and consequences for gut health. A position paper by the my new gut study group.

  2019cites this paper
• Fecal microbiome and metabolome of infants fed bovine MFGM supplemented formula or standard formula with breast-fed infants as reference: a randomized controlled trial

  2019cites this paper
• The gut microbiota metabolite indole alleviates liver inflammation in mice

  2018cites this paper
• Growth and Clinical Variables in Nitrogen-Restricted Piglets Fed an Adjusted Essential Amino Acid Mix: Effects of Partially Intact Protein-Based Diets.

  2018cites this paper
• Endogenous Amino Acid Losses from the Gastrointestinal Tract of the Adult Human-A Quantitative Model.

  2018cites this paper
• A Casein Hydrolysate Does Not Enhance Ileal Endogenous Protein Flows Compared With the Parent Intact Casein When Fed to Growing Pigs

  2018cites this paper
• Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Bariatric Patients: Tehran Obesity Treatment Study (TOTS)

  2018cites this paper
• Determination of threonine requirements and the metabolic availability of threonine from food sources in healthy school-aged children

  2018influential citation
• Intraileal casein infusion increases plasma concentrations of amino acids in humans: A randomized cross over trial.

  2017cites this paper
• Epithelial response to a high-protein diet in rat colon

  2017cites this paper
• 35 – Plant Protein, Animal Protein, and Protein Quality

  2017cites this paper
• The role of intestinal hydrogen sulfide on GLP-1 secretion and downstream metabolism

  2017cites this paper
• Dietary Protein and Amino Acid Supplementation in Inflammatory Bowel Disease Course: What Impact on the Colonic Mucosa?

  2017cites this paper
• In the elderly, meat protein assimilation from rare meat is lower than that from meat that is well done.

  2017cites this paper
• How Does Addition of Regular Aerobic Exercises, Influence the Efficacy of Calorie-Restricted Diet in Patients with Non-Alcoholic Steatohepatatis (NASH)?

  2017cites this paper
• Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans.

  2017cites this paper
• Effets des régimes hyperprotéiques et des métabolites bactériens dérivés des acides aminés sur la muqueuse du gros intestin

  2016cites this paper
• Approaches and Methods for Evaluating the Protein Quality of Human Foods Proposed by an FAO Expert Working Group in 20141 – 3

  2016cites this paper
• Liver Function Tests and Ultrasonography Findings in Iranian Morbid Obese Patients Undergoing Bariatric Surgery

  2016cites this paper
• Dietary Protein and Colonic Microbiota

  2016cites this paper
• Small intestinal targets involved in food intake regulation : 'from nutrient to satiety signal'

  2016cites this paper
• Research Approaches and Methods for Evaluating the Protein Quality of Human Foods Proposed by an FAO Expert Working Group in 2014.

  2016cites this paper
• Effects of threonine supplementation on whole-body protein synthesis and plasma metabolites in growing and mature horses.

  2016cites this paper
• Compared with Raw Bovine Meat, Boiling but Not Grilling, Barbecuing, or Roasting Decreases Protein Digestibility without Any Major Consequences for Intestinal Mucosa in Rats, although the Daily Ingestion of Bovine Meat Induces Histologic Modifications in the Colon.

  2016cites this paper
• Review article: insights into colonic protein fermentation, its modulation and potential health implications

  2016cites this paper
• Prevalence of Non-Alcoholic Fatty Liver Disease in Morbidly Obese Patients Undergoing Sleeve Bariatric Surgery in Iran and Association With Other Comorbid Conditions

  2015cites this paper
• Genetic Variants in the SAMM50 Gene Create Susceptibility to Nonalcoholic Fatty Liver Disease in a Chinese Han Population

  2015cites this paper
• Nutritional Aspects of Proteins

  2015cites this paper
• High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon.

  2015cites this paper
• Research approaches and methods for evaluating the protein quality of human foods - Report of a FAO Expert Working Group

  2015cites this paper
• Protein digestibility-corrected amino acid scores and digestible indispensable amino acid scores differentially describe protein quality in growing male rats.

  2015cites this paper
• High-protein diet modifies colonic microbiota and luminal environment but not colonocyte metabolism in the rat model: the increased luminal bulk connection.

  2014cites this paper
• EVALUATING DIETARY AMINO ACID ADEQUACY IN HORSES USING ISOTOPIC TECHNIQUES

  2014cites this paper
• Milk proteins: a cornucopia for developing functional foods

  2014cites this paper
• Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease; A Meta-Analysis

  2014cites this paper
• Correlation of Body Mass Index and Serum Parameters With Ultrasonographic Grade of Fatty Change in Non-alcoholic Fatty Liver Disease

  2014cites this paper
• The heat treatment and the gelation are strong determinants of the kinetics of milk proteins digestion and of the peripheral availability of amino acids.

  2013cites this paper
• Effects of Meat Cooking, and of Ingested Amount, on Protein Digestion Speed and Entry of Residual Proteins into the Colon: A Study in Minipigs

  2013cites this paper
• Les abondances naturelles des isotopes stables de l'azote chez le rat : facteurs de variabilité et application pour l'étude des flux azotés et de l'impact métabolique de conditions nutritionnelles et physiopathologiques par modélisation compartimentale.

  2013cites this paper
• Digestibility Issues of Vegetable versus Animal Proteins: Protein and Amino Acid Requirements—Functional Aspects

  2013cites this paper
• Intestinal luminal nitrogen metabolism: role of the gut microbiota and consequences for the host.

  2013cites this paper
• Isotopic and modeling investigation of long-term protein turnover in rat tissues.

  2013cites this paper