Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Cell Science

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.086231PMID 21670198PMCID PMC3113666
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High-resolution multiphoton imaging of tumors in vivo.

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• Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM

  2011cited by this paper
• Two-Photon Intravital Multicolor Imaging Combined with Inducible Gene Expression to Distinguish Metastatic Behavior of Breast Cancer Cells In Vivo

  2010cited by this paper
• Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors

  2010cited by this paper
• VASP is a processive actin polymerase that requires monomeric actin for barbed end association

  2010influential reference
• A new chemotaxis device for cell migration studies.

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• Ena/VASP: towards resolving a pointed controversy at the barbed end

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• The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12.

  2009influential reference
• An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2−/− γc−/− mouse

  2009cited by this paper
• Localised and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

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• The Macrophage Colony-Stimulating Factor 1 Response Signature in Breast Carcinoma

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• Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging.

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• Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

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  2009cited by this paper
• In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

  2009cited by this paper
• Mechanisms of collective cell migration at a glance

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• Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.

  2009influential reference
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  2009cited by this paper
• Faculty Opinions recommendation of Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.

  2009cited by this paper
• Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo

  2008influential reference
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  2008cited by this paper
• The expression of cytoskeleton regulatory protein Mena in colorectal lesions.

  2008cited by this paper
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• Human Mena+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines

  2008cited by this paper
• A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.

  2008influential reference
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  2008cited by this paper
• Intravital imaging of metastatic behavior through a mammary imaging window

  2008influential reference
• Ena/VASP Proteins Capture Actin Filament Barbed Ends*

  2008cited by this paper
• Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice

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• Structural basis for the recruitment of profilin–actin complexes during filament elongation by Ena/VASP

  2007cited by this paper
• Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.

  2007cited by this paper
• Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.

  2007cited by this paper
• Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

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• Microarray-based method for detection of unknown genetic modifications

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• Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.

  2007influential reference
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• The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors

  2006cited by this paper
• The Cytoskeleton Regulatory Protein hMena (ENAH) Is Overexpressed in Human Benign Breast Lesions with High Risk of Transformation and Human Epidermal Growth Factor Receptor-2–Positive/Hormonal Receptor–Negative Tumors

  2006influential reference
• Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

  2006cited by this paper
• Ena/VASP Proteins Enhance Actin Polymerization in the Presence of Barbed End Capping Proteins*[boxs]

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  2005cited by this paper
• Mechanisms of cancer cell invasion.

  2005cited by this paper
• Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.

  2005cited by this paper
• A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

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• Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy

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• Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors

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• Compensation mechanism in tumor cell migration

  2003cited by this paper
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  2003cited by this paper
• Intravital imaging of cell movement in tumours

  2003cited by this paper
• In vivo" depletion of macrophages by liposome-mediated "suicide".

  2003cited by this paper
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  2002cited by this paper
• The Journal of Cell Biology

  2002cited by this paper
• Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.

  2002cited by this paper
• Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

  2002influential reference
• Negative regulation of fibroblast motility by Ena/VASP proteins.

  2000cited by this paper
• The collection of the motile population of cells from a living tumor.

  2000influential reference
• Epidermal growth factor receptor distribution during chemotactic responses.

  2000cited by this paper
• A critical step in metastasis: in vivo analysis of intravasation at the primary tumor.

  2000influential reference
• PTP LAR Expression Compared to Prognostic Indices in Metastatic and Non-Metastatic Breast Cancer

  2000cited by this paper
• A novel proline‐rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

  1997cited by this paper
• CSF‐1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract

  1997cited by this paper
• Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

  1996cited by this paper
• Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells.

  1995cited by this paper
• Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis.

  1994cited by this paper
• Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation.

  1992cited by this paper
• FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro.

  1991cited by this paper
• Coexpression of cytokeratins characteristic for myoepithelial and luminal cell lineages in rat 13762NF mammary adenocarcinoma tumors and their spontaneous metastases.

  1991cited by this paper
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  1989cited by this paper
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  1986cited by this paper
• Comparison of 'spontaneous' and 'experimental' metastasis using rat 13762 mammary adenocarcinoma metastatic cell clones.

  1983cited by this paper
• Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma.

  1982influential reference
• Epidermal growth factor: effects of androgens and adrenergic agents.

  1974cited by this paper
• In Partial Fulfillment of the Requirements

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