Altered resting membrane potential in the supersensitive vas deferens of the guinea pig.

Microelectrodes have been used to obtain evidence for cellular changes associated with postjunctional supersensitivity in the vas deferens. Chronic decentralization or denervation caused a partial depolarization. A study of the time course of this depolarization in decentralized vasa deferentia indicated that the phenomenon appeared and reached a plateau between the 2nd and 4th postoperative day, i. e., at the same time as postjunctional supersensitivity develops in this tissue. Junction potentials induced by transmural stimulation and measured in impaled cells were not significantly different in control and decentralized cells. The results are discussed in relation to existing theories of supersensitivity and information in the literature regarding other cellular changes, especially of calcium. It is hypothesized that postjunctional supersensitivity is due, at least in part, to a reduction in resting membrane potential associated with a decrease in calcium bound to the cell membrane.

• Publication year

  1975

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1975-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)30073-xPMID 1117424
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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