Furan carcinogenicity: DNA binding and genotoxicity of furan in rats in vivo.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular Nutrition & Food Research

• Publication date

  2012-09-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/mnfr.201200226PMID 22865590PMCID PMC3892142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genotoxicity of furan in Big Blue rats.

  2012cited by this paper
• Identification and pathway mapping of furan target proteins reveal mitochondrial energy production and redox regulation as critical targets of furan toxicity.

  2012cited by this paper
• Furan induction of DNA cross-linking and strand breaks in turkey fetal liver in comparison to 1,3-propanediol.

  2012cited by this paper
• In vivo genotoxicity of furan in F344 rats at cancer bioassay doses.

  2012cited by this paper
• NOTE TO THE INITIAL REPORT OF THE SCIENTIFIC PANEL ON CONTAMINANTS IN THE FOOD CHAIN ON PROVISIONAL FINDINGS ON FURAN IN FOOD

  2011cited by this paper
• Identification of furan metabolites derived from cysteine-cis-2-butene-1,4-dial-lysine cross-links.

  2010cited by this paper
• Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes.

  2010cited by this paper
• Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats

  2010cited by this paper
• Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver.

  2010cited by this paper
• Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.

  2008influential reference
• Detection of Adriamycin–DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

  2008cited by this paper
• Formation of MTBE–DNA adducts in mice measured with accelerator mass spectrometry

  2005cited by this paper
• Quantitating isotopic molecular labels with accelerator mass spectrometry.

  2005cited by this paper
• V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals.

  2005cited by this paper
• Ochratoxin A: lack of formation of covalent DNA adducts.

  2004cited by this paper
• Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity.

  2004cited by this paper
• The formation of substituted 1,N6-etheno-2'-deoxyadenosine and 1,N2-etheno-2'-deoxyguanosine adducts by cis-2-butene-1,4-dial, a reactive metabolite of furan.

  2004influential reference
• Differential giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiography

  2004cited by this paper
• Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan.

  2002influential reference
• A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay.

  2000cited by this paper
• Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts.

  1999cited by this paper
• Dose-dependent binding of ortho-phenylphenol to protein but not DNA in the urinary bladder of male F344 rats.

  1999cited by this paper
• Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan.

  1997cited by this paper
• Comparisons of the binding of [14C]radiolabelled tamoxifen or toremifene to rat DNA using accelerator mass spectrometry.

  1997cited by this paper
• Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice.

  1997cited by this paper
• A facile route to 3a,8a-dihydrofuro[2,3-b]benzofurans

  1995cited by this paper
• A Facile Route to 3a,8a-Dihydrofuro(2,3-b)benzofurans.

  1995cited by this paper
• Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling.

  1995cited by this paper
• Studies on DNA adduction with heterocyclic amines by accelerator mass spectrometry: a new technique for tracing isotope-labelled DNA adduction.

  1993cited by this paper
• Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage Studies).

  1993cited by this paper
• Disposition of [14C]furan in the male F344 rat.

  1991influential reference
• Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.

  1990cited by this paper
• A simple technique for quantitation of low levels of DNA damage in individual cells.

  1988cited by this paper
• DNA‐damaging activity of biotic and xenobiotic aldehydes in chinese hamster ovary cells

  1984cited by this paper
• New Giemsa method for the differential staining of sister chromatids

  1974cited by this paper

• Uptake mechanisms and physiological effects of furanic compounds from the Maillard reaction in budding yeast

  2026cites this paper
• Process-induced toxicants in food: an overview on structures, formation pathways, sensory properties, safety and health implications

  2025cites this paper
• Characterizing phenotype variants of Cercosporidium personatum, causal agent of peanut late leaf spot disease, their morphology, genetics and metabolites

  2025cites this paper
• Mechanistic and predictive studies on the oxidation of furans by cytochrome P450: A DFT study.

  2024cites this paper
• Genotoxic and Mutagenic Assessment Induced by Vinasse, Before and After Being Subjected to Bio-oxidation and Fenton Processes

  2024cites this paper
• Appearance of sex‐determining region Y‐box 9 (SOX9)‐ and glutathione S‐transferase placental form (GST‐P)‐positive hepatocytes as possible carcinogenic events in the early stage of furan‐induced hepatocarcinogenesis

  2024cites this paper
• Salidroside Alleviates Furan-Induced Impaired Gut Barrier and Inflammation via Gut Microbiota-SCFA-TLR4 Signaling.

  2024cites this paper
• Dosimetry of human exposure to furan and 2-methylfuran by monitoring urinary biomarkers.

  2024cites this paper
• Neurotoxicity of furan in juvenile Wistar rats involves behavioral defects, microgliosis, astrogliosis and oxidative stress.

  2023cites this paper
• Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation?

  2023cites this paper
• Furan promotes cytotoxic effects through DNA damage and cell apoptosis in Leydig cells

  2023influential citation
• The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

  2022cites this paper
• A comprehensive review of furan in foods: From dietary exposures and in vivo metabolism to mitigation measures.

  2022cites this paper
• New derivative of trans-dehydrocrotonin isolated from Croton cajucara shows reduced cytotoxic and genotoxic effects in hepatocellular carcinoma (HepG2) cell line.

  2022cites this paper
• Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

  2022cites this paper
• Modulation of Disordered Bile Acid Homeostasis and Hepatic Tight Junctions Using Salidroside against Hepatocyte Apoptosis in Furan-Induced Mice.

  2022cites this paper
• Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study.

  2022cites this paper
• New insight into the molecular mechanism of protein cross-linking induced by cis-2-butene-1,4-dial, the metabolite of furan: Formation of 2-substituted pyrrole cross-links involving the cysteine and lysine residues.

  2022cites this paper
• Comet assay: a versatile but complex tool in genotoxicity testing.

  2021cites this paper
• Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan

  2021cites this paper
• Protective effect of Spirulina platensis against physiological, ultrastructural and cell proliferation damage induced by furan in kidney and liver of rat.

  2020cites this paper
• Furan MAK Value Documentation , supplement – Translation of the German version from 2017

  2020cites this paper
• A New UPLC-qTOF Approach for Elucidating Furan and 2-Methylfuran Metabolites in Human Urine Samples after Coffee Consumption

  2020cites this paper
• A review on furan: Formation, analysis, occurrence, carcinogenicity, genotoxicity and reduction methods

  2020cites this paper
• Risk Assessment of Furan Exposure in the Norwegian Population

  2019influential citation
• Spatial distributions of furan and 5-hydroxymethylfurfural in unroasted and roasted Coffea arabica beans.

  2019cites this paper
• Furan and Methylfurans in Foods: An Update on Occurrence, Mitigation, and Risk Assessment.

  2019cites this paper
• Furan and Alkylfurans: Occurrence and Risk Assessment

  2019cites this paper
• In Vitro DNA Adduction Resulting from Metabolic Activation of Diosbulbin B and 8-Epidiosbulbin E Acetate.

  2018cites this paper
• Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan.

  2018cites this paper
• Exposure assessment of process-related contaminants in food by biomarker monitoring

  2018influential citation
• Risks for public health related to the presence of furan and methylfurans in food

  2017influential citation
• Lack of genotoxic mechanisms in early‐stage furan‐induced hepatocellular tumorigenesis in gpt delta rats

  2017cites this paper
• Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.

  2017influential citation
• The role of epigenomic alterations in furan-induced hepatobiliary pathologies.

  2017cites this paper
• Identifying and collecting relevant literature related to the oral toxicity of furan and its methyl analogues, 2‐methylfuran and 3‐methylfuran

  2017cites this paper
• Furan in processed food: formation, toxicology and monitoring: a Review

  2017cites this paper
• Furan [MAK Value Documentation in German language, 2017]

  2017cites this paper
• Interventions to Encourage and Facilitate Greener Industrial Chemicals Selection

  2017cites this paper
• Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

  2016cites this paper
• Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study

  2016cites this paper
• Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats

  2016cites this paper
• New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

  2016cites this paper
• Scientific opinion on Flavouring Group Evaluation 67 Revision 2 (FGE.67Rev2): consideration of 28 furan-substituted compounds evaluated by JECFA at the 55th, 65th and 69th meetings (JECFA, 2001, 2006a, 2009b).

  2015cites this paper
• Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats.

  2015cites this paper
• Optimal dose selection of N-methyl-N-nitrosourea for the rat comet assay to evaluate DNA damage in organs with different susceptibility to cytotoxicity.

  2015cites this paper
• Comparative Metabolism of Furan in Rodent and Human Cryopreserved Hepatocytes

  2014cites this paper
• Biological and Chemical Activities of Furan

  2014cites this paper
• Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan.

  2014cites this paper
• Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.

  2014cites this paper
• Up-regulation on cytochromes P450 in rat mediated by total alkaloid extract from Corydalis yanhusuo

  2014cites this paper
• DMD057794 1132..1136

  2014cites this paper
• Furan: a critical heat induced dietary contaminant.

  2013cites this paper
• A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.

  2013cites this paper
• Reactive metabolites in the biotransformation of molecules containing a furan ring.

  2013cites this paper