Lack of genotoxic mechanisms in early‐stage furan‐induced hepatocellular tumorigenesis in gpt delta rats

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Applied Toxicology

• Publication date

  2017-02-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/jat.3331PMID 27143483
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• International Agency for Research on Cancer (IARC)

  2018cited by this paper
• Furan in food - a review.

  2018cited by this paper
• Lack of genotoxic mechanisms in early‐stage furan‐induced hepatocellular tumorigenesis in gpt delta rats

  2017cited by this paper
• [Not Available].

  2015cited by this paper
• Furan in Thermally Processed Foods - A Review

  2015cited by this paper
• Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.

  2014cited by this paper
• Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity

  2013cited by this paper
• In vivo genotoxicity of methyleugenol in gpt delta transgenic rats following medium-term exposure.

  2013cited by this paper
• Genotoxicity of furan in Big Blue rats.

  2012cited by this paper
• Furan carcinogenicity: DNA binding and genotoxicity of furan in rats in vivo.

  2012cited by this paper
• Toxicity and carcinogenicity of furan in human diet

  2010cited by this paper
• A Medium-Term, Rapid Rat Bioassay Model for the Detection of Carcinogenic Potential of Chemicals

  2010cited by this paper
• Subchronic Oral Toxicity Study of Furan in Fischer-344 Rats

  2010cited by this paper
• The Wnt/β-catenin signaling pathway in liver biology and disease

  2010cited by this paper
• Detailed Review Paper on Transgenic Rodent Mutation Assays

  2009cited by this paper
• Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.

  2008cited by this paper
• Data requirements for risk assessment of furan in food

  2007cited by this paper
• Safety evaluation of certain contaminants in food

  2006cited by this paper
• Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial.

  2006cited by this paper
• In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate

  2006cited by this paper
• Molecular nature of intrachromosomal deletions and base substitutions induced by environmental mutagens

  2005cited by this paper
• Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

  2004cited by this paper
• Value of GST-P Positive Preneoplastic Hepatic Foci in Dose-Response Studies of Hepatocarcinogenesis: Evidence for Practical Thresholds with Both Genotoxic and Nongenotoxic Carcinogens. A Review of Recent Work

  2003cited by this paper
• Recent advances in the protocols of transgenic mouse mutation assays.

  2000cited by this paper
• A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay.

  2000cited by this paper
• Oxazepam is mutagenic in vivo in Big Blue transgenic mice.

  1999cited by this paper
• Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents.

  1996cited by this paper
• IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

  1995cited by this paper
• Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.

  1994cited by this paper
• Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.

  1991cited by this paper
• SPONTANEOUS OCCURRENCE OF PLACENTAL GLUTATHIONE S‐TRANSFERASE‐POSITIVE FOCI IN THE LIVERS OF LEC RATS

  1988cited by this paper
• Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals.

  1986cited by this paper
• Phenotypic Properties of Preneoplastic Rat Liver Lesions and Applications to Detection of Carcinogens and Tumor Promoters.

  1982cited by this paper
• Phenotypic Properties of Preneoplastic Rat Liver Lesions and Applications to Detection of Carcinogens and Tumor Promoters

  1982cited by this paper
• A Letter from the Editor of Toxicologic Pathology

  1982cited by this paper
• Furans in foods.

  1979cited by this paper

• New insights into methylfuran metabolism.

  2025cites this paper
• Demystifying furan formation in foods: Implications for human health, detection, and control measures: A review.

  2024cites this paper
• Appearance of sex‐determining region Y‐box 9 (SOX9)‐ and glutathione S‐transferase placental form (GST‐P)‐positive hepatocytes as possible carcinogenic events in the early stage of furan‐induced hepatocarcinogenesis

  2024influential citation
• A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin.

  2023cites this paper
• Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes.

  2023cites this paper
• Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.

  2022cites this paper
• A comprehensive review of furan in foods: From dietary exposures and in vivo metabolism to mitigation measures.

  2022cites this paper
• Comprehensive analysis of the general toxicity, genotoxicity, and carcinogenicity of 3-acetyl-2,5-dimethylfuran in male gpt delta rats.

  2022cites this paper
• Impact of PCBs, Furan and Dioxin on Hepatocarcinogenesis

  2022cites this paper
• Comet assay: a versatile but complex tool in genotoxicity testing.

  2021cites this paper
• In vivo mutagenicity and tumor-promoting activity of 1,3-dichloro-2-propanol in the liver and kidneys of gpt delta rats

  2021cites this paper
• Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan

  2021cites this paper
• A review on furan: Formation, analysis, occurrence, carcinogenicity, genotoxicity and reduction methods

  2020cites this paper
• Background data of 2-year-old male and female F344 gpt delta rats

  2020cites this paper
• Lack of in vivo mutagenicity of acetamide in a 13-week comprehensive toxicity study using F344 gpt delta rats.

  2020cites this paper
• Furan Induced Characteristic Glutathione S-Transferase Placental Form-Positive Foci in Terms of Cell Kinetics and Gene Expression

  2020cites this paper
• SOME AROMATIC AMINES AND RELATED COMPOUNDS VOLUME 127 IARC MONOGRAPHS ON THE IDENTIFICATION OF CARCINOGENIC HAZARDS TO HUMANS

  2019cites this paper
• What is the meaning of ‘A compound is carcinogenic’?

  2018cites this paper
• Industrial furan and its biological effects on the body systems

  2018cites this paper
• Risks for public health related to the presence of furan and methylfurans in food

  2017cites this paper
• Furan in processed food: formation, toxicology and monitoring: a Review

  2017cites this paper
• Lack of genotoxic mechanisms in early‐stage furan‐induced hepatocellular tumorigenesis in gpt delta rats

  2017cites this paper
• The role of epigenomic alterations in furan-induced hepatobiliary pathologies.

  2017cites this paper