Recent advances in the protocols of transgenic mouse mutation assays.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Mutation research

• Publication date

  2000-11-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0027-5107(00)00077-4PMID 11113476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutational analysis of the liver, colon and kidney of Big Blue rats treated with 2-amino-3-methylimidazo[4,5-f]quinoline.

  2000cited by this paper
• Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.

  2000cited by this paper
• In vivo transgenic mutation assays

  2000cited by this paper
• Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments

  2000cited by this paper
• Mutagenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the new gpt delta transgenic mouse.

  1999cited by this paper
• Detection of cyclophosphamide‐induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice

  1999cited by this paper
• Induction of mutations in transgenic animal models: BigBlue and Muta Mouse.

  1999cited by this paper
• Mutation induction by N-propyl-N-nitrosourea in eight MutaMouse organs.

  1999cited by this paper
• Mutagenicity of 4-nitroquinoline 1-oxide in the MutaMouse.

  1999cited by this paper
• In vivo mutagenicity and hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in bitransgenic c-myc/lambda lacZ mice.

  1999cited by this paper
• Efficient detection of deletions induced by a single treatment of mitomycin C in transgenic mouse gpt delta using the Spi− selection

  1999cited by this paper
• Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations.

  1999cited by this paper
• Mutagenesis induced by benzo[a]pyrene in lacZ mouse mammary and oral tissues: comparisons with mutagenesis in other organs and relationships to previous carcinogenicity assays.

  1999cited by this paper
• Tamoxifen induces G:C-->T:A mutations in the cII gene in the liver of lambda/lacI transgenic rats but not at 5'-CpG-3' dinucleotide sequences as found in the lacI transgene.

  1999cited by this paper
• Evidence for the lack of base‐change and small‐deletion mutation induction by trichloroethylene in lacZ transgenic mice

  1999cited by this paper
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  1999cited by this paper
• Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3, cs70. II. Brain.

  1999cited by this paper
• Spontaneous mutation frequency and pattern in Big Blue® mice fed a vitamin E‐supplemented diet

  1999cited by this paper
• A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo.

  1999cited by this paper
• Hepatic gene mutations induced in Big Blue™ rats by both the potent rat liver Azo‐carcinogen 6BT and its reported noncarcinogenic analogue 5BT

  1999cited by this paper
• Multiple organ mutation in the lacZ transgenic mouse (Muta mouse) 6 months after oral treatment (5 days) with benzo[a]pyrene.

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• Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene.

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• Tissue‐specific mutant frequencies and mutational spectra in cyclophosphamide‐treated lacI transgenic mice

  1999cited by this paper
• The cII locus in the MutaMouse system.

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• Comparison of mutant frequencies at the transgenic lambda lacI and cII/cI loci in control and ENU‐treated Big Blue® mice

  1999cited by this paper
• The cII locus in the Muta™Mouse System

  1999cited by this paper
• Induction of lacZ mutation by 7,12-dimethylbenz[a]anthracene in various tissues of transgenic mice.

  1999cited by this paper
• An estimator of the mutant frequency in assays using transgenic animals.

  1999cited by this paper
• Effects of O 6‐alkylguanine‐DNA alkyltransferase deficiency in Escherichia coli as the host for the detection of mutations in lacI transgenic mice

  1999cited by this paper
• Mutagenesis induced by oral carcinogens in lacZ mouse (MutaMouse) tongue and other oral tissues.

  1999cited by this paper
• UVB‐induced gpt mutations in the skin of gpt delta transgenic mice

  1999cited by this paper
• Somatic mutation in the mammary gland: influence of time and estrus.

  1999cited by this paper
• Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.

  1999cited by this paper
• Effect of mitogenic or regenerative cell proliferation on lacz mutant frequency in the liver of MutaTMMice treated with 5, 9-dimethyldibenzo[c,g]carbazole.

  1999cited by this paper
• Ethylnitrosourea-induced mutation and molecular analysis of transgenic mice containing the gpt shuttle vector.

  1999cited by this paper
• N-Nitrosodi-n-propylamine induces organ specific mutagenesis with specific expression times in lacZ transgenic mice.

  1999cited by this paper
• Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice.

  1999cited by this paper
• Spectra of gpt mutations in ethylnitrosourea‐treated and untreated transgenic mice

  1999cited by this paper
• Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo.

  1999cited by this paper
• Analysis of gene mutations and clastogenicity following short‐term treatment with azathioprine in Muta™Mouse

  1999cited by this paper
• Effect of heterozygous loss of p53 on benzo[a]pyrene‐induced mutations and tumors in DNA repair‐deficient XPA mice

  1999cited by this paper
• Oxazepam is mutagenic in vivo in Big Blue transgenic mice.

  1999cited by this paper
• Spi− selection: An efficient method to detect γ‐ray‐induced deletions in transgenic mice

  1999cited by this paper
• The in vivo mutagenicity and mutational spectrum at the lacI transgene recovered from the spleens of B6C3F1 lacI transgenic mice following a 4-week inhalation exposure to 1,3-butadiene.

  1998cited by this paper
• Genetic instability in human T-lymphocytes.

  1998cited by this paper
• Bone marrow and liver mutagenesis in lacZ transgenic mice treated with hexavalent chromium.

  1998cited by this paper
• DNA adducts, mutant frequencies and mutation spectra in lambda lacZ transgenic mice treated with N-nitrosodimethylamine.

  1998cited by this paper
• Mutagenic activity of carcinogens detected in transgenic rodent mutagenicity assays at dose levels used in chronic rodent cancer bioassays.

  1998cited by this paper
• Hepatic lacI and cII mutation in transgenic (λLIZ) rats treated with dimethylnitrosamine

  1998cited by this paper
• Long‐term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice

  1998cited by this paper
• Antimutagenic structural modification of quinoline assessed by an in vivo mutagenesis assay using lacZ-transgenic mice.

  1998cited by this paper
• Enhanced liver cell mutations in trematode-infected Big Blue transgenic mice.

  1998cited by this paper
• Mutagenicity of the human bladder carcinogen 4-aminobiphenyl to the bladder of MutaMouse transgenic mice.

  1998cited by this paper
• Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.

  1998cited by this paper
• Mutation studies in lacI transgenic mice after exposure to radiation or cyclophosphamide.

  1998cited by this paper
• Effect of maternal folate levels on somatic mutation frequency in the developing colon.

  1998cited by this paper
• No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice.

  1998cited by this paper
• Benzo[a]pyrene site of contact mutagenicity in skin of Muta Mouse.

  1998cited by this paper
• Spontaneous mutation in lacI transgenic mice: a comparison of tissues.

  1998cited by this paper
• Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inhalation.

  1998cited by this paper
• Genetic analysis of PHIP intestinal mutations in MutaMouse.

  1998cited by this paper
• In vivo mutagenesis by the hepatocarcinogen quinoline in the lacZ transgenic mouse: evidence for its in vivo genotoxicity.

  1998cited by this paper
• Hepatic lacI and cII mutation in transgenic (lambdaLIZ) rats treated with dimethylnitrosamine.

  1998cited by this paper
• Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice.

  1998cited by this paper
• Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of Muta™Mouse mice

  1998cited by this paper
• Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse).

  1998cited by this paper
• The DNA damaging drug cyproterone acetate causes gene mutations and induces glutathione-S-transferase P in the liver of female Big Blue transgenic F344 rats.

  1998cited by this paper
• Statistical analysis of lacZ mutant frequency data from MutaMouse mutagenicity assays.

  1998cited by this paper
• DNA adducts, mutant frequencies, and mutation spectra in various organs of λlacZ mice exposed to ethylating agents

  1998cited by this paper
• Lack of mutagenicity of levofloxacin in lacZ transgenic mice.

  1998cited by this paper
• Induction of mutations by 2-acetylaminofluorene in lacI transgenic B6C3F1 mouse liver.

  1998cited by this paper
• Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue(R) rats treated with 7, 12-dimethylbenz[a]anthracene.

  1998cited by this paper
• Mutant frequencies in lacZ transgenic mice following the internal irradiation from 89Sr or the external gamma-ray irradiation.

  1998cited by this paper
• Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3 cs70 I. Spleen and testis.

  1998cited by this paper
• A comparative study of in vivo mutation assays: analysis of hprt, lacI, cII/cI and as mutational targets for N-nitroso-N-methylurea and benzo[a]pyrene in Big Blue mice.

  1998cited by this paper
• Mutagenicity of ethyl carbamate to lacZ- transgenic mice.

  1998cited by this paper
• The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

  1997cited by this paper
• UVB-induced mutagenesis in hairless lambda lacZ-transgenic mice.

  1997cited by this paper
• Assessment of the mutagenicity of dichloroacetic acid in lacI transgenic B6C3F1 mouse liver.

  1997cited by this paper
• X-ray- and ultraviolet-radiation-induced mutations in Muta mouse.

  1997cited by this paper
• UVB‐induced Cyclobutane Pyrimidine Dimer Frequency Correlates with Skin Cancer Mutational Hotspots in p53

  1997cited by this paper
• Germ cell mutagenesis in lacZ transgenic mice treated with methyl methanesulfonate.

  1997cited by this paper
• Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene.

  1997cited by this paper
• UVB‐induced mutagenesis in hairless λlacZ‐transgenic mice

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• Mammalian germ cell mutagenicity of ENU, IPMS and MMS, chemicals selected for a transgenic mouse collaborative study.

  1997cited by this paper
• Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats.

  1997cited by this paper
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  1997cited by this paper
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• A comparison of the genotoxicity of ethylnitrosourea and ethyl methanesulfonate in lacZ transgenic mice (Muta Mouse).

  1997cited by this paper
• On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice.

  1997cited by this paper
• Mutant frequency of lacI in transgenic mice following benzo[a]pyrene treatment and partial hepatectomy.

  1997cited by this paper
• Somatic and germ cell mutagenesis in lambda lacZ transgenic mice treated with acrylamide or ethylnitrosourea.

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• Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents.

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• Stability of CII is a key element in the cold stress response of bacteriophage lambda infection

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