Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Genetics

• Publication date

  2007-01-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng1952PMID 17237781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA methyltransferases control telomere length and telomere recombination in mammalian cells

  2006cited by this paper
• XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

  2005cited by this paper
• Shelterin: the protein complex that shapes and safeguards human telomeres.

  2005cited by this paper
• DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

  2005cited by this paper
• Telomeres and human disease: ageing, cancer and beyond

  2005cited by this paper
• The first molecular details of ALT in human tumor cells.

  2005cited by this paper
• Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

  2005cited by this paper
• A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.

  2004cited by this paper
• Modification of Subtelomeric DNA

  2004cited by this paper
• Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

  2004cited by this paper
• Heterochromatin and tri-methylated lysine 20 of histone H4 in animals

  2004cited by this paper
• Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

  2004cited by this paper
• Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression.

  2003cited by this paper
• Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

  2002cited by this paper
• Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

  2002cited by this paper
• New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

  2002cited by this paper
• A role for the Rb family of proteins in controlling telomere length

  2002cited by this paper
• Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

  2001cited by this paper
• Loss of the Suv 39 h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

  2001cited by this paper
• The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.

  2001cited by this paper
• Telomere Position Effect in Human Cells

  2001cited by this paper
• Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres

  2001cited by this paper
• Strand-Specific Postreplicative Processing of Mammalian Telomeres

  2001cited by this paper
• Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA

  2000cited by this paper
• The language of covalent histone modifications

  2000cited by this paper
• Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

  1999cited by this paper
• Mechanisms of silencing in Saccharomyces cerevisiae.

  1998cited by this paper
• Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

  1997cited by this paper
• The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing

  1995cited by this paper
• Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.

  1993cited by this paper

• Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

  2026cites this paper
• Epigenetic Regulation of Aging and its Rejuvenation

  2025cites this paper
• Telomeres as hallmarks of iPSC aging: a review on telomere dynamics during stemness and cellular reprogramming.

  2025cites this paper
• Epigenetics of Human Telomeres.

  2025cites this paper
• Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions.

  2025cites this paper
• The ZBTB24-CDCA7-HELLS axis suppresses the totipotent 2C-like reprogramming by maintaining Dux methylation and repression

  2025cites this paper
• The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis.

  2025cites this paper
• A predictive chromatin architecture nexus regulates transcription and DNA damage repair

  2025cites this paper
• The Cellular Mechanism of Aging as Programmed Epigenetic Phenomenon: From Hypothesis to Scientific Evidence

  2025cites this paper
• Particulate matter 2.5 accelerates aging: Exploring cellular senescence and age-related diseases.

  2024cites this paper
• Reprogramming Chromosome Ends by Functional Histone Acetylation

  2024cites this paper
• Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells

  2024cites this paper
• Epigenetic biomarkers in aging and longevity: Current and future application.

  2024cites this paper
• Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics

  2024cites this paper
• Telomere-based treatment strategy of cardiovascular diseases: imagination comes to reality

  2024cites this paper
• Targeting 'histone mark': Advanced approaches in epigenetic regulation of telomere dynamics in cancer.

  2024cites this paper
• Reduced SIRT1 and SIRT3 and Lower Antioxidant Capacity of Seminal Plasma Is Associated with Shorter Sperm Telomere Length in Oligospermic Men

  2024cites this paper
• Relationship between aging and control of metabolic syndrome with telomere shortening: a cross-sectional study

  2023cites this paper
• Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription

  2023cites this paper
• ALTercations at telomeres: stress, recombination and extrachromosomal affairs.

  2023cites this paper
• Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease

  2023cites this paper
• Editorial: Dietary factors, epigenetics and their implications for human obesity - volume II

  2023cites this paper
• Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells

  2022cites this paper
• Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers

  2022cites this paper
• Breaking the aging epigenetic barrier

  2022cites this paper
• Telomeres as dynamic structures of human genome: the effect of endogenous and exogenous factors

  2022cites this paper
• TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer.

  2022cites this paper
• Gestational exposure to NO2 aggravates placental senescence.

  2022cites this paper
• Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress

  2022cites this paper
• TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance

  2022cites this paper
• Is Human Aging a Form of Phenoptosis?

  2022cites this paper
• Zscan4 Contributes to Telomere Maintenance in Telomerase-Deficient Late Generation Mouse ESCs and Human ALT Cancer Cells

  2022cites this paper
• Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs

  2021cites this paper
• Subtelomere-Telomere Aging Theory

  2021cites this paper
• Существуют ли доказательства в пользу субтеломерно-теломерной теории старения?

  2021cites this paper
• Is Evidence Supporting the Subtelomere–Telomere Theory of Aging?

  2021cites this paper
• A Tale of Two States: Pluripotency Regulation of Telomeres

  2021cites this paper
• Epigenetic features in regulation of telomeres and telomerase in stem cells.

  2021cites this paper
• Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

  2021cites this paper
• Effects of Psychological Stress on Telomeres as Genome Regulators

  2021cites this paper
• G-Quadruplex Structures Colocalize with Transcription Factories and Nuclear Speckles Surrounded by Acetylated and Dimethylated Histones H3

  2021cites this paper
• Multiple Chromosomal Polymorphism of “Evoron” Chromosomal Race of the Evoron Vole (Rodentia, Arvicolinae)

  2021cites this paper
• Multiple Chromosomal Polymorphism of “Evoron” Chromosomal Race of the Evoron Vole (Rodentia, Arvicolinae)

  2021cites this paper
• The epigenetic regulation of centromeres and telomeres in plants and animals

  2020influential citation
• CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

  2020cites this paper
• Importance and Meaning of TERRA Sequences for Aging Mechanisms

  2020cites this paper
• Последовательности TERRA имеют большое значение для механизмов старения

  2020cites this paper
• Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically

  2020cites this paper
• Subtelomeric Transcription and its Regulation

  2020cites this paper
• Regulatory mechanisms governing epidermal stem cell function during development and homeostasis

  2020cites this paper
• On the relations of phase separation and Hi-C maps to epigenetics

  2020cites this paper
• Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners

  2020cites this paper
• H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres

  2020cites this paper
• DNA Methylation Profiling of hTERT Gene Alongside with the Telomere Performance in Gastric Adenocarcinoma

  2020cites this paper
• Oxidative stress induces transcription of telomeric repeat-containing RNA (TERRA) by engaging PKA signaling and cytoskeleton dynamics.

  2020cites this paper
• Therapeutic Targets in Telomerase and Telomere Biology of Cancers

  2020cites this paper
• Environmental pollutants exposure: A potential contributor for aging and age-related diseases.

  2020cites this paper
• Alternative paths to telomere elongation.

  2020cites this paper
• On the relation of phase separation and Hi-C maps to epigenetics

  2019cites this paper
• The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases

  2019cites this paper
• Nature and Functions of Telomeric Transcripts

  2019cites this paper
• Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

  2019cites this paper
• Epigenetic regulations in alternative telomere lengthening: Understanding the mechanistic insight in arsenic-induced skin cancer patients.

  2019cites this paper
• Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation

  2019cites this paper
• Genetic Syndromes and Aging

  2019cites this paper
• Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling

  2019cites this paper
• Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?

  2019cites this paper
• Methylation of global DNA repeat LINE-1 and subtelomeric DNA repeats D4Z4 in leukocytes is associated with biochemical recurrence in African American prostate cancer patients.

  2019cites this paper
• TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

  2019cites this paper
• Short telomere subtelomeric hypomethylation is associated with telomere attrition in elderly diabetic patients 1.

  2019cites this paper
• X-rays Activate Telomeric Homologous Recombination Mediated Repair in Primary Cells

  2019cites this paper
• Epigenetics of Aging and Age-Related Disorders

  2019cites this paper
• Role of arsenic, lead and cadmium on telomere length and the risk of carcinogenesis: a mechanistic insight

  2019cites this paper
• Effect of Environmental and Occupational Exposures on Human Telomere Length and Aging: A Review

  2019cites this paper
• Models, Molecules and Mechanisms in Biogerontology: Physiological Abnormalities, Diseases and Interventions

  2019cites this paper
• 2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state

  2019cites this paper
• Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma

  2019cites this paper
• Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects

  2019cites this paper
• SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

  2019cites this paper
• Alternative Lengthening of Telomeres and Chromatin Status

  2019influential citation
• Epigenetic aspects of telomeric chromatin in Arabidopsis thaliana

  2019cites this paper
• Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

  2019cites this paper
• Inhibiting repressive epigenetic modification promotes telomere rejuvenation in somatic cell reprogramming

  2019cites this paper
• Biochemical and structural analysis of shelterin subcomplexes

  2018cites this paper
• The DNA damage response at dysfunctional telomeres, and at interstitial and subtelomeric DNA double-strand breaks.

  2018cites this paper
• TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

  2018cites this paper
• Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres

  2018cites this paper
• Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability.

  2018cites this paper
• Heart-Breaking Telomeres

  2018cites this paper
• The methylation and telomere landscape in two families of marsupials with different rates of chromosome evolution

  2018cites this paper
• Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability.

  2018cites this paper
• Naphthalene diimide‐derivatives G‐quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells

  2018cites this paper
• Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan

  2018influential citation
• Telomeres, Telomerase and Ageing.

  2018cites this paper
• Fertility, IVF and reproductive genetics

  2018cites this paper
• Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase in C. elegans

  2018cites this paper
• The Epigenetic Regulation of Telomere Maintenance in Aging

  2018cites this paper
• Cancer RNome: Evolution and Sustenance

  2018cites this paper
• In medio stat virtus: unanticipated consequences of telomere dysequilibrium

  2018cites this paper
• A regulatory circuit HP1γ/miR-451a/c-Myc promotes prostate cancer progression

  2018cites this paper