Dextromethorphan reduces neocortical ischemic neuronal damage in vivo.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Brain Research

• Publication date

  1988-02-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0006-8993(88)91011-6PMID 3359222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity.

  1987cited by this paper
• Vigabatrin for refractory complex partial seizures

  1987cited by this paper
• Excitotoxity and the NMDA receptor

  1987cited by this paper
• Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture.

  1987cited by this paper
• Glutamate Antagonist Therapy Reduces Ischemic Damage

  1987cited by this paper
• Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.

  1987cited by this paper
• Pharmacogenetics of dextromethorphan O-demethylation in man.

  1986cited by this paper
• Correlation between somatosensory evoked potentials and neuronal ischemic changes following middle cerebral artery occlusion.

  1986cited by this paper
• Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

  1986cited by this paper
• Ketamine protects cultured neocortical neurons from hypoxic injury.

  1986cited by this paper
• Cerebral Ischemia in Rabbit: A New Experimental Model with Immunohistochemical Investigation

  1985cited by this paper
• Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.

  1985cited by this paper
• Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

  1985cited by this paper
• Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

  1984cited by this paper
• Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.

  1981cited by this paper
• Modification of Acute Focal Ischemia by Treatment with Mannitol

  1978cited by this paper
• Metabolism and excretion of tritiated dextromethorphan by the rat.

  1967cited by this paper

• Sigma-1 receptor and seizures

  2023cites this paper
• Full Issue: Volume 4, Number 1

  2020cites this paper
• Desferrioxamine and dextromethorphan combination exhibited synergistic effect and reversed the catalepsy behaviour in 6‐hydroxydopamine hydroydopamine administered rats through regulating brain glutamate levels

  2019cites this paper
• MK‐801, but not naloxone, attenuates high‐dose dextromethorphan‐induced convulsive behavior: Possible involvement of the GluN2B receptor

  2017cites this paper
• Neuroprotection Following Stroke in the Gyrencephalic Non-Human Primate Brain

  2016cites this paper
• in Functional Compromise Following Simulated Stroke Blocking the Anoxic Depolarization Protects Without

  2015cites this paper
• Determining the role of NMDA receptors and ATP receptors in the pathological damage following stroke

  2015cites this paper
• eview nderstanding history , and not repeating it . Neuroprotection for cute ischemic stroke : From review to preview

  2015cites this paper
• Understanding history, and not repeating it. Neuroprotection for acute ischemic stroke: from review to preview.

  2015cites this paper
• Unification of Neuronal Spikes, Seizures, and Spreading Depression

  2014cites this paper
• Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats.

  2012cites this paper
• Low-Dose Dextromethorphan, a NADPH Oxidase Inhibitor, Reduces Blood Pressure and Enhances Vascular Protection in Experimental Hypertension

  2012cites this paper
• Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs.

  2011cites this paper
• Brain protection in cardiac surgery

  2011cites this paper
• experimental stroke in rats noncompetitive N-methyl-D-aspartate antagonist and reperfusion in Diffusion and perfusion magnetic resonance imaging studies to evaluate a

  2011cites this paper
• Developing novel therapeutics for excitotoxic neuronal death following stroke

  2011cites this paper
• Pharmacological Studies to Reduce Brain Injury in Cardiac Surgery

  2011cites this paper
• Neuropsychopharmacological understanding for therapeutic application of morphinans

  2010cites this paper
• Excitoxicity in Retinal Ischemia and TreatmentUsing Non-Competitive Receptor Antagonists

  2010cites this paper
• Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan.

  2009cites this paper
• Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects.

  2008cites this paper
• Study Design in Animal Models of Stroke

  2008cites this paper
• New neuroprotective approaches for stroke: use of decoy peptides targeting specific molecular events

  2007cites this paper
• Dextromethorphan as a Potential Neuroprotective Agent With Unique Mechanisms of Action

  2007cites this paper
• Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine‐addicted mother: Beneficial effect of dextromethorphan

  2006cites this paper
• Pretreatment with a competitive NMDA antagonist D-CPPene attenuates focal cerebral infarction and brain swelling in awake rats

  2005cites this paper
• Effects of Dextromethorphan on Rat Brain During Ischemia and Reperfusion Assessed by Magnetic Resonance Spectroscopy

  2005cites this paper
• Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices.

  2005cites this paper
• Dextromethorphan attenuates the effects of ischemia on rabbit electroretinographic oscillatory potentials

  2005cites this paper
• The Ischemic Penumbra and Neuronal Salvage

  2005cites this paper
• Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage

  2005cites this paper
• Retinal ischemia: mechanisms of damage and potential therapeutic strategies.

  2004cites this paper
• Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase

  2004cites this paper
• Morphinan neuroprotection: new insight into the therapy of neurodegeneration.

  2004influential citation
• Dextromethorphan Protects Dopaminergic Neurons against Inflammation-Mediated Degeneration through Inhibition of Microglial Activation

  2003cites this paper
• Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax‐cytochrome C‐caspase pathway: the causative role of Ca2+ deficiency

  2003cites this paper
• Imaging and preventing spreading depression independent of cerebral blood flow

  2002cites this paper
• Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine.

  2002cites this paper
• Spreading depression: imaging and blockade in the rat neocortical brain slice.

  2002cites this paper
• Effects of methylprednisolone and dextromethorphan on lipid peroxidation in an experimental model of spinal cord injury

  2002cites this paper
• Glutamate-Induced Excitotoxicity in Retina: Neuroprotection with Receptor Antagonist, Dextromethorphan, but Not with Calcium Channel Blockers

  2002cites this paper
• Translating Experimental Stroke Research into the Clinical Arena

  2001cites this paper
• Reduction of ischemic spinal cord injury by dextrorphan: comparison of several methods of administration.

  2001cites this paper
• Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring.

  2001cites this paper
• delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury.

  2000cites this paper
• δ-, but not μ- and κ-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury

  2000cites this paper
• Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.

  1999cites this paper
• Neuronal death after brain injury. Models, mechanisms, and therapeutic strategies in vivo.

  1999cites this paper
• Limiting Neurological Damage After Stroke

  1999cites this paper
• Neuroprotective Effects of Magnesium Sulfate and Dextromethorphan on Cerebral Ischemia after Middle Cerebral Artery Occlusion in Rats.

  1999cites this paper
• Neuronal death after brain injury

  1999cites this paper
• A Case of Severe Cerebral Trauma in a Patient Under Chronic Treatment with Cyclosporine A

  1998cites this paper
• Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices.

  1998cites this paper
• Dextromethorphan and pain after total abdominal hysterectomy.

  1998cites this paper
• Dose Escalation Safety and Tolerance Study of the Competitive NMDA Antagonist Selfotel (CGS 19755) in Neurosurgery Patients

  1998cites this paper
• Thiopental Inhibits Increases in [Ca2+]i Induced by Membrane Depolarization, NMDA Receptor Activation, and Ischemia in Rat Hippocampal and Cortical Slices

  1998cites this paper
• Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid.

  1997cites this paper
• A review of earlier clinical studies on neuroprotective agents and current approaches.

  1997cites this paper
• Hypoxic-ischemic brain injury in the term newborn. Neuropathology, clinical aspects, and neuroimaging.

  1997cites this paper
• Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies.

  1997cites this paper
• New and Investigational Treatment Options for Ischemic Stroke

  1997cites this paper
• GABA and neuroprotection.

  1997cites this paper
• Effect of infection brain edema on NMDA receptor binding in rat brain in vivo.

  1997cites this paper
• Administration of a competitive NMDA antagonist MDL-100,453 reduces infarct size after permanent middle cerebral artery occlusion in rat.

  1996cites this paper
• Oral administration of dextromethorphan prevents the development of morphine tolerance and dependence in rats

  1996cites this paper
• Neuroprotection by Dextromethorphan in Acute Experimental Subdural Hematoma in the Rat

  1996cites this paper
• Chapter 10 GABA and Neuroprotection

  1996cites this paper
• Inhibitory effects of dextromethorphan on c-fos protein expression during focal cerebral ischemia in rats.

  1996cites this paper
• Medical therapy for ischemic stroke.

  1996cites this paper
• The effects of dextromethorphan on kainic acid-induced seizures in the rat.

  1996cites this paper
• Dextrorphan Reduces Infarct Volume, Vascular Injury, and Brain Edema after Ischemic Brain Injury

  1996cites this paper
• Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia.

  1996cites this paper
• Effects of N-methyl-D-aspartate receptor antagonists on cisplatin-induced emesis in the ferret.

  1996cites this paper
• Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats.

  1996cites this paper
• Dose escalation safety and tolerance study of the N-methyl-D-aspartate antagonist dextromethorphan in neurosurgery patients.

  1996cites this paper
• Hypothermia and metabolic stress: narrowing the cellular site of early neuroprotection.

  1996cites this paper
• Spinal cord neurons are vulnerable to rapidly triggered kainate neurotoxicity in vitro.

  1995cites this paper
• Neuroprotection by N-methyl-D-aspartate antagonists in focal cerebral ischemia is dependent on continued maintenance dosing.

  1995cites this paper
• Safety, Tolerability, and Pharmacokinetics of the N-Methyl-d-Aspartate Antagonist Dextrorphan in Patients With Acute Stroke

  1995cites this paper
• Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke. Dextrorphan Study Group.

  1995cites this paper
• The partial μ opiate agonist buprenorphine protects a sub-population of thalamic reticular neurons following cardiac arrest in rats

  1995cites this paper
• NMDA Receptor Subtype Selectivity: Eliprodil, Polyamine Spider Toxins, Dextromethorphan, and Desipramine Selectively Block NMDA‐Evoked Striatal Acetylcholine but Not Spermidine Release

  1995cites this paper
• Recent advances in neuropharmacology of the centrally acting antitussive drugs.

  1995cites this paper
• Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile.

  1994cites this paper
• Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage

  1994cites this paper
• The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

  1994cites this paper
• Dextromethorphan attenuates hypoxia-induced neuronal dysfunction in rat neocortical slices.

  1994cites this paper
• Neurochemical sequelae of traumatic brain injury: therapeutic implications.

  1994cites this paper
• Glutamate‐Mediated Injury in Focal Cerebral Ischemia: The Excitotoxin Hypothesis Revised

  1994cites this paper
• Effects of dextromethorphan on ischemia induced electroretinogram changes in rabbit.

  1994cites this paper
• Peripartum asphyxia.

  1994cites this paper
• Exciting your neurons to death: can we prevent cell loss after brain injury?

  1994cites this paper
• Dextromethorphan potentiation of d-amphetamine-induced behavior and neurodegeneration in rats.

  1994cites this paper
• Hypoxic-ischemic brain injury in the newborn.

  1993cites this paper
• Dextromethorphan and its combination with phenytoin facilitate kindling

  1993cites this paper
• Novel Pharmacologic Therapies in the Treatment of Experimental Traumatic Brain Injury: A Review

  1993cites this paper
• Diffusion and Perfusion Magnetic Resonance Imaging Studies to Evaluate a Noncompetitive N‐Methyl‐D‐aspartate Antagonist and Reperfusion in Experimental Stroke in Rats

  1993cites this paper
• Comparison of Single and Combination Drug Treatment Strategies in Experimental Brain Trauma

  1993cites this paper
• The evolution of acute stroke recorded by multimodal magnetic resonance imaging.

  1993cites this paper
• Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion‐weighted MRI

  1993cites this paper