The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2015-02-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2014.12.013PMID 25528518
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isoform‐Specific SCFFbw7 Ubiquitination Mediates Differential Regulation of PGC‐1α

  2015cited by this paper
• An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders.

  2015cited by this paper
• Melatonin Antagonizes Mn-Induced Oxidative Injury Through the Activation of Keap1–Nrf2–ARE Signaling Pathway in the Striatum of Mice

  2015cited by this paper
• Retraction: INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

  2014cited by this paper
• Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

  2014cited by this paper
• Ectromelia Virus Encodes a BTB/kelch Protein, EVM150, That Inhibits NF-κB Signaling

  2014cited by this paper
• Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

  2014cited by this paper
• APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

  2014cited by this paper
• Proteasome inhibitors in progressive renal diseases.

  2014cited by this paper
• Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis.

  2014cited by this paper
• Transcriptional and post‐translational regulation of Bim controls apoptosis in melatonin‐treated human renal cancer Caki cells

  2014influential reference
• NADH Binds and Stabilizes the 26S Proteasomes Independent of ATP*

  2014cited by this paper
• Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

  2014cited by this paper
• Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin

  2014cited by this paper
• Light Exposure at Night Disrupts Host/Cancer Circadian Regulatory Dynamics: Impact on the Warburg Effect, Lipid Signaling and Tumor Growth Prevention

  2014cited by this paper
• Dietary melatonin attenuates age-related changes in morphology and in levels of key proteins in globus pallidus of mouse brain.

  2014cited by this paper
• Exogenous melatonin supplementation prevents oxidative stress‐evoked DNA damage in human spermatozoa

  2014cited by this paper
• Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

  2014cited by this paper
• Proteasome Inhibition Induces Both Antioxidant and Hb F Responses in Sickle Cell Disease Via the Nrf2 Pathway

  2014influential reference
• A review of melatonin as a suitable antioxidant against myocardial ischemia–reperfusion injury and clinical heart diseases

  2014cited by this paper
• Melatonin reduces lipid peroxidation and membrane viscosity

  2014cited by this paper
• Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer

  2014cited by this paper
• Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin

  2014cited by this paper
• Melatonin as a proteasome inhibitor. Is there any clinical evidence?

  2014cited by this paper
• Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

  2014cited by this paper
• Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism.

  2014cited by this paper
• The Role of Oxidative Stress in Parkinson's Disease

  2013cited by this paper
• When ubiquitin meets NF-κB: a trove for anti-cancer drug development.

  2013cited by this paper
• Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases

  2013cited by this paper
• Redox regulation of the proteasome via S-glutathionylation

  2013influential reference
• The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives.

  2013cited by this paper
• Melatonin modulates the expression of Bcl-2 family proteins in liver after thermal injury in rats

  2013cited by this paper
• Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

  2013cited by this paper
• Role of Oxidative Stress in Parkinson's Disease

  2013cited by this paper
• Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein.

  2013cited by this paper
• Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.

  2013cited by this paper
• Peroxisome Proliferator-activated Receptor γ Co-activator 1-α as a Critical Co-activator of the Murine Hepatic Oxidative Stress Response and Mitochondrial Biogenesis in Staphylococcus aureus Sepsis*

  2013cited by this paper
• The Effect of Melatonin on Plasma Markers of Inflammation and on Expression of Nuclear Factor-Kappa Beta in Acetic Acid-Induced Colitis in the Rat

  2013cited by this paper
• Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide‐induced apoptosis in vitro

  2013cited by this paper
• Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection.

  2013influential reference
• Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR‐induced depletion, and protects against the formation of DNA damage (8‐hydroxy‐2'‐deoxyguanosine) in ex vivo human skin

  2013cited by this paper
• Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma.

  2013cited by this paper
• Melatonin decreases levels of S100β and NFΚB, increases levels of synaptophysin in a rat model of Alzheimer's disease.

  2013cited by this paper
• Melatonin: The watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis

  2013cited by this paper
• Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

  2013cited by this paper
• Pharmacological doses of melatonin induce alterations in mitochondrial mass and potential, bcl‐2 levels and K+ currents in UVB‐exposed U937 cells

  2013cited by this paper
• Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity.

  2013cited by this paper
• Acetyl‐L‐carnitine‐mediated neuroprotection during hypoxia is attributed to ERK1/2‐Nrf2‐regulated mitochondrial biosynthesis

  2012cited by this paper
• Melatonin activates the Nrf2‐ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model

  2012cited by this paper
• Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging.

  2012cited by this paper
• Melatonin suppresses proinflammatory mediators in lipopolysaccharide‐stimulated CRL1999 cells via targeting MAPK, NF‐κB, c/EBPβ, and p300 signaling

  2012cited by this paper
• RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection.

  2012cited by this paper
• Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.

  2012cited by this paper
• Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

  2012cited by this paper
• Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation.

  2012cited by this paper
• Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis.

  2012cited by this paper
• Expression of heme oxygenase-1 in response to proteasomal inhibition.

  2012cited by this paper
• PGC1&agr; and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

  2012cited by this paper
• The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases.

  2012cited by this paper
• The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism.

  2012influential reference
• Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

  2012cited by this paper
• Inhibitory effects of melatonin on the lipopolysaccharide‐induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt‐induced NF‐κB and STAT/GAS activity

  2012cited by this paper
• Regulation of NF‐κB by ubiquitination and degradation of the IκBs

  2012cited by this paper
• The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

  2012cited by this paper
• Impaired ubiquitin‐proteasome‐mediated PGC‐1α protein turnover and induced mitochondrial biogenesis secondary to complex‐I deficiency

  2012cited by this paper
• Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

  2012influential reference
• INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

  2011cited by this paper
• Melatonin as a natural ally against oxidative stress: a physicochemical examination

  2011cited by this paper
• Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-apoptotic effects.

  2011cited by this paper
• Mitochondrial quality control by the ubiquitin-proteasome system.

  2011cited by this paper
• Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway.

  2011influential reference
• Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells.

  2011cited by this paper
• Melatonin--a pleiotropic, orchestrating regulator molecule.

  2011cited by this paper
• Ubiquitin-proteasome pathway and cellular responses to oxidative stress.

  2011cited by this paper
• Inhibitor of Nrf2 (INrf2 or Keap1) Protein Degrades Bcl-xL via Phosphoglycerate Mutase 5 and Controls Cellular Apoptosis*

  2011cited by this paper
• Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

  2011influential reference
• On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals.

  2011cited by this paper
• Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

  2010cited by this paper
• Neuroprotection through Stimulation of Mitochondrial Antioxidant Protein Expression

  2010cited by this paper
• Effect of melatonin on the expression of Nrf2 and NF‐κB during cyclophosphamide‐induced urinary bladder injury in rat

  2010cited by this paper
• Melatonin ameliorates cerulein‐induced pancreatitis by the modulation of nuclear erythroid 2‐related factor 2 and nuclear factor‐kappaB in rats

  2010cited by this paper
• Melatonin inhibits Prevotella intermedia lipopolysaccharide‐induced production of nitric oxide and interleukin‐6 in murine macrophages by suppressing NF‐κB and STAT1 activity

  2010cited by this paper
• Melatonin: action as antioxidant and potential applications in human disease and aging.

  2010cited by this paper
• Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF‐κB and Nrf2 cascades

  2010cited by this paper
• Melatonin induces pro‐apoptotic signaling pathway in human pancreatic carcinoma cells (PANC‐1)

  2010cited by this paper
• Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

  2010cited by this paper
• Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry.

  2010cited by this paper
• Rotavirus NSP1 Inhibits NFκB Activation by Inducing Proteasome-Dependent Degradation of β-TrCP: A Novel Mechanism of IFN Antagonism

  2009cited by this paper
• Melatonin downregulates nuclear erythroid 2‐related factor 2 and nuclear factor‐kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model

  2009cited by this paper
• KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.

  2009cited by this paper
• Nuclear Ubiquitin Ligases, NF-κB Degradation, and the Control of Inflammation

  2008cited by this paper
• Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl‐2

  2008cited by this paper
• Melatonin decreases TLR3‐mediated inflammatory factor expression via inhibition of NF‐κB activation in respiratory syncytial virus‐infected RAW264.7 macrophages

  2008cited by this paper
• Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

  2008cited by this paper
• Evaluation of potential pro‐survival pathways regulated by melatonin in a murine senescence model

  2008cited by this paper
• Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

  2008cited by this paper
• Integrating cell-signalling pathways with NF-κB and IKK function

  2007influential reference
• Antioxidant effects of melatonin in rats during chronic exposure to hyperbaric oxygen

  2007cited by this paper
• Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

  2007cited by this paper
• The effects of oxidative stress on parkin and other E3 ligases

  2007cited by this paper

• UBE2C-orchestrated ubiquitination networks in cancer progression and therapy resistance.

  2026cites this paper
• Melatonin Interplay in Physiology and Disease—The Fountain of Eternal Youth Revisited

  2025cites this paper
• Melatonin Protects Intact Rat Ovarian Transplantation via the MT1/Nrf2/ARE Pathway

  2025influential citation
• Melatonin attenuates heat stress-induced oxidative stress and apoptosis in mouse testicular Leydig cells via the KEAP1-NRF2 pathway.

  2025cites this paper
• Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury.

  2025cites this paper
• Salvianolic Acid A Activates Nrf2-Related Signaling Pathways to Inhibit Ferroptosis to Improve Ischemic Stroke

  2025cites this paper
• The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine.

  2025cites this paper
• Signaling Pathways in Oxidative Stress-Induced Neurodegenerative Diseases: A Review of Phytochemical Therapeutic Interventions

  2025cites this paper
• Melatonin’s Role in Redox Homeostasis: A Preclinical and Clinical Perspective

  2025cites this paper
• Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases

  2025cites this paper
• Effects of gallic acid on growth performance, intestinal histomorphology, antioxidative status and cecum microbiota in broilers challenged with aflatoxin B1.

  2025cites this paper
• Melatonin-Mediated Nrf2 Activation as a Potential Therapeutic Strategy in Mutation-Driven Neurodegenerative Diseases

  2025cites this paper
• Primary Human Macrophage and Tenocyte Tendon Healing Phenotypes Changed by Exosomes Per Cell Origin

  2025cites this paper
• Flavuside B exhibits antioxidant and anti-inflammatory properties in Staphylococcus aureus infected skin wound and affect the expression of genes controlling bacterial quorum sensing.

  2025cites this paper
• The effect of melatonin implants on the embryo yield and oxidative stress levels in superovulated Holstein heifers

  2025cites this paper
• Chemical compositions and antioxidant activities of the essential oil from aerial parts of Caryopteris mongolica Bunge grown in Mongolia

  2025cites this paper
• Antioxidants in Age-Related Macular Degeneration: Lights and Shadows

  2025cites this paper
• TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation

  2025cites this paper
• Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies

  2024cites this paper
• Melatonin mitigates doxorubicin induced chemo brain in a rat model in a NRF2/p53–SIRT1 dependent pathway

  2024cites this paper
• New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.

  2024cites this paper
• ET1 acts as a potential plasma biomarker and therapeutic target in deep venous thrombosis rat model

  2024cites this paper
• High Fat Diet–Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies

  2024cites this paper
• Cytoprotective effect of melatonin against MPP+ toxicity in SH-SY5Y cells: Role sharing of two types of antioxidative activities of melatonin.

  2024cites this paper
• Effect of Hibiscus sabdariffa L. leaf flavonoid-rich extract on Nrf-2 and HO-1 pathways in liver damage of streptozotocin-induced diabetic rats

  2024cites this paper
• Melatonin as a multifunctional modulator: emerging insights into its role in health, reproductive efficiency, and productive performance in livestock

  2024cites this paper
• The Effects of Silymarin on Calcium Chloride-Induced Arrhythmia in Male Rat

  2024cites this paper
• Evaluating the Role of Nrf-2/HO-1 Pathway in Glioblastoma Treatment Efficacy: A Co-Culture Study

  2024cites this paper
• Dysfunctional Mitochondria in Age-related Neurodegeneration: Utility of Melatonin as an Antioxidant Treatment.

  2024cites this paper
• Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties

  2024cites this paper
• Clinical Studies Using Topical Melatonin

  2024cites this paper
• Regulation of ubiquitin-proteasome system and its relative pathways in pancreatic adenocarcinoma

  2024cites this paper
• Melatonin-mediated Actions and Circadian Functions that Improve Implantation, Fetal Health and Pregnancy Outcome.

  2024cites this paper
• Bioguided isolation, identification and bioactivity evaluation of anti-fatigue constituents from Schizophyllum commune.

  2024cites this paper
• A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application

  2024cites this paper
• New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases

  2024cites this paper
• A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms with their divergent effects on these distinct family transcription factors.

  2024cites this paper
• Melatonin Delays Arthritis Inflammation and Reduces Cartilage Matrix Degradation through the SIRT1-Mediated NF-κB/Nrf2/TGF-β/BMPs Pathway

  2024cites this paper
• SGLT2 Inhibitors in Long COVID Syndrome: Is There a Potential Role?

  2023cites this paper
• Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)‐Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib

  2023cites this paper
• Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function

  2023cites this paper
• The Kelch/Nrf2 Antioxidant System as a Target for Some Marine Fungal Metabolites

  2023cites this paper
• Role of the antioxidant defence system and transcription factors in preventing heat stress in poultry: a dietary approach

  2023cites this paper
• Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

  2023cites this paper
• Cytoprotective Effect of Bambusae caulis in Liquamen by Blocking Oxidative Stress in Hepatocytes

  2023cites this paper
• Melatonin: A Potential Regulator of DNA Methylation

  2023cites this paper
• Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

  2023cites this paper
• Dietary ferulic acid supplementation improves antioxidant capacity and lipid metabolism in liver of piglets with intrauterine growth retardation

  2023cites this paper
• Crosstalk Between Aging, Circadian Rhythm, and Melatonin

  2023cites this paper
• Mesenchymal Stem Cells for Treating Alzheimer’s Disease: Cell Therapy and Chemical Reagent Pretreatment

  2023cites this paper
• Virgin Olive Oil By-Products: Biological Activity of Phenolic Extract of Pâté on AGS Gastric Cells

  2023cites this paper
• Melatonin and related compounds as antioxidants.

  2023cites this paper
• Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

  2023cites this paper
• Astragaloside IV attenuates lipopolysaccharide induced liver injury by modulating Nrf2-mediated oxidative stress and NLRP3-mediated inflammation

  2023cites this paper
• Taraxasterol alleviates aflatoxin B1-induced liver damage in broiler chickens via regulation of oxidative stress, apoptosis and autophagy.

  2023cites this paper
• Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

  2023cites this paper
• MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling

  2023cites this paper
• A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms

  2023cites this paper
• Effects and Mechanisms of Non-Thermal Plasma-Mediated ROS and Its Applications in Animal Husbandry and Biomedicine

  2023cites this paper
• Melatonin Protects Against Titanium Oxide-Induced Neurotoxicity: Neurochemical, Neurobehavioral, and Histopathological Evidences

  2022cites this paper
• FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling.

  2022cites this paper
• Modulating antioxidant systems as a therapeutic approach to retinal degeneration

  2022cites this paper
• Research Note: Taraxasterol alleviates aflatoxin B1-induced oxidative stress in chicken primary hepatocytes

  2022cites this paper
• Role of Keap1-Nrf2/ARE signal transduction pathway in protection of dexmedetomidine preconditioning against myocardial ischemia/reperfusion injury

  2022cites this paper
• Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis.

  2022cites this paper
• New insights into the role of melatonin in photosynthesis.

  2022cites this paper
• Research Progress on Targeted Antioxidant Therapy and Vitiligo

  2022cites this paper
• ANTI-FATIGUE EFFICACY OF CROCIN IN MICE VIA REGULATION OF NRF-2/HO-1 PATHWAY-MEDIATED OXIDATIVE STRESS

  2022cites this paper
• A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19

  2022cites this paper
• Melatonin alleviates lipopolysaccharide (LPS) / adenosine triphosphate (ATP)-induced pyroptosis in rat alveolar Type II cells (RLE-6TN) through nuclear factor erythroid 2-related factor 2 (Nrf2)-driven reactive oxygen species (ROS) downregulation

  2022cites this paper
• Melatonin-related signaling pathways and their regulatory effects in aging organisms

  2022influential citation
• Proteome-wide analysis reveals molecular pathways affected by AgNP in a ROS-dependent manner

  2022cites this paper
• Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

  2022cites this paper
• Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases

  2022cites this paper
• Epigallocatechin Gallate Attenuates Gentamicin-Induced Nephrotoxicity by Suppressing Apoptosis and Ferroptosis

  2022influential citation
• Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells

  2022cites this paper
• “LONG COVID”—A hypothesis for understanding the biological basis and pharmacological treatment strategy

  2022cites this paper
• Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

  2022cites this paper
• Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway

  2021cites this paper
• Short overview on the relevance of microRNA-reactive oxygen species (ROS) interactions and lipid peroxidation for modulation of oxidative stress-mediated signalling pathways in cancer treatment.

  2021cites this paper
• Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa

  2021cites this paper
• Melatonin for the Management of Preeclampsia: A Review

  2021influential citation
• Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

  2021cites this paper
• Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

  2021cites this paper
• Protective effects of melatonin and l-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes

  2021cites this paper
• Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring

  2021cites this paper
• Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora

  2021cites this paper
• L-arginine reduces injury from heat stress to bovine intestinal epithelial cells by improving antioxidant and inflammatory response

  2021cites this paper
• Retinal oxidative stress activates the NRF2/ARE pathway: An early endogenous protective response to ocular hypertension

  2021cites this paper
• Antifatigue effects of Hechong (Tylorrhynchus heterochaetus) through modulation of Nrf2/ARE- mediated antioxidant signaling pathway.

  2021cites this paper
• Identification and characterization of tilapia antioxidant peptides that protect AAPH-induced HepG2 cell oxidative stress

  2021cites this paper
• Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties

  2021cites this paper
• Anti-fatigue liquid formulations made from fruits

  2021cites this paper
• Drug Repurposing: An Avenue Toward Stress Medicine in Cancer Therapy

  2021cites this paper
• The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease

  2021cites this paper
• Antioxidant mechanism exploration of the tripeptide Val-Asn-Pro generated from Jiuzao and its potential application in baijiu.

  2021cites this paper
• Melatonin Protects against the Side-Effects of 5-Fluorouracil on Hippocampal Neurogenesis and Ameliorates Antioxidant Activity in an Adult Rat Hippocampus and Prefrontal Cortex

  2021cites this paper
• Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway.

  2021cites this paper
• Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity

  2021cites this paper
• Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury

  2021cites this paper