Urinary p-cresol is elevated in small children with severe autism spectrum disorder

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biomarkers

• Publication date

  2011-04-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/1354750X.2010.548010PMID 21329489
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• [Polish version of the ADI-R (Autism Diagnostic Interview-Revised)].

  2012cited by this paper
• Principal pathogenetic components and biological endophenotypes in autism spectrum disorders

  2010cited by this paper
• Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls.

  2010influential reference
• Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia

  2010cited by this paper
• Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives

  2010cited by this paper
• Pyrosequencing study of fecal microflora of autistic and control children.

  2010cited by this paper
• Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report

  2010cited by this paper
• Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression

  2009cited by this paper
• Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

  2009cited by this paper
• Measurement of phenol and p-cresol in urine and feces using vacuum microdistillation and high-performance liquid chromatography.

  2009cited by this paper
• Estimation of urinary cotinine cut-off points distinguishing non-smokers, passive and active smokers

  2007cited by this paper
• The genetics of autistic disorders and its clinical relevance: a review of the literature

  2007cited by this paper
• Fasting enhances p-Cresol production in the rat intestinal tract.

  2007cited by this paper
• Spot urinary creatinine excretion in pervasive developmental disorders

  2006cited by this paper
• The immune response in autism: a new frontier for autism research

  2006cited by this paper
• Searching for ways out of the autism maze: genetic, epigenetic and environmental clues.

  2006cited by this paper
• Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children.

  2005influential reference
• Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention

  2005cited by this paper
• Mutation of Glutamic Acid 103 of Toluene o-Xylene Monooxygenase as a Means To Control the Catabolic Efficiency of a Recombinant Upper Pathway for Degradation of Methylated Aromatic Compounds

  2005cited by this paper
• General Summary

  2004cited by this paper
• Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children

  2004influential reference
• P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro

  2004cited by this paper
• The screening and diagnosis of autistic spectrum disorders.

  2004cited by this paper
• Intestinal Pathophysiology in Autism

  2003cited by this paper
• Toxicity of free p-cresol: a prospective and cross-sectional analysis.

  2003influential reference
• Contaminant risks from biosolids land application: contemporary organic contaminant levels in digested sewage sludge from five treatment plants in Greater Vancouver, British Columbia.

  2003cited by this paper
• Variation in human intestinal microbiota with age.

  2002cited by this paper
• Gastrointestinal microflora studies in late-onset autism.

  2002cited by this paper
• Epidemiological trends in rates of autism

  2002cited by this paper
• EFFECTS OF CRESOLS (O-, M-, AND P-ISOMERS) ON THE BIOENERGETIC SYSTEM IN ISOLATED RAT LIVER MITOCHONDRIA

  2001cited by this paper
• p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol.

  2001cited by this paper
• Sulphation deficit in "low-functioning" autistic children: a pilot study.

  1999cited by this paper
• Abnormal intestinal permeability in children with autism

  1996cited by this paper
• Simple high-performance liquid chromatographic analysis of phenol and p-cresol in urine and feces.

  1995cited by this paper
• Mechanisms of uremic inhibition of phagocyte reactive species production: characterization of the role of p-cresol.

  1995cited by this paper
• A Review of the Vineland Adaptive Behavior Scales, Survey Form

  1985influential reference

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  2026cites this paper
• Towards treatments targeting the gut to improve behavioural outcomes in autism spectrum disorder.

  2026cites this paper
• Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

  2026cites this paper
• Elevated Microbially-Derived Metabolites in Autism: A Possible Diagnostic Screening Test for a Distinct ASD Phenotype

  2025cites this paper
• The gut microbiome shapes social behaviour across animal species.

  2025cites this paper
• Implications of Gut Microbiota-Derived Metabolites in Neurological Disorders.

  2025cites this paper
• Gut and Metabolic Biomarkers in Autism Spectrum Disorder: A Systematic Review of Body Fluid Signatures for Early Detection.

  2025cites this paper
• Para-Cresol and the Brain: Emerging Role in Neurodevelopmental and Neurodegenerative Disorders and Therapeutic Perspectives.

  2025cites this paper
• Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders

  2025cites this paper
• The Role of Microbial-Derived p-Cresol in Autism Spectrum Disorder: A Systematic Review of the Gut-Brain Axis.

  2025cites this paper
• A sulfotransferase from a gut microbe acts on diverse phenolic sulfate compounds, including acetaminophen sulfate

  2025influential citation
• Psychobiotic Properties of Probiotic Lactic Acid Bacteria and Bifidobacteria in Paediatric Neurological Disorders

  2025cites this paper
• Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis

  2025cites this paper
• The Effect of Parental Faecal Microbiome Transplantation from Children with Autism Spectrum Disorder on Behavior and Gastrointestinal Manifestations in the Male Offspring of Shank3 Mice

  2025cites this paper
• p‐Cresol and p‐Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence

  2025cites this paper
• Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder

  2025cites this paper
• Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior

  2025cites this paper
• Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms

  2025influential citation
• Investigation of a targeted panel of gut microbiome–derived toxins in children with chronic kidney disease

  2025cites this paper
• Targeted Metabolomics for the Analysis of p-Cresol in Mouse Brain: Impact of Biological Sex and Strain.

  2025cites this paper
• The Gut–Brain Axis in Autism: Inflammatory Mechanisms, Molecular Insights, and Emerging Microbiome-Based Therapies

  2025cites this paper
• The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits

  2025cites this paper
• Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats

  2024cites this paper
• IUPHAR Review: Targeted Therapies of Signaling Pathways Based on the Gut Microbiome in Autism Spectrum Disorders: Mechanistic and Therapeutic Applications.

  2024cites this paper
• Exploring the neurotoxic effects of microbial metabolites: A potential link between p-Cresol and autism spectrum disorders?

  2024cites this paper
• The pediatric psychopharmacology of autism spectrum disorder: A systematic review part II: The future.

  2024cites this paper
• Investigating brain-gut microbiota dynamics and inflammatory processes in an autistic-like rat model using MRI biomarkers during childhood and adolescence

  2024cites this paper
• Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

  2024cites this paper
• Probiotics in autism spectrum disorder: Recent insights from animal models

  2024cites this paper
• Host–microbiome orchestration of the sulfated metabolome

  2024cites this paper
• Inhibition of the Beta-oxidation Pathway of Fatty Acids and Dopamine- Beta-hydroxylase by Phenyl Derivatives of Short- Chain Fatty Acids from Gastrointestinal Clostridia Bacteria is a (the) Major Cause of Autism.

  2023cites this paper
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  2023cites this paper
• Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives

  2023cites this paper
• Investigating the Urinary Metabolome in the First Year of Life and Its Association with Later Diagnosis of Autism Spectrum Disorder or Non-Typical Neurodevelopment in the MARBLES Study

  2023cites this paper
• Relationship between Excreted Uremic Toxins and Degree of Disorder of Children with ASD

  2023influential citation
• A review of probiotics in the treatment of autism spectrum disorders: Perspectives from the gut–brain axis

  2023cites this paper
• Metabolic and Transcriptomic Changes in the Mouse Brain in Response to Short-Term High-Fat Metabolic Stress

  2023cites this paper
• Metabolite interactions between host and microbiota during health and disease: Which feeds the other?

  2023cites this paper
• Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s disease

  2022cites this paper
• Psychobiotics: a new way in psychopharmacology, or How do bacteria manage our brain?

  2022cites this paper
• Targeting Gut Dysbiosis and Microbiome Metabolites for the Development of Therapeutic Modalities for Neurological Disorders

  2022cites this paper
• The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10

  2022cites this paper
• Urinary Untargeted Metabolic Profile Differentiates Children with Autism from Their Unaffected Siblings

  2022cites this paper
• Global metabolic profiles in a non-human primate model of maternal immune activation: implications for neurodevelopmental disorders

  2022cites this paper
• Microbiota-derived metabolites as drivers of gut–brain communication

  2022cites this paper
• The Role of Microbiome in Brain Development and Neurodegenerative Diseases

  2022cites this paper
• Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives

  2022cites this paper
• The metabolite p‐cresol impairs dendritic development, synaptogenesis, and synapse function in hippocampal neurons: Implications for autism spectrum disorder

  2022cites this paper
• Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial

  2022cites this paper
• FTACMT study protocol: a multicentre, double-blind, randomised, placebo-controlled trial of faecal microbiota transplantation for autism spectrum disorder

  2022cites this paper
• The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

  2022cites this paper
• Alterations of the Intestinal Permeability are Reflected by Changes in the Urine Metabolome of Young Autistic Children: Preliminary Results

  2022cites this paper
• The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

  2021cites this paper
• The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

  2021cites this paper
• Treating autism spectrum disorder by intervening with gut microbiota.

  2021cites this paper
• Possible role of the gut microbiota in the pathogenesis of anorexia nervosa

  2021cites this paper
• Gut mobilization improves behavioral symptoms and modulates urinary p‐cresol in chronically constipated autistic children: A prospective study

  2021influential citation
• The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review

  2021influential citation
• The Impacts of Probiotics on Microbiota in Patients With Autism Spectrum Disorder

  2021cites this paper
• The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders

  2021cites this paper
• Interactions between the intestinal microbiota and epigenome in individuals with autism spectrum disorder

  2021cites this paper
• Effects of the l-tyrosine-derived bacterial metabolite p-cresol on colonic and peripheral cells

  2021cites this paper
• Gut Microbiota Biomarkers in Autism Spectrum Disorders

  2021cites this paper
• Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification

  2021cites this paper
• Role of Microbes in the Pathogenesis of Neuropsychiatric Disorders.

  2021cites this paper
• The chemistry of gut microbiome in health and diseases

  2021cites this paper
• Gut microbiota metabolites in autistic children: An epigenetic perspective

  2021cites this paper
• Role of the Gut Microbiota in the Pathophysiology of Autism Spectrum Disorder: Clinical and Preclinical Evidence

  2020cites this paper
• The Effects of Probiotics and Prebiotics on Mental Disorders: a Review on Depression, Anxiety, Alzheimer, and Autism Spectrum Disorders.

  2020cites this paper
• Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder

  2020cites this paper
• The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder

  2020cites this paper
• P-cresol Alters Brain Dopamine Metabolism and Exacerbates Autism-Like Behaviors in the BTBR Mouse

  2020influential citation
• Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis

  2020cites this paper
• Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

  2020cites this paper
• A metabolomics approach to investigate urine levels of neurotransmitters and related metabolites in autistic children.

  2020cites this paper
• Development of the Korean Form of the Premonitory Urge for Tics Scale: A Reliability and Validity Study

  2020cites this paper
• Alteration of Gut Microbiota in Autism Spectrum Disorder: An Overview

  2020cites this paper
• Near real-time analysis of para-cresol in wastewater with a laccase-carbon nanotube-based biosensor.

  2020cites this paper
• Microbiota‐gut‐brain axis as a regulator of reward processes

  2020cites this paper
• The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17

  2020cites this paper
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  2020cites this paper
• The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

  2020cites this paper
• Metabolomics approach for gaining insights into pathological mechanisms of irritable bowel syndrome and inflammatory bowel disease

  2019cites this paper
• Autism Spectrum Disorders and the Gut Microbiota

  2019cites this paper
• Improvised method for urinary p-cresol detection and measurement using high performance liquid chromatography/mass spectrometry

  2019cites this paper
• GUT MICROBIOTA AND NEUROLOGICAL EFFECTS OF GLYPHOSATE.

  2019cites this paper
• Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case–control study

  2019cites this paper
• The phenolic interactome and gut microbiota: opportunities and challenges in developing applications for schizophrenia and autism

  2019cites this paper
• Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review

  2019cites this paper
• Gastrointestinal Symptoms in Autism Spectrum Disorders

  2019influential citation
• Gut–brain axis in the executive function of austism spectrum disorder

  2018cites this paper
• Targeting gut microbiome: A novel and potential therapy for autism

  2018cites this paper
• Metabolic functions of the human gut microbiota: the role of metalloenzymes

  2018cites this paper
• Defining Dysbiosis in Disorders of Movement and Motivation

  2018cites this paper
• The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders

  2018cites this paper
• Intestinal microbiota, metabolome and gender dimorphism in autism spectrum disorders

  2018cites this paper
• Indole, a Signaling Molecule Produced by the Gut Microbiota, Negatively Impacts Emotional Behaviors in Rats

  2018cites this paper
• Dietary Considerations in Autism Spectrum Disorders: The Potential Role of Protein Digestion and Microbial Putrefaction in the Gut-Brain Axis

  2018cites this paper
• Rapid Assessment of Microbiota Changes in Individuals with Autism Spectrum Disorder Using Bacteria-derived Membrane Vesicles in Urine

  2017cites this paper
• Neurotoxins and Autism

  2017cites this paper