Increased ACE 2 and Decreased ACE Protein in Renal Tubules From Diabetic Mice: A Renoprotective Combination?

No abstract is available for this paper.

• Publication year

  2004

• Venue

  HYPERTENSION

• Publication date

  2004-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.HYP.0000126192.27644.76PMID 15078862
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Angiotensin-I-converting enzyme and its relatives

  2003cited by this paper
• Commentary on Tikellis et al: There is more to discover about angiotensin-converting enzyme.

  2003cited by this paper
• Diabetic kidney disease in the db/db mouse.

  2003cited by this paper
• There Is More to Discover About Angiotensin-Converting Enzyme

  2003cited by this paper
• The renin–angiotensin system and the long‐term complications of diabetes: pathophysiological and therapeutic considerations

  2003cited by this paper
• Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy

  2003cited by this paper
• An ACE structure

  2003cited by this paper
• Just the beginning: novel functions for angiotensin-converting enzymes.

  2002cited by this paper
• Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat.

  2002cited by this paper
• Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase*

  2002cited by this paper
• Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat.

  2002cited by this paper
• Angiotensin-converting enzyme 2 is an essential regulator of heart function

  2002cited by this paper
• Practical guidelines for the use of NESP in treating renal anaemia.

  2001cited by this paper
• Prevention, protection, and the intrarenal renin-angiotensin systems.

  2001cited by this paper
• Pathways of angiotensin-(1-7) metabolism in the kidney.

  2001cited by this paper
• Vascular gp91(phox): beyond the endothelium.

  2000cited by this paper
• A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

  2000cited by this paper
• Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin.

  2000cited by this paper
• Angiotensin-(1-7): an update.

  2000cited by this paper
• A Human Homolog of Angiotensin-converting Enzyme

  2000cited by this paper
• Angiotensin-converting enzyme in non-neoplastic kidney diseases.

  1999cited by this paper
• Regulation of renal laminin in mice with type II diabetes.

  1999cited by this paper
• Evolution of renal function abnormalities in the db/db mouse that parallels the development of human diabetic nephropathy.

  1996cited by this paper
• ANGIOTENSIN-(1-7): A NEW HORMONE OF THE ANGIOTENSIN SYSTEM

  1996cited by this paper
• Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

  1996cited by this paper
• Histocompatibility testing for kidney transplantation: an update.

  1995cited by this paper
• Effects of ACE inhibitors and calcium channel blockers on the development of glomerular sclerosis in models of renal damage.

  1995cited by this paper
• Regulation of rat renal alpha 2 B-adrenergic receptors by potassium depletion.

  1994cited by this paper
• Tissue renin angiotensin systems: theoretical implications for the development of hyperkalemia using angiotensin-converting enzyme inhibitors.

  1994cited by this paper
• Tissue renin-angiotensin system in myocardial hypertrophy and failure.

  1993cited by this paper
• Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations.

  1993cited by this paper
• The intrarenal renin-angiotensin system.

  1993cited by this paper
• Angiotensin-converting enzyme inhibition and renal protection. An assessment of implications for therapy.

  1993cited by this paper
• The intrarenal renin-angiotensin system.

  1993cited by this paper
• Bradykinin inhibition of EGF- and PDGF-induced DNA synthesis in human fibroblasts.

  1993cited by this paper
• Angiotensin-(1-7): a new hormone of the angiotensin system.

  1991cited by this paper
• Reduced activity of renal angiotensin-converting enzyme in streptozotocin-induced diabetic rats.

  1991cited by this paper
• Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria.

  1972cited by this paper
• Diabetes, a New Mutafton in the Mouse

  1966cited by this paper

• The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update.

  2025cites this paper
• SARS‐CoV‐2: A Liver Brief

  2025cites this paper
• SGLT2i and GLP1-RA exert additive cardiorenal protection with a RAS blocker in uninephrectomized db/db mice

  2024cites this paper
• ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023.

  2024cites this paper
• Aerobic training increases renal antioxidant defence and reduces angiotensin II levels, mitigating the high mortality in SHR-STZ model

  2024cites this paper
• Targeting the epidermal growth factor receptor (EGFR/ErbB) for the potential treatment of renal pathologies

  2024cites this paper
• Delayed Graft Function and the Renin-angiotensin System

  2024cites this paper
• Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway

  2024cites this paper
• ACE2 Regulates Glycolipid Metabolism in Multiple Tissues.

  2024cites this paper
• Altered distribution and loss of ACE2 into the urine in acute kidney injury.

  2024cites this paper
• SARS-CoV-2 Spike Protein Enhances Carboxypeptidase Activity of Angiotensin-Converting Enzyme 2

  2024cites this paper
• The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics.

  2023cites this paper
• Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection

  2023cites this paper
• Diabetes Mellitus and the Kidneys.

  2023cites this paper
• ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification

  2023cites this paper
• Diabetes, COVID‐19, and questions unsolved

  2023cites this paper
• Diverse biological functions of the renin‐angiotensin system

  2023cites this paper
• Role of Endothelium in Cardiovascular Sequelae of Long COVID

  2023cites this paper
• Integrin β1 is a key determinant of the expression of angiotensin-converting enzyme 2 (ACE2) in the kidney epithelial cells

  2023cites this paper
• Nephrotic Syndrome and Renin Angiotensin System: pathophysiological role and therapeutic potential.

  2022cites this paper
• A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

  2022cites this paper
• Severe acute respiratory syndrome and thyroid: A molecular point of view

  2022cites this paper
• Effect of renin-angiotensin system blocker on COVID-19 in young patients with hypertension

  2022cites this paper
• Saccharomyces boulardii exerts renoprotection by modulating oxidative stress, renin angiotensin system and uropathogenic microbiota in a murine model of diabetes.

  2022cites this paper
• Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy

  2022cites this paper
• Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting

  2022cites this paper
• A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection

  2022cites this paper
• Renal biomarkers of acute kidney injury in response to increasing intermittent hypoxia episodes in the neonatal rat

  2021cites this paper
• Resistance exercise shifts the balance of renin-angiotensin system toward ACE2/Ang 1-7 axis and reduces inflammation in the kidney of diabetic rats.

  2021cites this paper
• The complex combination of COVID-19 and diabetes: pleiotropic changes in glucose metabolism

  2021cites this paper
• RAAS Blockade and COVID‐19: Mechanistic Modeling of Mas and AT1 Receptor Occupancy as Indicators of Pro‐Inflammatory and Anti‐Inflammatory Balance

  2021cites this paper
• Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

  2021cites this paper
• ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders.

  2021cites this paper
• Ginsenoside Rc Ameliorates Endothelial Insulin Resistance via Upregulation of Angiotensin-Converting Enzyme 2

  2021cites this paper
• A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency

  2021cites this paper
• A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

  2021cites this paper
• New perspectives on angiotensin-converting enzyme 2 and its related diseases

  2021cites this paper
• Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease

  2021cites this paper
• Mechanisms of SARS-CoV-2 entry into cells

  2021cites this paper
• POTENTIAL ROLE OF CURCUMIN AS A TREATMENT OPTION FOR COVID-19: A REVIEW

  2021influential citation
• Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

  2021cites this paper
• Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.

  2021cites this paper
• Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population

  2021cites this paper
• Effect of ramipril on kidney, lung and heart ACE2 in a diabetic mice model

  2021cites this paper
• Expression of ACE2, the SARS-CoV-2 Receptor, in Lung Tissue of Patients With Type 2 Diabetes

  2020cites this paper
• SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease

  2020cites this paper
• Interaction of SARS-CoV-2 and Other Coronavirus With ACE (Angiotensin-Converting Enzyme)-2 as Their Main Receptor

  2020cites this paper
• Brain angiotensin converting enzyme-2 in central cardiovascular regulation.

  2020cites this paper
• Kidney and Lung ACE2 expression after an ACE inhibitor or an Ang II receptor blocker: implications for COVID-19

  2020influential citation
• Vitamin D can prevent COVID-19 infection-induced multiple organ damage

  2020cites this paper
• Potential effects of curcumin in the treatment of COVID‐19 infection

  2020cites this paper
• Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.

  2020cites this paper
• The Science Underlying COVID-19: Implications for the Cardiovascular System.

  2020cites this paper
• Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System

  2020cites this paper
• Commentary: COVID-19 and diabetes mellitus: What we know, how our patients should be treated now, and what should happen next

  2020cites this paper
• Vitamin D may protect against multiple organ damage caused by COVID-19.

  2020cites this paper
• SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury

  2020cites this paper
• ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery.

  2020cites this paper
• ACE2: The Major Cell Entry Receptor for SARS-CoV-2

  2020cites this paper
• Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice.

  2020cites this paper
• Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies

  2020cites this paper
• Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets

  2020cites this paper
• ACE2 as a potential therapeutic target for pandemic COVID-19

  2020cites this paper
• Azilsartan causes natriuresis due to its sympatholytic action in kidney disease

  2019cites this paper
• Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells

  2019cites this paper
• Molecular and Cellular Effect of Angiotensin 1–7 on Hypertensive Kidney Disease

  2019cites this paper
• Sex differences in the metabolic effects of the renin-angiotensin system

  2019cites this paper
• Chymase inhibition retards albuminuria in type 2 diabetes

  2019cites this paper
• Antifibrotic Roles of RAAS Blockers: Update

  2019cites this paper
• Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System

  2019cites this paper
• Low urinary levels of angiotensin‐converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia

  2018cites this paper
• Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy

  2018cites this paper
• Role of Wnt4/&bgr;‐catenin, Ang II/TGF&bgr;, ACE2, NF‐&kgr;B, and IL‐18 in attenuating renal ischemia/reperfusion‐induced injury in rats treated with Vit D and pioglitazone

  2018cites this paper
• Microvascular Damage and Hemodynamic Alterations in Diabetic Nephropathy

  2018cites this paper
• Intestinal dysbiosis activates renal renin-angiotensin system contributing to incipient diabetic nephropathy

  2018cites this paper
• Effects of a novel curcumin derivative on the functions of kidney in streptozotocin-induced type 2 diabetic rats

  2018cites this paper
• Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes.

  2018cites this paper
• Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease.

  2017cites this paper
• Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse

  2017cites this paper
• The relationship between urinary renin-angiotensin system markers, renal function, and blood pressure in adolescents with type 1 diabetes.

  2017cites this paper
• Circulating ACE2 in Cardiovascular and Kidney Diseases.

  2017cites this paper
• Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy.

  2017cites this paper
• Imbalanced plasma ACE and ACE2 level in the uremic patients with cardiovascular diseases and its change during a single hemodialysis session

  2017cites this paper
• Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes

  2017influential citation
• Measurement of Angiotensin Converting Enzyme 2 Activity in Biological Fluid (ACE2)

  2017cites this paper
• Angiotensin converting enzyme 2 and the kidney

  2016cites this paper
• Role of Angiotensin-(1-7) on Renal Hypertrophy in Streptozotocin-Induced Diabetes Mellitus

  2016cites this paper
• Nodular glomerulosclerosis and renin angiotensin system in Chinese patients with type 2 diabetes.

  2016cites this paper
• Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats.

  2016cites this paper
• Sex-Specific Changes in Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression and Enzyme Activity at Birth and Over the First Year of Life

  2016cites this paper
• The Relationship between Urinary Renin Angiotensin System Markers, Renal and Vascular Function in Adolescents with Type 1 Diabetes

  2016cites this paper
• Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.

  2015cites this paper
• Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin

  2015cites this paper
• ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension

  2015cites this paper
• Loss of Prolyl Carboxypeptidase in Two-Kidney, One-Clip Goldblatt Hypertensive Mice

  2015cites this paper
• Functional and molecular evidence for expression of the renin angiotensin system and ADAM17-mediated ACE2 shedding in COS7 cells.

  2015cites this paper
• The effects of apelin treatment on a rat model of type 2 diabetes.

  2015cites this paper
• ACE and ACE 2 in kidney disease

  2015cites this paper
• Functional and molecular evidence for expression of the renin angiotensin system and ADAM 17-mediated ACE 2 shedding in COS 7 cells

  2015cites this paper
• Differential regulation of angiotensin converting enzyme 2 and nuclear factor-κB by angiotensin II receptor subtypes in type 2 diabetic kidney.

  2015cites this paper