Regulation of connexin biosynthesis, assembly, gap junction formation, and removal.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2004-03-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.BBAMEM.2004.01.007PMID 15033576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quality control in the endoplasmic reticulum

  2003cited by this paper
• Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway.

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• LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells.

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• Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreaticβ -cells

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• Beyond the gap: functions of unpaired connexon channels

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• Cooperative Regulation by Rac and Rho of Agrin-induced Acetylcholine Receptor Clustering in Muscle Cells*

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• A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover

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• Gating and regulation of connexin 43 (Cx43) hemichannels

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• Differential connexin expression, gap junction intercellular coupling, and hemichannel formation in NT2/D1 human neural progenitors and terminally differentiated hNT neurons

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• Agrin Regulates Rapsyn Interaction with Surface Acetylcholine Receptors, and This Underlies Cytoskeletal Anchoring and Clustering*

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• Proteomic analysis of a neoplastic mouse lung epithelial cell line whose tumorigenicity has been abrogated by transfection with the gap junction structural gene for connexin 43, Gja1.

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• New roles for astrocytes: gap junction hemichannels have something to communicate.

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• Toward an Understanding of Cochlear Homeostasis: The Impact of Location and the Role of OCP1 and OCP2

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• THE ULTRASTRUCTURE OF THE NEXUS A Correlated Thin-Section and Freeze-Cleave Study

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• New roles for connexons.

  2003cited by this paper
• Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43

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• Gap junctions in the inner ear: Comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals

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• Lysosomal and Proteasomal Degradation Play Distinct Roles in the Life Cycle of Cx43 in Gap Junctional Intercellular Communication-deficient and -competent Breast Tumor Cells*

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• Protein kinase Cgamma regulation of gap junction activity through caveolin-1-containing lipid rafts.

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• Role of catenins in the development of gap junctions in rat cardiomyocytes

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• Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells.

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• Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release

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• Quality improvement guidelines for diagnostic arteriography.

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• Principles of protein-protein interactions

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• Multicolor and Electron Microscopic Imaging of Connexin Trafficking

  2002influential reference
• Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40.

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• The integrin β1 subunit cytoplasmic tail forms oligomers: a potential role in β1 integrin clustering

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• LEDGF Activation Of PKC And Gap Junction Disassembly In Lens Epithelial Cells

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• Increased Association of ZO-1 With Connexin43 During Remodeling of Cardiac Gap Junctions

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• Unique and Redundant Connexin Contributions to Lens Development

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• Post-translational integration and oligomerization of connexin 26 in plasma membranes and evidence of formation of membrane pores: implications for the assembly of gap junctions.

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• Formation of the gap junction nexus: binding partners for connexins.

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• Connexin family members target to lipid raft domains and interact with caveolin-1.

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• Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome

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• JNK bond regulation: why do mammalian hearts invest in connexin43?

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• Casein Kinase 1 Regulates Connexin-43 Gap Junction Assembly*

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• PREPARATION *

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• Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells

  2002influential reference
• Structure and function of dendritic spines.

  2002cited by this paper
• The integrin beta1 subunit cytoplasmic tail forms oligomers: a potential role in beta1 integrin clustering.

  2002cited by this paper
• Intercellular adhesion, signalling and the cytoskeleton

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• Targeted Gap Junction Protein Constructs Reveal Connexin-specific Differences in Oligomerization*

  2002cited by this paper
• Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules.

  2002cited by this paper
• Genetic tags for labelling live cells: gap junctions and beyond.

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• Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

  2001cited by this paper
• Distribution and Dynamics of Gap Junction Channels Revealed in Living Cells

  2001cited by this paper
• Multimeric connexin interactions prior to the trans-Golgi network.

  2001cited by this paper
• trans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation.

  2001cited by this paper
• Identification of Cells Expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in Gap Junctions of Rat Brain and Spinal Cord

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• Increased Co-localization of Connexin43 and ZO-1 in Dissociated Adult Myocytes

  2001cited by this paper
• Role of Cytoskeletal Elements in the Recruitment of Cx43-GFP and Cx26-YFP into Gap Junctions

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• Size Selectivity Between Gap Junction Channels Composed of Different Connexins

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• The origin of annular junctions: a mechanism of gap junction internalization.

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• Refined crystal structure of DsRed, a red fluorescent protein from coral, at 2.0-A resolution.

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• Multicolour imaging of post-Golgi sorting and trafficking in live cells

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• Multifunctional strands in tight junctions

  2001cited by this paper
• Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels.

  2001cited by this paper
• Hemichannel-Mediated Inhibition in the Outer Retina

  2001cited by this paper
• Gap junction protein connexin-43 interacts directly with microtubules.

  2001cited by this paper
• Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons.

  2001cited by this paper
• Gap junction channels formed by coexpressed connexin40 and connexin43.

  2001cited by this paper
• Quality control in the endoplasmic reticulum: PDI mediates the ER retention of unassembled procollagen C-propeptides.

  2001cited by this paper
• Heteromeric connexons formed by the lens connexins, connexin43 and connexin56.

  2001influential reference
• Multiple connexin expression in regenerating arterial endothelial gap junctions.

  2000cited by this paper
• Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking.

  2000cited by this paper
• Intracellular transport, assembly, and degradation of wild-type and disease-linked mutant gap junction proteins.

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• Physiological Role of Gap-Junctional Hemichannels

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• Paxillin and focal adhesion signalling

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  2000influential reference
• Identification of connexin-interacting proteins: application of the yeast two-hybrid screen.

  2000cited by this paper
• Structural organization of gap junctions as revealed by freeze-fracture and SDS fracture-labeling.

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• Mutations in GJB6 cause hidrotic ectodermal dysplasia

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• Unique and shared functions of different connexins in mice.

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• Lipid rafts and signal transduction

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• Connexin-specific distribution within gap junctions revealed in living cells.

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• Physiological Role of Gap-Junctional Hemichannels: Extracellular Calcium-Dependent Isosmotic Volume Regulation

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• Imaging Constitutive Exocytosis with Total Internal Reflection Fluorescence Microscopy

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• Cell-free synthesis for analyzing the membrane integration, oligomerization, and assembly characteristics of gap junction connexins.

  2000cited by this paper
• Regulation of Connexin Degradation as a Mechanism to Increase Gap Junction Assembly and Function*

  2000cited by this paper
• Trafficking, assembly, and function of a connexin43-green fluorescent protein chimera in live mammalian cells.

  1999cited by this paper
• Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions.

  1999cited by this paper
• Selective transfer of endogenous metabolites through gap junctions composed of different connexins

  1999cited by this paper
• Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells.

  1999cited by this paper
• Molecular biology of the interactions between connexins.

  1999influential reference
• Connexin-43 Hemichannels Opened by Metabolic Inhibition*

  1999cited by this paper
• Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells.

  1999cited by this paper
• Three-dimensional structure of a recombinant gap junction membrane channel.

  1999influential reference
• Synthesis and assembly of connexins in vitro into homomeric and heteromeric functional gap junction hemichannels.

  1999cited by this paper
• Trafficking pathways leading to the formation of gap junctions.

  1999cited by this paper
• Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals

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• Connexin Make-up of Endothelial Gap Junctions in the Rat Pulmonary Artery as Revealed by Immunoconfocal Microscopy and Triple-label Immunogold Electron Microscopy

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• (-) - (11R, 12S)-mefloquine ameliorates neuropathic pain by modulating Cx36-ER stress interaction in the pain-related central nervous system in rats.

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• Retinal Calcium Waves Coordinate Uniform Tissue Patterning of the Drosophila Eye

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• Assessing Hemichannel and Gap Junctional Channel Activities in HaCaT Keratinocyte Cells.

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• Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye.

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• FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking.

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• Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55

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• Association of connexin36 with adherens junctions at mixed synapses and distinguishing electrophysiological features of those at mossy fiber terminals in rat ventral hippocampus.

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• Trafficking of Connexin36 (Cx36) in the early secretory pathway

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• Connexin-43 in Cancer: Above and Beyond Gap Junctions!

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• Modeling and analysis of voltage gating of gap junction channels at a single-channel level.

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• Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro

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• Pattern Distribution of Connexins in the Ortho- and Parakeratinized Epithelium of the Lingual Mucosa in Birds

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• Role of Connexin 43 phosphorylation on Serine-368 by PKC in cardiac function and disease

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• Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein

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• The effect of forskolin and the role of Epac2A during activation, activity, and deactivation of beta cell networks

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• Maintenance of hematopoietic stem cell niche homeostasis requires gap junction–mediated calcium signaling

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• Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

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• CDK5 activity in retinal pigment epithelium contributes to gap junction dynamics during phagocytosis

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• Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS-STING immune pathway.

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• Potential Role of Fenestrated Septa in Axonal Transport of Golgi Cisternae and Gap Junction Formation/Function

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• Diversity in connexin biology

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• Second Messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP):Synthesis, transmission, and degradation.

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• The impact of Lactobacillus and Bifidobacterium probiotic cocktail on modulation of gene expression of gap junctions dysregulated by intestinal pathogens

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• Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy

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• ERGIC2 and ERGIC3 regulate the ER‐to‐Golgi transport of gap junction proteins in metazoans

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• Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology

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