Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of Clinical Investigation

• Publication date

  1997-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI119746PMID 9329978PMCID PMC508404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chinese hamster ovary cell mutants affecting cholesterol metabolism.

  1997cited by this paper
• Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).

  1997cited by this paper
• Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

  1997influential reference
• Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

  1997influential reference
• The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.

  1997influential reference
• Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

  1996influential reference
• ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

  1996cited by this paper
• Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.

  1996cited by this paper
• Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.

  1995cited by this paper
• Positional cloning of the mouse obese gene and its human homologue

  1995cited by this paper
• Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.

  1995cited by this paper
• Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

  1995cited by this paper
• Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines

  1995cited by this paper
• Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection *

  1995cited by this paper
• Inducible gene targeting in mice

  1995cited by this paper
• Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

  1994influential reference
• Isolation and characterization of the gene for mouse hormone-sensitive lipase.

  1994cited by this paper
• Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

  1994cited by this paper
• Positional cloning of the mouse obese gene and its human homologue

  1994cited by this paper
• Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

  1994cited by this paper
• SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

  1993cited by this paper
• Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

  1993cited by this paper
• Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene.

  1992cited by this paper
• The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.

  1986cited by this paper

• Site-1 protease–mediated cholesterol metabolism is essential for lymphatic development in mice

  2025cites this paper
• Dendrobium nobile Lindl. alkaloids improve lipid metabolism by increasing LDL uptake through regulation of the LXRα/IDOL/LDLR pathway and inhibition of PCSK9 expression in HepG2 cells

  2025cites this paper
• Therapeutic strategies targeting SREBP transcription factors: an update to 2024

  2025cites this paper
• The methyl-CpG-binding protein 2 (Mecp2) regulates the hypothalamic mitochondrial function and white adipose tissue lipid metabolism.

  2025cites this paper
• SPRINGing off the lock: the role of SPRING in S1P activity and SREBP-regulated lipid metabolism

  2025cites this paper
• The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid Metabolism

  2025cites this paper
• Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis

  2025cites this paper
• Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening

  2024cites this paper
• ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes

  2024cites this paper
• Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy

  2024cites this paper
• Ferredoxin 2 is critical for tumor suppression and lipid homeostasis but dispensable for embryonic development.

  2024cites this paper
• FoxO transcription factors regulate urea cycle through Ass1.

  2024cites this paper
• Cellular metabolism regulates the differentiation and function of T-cell subsets

  2024cites this paper
• Novel insights into regulators and functional modulators of adipogenesis.

  2024cites this paper
• Macrophage SREBP1 regulates skeletal muscle regeneration

  2024cites this paper
• Deciphering adipose development: Function, differentiation and regulation

  2024cites this paper
• Deciphering the Role of the SREBF1 Gene in the Transcriptional Regulation of Porcine Adipogenesis Using CRISPR/Cas9 Editing

  2024cites this paper
• Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfunction

  2024cites this paper
• Oleic acid differentially affects lipid droplet storage of de novo synthesized lipids in hepatocytes and adipocytes

  2024cites this paper
• The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis

  2024cites this paper
• Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer

  2023cites this paper
• Deregulated transcription factors in the emerging cancer hallmarks.

  2023cites this paper
• Decoding the crosstalk between mevalonate metabolism and T cell function

  2023cites this paper
• Spatial sterol metabolism unveiled by stimulated Raman imaging

  2023cites this paper
• Metabolic Profile of Patients with Smith-Magenis Syndrome: An Observational Study with Literature Review

  2023cites this paper
• Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia

  2023cites this paper
• Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

  2023cites this paper
• Physiological and pathological roles of lipogenesis

  2023cites this paper
• A transcriptomic intratumour heterogeneity-free signature overcomes sampling bias in prognostic risk classification for hepatocellular carcinoma

  2023cites this paper
• Oleic acid differentially affects de novo lipogenesis in adipocytes and hepatocytes

  2023cites this paper
• C–C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease

  2023cites this paper
• Antidiabetic and antihyperlipidemic activities of Phyllanthus emblica L. extract in vitro and the regulation of Akt phosphorylation, gluconeogenesis, and peroxisome proliferator-activated receptor α in streptozotocin-induced diabetic mice

  2023cites this paper
• A Very Rare Variant in SREBF2, a Possible Cause of Hypercholesterolemia and Increased Glycemic Levels

  2022cites this paper
• Deregulated transcription factors in cancer cell metabolisms and reprogramming.

  2022cites this paper
• Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

  2022cites this paper
• Hepatocyte or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced NAFLD.

  2022cites this paper
• Visualization and quantification of de novo lipogenesis using a FASN-2A-GLuc mouse model

  2022cites this paper
• Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater

  2022cites this paper
• Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα

  2022cites this paper
• Long non-Coding RNAs and Obesity: New Potential Pathogenic Biomarkers.

  2022cites this paper
• The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation

  2022cites this paper
• Balancing cholesterol in the brain: from synthesis to disposal

  2022cites this paper
• Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation

  2021cites this paper
• Metabolic Alterations in Myotonic Dystrophy Type 1 and Their Correlation with Lipin

  2021cites this paper
• Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues

  2021cites this paper
• SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC.

  2021cites this paper
• A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity

  2021cites this paper
• Lysophosphatidylcholine acyltransferase 3 deficiency activates the Wnt/ β -catenin pathway and thereby impairs adipogenesis in preadipocytes

  2021cites this paper
• Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

  2020cites this paper
• Self-assembled hyaluronic acid nanoparticle suppresses fat accumulation via CD44 in diet-induced obese mice.

  2020cites this paper
• Progress in the Study of Sterol Regulatory Element Binding Protein 1 Signal Pathway

  2020cites this paper
• Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

  2020cites this paper
• MED1 is a lipogenesis coactivator required for postnatal adipose expansion

  2020cites this paper
• 14-3-3zeta is required for PKA-dependent lipolysis in mature adipocytes

  2020cites this paper
• Identification of human long non-coding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis.

  2020cites this paper
• Lipodystrophies—Disorders of the Fatty Tissue

  2020cites this paper
• NUTRIGENÉTICA E NUTRIGENÔMICA: CONCEITOS E ABORDAGENS ESQUEMÁTICAS PARA O PROCESSO ENSINO-APRENDIZAGEM DESTE SABER / NUTRIGENETICS AND NUTRIGENOMICS: CONCEPTS AND SCHEMATIC APPROACHES FOR THE TEACHING-LEARNING PROCESS OF THIS KNOWLEDGE

  2020cites this paper
• A novel lncRNA BADLNCR1 inhibits bovine adipogenesis by repressing GLRX5 expression

  2020cites this paper
• Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways

  2020cites this paper
• Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α

  2020cites this paper
• A moderate physiological dose of benzyl butyl phthalate exacerbates the high fat diet-induced diabesity in male mice.

  2020cites this paper
• Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)

  2020cites this paper
• Brahma Related Gene 1 (Brg1) Regulates Cellular Cholesterol Synthesis by Acting as a Co-factor for SREBP2

  2020cites this paper
• Effects of (+)-catechin on the differentiation and lipid metabolism of 3T3-L1 adipocytes

  2019cites this paper
• The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.

  2019cites this paper
• Oxysterols and Gastrointestinal Cancers Around the Clock

  2019cites this paper
• Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet

  2019cites this paper
• SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1.

  2019cites this paper
• Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis.

  2019cites this paper
• Brown Adipose Tissue Energy Metabolism

  2019cites this paper
• Transcriptional and Epigenomic Regulation of Adipogenesis

  2019cites this paper
• Oral solution of fructose promotes SREBP-1c high-expression in the hypothalamus of Wistar rats

  2019cites this paper
• Interactions between carbohydrate and lipid metabolism in metabolic disorders

  2019cites this paper
• Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA

  2019cites this paper
• Lipid metabolism reprogramming and its potential targets in cancer

  2018cites this paper
• CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling

  2018cites this paper
• Farnesoid X receptor: A "homeostat" for hepatic nutrient metabolism.

  2018cites this paper
• microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler's Virus-Induced Demyelinating Disease.

  2018cites this paper
• Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues

  2018influential citation
• Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux

  2018cites this paper
• GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice.

  2018cites this paper
• Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis

  2018influential citation
• The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice.

  2018cites this paper
• SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy.

  2018cites this paper
• SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress

  2018cites this paper
• Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice

  2018cites this paper
• Long-term exposure to elevated temperature in Atlantic salmon (Salmo salar)

  2018cites this paper
• Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability

  2018cites this paper
• Lysophosphatidylcholine acyltransferase 3 deficiency impairs 3T3L1 cell adipogenesis through activating Wnt/β-catenin pathway.

  2018cites this paper
• Clusterin deficiency induces lipid accumulation and tissue damage in kidney.

  2018cites this paper
• Involvement of orexin in lipid accumulation in the liver

  2018cites this paper
• Metabolomics of Immunity and Its Clinical Applications

  2018cites this paper
• Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice

  2018cites this paper
• Adipose Tissue Heterogeneity - Development and Application of Nonlinear Microscopy Methods

  2018cites this paper
• Regulatory roles of sterol regulatory element-binding protein (SREBP) on lipid metabolism in marine invertebrate Chlamys nobilis

  2018cites this paper
• Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines

  2017cites this paper
• Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance

  2017cites this paper
• (−)-Epicatechin-3-O-β-D-allopyranoside from Davallia formosana prevents diabetes and dyslipidemia in streptozotocin-induced diabetic mice

  2017cites this paper
• Regulation of INSIG2 by microRNA-96

  2017cites this paper
• Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer

  2017cites this paper