Leptospirosis vaccines: past, present, and future.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Postgraduate Medicine

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 16333195
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Whole-genome analysis of Leptospira interrogans to identify potential vaccine candidates against leptospirosis.

  2005cited by this paper
• Omp52 is a growth-phase-regulated outer membrane protein of Leptospira santarosai serovar Shermani.

  2005cited by this paper
• Six Revolutions in Vaccinology

  2005cited by this paper
• Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of Leptospira interrogans serovar Copenhageni

  2005cited by this paper
• Osmolarity, a Key Environmental Signal Controlling Expression of Leptospiral Proteins LigA and LigB and the Extracellular Release of LigA

  2005cited by this paper
• Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens.

  2004cited by this paper
• Outer membrane proteins of pathogenic spirochetes.

  2004cited by this paper
• Leptospiral immunoglobulin-like proteins elicit protective immunity.

  2004influential reference
• Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISA.

  2004cited by this paper
• Genome features of Leptospira interrogans serovar Copenhageni.

  2004cited by this paper
• [Efficacy and safety of a vaccine against human leptospirosis in Cuba].

  2004cited by this paper
• Host-Inducible Immunogenic Sphingomyelinase-Like Protein, Lk73.5, of Leptospira interrogans

  2004cited by this paper
• Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis

  2004cited by this paper
• LipL21 Is a Novel Surface-Exposed Lipoprotein of Pathogenic Leptospira Species

  2003cited by this paper
• Leptospira interrogans Activation of Human Peripheral Blood Mononuclear Cells: Preferential Expansion of TCRγδ+ T Cells vs TCRαβ+ T Cells 1

  2003cited by this paper
• Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

  2003cited by this paper
• Identification of a novel antigen of pathogenic Leptospira spp. that reacted with convalescent mice sera.

  2003cited by this paper
• Duration of immunity in dogs vaccinated against leptospirosis with a bivalent inactivated vaccine.

  2003cited by this paper
• An evaluation of the serological and epidemiological effects of the outer envelope vaccine to leptospira.

  2003cited by this paper
• Interleukin 12 in Part Regulates Gamma Interferon Release in Human Whole Blood Stimulated with Leptospira interrogans

  2003cited by this paper
• Comparison of three different leptospiral vaccines for induction of a type 1 immune response to Leptospira borgpetersenii serovar Hardjo.

  2003cited by this paper
• Leptospirosis: a zoonotic disease of global importance.

  2003cited by this paper
• Pathogenic Leptospira species express surface‐exposed proteins belonging to the bacterial immunoglobulin superfamily

  2003cited by this paper
• Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri.

  2003cited by this paper
• Molecular cloning and characterization of a novel leptospiral lipoprotein with OmpA domain.

  2003cited by this paper
• Global Analysis of Outer Membrane Proteins from Leptospira interrogans Serovar Lai

  2002cited by this paper
• Peripheral Blood Mononuclear Cell Activation Induced by Leptospira interrogans Glycolipoprotein

  2002cited by this paper
• [Reactogenecity and immunogenecity of Cuban trivalent inactivated vaccine against human leptospirosis in different vaccination schedules].

  2002cited by this paper
• Characterization of the Leptospiral Outer Membrane and Description of Three Novel Leptospiral Membrane Proteins

  2002cited by this paper
• Novel 45-Kilodalton Leptospiral Protein That Is Processed to a 31-Kilodalton Growth-Phase-Regulated Peripheral Membrane Protein

  2002cited by this paper
• Ocular leptospirosis.

  2002cited by this paper
• Cloning and Molecular Characterization of an Immunogenic LigA Protein of Leptospira interrogans

  2002cited by this paper
• First evidence for gene replacement in Leptospira spp. Inactivation of L. biflexa flaB results in non‐motile mutants deficient in endoflagella

  2001cited by this paper
• Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans

  2001cited by this paper
• Evaluation of Recombinant Leptospira Antigen-Based Enzyme-Linked Immunosorbent Assays for the Serodiagnosis of Leptospirosis

  2001cited by this paper
• Identification of the Hemolysis-Associated Protein 1 as a Cross-Protective Immunogen of Leptospira interrogans by Adenovirus-Mediated Vaccination

  2001cited by this paper
• Reverse vaccinology, a genome-based approach to vaccine development.

  2001cited by this paper
• Molecular Characterization of Thermoinduced Immunogenic Proteins Q1p42 and Hsp15 of Leptospira interrogans

  2001cited by this paper
• Control of Immunologically Crossreactive Leptospiral Infection by Administration of Lipopolysaccharides from a Nonpathogenic Strain of Leptospira biflexa

  2000cited by this paper
• Crystal structure of enteropathogenic Escherichia coli intimin–receptor complex

  2000cited by this paper
• Utilization of Exocellular Mannan from Rhodotorula glutinis as an Immunoreactive Antigen in Diagnosis of Leptospirosis

  2000cited by this paper
• The Leptospiral Major Outer Membrane Protein LipL32 Is a Lipoprotein Expressed during Mammalian Infection

  2000influential reference
• Evidence of cross-protection within Leptospira interrogans in an experimental model.

  2000cited by this paper
• [Evaluation of the effectiveness of a new vaccine against human leptospirosis in groups at risk].

  2000cited by this paper
• Identification and partial characterization of a novel hemolysin from Leptospira interrogans serovar lai.

  2000cited by this paper
• The LE1 Bacteriophage Replicates as a Plasmid within Leptospira biflexa: Construction of an L. biflexa-Escherichia coli Shuttle Vector

  2000cited by this paper
• Crystal structure of invasin: a bacterial integrin-binding protein.

  1999cited by this paper
• International Multicenter Evaluation of the Clinical Utility of a Dipstick Assay for Detection ofLeptospira-Specific Immunoglobulin M Antibodies in Human Serum Specimens

  1999cited by this paper
• Expression and Immunologic Characterization of Recombinant Heat Shock Protein 58 of Leptospira Species: A Major Target Antigen of the Humoral Immune Response

  1999cited by this paper
• Leptospiral Outer Membrane Proteins OmpL1 and LipL41 Exhibit Synergistic Immunoprotection

  1999cited by this paper
• Characterization of Leptospiral Outer Membrane Lipoprotein LipL36: Downregulation Associated with Late-Log-Phase Growth and Mammalian Infection

  1998cited by this paper
• [The reactogenicity and immunogenicity of the first Cuban vaccine against human leptospirosis].

  1998cited by this paper
• LEPTO Dipstick, a Dipstick Assay for Detection of Leptospira- Specific Immunoglobulin M Antibodies in Human Sera

  1996cited by this paper
• Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults.

  1996cited by this paper
• The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin

  1995cited by this paper
• Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA

  1993cited by this paper
• Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp

  1993cited by this paper
• Changes in the surface of Leptospira interrogans serovar grippotyphosa during in vitro cultivation

  1991cited by this paper
• [Development and present status of a leptospiral vaccine and the technology of vaccine production in China].

  1985influential reference
• A new leptospiral vaccine for use in man. I. Development of a vaccine from Leptospira grown on a chemically defined medium.

  1973cited by this paper
• A new leptospiral vaccine for use in man. II. Clinical and serologic evaluation of a field trial with volunteers.

  1973cited by this paper
• Leptospirosis. II. Serology.

  1968cited by this paper
• Water strains of Leptospira in the serodiagnosis of human and animal leptospirosis.

  1968cited by this paper
• Growth of Pathogenic Leptospira in Chemically Defined Media

  1967cited by this paper
• Leptospirosis: a report from one practice on the use of a leptospiral vaccine for a period of three years.

  1966cited by this paper
• AN EXOCELLULAR MANNAN, ALTERNATELY LINKED 1,3-β AND 1,4-β FROM RHODOTORULA GLUTINIS

  1965cited by this paper

• Current treatment options for leptospirosis: a mini-review

  2024cites this paper
• Design, Development and Immunogenic Evaluation of a Novel Lipl32 Recombinant Protein of Local Pathogenic Leptospira Serovars.

  2024cites this paper
• Epitopes mapping for identification of potential cross-reactive peptide against leptospirosis

  2023cites this paper
• Multinational municipal waste collectors and leptospirosis prevention: Assessment of knowledge, attitudes, practices and the associated factors

  2023cites this paper
• Human leptospirosis: In search for a better vaccine

  2023cites this paper
• Leptospirosis at human-animal-environment interfaces in Latin-America: drivers, prevention, and control measures

  2021cites this paper
• Canine Leptospirosis Outbreak in Japan

  2021cites this paper
• Immunoinformatics-Based Designing of a Multi-Epitope Chimeric Vaccine From Multi-Domain Outer Surface Antigens of Leptospira

  2021cites this paper
• In silico screening and epitope mapping of leptospiral outer membrane protein—Lsa46

  2021cites this paper
• A multipronged approach for the detection of leptospirosis in captive sloth bears (Melursus ursinus) in Agra and Bannerghatta sloth bear rescue centers in India

  2021cites this paper
• Análise de polimorfismos gênicos do Fator H do Sistema Complemento e sua influência na susceptibilidade à leptospirose

  2021cites this paper
• Vaccine Preperative Trial for Leptospirosis and their Pathological, Immunological Study by Serum Electrophoresis

  2020cites this paper
• Expression and purification of the Lipl41, a surface-exposed lipoprotein antigen of pathogenic Leptospira spp.

  2020cites this paper
• Comparative genomic analysis of Chinese human leptospirosis vaccine strain and circulating isolate

  2020cites this paper
• Age-specific epidemiology of human leptospirosis in New Caledonia, 2006-2016

  2020cites this paper
• Assessment of the immunogenicity of the leptospiral LipL32, LigAni, and LigBrep recombinant proteins in the sheep model.

  2019cites this paper
• Leptospirosis: An important infectious disease in North American horses

  2019cites this paper
• In Silico B Cell and T Cell Epitopes Evaluation of lipL32 and OmpL1 Proteins for Designing a Recombinant Multi-Epitope Vaccine Against Leptospirosis

  2018cites this paper
• Advances & challenges in leptospiral vaccine development

  2018cites this paper
• Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach

  2018cites this paper
• Immuno‐informatics based approaches to design a novel multi epitope‐based vaccine for immune response reinforcement against Leptospirosis

  2018cites this paper
• Heterologous DNA prime-protein boost immunization with RecA and FliD offers cross-clade protection against leptospiral infection

  2018cites this paper
• Chimera of Heat-labile Enterotoxin B chain conjugate with LipL32 and or LipL21 proteins induces strong reactive antibodies in experimental mice

  2018cites this paper
• Human leptospirosis vaccines in China

  2018cites this paper
• Triton X-100 Vs. Triton X-114: Isolation of Outer Membrane Proteins from Leptospira Spp.?

  2017cites this paper
• Immunoprotective properties of recombinant LigA and LigB in a hamster model of acute leptospirosis

  2017cites this paper
• Self-assembly of virus-like particles of rabbit hemorrhagic disease virus capsid protein expressed in Escherichia coli and their immunogenicity in rabbits.

  2016cites this paper
• Evaluation of two novel leptospiral proteins for their interaction with human host components.

  2016cites this paper
• Understanding transmission of Leptospira at the household level through an examination of human behaviors, environmental water contamination, and animal carriers

  2016cites this paper
• Efficient Detection of Pathogenic Leptospires Using 16S Ribosomal RNA

  2015cites this paper
• DNA prime-protein boost based vaccination with a conserved region of leptospiral immunoglobulin-like A and B proteins enhances protection against leptospirosis

  2015cites this paper
• Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants.

  2015cites this paper
• Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity

  2015influential citation
• Inactivated Trivalent Vaccine for Leptospira in Andhra Pradesh

  2015cites this paper
• Using discrete choice modeling to evaluate the preferences and willingness to pay for leptospirosis vaccine

  2015cites this paper
• Evaluation of the Leptospira interrogans Outer Membrane Protein OmpL37 as a Vaccine Candidate

  2015cites this paper
• Characterization, Comparison Study of Outer Membrane Protein OMPL1 of Pathogenic Leptospira Species for Disease Diagnosis

  2015cites this paper
• Molecular detection of pathogenic leptospiral serovars by PCR, based on lipL21 gene

  2015cites this paper
• Presencia de anticuerpos contra serogrupos patógenos de Leptospira spp. en el zorro sechurano (Lycalopex sechurae) de vida libre y caninos domésticos en la comunidad campesina José Ignacio Távara Pasapera, Piura

  2015cites this paper
• Una visión general de la leptospirosis

  2015cites this paper
• Immunogenicity of Leptospira interrogans Outer Membrane Vesicles in a Hamster Model

  2014influential citation
• INTERAÇÃO DE PROTEÍNAS DE MEMBRANA DE LEPTOSPIRA COM OS REGULADORES FATOR H E C4BP DO SISTEMA COMPLEMENTO HUMANO

  2014cites this paper
• [Leptospirosis seroprevalence and associated features in rice farmers of tropical region of Peru].

  2014cites this paper
• Seroprevalencia de leptospirosis y características asociadas en agricultores de arroz de una región tropical del Perú

  2014cites this paper
• Functional and immunological evaluation of two novel proteins of Leptospira spp.

  2014cites this paper
• Vaccination with Leptospiral Outer Membrane Lipoprotein LipL32 Reduces Kidney Invasion of Leptospira interrogans Serovar Canicola in Hamsters

  2014cites this paper
• Leptospiral Immunoproteins as Potential Elements for Diagnostic Tests and Vaccine Development

  2013influential citation
• Anticorpos revelados pelo teste de inibição do crescimento de leptospiras in vitro (TICL) contra os sorovares Canicola, Icterohaemorrhagiae e Copenhageni em cães adultos revacinados anualmente com vacina comercial contendo bacterinas dos sorovares Canicola, Icterohaemorrhagiae, Grippotyphosa e Pomon

  2013cites this paper
• A Conserved Region of Leptospiral Immunoglobulin-Like A and B Proteins as a DNA Vaccine Elicits a Prophylactic Immune Response against Leptospirosis

  2013cites this paper
• EKOLOGI DAN PATOGENITAS KUMAN LEPTOSPIRA

  2013cites this paper
• Smoke and mirrors

  2013cites this paper
• Produção e purificação de imunoglobulinas Y policlonais anti-Leptospira spp.

  2013cites this paper
• Oral Immunization with Escherichia coli Expressing a Lipidated Form of LigA Protects Hamsters against Challenge with Leptospira interrogans Serovar Copenhageni

  2013cites this paper
• Leptospirosis and Weil's disease in the UK.

  2012cites this paper
• OmpL 1 is an extracellular matrix-and plasminogen-interacting protein of 1 Leptospira spp . 2 3 4

  2012cites this paper
• Colecistopatía como manifestación de enfermedad de Weil. Reporte de un caso en un habitante de la Ciudad de México

  2012cites this paper
• Concurrent Leptospira borgpetersenii Serogroup Ballum and Ehrlichia canis Infection in a Dog in Israel: A Case Report

  2012cites this paper
• Clonagem e expressão gênica de antígenos candidatos vacinais contra leptospirose.

  2012cites this paper
• Avaliação da eficácia de bacterina antileptospirose suína: relação entre o resultado do teste de inibição de crescimento de leptospiras in vitro aplicado ao soro de suínos com o obtido no teste de potência in vivo em hamsters

  2012cites this paper
• Analysis of Multiple Leptospira interrogans Serovar Canicola Vaccine Proteomes and Identification of LipL32 as a Biomarker for Potency

  2012cites this paper
• Leptospirosis prevalence in Chinese populations in the last two decades.

  2012cites this paper
• Concurrent Leptospira borgpetersenii Serogroup Ballum and Ehrlichia canis Infection in a Dog in Israel : A Case Report

  2012cites this paper
• OmpL1 Is an Extracellular Matrix- and Plasminogen-Interacting Protein of Leptospira spp

  2012cites this paper
• Vaccines to combat the neglected tropical diseases

  2011cites this paper
• Emprego da reação em cadeia pela polimerase em tempo real para o controle de eficiência de bacterinas anti-leptospirose

  2011cites this paper
• Improvement of trivalent leptospira vaccine by removal of anaphylactic agents

  2011cites this paper
• Determination of an infectious dose of leptospira for the performance of challenge test in assessing the efficacy of leptospira vaccines

  2011cites this paper
• Prospects for the future using genomics and proteomics in clinical microbiology.

  2011cites this paper
• Evaluation of the Use of Selective PCR Amplification of LPS Biosynthesis Genes for Molecular Typing of Leptospira at the Serovar Level

  2011cites this paper
• Assessment of exposure to Leptospira serovars in veterinary staff and dog owners in contact with infected dogs.

  2011cites this paper
• Recombinant vaccines against Leptospirosis

  2011cites this paper
• Evaluation of the Expression and Protective Potential of Leptospiral Sphingomyelinases

  2010cites this paper
• Study on the efficacy of Leptospira vaccines developed from serovars isolated from Trinidad and comparison with commercial vaccines using a hamster model.

  2010cites this paper
• Perfil de seguridad de la vacuna antileptospirósica trivalente vax-SPIRAL®

  2010cites this paper
• Aplicación de las pruebas de PCR convencional simple y múltiple para la identificación de aislamientos de Leptospira spp. en Colombia

  2010cites this paper
• Poder imunogênico de bacterina experimental anti leptospirose canina: ensaio em hamsters desafiados com estirpes de leptospiras dos sorovares Copenhageni e Canicola isoladas no Brasil

  2010cites this paper
• Identification and characterization of OmpA-like proteins as novel vaccine candidates for Leptospirosis.

  2010cites this paper
• SOROPREVALÊNCIA DE AGLUTININAS ANTI-LEPTOSPIRA E REAÇÃO ANTI-BRUCELLA EM CÃES NO MUNICÍPIO DE CUIABÁ, MATO GROSSO, BRASIL

  2010cites this paper
• An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis.

  2009cites this paper
• Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen

  2009cites this paper
• Genomic research for important pathogenic bacteria in China

  2009cites this paper
• Rodent-borne diseases and their risks for public health

  2009cites this paper
• Development Of Experimental Inactivated Vaccine For Bovine Leptospirosis

  2009influential citation
• Bmc Microbiology Characterization of the Ompl1 Gene of Pathogenic Leptospira Species in China and Cross-immunogenicity of the Ompl1 Protein

  2008cites this paper
• Genetic diversity among major endemic strains of Leptospira interrogans in China

  2007cites this paper
• Bacterial genome sequencing and its use in infectious diseases.

  2007cites this paper
• Leptospirosis vaccines

  2007cites this paper
• LEPTOSPIROSE SUÍNA

  2007cites this paper
• La leptospirose : Les défis actuels d'une ancienne maladie

  2007cites this paper
• LEPTOSPIROSIS: CURRENT CHALLENGES OF AN OLD DISEASE

  2007cites this paper
• Leptospirosis : Recent Observations 617 105 Leptospirosis : Recent Observations R

  2007cites this paper
• The antipoverty vaccines.

  2006cites this paper
• Optimal treatment of leptospirosis: queries and projections.

  2006cites this paper
• Hamster Model of Leptospirosis

  2006cites this paper
• Prospects of developing leptospiral vaccines for animals.

  2006cites this paper
• In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans

  2006cites this paper
• IMUNIDADE ATIVA E PASSIVA EM SUÍNOS VACINADOS CONTRA A LEPTOSPIROSE. EMPREGO DE VACINA EXPERIMENTAL DE SUBUNIDADE E DUAS BACTERINAS COMERCIAIS DE BACTÉRIAS COMPLETAS

  2006cites this paper
• Send Orders of Reprints at Reprints@benthamscience.org Evaluation of Immunoprotective Activity of Six Leptospiral Proteins in the Hamster Model of Leptospirosis

  year unknowncites this paper