Annexin A2 Heterotetramer: Structure and Function

Annexin A2 is a pleiotropic calcium- and anionic phospholipid-binding protein that exists as a monomer and as a heterotetrameric complex with the plasminogen receptor protein, S100A10. Annexin A2 has been proposed to play a key role in many processes including exocytosis, endocytosis, membrane organization, ion channel conductance, and also to link F-actin cytoskeleton to the plasma membrane. Despite an impressive list of potential binding partners and regulatory activities, it was somewhat unexpected that the annexin A2-null mouse should show a relatively benign phenotype. Studies with the annexin A2-null mouse have suggested important functions for annexin A2 and the heterotetramer in fibrinolysis, in the regulation of the LDL receptor and in cellular redox regulation. However, the demonstration that depletion of annexin A2 causes the depletion of several other proteins including S100A10, fascin and affects the expression of at least sixty-one genes has confounded the reports of its function. In this review we will discuss the annexin A2 structure and function and its proposed physiological and pathological roles.

• Publication year

  2013

• Venue

  International Journal of Molecular Sciences

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms14036259PMID 23519104PMCID 3634455
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• And Its Precursors Loss of Annexin Ii Heavy and Light Chains in Prostate Cancer Updated Version Citing Articles E-mail Alerts Loss of Annexin Ii Heavy and Light Chains in Prostate Cancer and Its Precursors 1

  2013cited by this paper
• Annexin A2 Modulates Radiation-Sensitive Transcriptional Programming and Cell Fate

  2013cited by this paper
• Gene‐expression signature of tumor recurrence in patients with stage II and III colon cancer treated with 5′fluoruracil‐based adjuvant chemotherapy

  2013cited by this paper
• Plasminogen Receptors

  2012cited by this paper
• Interferon‐γ stimulates p11‐dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis

  2012cited by this paper
• Regulation of inflammatory response in human chondrocytes by lentiviral mediated RNA interference against S100A10

  2012cited by this paper
• Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes

  2012cited by this paper
• Tissue plasminogen activator activates NF-κB through a pathway involving annexin A2/CD11b and integrin-linked kinase.

  2012cited by this paper
• A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies.

  2012cited by this paper
• Redox Sensing by Proteins: Oxidative Modifications on Cysteines and the Consequent Events

  2012cited by this paper
• Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma

  2012cited by this paper
• Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2.

  2012cited by this paper
• Genotoxic Agents Promote the Nuclear Accumulation of Annexin A2: Role of Annexin A2 in Mitigating DNA Damage

  2012cited by this paper
• Overexpression of Annexin A2 Is Associated with Abnormal Ubiquitination in Breast Cancer

  2012cited by this paper
• The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis

  2012influential reference
• Evolutionary adaptation of plant annexins has diversified their molecular structures, interactions and functional roles.

  2012cited by this paper
• Unconventional secretion: a stress on GRASP.

  2011cited by this paper
• The role of the annexin A2 heterotetramer in vascular fibrinolysis.

  2011cited by this paper
• Tyrosine 23 Phosphorylation-Dependent Cell-Surface Localization of Annexin A2 Is Required for Invasion and Metastases of Pancreatic Cancer

  2011influential reference
• Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

  2011cited by this paper
• Annexin A2 as a differential diagnostic marker of hepatocellular tumors.

  2011cited by this paper
• The Unconventional Secretory Machinery of Fibroblast Growth Factor 2

  2011cited by this paper
• The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis

  2011cited by this paper
• The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia.

  2011cited by this paper
• Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells.

  2011cited by this paper
• Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites.

  2011influential reference
• Regulation of S100A10 by the PML-RAR-α oncoprotein.

  2011cited by this paper
• Annexins as organizers of cholesterol- and sphingomyelin-enriched membrane microdomains in Niemann-Pick type C disease

  2011cited by this paper
• Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis

  2011cited by this paper
• Lipid Raft Endocytosis and Exosomal Transport Facilitate Extracellular Trafficking of Annexin A2*

  2011cited by this paper
• DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism.

  2011cited by this paper
• Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment

  2011influential reference
• Regulation of fibrinolysis by S100A10 in vivo.

  2011cited by this paper
• Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion.

  2010cited by this paper
• Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK.

  2010cited by this paper
• Annexin A2 tetramer activates human and murine macrophages through TLR4.

  2010cited by this paper
• Feedback Regulation of Endothelial Cell Surface Plasmin Generation by PKC-dependent Phosphorylation of Annexin A2*

  2010cited by this paper
• Redox sensing: orthogonal control in cell cycle and apoptosis signalling

  2010cited by this paper
• Annexin 2 Regulates Endothelial Morphogenesis by Controlling AKT Activation and Junctional Integrity*

  2010cited by this paper
• S100A10‐Mediated Translocation of Annexin‐A2 to SNARE Proteins in Adrenergic Chromaffin Cells Undergoing Exocytosis

  2010cited by this paper
• Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation.

  2010cited by this paper
• S100A10 regulates plasminogen-dependent macrophage invasion.

  2010cited by this paper
• Polymeric nanoparticles for sustained down-regulation of annexin A2 inhibit prostate tumor growth.

  2009cited by this paper
• Unique S100 target protein interactions.

  2009cited by this paper
• Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy.

  2009cited by this paper
• Thiol-Based Redox Switches in Eukaryotic Proteins

  2009cited by this paper
• Annexin II represents metastatic potential in clear-cell renal cell carcinoma

  2009cited by this paper
• Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy

  2009cited by this paper
• Arsenic trioxide downregulates the expression of annexin II in bone marrow cells from patients with acute myelogenous leukemia.

  2009cited by this paper
• Annexin A2 Is a Molecular Target for TM601, a Peptide with Tumor-targeting and Anti-angiogenic Effects

  2009cited by this paper
• Annexin A2 positively contributes to the malignant phenotype and secretion of IL‐6 in DU145 prostate cancer cells

  2009cited by this paper
• Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells.

  2009cited by this paper
• Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation.

  2009cited by this paper
• Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.

  2008cited by this paper
• Endothelial Cell Annexin A2 Regulates Polyubiquitination and Degradation of Its Binding Partner S100A10/p11*

  2008cited by this paper
• Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion

  2008cited by this paper
• Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

  2008cited by this paper
• Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma.

  2008cited by this paper
• Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.

  2008cited by this paper
• Annexin II Overexpression Predicts Rapid Recurrence after Surgery in Pancreatic Cancer Patients Undergoing Gemcitabine-Adjuvant Chemotherapy

  2008cited by this paper
• Annexin II Overexpression Predicts Rapid Recurrence after Surgery in Pancreatic Cancer Patients Undergoing Gemcitabine-Adjuvant Chemotherapy

  2008cited by this paper
• Annexin A2 localizes to the basal epithelial layer and is down-regulated in dysplasia and head and neck squamous cell carcinoma.

  2008cited by this paper
• Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data.

  2008influential reference
• Annexin A2 Interactions with Rab14 in Alveolar Type II Cells*

  2008cited by this paper
• A Direct Role for Phosphatidylinositol‐4,5‐bisphosphate in Unconventional Secretion of Fibroblast Growth Factor 2

  2008cited by this paper
• Annexin A2 Regulates the Levels of Plasmin, S100A10 and Fascin in L5178Y Cells

  2008cited by this paper
• Annexin A2: biology and relevance to the antiphospholipid syndrome

  2008cited by this paper
• Histone H2B as a functionally important plasminogen receptor on macrophages.

  2007cited by this paper
• Annexin A2 Phosphorylation Mediates Cell Scattering and Branching Morphogenesis via Cofilin Activation

  2007cited by this paper
• Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs.

  2007cited by this paper
• Hydrogen peroxide sensing and signaling.

  2007cited by this paper
• Plasmin Triggers Cytokine Induction in Human Monocyte-Derived Macrophages

  2007cited by this paper
• Annexin A2 is a soluble mediator of macrophage activation

  2007influential reference
• Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer.

  2007cited by this paper
• Evaluation of S100A10, annexin II and B‐FABP expression as markers for renal cell carcinoma

  2007cited by this paper
• [Dysregulation of Annexin II expression in esophageal squamous cell cancer and adjacent tissues from a high-incidence area for esophageal cancer in Henan province].

  2007cited by this paper
• Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer.

  2007cited by this paper
• Annexin A2/P11 interaction: New insights into annexin A2 tetramer structure by chemical crosslinking, high‐resolution mass spectrometry, and computational modeling

  2007cited by this paper
• Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling.

  2007cited by this paper
• Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells

  2007cited by this paper
• Proteome Analysis of Human Pancreatic Ductal Adenocarcinoma Tissue Using Two-Dimensional Gel Electrophoresis and Tandem Mass Spectrometry for Identification of Disease-Related Proteins

  2007cited by this paper
• The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV.

  2007cited by this paper
• Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2*

  2006cited by this paper
• [The fibrinolytic activity in leukemic cell lines and its alteration on all-trans retinoic acid treatment].

  2006cited by this paper
• Regulation of actin dynamics by annexin 2

  2006cited by this paper
• H2O2, a Necessary Evil for Cell Signaling

  2006cited by this paper
• Tenascin C and annexin II expression in the process of pancreatic carcinogenesis

  2006influential reference
• Annexin A2 recognises a specific region in the 3'-UTR of its cognate messenger RNA.

  2006cited by this paper
• Cell signaling. H2O2, a necessary evil for cell signaling.

  2006cited by this paper
• Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes.

  2006cited by this paper
• Structural basis of the cofactor function of denatured albumin in plasminogen activation by tissue-type plasminogen activator.

  2006cited by this paper
• Antibody-directed targeting of angiostatin's receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin's action.

  2006cited by this paper
• Phosphoinositide Specificity of and Mechanism of Lipid Domain Formation by Annexin A2-p11 Heterotetramer*

  2005influential reference
• S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors.

  2005cited by this paper
• Involvement of the Annexin II-S100A10 Complex in the Formation of E-cadherin-based Adherens Junctions in Madin-Darby Canine Kidney Cells*

  2005cited by this paper
• Phosphatidylserine membrane domain clustering induced by annexin A2/S100A10 heterotetramer.

  2005cited by this paper
• Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies.

  2005cited by this paper
• Annexin 2 promotes the formation of lipid microdomains required for calcium-regulated exocytosis of dense-core vesicles.

  2005cited by this paper
• Annexin A2 binds to the localization signal in the 3′ untranslated region of c‐myc mRNA

  2005cited by this paper
• Annexin II Stimulates RANKL Expression Through MAPK

  2005cited by this paper

• Annexin A1 and A2 in inflammatory bowel disease pathogenesis: exploring new avenues for diagnosis and treatment

  2026influential citation
• Mastitis-associated production of S100A10 in the mammary gland of goats

  2026cites this paper
• Oxidative profile and degradation patterns of plasma-activated water-treated golden pompano (Trachinotus ovatus) during chilled storage: Insights based on data independent acquisition (DIA) quantitative proteomics.

  2026cites this paper
• The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

  2026cites this paper
• Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.

  2025cites this paper
• The RNA-binding properties of Annexins.

  2025cites this paper
• Assessment of Phage‐Displayed Peptides Targeting Cancer Cell Surface Proteins: A Comprehensive Molecular Docking Study

  2025cites this paper
• Characterisation of the periodontal proteome in gingival crevicular fluid and saliva using SWATH-MS

  2025cites this paper
• A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness

  2025cites this paper
• ANXA2 Protein and Its Role in Neurodegeneration Processes

  2025influential citation
• Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy.

  2025cites this paper
• Identification of potential geosmin-binding proteins in grass carp gill based on affinity responsive target stability and tandem mass tag proteomics.

  2025cites this paper
• Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition

  2025cites this paper
• Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories

  2025cites this paper
• AnxA2-EGFR pro-inflammatory signaling potentiates EMT-induced fibrotic stress and its modulation by short-chain fatty acid butyrate in idiopathic pulmonary fibrosis.

  2025cites this paper
• The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

  2025cites this paper
• ANXA2 in cancer: aberrant regulation of tumour cell apoptosis and its immune interactions

  2025cites this paper
• miR-151 in health and disease: A comprehensive review of its implications in Cancer, diabetes, and more

  2025cites this paper
• Annexin A2 is a potential membrane protein target of cobra venom cytotoxin.

  2025cites this paper
• Stool-Based Proteomic Signature for the Noninvasive Classification of Crohn's Disease and Ulcerative Colitis Using Machine Learning

  2025cites this paper
• Internalization of extracellular Tau oligomers in Alzheimer's disease.

  2025cites this paper
• ANXA2 in hepatocellular carcinoma: orchestrating tumorigenesis, progression, and therapeutic resistance toward precision targeting

  2025cites this paper
• Annexin A2 Contributes to Release of Extracellular Vimentin in Response to Inflammation

  2025cites this paper
• Calreticulin—From the Endoplasmic Reticulum to the Plasma Membrane—Adventures of a Wandering Protein

  2025cites this paper
• Differential protein and mRNA cargo loading into engineered large and small extracellular vesicles reveals differences in in vitro and in vivo assays.

  2025cites this paper
• Proteomic Biomarkers Associated with Low Bone Mineral Density: A Systematic Review

  2024cites this paper
• Calpains Orchestrate Secretion of Annexin-containing Microvesicles during Membrane Repair

  2024cites this paper
• LncRNAs in tumor metabolic reprogramming and tumor microenvironment remodeling

  2024cites this paper
• Candidate proteins interacting with cytoskeleton in cells from the basal airway epithelium in vitro

  2024influential citation
• The Pathogenesis of Nephrotic Syndrome: A Perspective from B Cells

  2024cites this paper
• Annexin A2 and lamin B join membrane recycling compartments for the assembly of biomolecular condensates operating in mitotic partitioning

  2024cites this paper
• Covalent binding of withanolides to cysteines of protein targets.

  2024cites this paper
• Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection

  2024cites this paper
• Comparative analysis of milk fat globule membrane proteins between porcine and human colostrum by a label‐free proteomics approach

  2024cites this paper
• According to the manufactuDHAV-1 3C protein promotes virus proliferation by antagonizing type I interferon by upregulating the ANXA2 protein.

  2024cites this paper
• Annexin A2 in Tumors of the Gastrointestinal Tract, Liver, and Pancreas

  2024cites this paper
• Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma

  2024cites this paper
• Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice

  2024cites this paper
• Annexin A2: A Double-Edged Sword in Pathogen Infection

  2024influential citation
• FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma

  2024cites this paper
• Impact of Annexin A2 on virus life cycles

  2024cites this paper
• Characterization and Comparison Analysis of Milk Fat Globule Membrane Proteins between Human and Porcine Milk.

  2024cites this paper
• Comprehensive Elucidation of the Role of L and 2A Security Proteins on Cell Death during EMCV Infection

  2024cites this paper
• Dysregulated hemostasis in acute promyelocytic leukemia

  2024cites this paper
• Coarse-grained modeling of annexin A2-induced microdomain formation on a vesicle

  2024cites this paper
• Autophagy-Dependent Secretion: Crosstalk between Autophagy and Exosome Biogenesis

  2024cites this paper
• The structural properties of full-length annexin A11

  2024cites this paper
• Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface

  2024cites this paper
• Annexin A2: the feasibility of being a therapeutic target associated with cancer metastasis and drug resistance in cancer microenvironment

  2024cites this paper
• Effect of morpholino oligonucleotides to gene anxa2a on the embryo development of Danio rerio

  2023cites this paper
• Recent Advances in Molecular and Cellular Functions of S100A10

  2023influential citation
• S100A10 Overexpression Correlates with Adverse Prognosis, Tumor Microenvironment, and Aggressive Behavior In Vitro and In Vivo of Cervical Cancer

  2023cites this paper
• Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells

  2023cites this paper
• Interactions and conformational changes of annexin A2/p11 heterotetramer models on a membrane: a molecular dynamics study

  2023cites this paper
• Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis.

  2023cites this paper
• ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3

  2023cites this paper
• Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis

  2023cites this paper
• Translational implications of targeting annexin A2: From membrane repair to muscular dystrophy, cardiovascular disease and cancer.

  2023cites this paper
• Catch Bond-Mediated Adhesion Drives Staphylococcus aureus Host Cell Invasion.

  2023cites this paper
• Molecular cloning and sequence analysis of Annexin A2a and Annexin A2b coding sequences from grass carp (Ctenopharyngodon idella)

  2023cites this paper
• Açaí (Euterpe oleracea Mart.) Seed Oil Exerts a Cytotoxic Role over Colorectal Cancer Cells: Insights of Annexin A2 Regulation and Molecular Modeling

  2023cites this paper
• Identification of alternative splicing and RNA-binding proteins involved in myocardial ischemia-reperfusion injury.

  2023cites this paper
• RNA-binding is an ancient trait of the Annexin family

  2023cites this paper
• Unravelling the Basic Calcium Phosphate crystal-dependent chondrocyte protein secretome; a role for TGF-β signaling.

  2023cites this paper
• Protein Profiling in Human Papillomavirus-Associated Cervical Carcinogenesis: Cornulin as a Biomarker for Disease Progression

  2023cites this paper
• Ca2+ ions facilitate the organization of the Annexin A2/S100A10 heterotetramer

  2023influential citation
• Ca2+ and Annexins - Emerging Players for Sensing and Transferring Cholesterol and Phosphoinositides via Membrane Contact Sites.

  2023cites this paper
• Grouper annexin A2 affects RGNNV by regulating the host immune response.

  2023cites this paper
• LppA is a novel plasminogen receptor of Mycoplasma bovis that contributes to adhesion by binding the host extracellular matrix and Annexin A2

  2023cites this paper
• Molecular Engineering of Sulfone-Xanthone Chromophore for Enhanced Fluorescence Navigation

  2023cites this paper
• Calcium influx promotes PLEKHG4B localization to cell–cell junctions and regulates the integrity of junctional actin filaments

  2023cites this paper
• The intricate role of annexin A2 in kidney: a comprehensive review

  2023cites this paper
• Annexin A2: the missing piece in the puzzle of pathogen-induced damage

  2023cites this paper
• Annexin A1, A2, A5, and A6 involvement in human pathologies

  2023cites this paper
• Collagen-I influences the post-translational regulation, binding partners and role of Annexin A2 in breast cancer progression

  2023cites this paper
• Assessment of the Annexin A2 as a Predictive Biomarker for the Severity of Disseminated Intravascular Coagulation in Acute Leukemia Patients

  2023cites this paper
• Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer

  2023cites this paper
• The Effect of Morpholino Oligonucleotides to Gene Anxa2a on the Embryonic Development of Danio rerio

  2023cites this paper
• Alterations of actin cytoskeleton and arterial protein level in patients with obstructive jaundice

  2022cites this paper
• Higher Expression of Annexin A2 in Metastatic Bladder Urothelial Carcinoma Promotes Migration and Invasion

  2022cites this paper
• A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren’s Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mouse

  2022cites this paper
• Annexins and cardiovascular diseases: Beyond membrane trafficking and repair

  2022cites this paper
• Annexin A2 and Kidney Diseases

  2022influential citation
• The cooperative folding of annexin A2 relies on a transient nonnative intermediate

  2022cites this paper
• Annexin A Protein Family in Atherosclerosis.

  2022cites this paper
• Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched

  2022cites this paper
• Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

  2022cites this paper
• Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes.

  2022cites this paper
• Annexin A2: The diversity of pathological effects in tumorigenesis and immune response

  2022influential citation
• Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals

  2022cites this paper
• The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets

  2022cites this paper
• Immunogenic cell death-related gene landscape predicts the overall survival and immune infiltration status of ovarian cancer

  2022cites this paper
• Fatty acid translocase: a culprit of lipid metabolism dysfunction in disease

  2022cites this paper
• Current Insights into Mesenchymal Signatures in Glioblastoma.

  2022cites this paper
• Screening of an annexin‐A2‐targeted heptapeptide for pancreatic adenocarcinoma localization

  2022cites this paper
• Dimethylaminomicheliolide (DMAMCL) Inhibits Cell Proliferation and Increases Apoptosis and Efficacy of Gemcitabine via Annexin A2 in Pancreatic Adenocarcinoma

  2021cites this paper
• The important roles and molecular mechanisms of annexin A2 autoantibody in children with nephrotic syndrome

  2021cites this paper
• The S100A10–AnxA2 complex is associated with the exocytosis of hepatitis B virus in intrauterine infection

  2021cites this paper
• Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications

  2021cites this paper
• Identi�cation, Characterization and Expression Analysis Reveal the Potential Function of Annexin Genes in Response to Abiotic stress, Calcium and Hormones in Cassava (Manihot esculeta Crantz)

  2021cites this paper