Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Circulation Research

• Publication date

  1994-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.RES.75.3.434PMID 8062417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.

  1994cited by this paper
• Influence of the force-frequency relationship on haemodynamics and left ventricular function in patients with non-failing hearts and in patients with dilated cardiomyopathy.

  1994cited by this paper
• Probing functional regions in cardiac isomyosins with monoclonal antibodies.

  1993cited by this paper
• Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.

  1993cited by this paper
• Angiotensin I and II exert inotropic effects in atrial but not in ventricular human myocardium. An in vitro study under physiological experimental conditions.

  1993cited by this paper
• Intracellular Calcium Handling in Isolated Ventricular Myocytes From Patients With Terminal Heart Failure

  1992cited by this paper
• Alterations of the force-frequency relationship in the failing human heart depend on the underlying cardiac disease.

  1992cited by this paper
• Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy.

  1992cited by this paper
• Contractile Properties and Ca2+ Release Activit of the Sarcoplasmic Reticulum in Dilated Cardiomyopathy

  1992cited by this paper
• Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca(2+)-ATPase gene.

  1992cited by this paper
• The regulation of calcium cycling in stressed hearts.

  1992cited by this paper
• Enhancement of the Force‐Frequency Effect on Myocardial Contractility by Adrenergic Stimulation in Conscious Dogs

  1992cited by this paper
• Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy.

  1992cited by this paper
• Altered Myocardial Force‐Frequency Relation in Human Heart Failure

  1992cited by this paper
• Contraction frequency dependence of twitch and diastolic tension in human dilated cardiomyopathy (tension-frequency relation in cardiomyopathy).

  1992cited by this paper
• Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group.

  1991cited by this paper
• The role of Ca2+ in the function and dysfunction of heart mitochondria

  1990cited by this paper
• Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium.

  1990cited by this paper
• Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

  1990cited by this paper
• Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.

  1990cited by this paper
• Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum calcium pump. Ryanodine and voltage sensitivity.

  1989cited by this paper
• Protection of Human Left Ventricular Myocardium From Cutting Injury With 2,3 -Butanedione Monoxime

  1989cited by this paper
• Ca2+ uptake by cardiac sarcoplasmic reticulum from patients with idiopathic dilated cardiomyopathy.

  1989cited by this paper
• Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

  1989cited by this paper
• Depression of systolic and diastolic myocardial reserve during atrial pacing tachycardia in patients with dilated cardiomyopathy.

  1988cited by this paper
• Reversal of the force-frequency relationship in working myocardium from patients with end-stage heart failure

  1988cited by this paper
• A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study.

  1988cited by this paper
• Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction?

  1988cited by this paper
• Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

  1987cited by this paper
• Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy.

  1987cited by this paper
• Influence of Heart Rate on Left Ventricular Performance in Conscious Dogs

  1987cited by this paper
• The homeostasis of calcium in heart cells.

  1985cited by this paper
• Methods for Measuring Functional Properties of Sarcoplasmic Reticulum and Myofibrils in Small Samples of Myocardium

  1984cited by this paper
• The sequestration of Ca2+ by mitochondria in rat heart cells.

  1983cited by this paper
• The cardiac excitation-contraction cycle.

  1982cited by this paper
• Criteria for adequate oxygenation of isometric kitten papillary muscle.

  1981cited by this paper
• The time-course of Ca2+ exchange with calmodulin, troponin, parvalbumin, and myosin in response to transient increases in Ca2+.

  1981cited by this paper
• The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase.

  1980cited by this paper
• Effects of Changing Heart Rate in Man by Electrical Stimulation of the Right Atrium: Studies at Rest, during Exercise, and with Isoproterenol

  1965cited by this paper
• Analysis of the effects of changes in rate and rhythm upon myocardial contractility.

  1961cited by this paper
• Über die Eigenthümlichkeiten der Reizbarkeit, welche die Muskelfasern des Herzens zeigen

  year unknowncited by this paper

• A piperidinyl amide compound enhances Ca2+ signaling in cardiomyocytes by increasing activity of Ca2+ pump

  2026cites this paper
• SAR-Guided Development of Small-Molecule SERCA2a Activators: Discovery of Potent Indoline, Benzofuran, and Benzodioxole Analogs for Cardiovascular Applications.

  2025cites this paper
• Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review.

  2025cites this paper
• SERCA2a dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established

  2025cites this paper
• Cardiac dysfunction due to mitochondrial impairment assessed by human iPS cells caused by DNM1L mutations

  2025cites this paper
• The crosstalk between mitochondrial dysfunction and fatty acid metabolism in heart failure: mechanisms and therapeutic strategies

  2025cites this paper
• Calcium-dependent regulation of physiological vs pathological cardiomyocyte hypertrophy.

  2025cites this paper
• Dysferlin Regulates Cardiac T-tubule Structure and Excitation-contraction Coupling in Isolated Cardiac Myocytes at Rest and in Response to Acute Hypo-osmotic Stress and is Protective Against Arrhythmias in Langendorff-perfused Hearts

  2025cites this paper
• Sarco/Endoplasmic Reticulum Ca2+ ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice

  2025cites this paper
• Peroxisome protein import deficiency causes heart failure in mouse and human

  2025cites this paper
• The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

  2025cites this paper
• p22phox prevents the oxidation of SERCA2a and stabilizes it in the heart

  2025cites this paper
• Using a Failing Human Ventricular Cardiomyocyte Model to Re-Evaluate Ca2+ Cycling, Voltage Dependence, and Spark Characteristics

  2024cites this paper
• Device‐therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy

  2024cites this paper
• Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

  2024cites this paper
• Fructose aggravates copper-deficiency-induced cardiac remodeling by inhibiting SERCA2a.

  2024cites this paper
• X-Chromosome–Linked miRNAs Regulate Sex Differences in Cardiac Physiology

  2024cites this paper
• Male Wistar Rats Chronically Fed with a High-Fat Diet Develop Inflammatory and Ionic Transport Angiotensin-(3–4)-Sensitive Myocardial Lesions but Preserve Echocardiographic Parameters

  2024cites this paper
• Seeking for Regulatory Mechanisms of Phospholamban Expression.

  2024cites this paper
• Potential Roles of IP3 Receptors and Calcium in Programmed Cell Death and Implications in Cardiovascular Diseases

  2024cites this paper
• B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure.

  2024cites this paper
• The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

  2024cites this paper
• Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine

  2024cites this paper
• Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction

  2024cites this paper
• Phospholamban inhibits the cardiac calcium pump by interrupting an allosteric activation pathway

  2024cites this paper
• Challenging and target-based shifting strategies for heart failure treatment: An update from the last decades.

  2024cites this paper
• Myocardial Metabolism in Heart Failure

  2023cites this paper
• Cardiac calcium regulation in human induced pluripotent stem cell cardiomyocytes: Implications for disease modeling and maturation

  2023cites this paper
• Genome Editing and Heart Failure.

  2023cites this paper
• SERCA2 phosphorylation at the heart of the disease.

  2023cites this paper
• A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca2+ uptake

  2023cites this paper
• Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target

  2023cites this paper
• Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart

  2023cites this paper
• Basic Science of Cardiac Contractility Modulation Therapy: Molecular and Electrophysiological Mechanisms.

  2023cites this paper
• Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

  2023influential citation
• The role of Ca2+-signaling in the regulation of epigenetic mechanisms.

  2023cites this paper
• Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure

  2023cites this paper
• A multiscale predictive digital twin for neurocardiac modulation

  2023cites this paper
• Targeting calcium regulators as therapy for heart failure: focus on the sarcoplasmic reticulum Ca-ATPase pump

  2023cites this paper
• SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases

  2023cites this paper
• Hypereosinophilia causes progressive cardiac pathologies in mice

  2022cites this paper
• Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α

  2022cites this paper
• Innovations in medical therapy of heart failure with reduced ejection fraction

  2022cites this paper
• Skeletal and cardiac muscle calcium transport regulation in health and disease

  2022cites this paper
• A novel modular modeling approach for understanding different electromechanics between left and right heart in rat

  2022cites this paper
• New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+ dynamics by increasing SERCA2a Ca2+ pumping.

  2022cites this paper
• Increased SERCA2a sub-cellular heterogeneity in right-ventricular heart failure inhibits excitation-contraction coupling and modulates arrhythmogenic dynamics

  2022cites this paper
• Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure

  2022cites this paper
• Natural products from traditional Chinese medicine for the prevention and treatment of heart failure: progress and perspectives.

  2022cites this paper
• SAR296968, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Ca2+ Handling and Contractile Function in Human Atrial Cardiomyocytes

  2022cites this paper
• Impact of baseline left ventricular ejection fraction on long‐term outcomes in cardiac contractility modulation therapy

  2022cites this paper
• Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling – Insights From Computational Modelling

  2022cites this paper
• Housekeeping Proteins Exhibit a High Level of Expression Variability Within Control Group and Between Ischemic Human Heart Biopsies

  2022cites this paper
• Multifaceted remodelling of cAMP microdomains driven by different aetiologies of heart failure

  2021cites this paper
• The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes

  2021cites this paper
• Inhibitory and stimulatory micropeptides preferentially bind to different conformations of the cardiac calcium pump

  2021cites this paper
• Complex functionality of protein phosphatase 1 isoforms in the heart.

  2021cites this paper
• Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction

  2021cites this paper
• Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure.

  2021cites this paper
• MicroRNAs and Calcium Signaling in Heart Disease

  2021cites this paper
• Attenuation of the upregulation of NF-κB and AP-1 DNA-binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression

  2021cites this paper
• Association of heart failure duration with clinical outcomes after transcatheter mitral valve repair for functional mitral regurgitation

  2020cites this paper
• Stem Cell-Based and Gene Therapies in Heart Failure

  2020cites this paper
• Protective effects of pravastatin on the embryonic cardiovascular system during hypoxic development

  2020cites this paper
• The Effect of Estrogen on Intracellular Ca2+ and Na+ Regulation in Heart Failure

  2020cites this paper
• Cholinergic stimulation improves electrophysiological rate adaptation during pressure overload-induced heart failure in rats

  2020cites this paper
• Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats.

  2020cites this paper
• Heart Rate–Induced Myocardial Ca2+ Retention and Left Ventricular Volume Loss in Patients With Heart Failure With Preserved Ejection Fraction

  2020cites this paper
• The Degree of t-System Remodeling Predicts Negative Force-Frequency Relationship and Prolonged Relaxation Time in Failing Human Myocardium

  2020cites this paper
• Etablierung von zirkulierenden DNA-Fragmenten als Biomarker für die klinische Progression einer Herzinsuffizienz mit erhaltener Ejektionsfraktion

  2020cites this paper
• Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling.

  2020cites this paper
• Cellular and Molecular Differences between HFpEF and HFrEF: A Step Ahead in an Improved Pathological Understanding

  2020cites this paper
• Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies

  2020cites this paper
• Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells.

  2020cites this paper
• Full Issue PDF

  2020cites this paper
• Current Landscape of Heart Failure Gene Therapy

  2019cites this paper
• Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses

  2019cites this paper
• Association of heart failure duration with clinical prognosis in advanced heart failure

  2019cites this paper
• B-type natriuretic peptide and its role in altering Ca2+-regulatory proteins in heart failure—mechanistic insights

  2019cites this paper
• The role of end‐diastolic myocardial fibre stretch on infarct extension

  2019cites this paper
• Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study

  2019cites this paper
• Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs

  2019cites this paper
• Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium.

  2019cites this paper
• Gene Therapy in Cardiac Disease

  2019cites this paper
• Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment.

  2019cites this paper
• Sarco/Endoplasmic Reticulum Ca2+-ATPase is a more effective calcium remover than Sodium-Calcium Exchanger in human embryonic stem cell-derived cardiomyocytes.

  2019cites this paper
• Novel approach for quantification of endoplasmic reticulum Ca2+ transport.

  2019cites this paper
• Herzinsuffizienz: "From Bench to Bedside"-Neues im Bereich der Ionenhomöostase

  2019influential citation
• Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

  2019cites this paper
• EGR-mediated control of STIM expression and function.

  2019cites this paper
• Force‐frequency relationship and early relaxation kinetics are preserved upon sarcoplasmic blockade in human myocardium

  2018cites this paper
• Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice

  2018cites this paper
• Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1‐receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction

  2018cites this paper
• Diastolic Stress Testing Along the Heart Failure Continuum

  2018cites this paper
• Small arteries, big problems: New insights in the mechanisms of small artery remodeling in hypertension

  2018cites this paper
• Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity

  2018cites this paper
• Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells

  2018cites this paper
• Heart rate variability alters cardiac repolarization and electromechanical dynamics.

  2018cites this paper
• SERCA is critical to control the Bowditch effect in the heart

  2018cites this paper
• Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension.

  2018cites this paper