Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Liver international (Print)

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/liv.12638PMID 25040634
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

  2011cited by this paper
• Mechanisms of hepatic fibrogenesis.

  2011cited by this paper
• New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis.

  2010cited by this paper
• Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats

  2009cited by this paper
• Distribution and biological activities of the flavonoid luteolin.

  2009cited by this paper
• Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin.

  2009cited by this paper
• PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling

  2009cited by this paper
• Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin

  2009influential reference
• Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies

  2009cited by this paper
• Therapeutic targeting of the PDGF and TGF-β-signaling pathways in hepatic stellate cells by PTK787/ZK22258

  2009cited by this paper
• Inhibition of extracellular signal‐regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats

  2009cited by this paper
• Mechanisms of hepatic fibrogenesis.

  2008cited by this paper
• Anti-carcinogenic Effects of the Flavonoid Luteolin

  2008cited by this paper
• Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis.

  2008cited by this paper
• Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin

  2008cited by this paper
• Dose- and Time-Dependent Effects of Luteolin on Liver Metallothioneins and Metals in Carbon Tetrachloride-Induced Hepatotoxicity in Mice

  2008cited by this paper
• Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell‐to‐cell interaction and transition

  2008cited by this paper
• Evaluation of the Anti-inflammatory Activity of Luteolin in Experimental Animal Models

  2007cited by this paper
• Transcriptional regulation of stellate cell activation

  2006cited by this paper
• Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis.

  2006cited by this paper
• Therapeutic strategies against TGF‐β signaling pathway in hepatic fibrosis

  2006cited by this paper
• Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans

  2005cited by this paper
• From quiescence to activation: Gene regulation in hepatic stellate cells.

  2004cited by this paper
• Adenoviral-mediated transfer of p53 or retinoblastoma protein blocks cell proliferation and induces apoptosis in culture-activated hepatic stellate cells.

  2003cited by this paper
• The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression*

  2003cited by this paper
• Pirfenidone effectively reverses experimental liver fibrosis.

  2002cited by this paper
• [Mechanisms of hepatic fibrogenesis].

  2002cited by this paper
• Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.

  2002cited by this paper
• Effect of genistein and quercetin on proliferation, collagen synthesis, and type I procollagen mRNA levels of rat hepatic stellate cells.

  2001cited by this paper
• Hepatic Stellate Cells as a Target for the Treatment of Liver Fibrosis

  2001cited by this paper
• Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts.

  2001cited by this paper
• Activity of artichoke leaf extract on reactive oxygen species in human leukocytes

  2000cited by this paper
• PDGF-Mediated Chemoattraction of Hepatic Stellate Cells by Bile Duct Segments in Cholestatic Liver Injury

  2000cited by this paper
• Advances in flavonoid research since 1992.

  2000cited by this paper
• The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

  2000cited by this paper
• Monocyte chemotactic protein‐1 as a chemoattractant for human hepatic stellate cells

  1999cited by this paper
• Extracellular signal‐regulated kinase activation differentially regulates platelet‐derived growth factor's actions in hepatic stellate cells, and is induced by In Vivo liver injury in the rat

  1999cited by this paper
• Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

  1998cited by this paper
• Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats.

  1995cited by this paper
• The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex

  1988cited by this paper

• Molecular Mechanism of Luteolin’s Inhibition of PTK2, a Key Protein in Liver Fibrosis: A Study Based on Molecular Dynamics Simulation

  2026cites this paper
• Mailuoning Oral Liquid and Its Effective Ingredient Luteolin Ameliorate Lipopolysaccharide‐ and Cigarette Smoke Extract‐Induced Pulmonary Injury by Regulating cGAS–STING–IRF3–PAI‐1 Pathway

  2025cites this paper
• Natural medicines for treating liver fibrosis by modulating post-translational modifications

  2025cites this paper
• Hepatoprotective Effects of Vernonia amygdalina Leaf Extract: In Vivo and In Silico Evidence Against Ethanol-Induced Liver Injury

  2025cites this paper
• The mechanisms and therapeutic potential of Atractylodes macrocephala Koidz in chronic liver disease management.

  2025cites this paper
• Therapeutic potential of traditional Chinese medicine in pancreatic fibrosis: mechanisms of TCM formulas and active ingredients

  2025cites this paper
• aHSCs-targeted bimetallic nanozymes and luteolin-loaded liposomes: Synergistic reversal of liver fibrosis via antioxidant, cellular senescence, and cellular apoptotic mechanisms

  2025cites this paper
• Phenolic-rich extracts of Teucrium oliverianum confer protection against thioacetamide-induced liver fibrosis in rats: Insights from metabolomics, biochemical and histopathological analysis

  2025cites this paper
• Luteolin as a multi-targeted polyphenol in pulmonary fibrosis: network pharmacology, mechanistic insights, and formulation advances

  2025cites this paper
• Luteolin for the Treatment of Organ Fibrosis: A Mini Review.

  2025cites this paper
• Herbal management of TAA-induced liver toxicity: Fibrosis, cirrhosis, and hepatocellular carcinoma.

  2025cites this paper
• A Sandwiched Patch for Prevention of Pelvic Adhesion After Uterine Operation.

  2025cites this paper
• Ellagic acid alleviates iron overload-induced liver damage by mitigating ferroptosis through modulation of the TGFβ/Smad signaling pathway.

  2025cites this paper
• Mechanistic insights into Schisandrin C as the active anti-renal fibrosis ingredient of Schisandra chinensis: a network pharmacology analysis and transcriptomics integrated experimental verification

  2025cites this paper
• The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols

  2024cites this paper
• The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model

  2024cites this paper
• Transient receptor potential channel 6 knockout ameliorates hepatic fibrosis by inhibiting the activation and proliferation of hepatic stellate cells

  2024cites this paper
• Acacetin, a Natural Flavone with Potential in Improving Liver Disease Based on Its Anti-Inflammation, Anti-Cancer, Anti-Infection and Other Effects

  2024cites this paper
• Advancements in Plant-Based Therapeutics for Hepatic Fibrosis: Molecular Mechanisms and Nanoparticulate Drug Delivery Systems

  2024cites this paper
• Computational analysis of phytocompounds in Centella asiatica for its antifibrotic and drug-likeness properties - Herb to drug study

  2024cites this paper
• Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications

  2024cites this paper
• The Ameliorative Effect of Litsea martabanica (Kurz) Hook. f. Leaf Water Extract on Chlorpyrifos-Induced Toxicity in Rats and Its Antioxidant Potentials

  2024cites this paper
• Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action

  2024cites this paper
• Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11

  2024cites this paper
• TCM targets ferroptosis: potential treatments for cancer

  2024cites this paper
• Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis

  2024cites this paper
• Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells.

  2024cites this paper
• The role of PI3k/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review

  2024cites this paper
• Remodeling of white adipose tissue microenvironment against obesity by phytochemicals

  2023cites this paper
• Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

  2023influential citation
• Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions.

  2023cites this paper
• Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

  2023cites this paper
• Integrated network analysis and metabolomics reveal the molecular mechanism of Yinchen Sini decoction in CCl4-induced acute liver injury

  2023cites this paper
• Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies.

  2023cites this paper
• Isolation and Biological Evaluation of Alfa-Mangostin as Potential Therapeutic Agents against Liver Fibrosis

  2023cites this paper
• From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

  2023cites this paper
• Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling.

  2023cites this paper
• Phytobioactive compounds as therapeutic agents for human diseases: A review

  2023cites this paper
• Engineered fibrotic liver-targeted truncated transforming growth factor β receptor type II variant for superior anti-liver fibrosis therapy

  2023cites this paper
• The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway

  2023cites this paper
• Heparan sulfate proteoglycans-mediated targeted delivery of TGF-β1-binding peptide to liver for improved anti-liver fibrotic activity in vitro and in vivo.

  2022cites this paper
• Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis

  2022cites this paper
• Thymus fontanesii attenuates CCl4-induced oxidative stress and inflammation in mild liver fibrosis.

  2022cites this paper
• Luteolin can ameliorate renal interstitial fibrosis-induced renal anaemia through the SIRT1/FOXO3 pathway.

  2022cites this paper
• Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts.

  2022cites this paper
• Traditional Chinese medicine: An important source for discovering candidate agents against hepatic fibrosis

  2022cites this paper
• The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis

  2022cites this paper
• Exploring mechanisms of Chaihu-Shugan-San against liver fibrosis by integrated multi-omics and network pharmacology approach

  2022cites this paper
• Antioxidant and hepatoprotective potentials of olive (Olea europaea L. var. Sigoise) leaves against carbon tetrachloride-induced hepatic damage in rats, and investigation of its constituents by high-performance liquid chromatography-mass spectrometry

  2022cites this paper
• Inonotsuoxide B suppresses hepatic stellate cell activation and proliferation via the PI3K/AKT and ERK1/2 pathway.

  2022cites this paper
• Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics

  2022cites this paper
• Exploring the Pharmacological Mechanism of Radix Salvia Miltiorrhizae in the Treatment of Radiation Pneumonia by Using Network Pharmacology

  2021cites this paper
• Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice.

  2021cites this paper
• Ethyl Acetate Fraction of Dicliptera chinensis (L.) Juss. Ameliorates Liver Fibrosis by Inducing Autophagy via PI3K/AKT/mTOR/p70S6K Signaling Pathway

  2021cites this paper
• Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis

  2021cites this paper
• Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis

  2021cites this paper
• Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways

  2021cites this paper
• Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway

  2021cites this paper
• Loss of RAR-α and RXR-α and enhanced caspase-3-dependent apoptosis in N-acetyl-p-aminophenol-induced liver injury in mice is tissue factor dependent

  2021cites this paper
• Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function

  2021cites this paper
• MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs

  2021cites this paper
• Exploring the Gamut of Receptor Tyrosine Kinases for Their Promise in the Management of Non-Alcoholic Fatty Liver Disease

  2021cites this paper
• ZIP10 is a negative determinant for anti-tumor effect of mannose in thyroid cancer by activating phosphate mannose isomerase

  2021cites this paper
• The CD200-CD200R cross-talk helps Leishmania donovani to down regulate macrophage and CD4+CD44+ T cells effector functions in an NFκB independent manner.

  2020cites this paper
• Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

  2020cites this paper
• A chitosan solution-based vortex-forced matrix solid phase dispersion method for the extraction and determination of four bioactive constituents from Ligustri Lucidi Fructus by high performance liquid chromatography.

  2020cites this paper
• Tβ4 suppresses lincRNA-p21-mediated hepatic apoptosis and fibrosis by inhibiting PI3K-AKT-NF-κB pathway.

  2020cites this paper
• Protective effects of luteolin on vascular endothelial injury in rats with atherosclerosis

  2019cites this paper
• Danshensu, a novel indoleamine 2,3-dioxygenase1 inhibitor, exerts anti-hepatic fibrosis effects via inhibition of JAK2-STAT3 signaling.

  2019cites this paper
• Research progress on the anti-hepatic fibrosis action and mechanism of natural products.

  2019cites this paper
• Expression of neuropeptide Y is increased in an activated human HSC cell line

  2019cites this paper
• Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis

  2019cites this paper
• Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases.

  2019cites this paper
• Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-β1/Smad and MAPK signaling pathways

  2019cites this paper
• lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway.

  2019cites this paper
• Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin

  2019cites this paper
• Ameliorative effects of luteolin against endometriosis progression in vitro and in vivo.

  2019cites this paper
• Bioavailability and Pharmaco-therapeutic potential of luteolin in overcoming Alzheimer's disease.

  2019cites this paper
• Platyconic Acid A, Platycodi Radix-Derived Saponin, Suppresses TGF-β1-Induced Activation of Hepatic Stellate Cells via Blocking SMAD and Activating the PPARγ Signaling Pathway

  2019cites this paper
• Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy pathway.

  2019cites this paper
• Methyl Helicterate Inhibits Hepatic Stellate Cell Activation Through Modulation of Apoptosis and Autophagy

  2018cites this paper
• Regulatory mechanisms of miR-96-mediated AKT / mTOR signaling pathways for non-alcoholic steatohepatitis

  2018cites this paper
• Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-β receptor II as a cleavable His-SUMO fusion protein

  2018cites this paper
• The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

  2018cites this paper
• mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans

  2018cites this paper
• Natural Products as a Source for Antifibrosis Therapy.

  2018cites this paper
• Luteolin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting TGFBR1 Signaling

  2018cites this paper
• Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats.

  2018cites this paper
• Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway

  2018cites this paper
• The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability – A Network Pharmacology and Transcriptomics Approach

  2018cites this paper
• Melatonin Ameliorates Liver Fibrosis Induced by Carbon Tetrachloride in Rats via Inhibiting TGF-β1/Smad Signaling Pathway

  2018cites this paper
• Luteolin Ameliorates Experimental Chronic Pancreatitis Induced by Trinitrobenzenesulfonic Acid in Rats

  2018cites this paper
• Combination of Luteolin and Solifenacin Improves Urinary Dysfunction Induced by Diabetic Cystopathy in Rats

  2018cites this paper
• Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis

  2017cites this paper
• Caffeic acid phenethyl ester attenuates liver fibrosis via inhibition of TGF-β1/Smad3 pathway and induction of autophagy pathway.

  2017cites this paper
• Naringin attenuates thioacetamide‐induced liver fibrosis in rats through modulation of the PI3K/Akt pathway

  2017cites this paper
• Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

  2017cites this paper
• Conductive polymer-based bioelectrochemical assembly for in vitro cytotoxicity evaluation: Renoprotective assessment of Salvia officinalis against carbon tetrachloride induced nephrotoxicity.

  2017cites this paper
• Propofol promotes apoptosis and suppresses the HOTAIR-mediated mTOR/p70S6K signaling pathway in melanoma cells.

  2017cites this paper
• Sorafenib induces autophagic cell death and apoptosis in hepatic stellate cell through the JNK and Akt signaling pathways

  2016cites this paper