Quantum conformational transition in biological macromolecule

BackgroundRecently we proposed a quantum theory on the conformational change of biomolecule, deduced several equations on protein folding rate from the first principles and discussed the experimental tests of the theory. The article is a review of these works.MethodsBased on the general equation of the conformation-transitional rate several theoretical results are deduced and compared with experimental data through bioinformatics methods.ResultsThe temperature dependence and the denaturant concentration dependence of the protein folding rate are deduced and compared with experimental data. The quantitative relation between protein folding rate and torsional mode number (or chain length) is deduced and the obtained formula can be applied to RNA folding as well. The quantum transition theory of two-state protein is successfully generalized to multi-state protein folding. Then, how to make direct experimental tests on the quantum property of the conformational transition of biomolecule is discussed, which includes the study of protein photo-folding and the observation of the fluctuation of the fluorescence intensity emitted from the protein folding/unfolding event. Finally, the potential applications of the present quantum folding theory to molecular biological problems are sketched in two examples: the glucose transport across membrane and the induced pluripotency in stem cell.ConclusionsThe above results show that the quantum mechanics provides a unifying and logically simple theoretical starting point in studying the conformational change of biological macromolecules. The far-reaching results in practical application of the theory are expected.

• Publication year

  2013

• Venue

  Quantitative Biology

• Publication date

  2013-01-11

• Fields of study

  Biology, Physics, Chemistry, Computer Science

• Identifiers
  DOI 10.1007/s40484-016-0087-9arXiv 1301.2417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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