Anticancer effects of tanshinone I in human non-small cell lung cancer

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2008-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1158/1535-7163.MCT-07-2288PMID 19001436
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 11

  2007cited by this paper
• CRSD: a comprehensive web server for composite regulatory signature discovery

  2006cited by this paper
• PDGF Gene Therapy Enhances Expression of VEGF and bFGF Genes and Activates the NF-&kgr;B Gene in Signal Pathways in Ischemic Flaps

  2006cited by this paper
• (Nucleic Acids Res., 34:W571-W577)CRSD: a comprehensive web server for composite regulatory signature discovery

  2006cited by this paper
• NF-kappaB: linking inflammation and immunity to cancer development and progression.

  2005cited by this paper
• Perioperative herbal supplement use in cancer patients: potential implications and recommendations for presurgical screening.

  2005cited by this paper
• Quantitative analysis of the marker compounds in Salvia miltiorrihiza root and its phytomedicinal preparations.

  2005cited by this paper
• Autocrine and paracrine regulation of interleukin-8 expression in lung cancer cells.

  2005influential reference
• Tumor-associated macrophages: the double-edged sword in cancer progression.

  2005influential reference
• Differential Involvement of Calmodulin-dependent Protein Kinase II-activated AP-1 and c-Jun N-terminal Kinase-activated EGR-1 Signaling Pathways in Tumor Necrosis Factor-α and Lipopolysaccharide-induced CD44 Expression in Human Monocytic Cells*

  2005influential reference
• Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation

  2005cited by this paper
• NF-κB: linking inflammation and immunity to cancer development and progression

  2005cited by this paper
• Mechanism and biological significance of CD44 cleavage

  2004cited by this paper
• PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma.

  2004cited by this paper
• Tumour-educated macrophages promote tumour progression and metastasis

  2004cited by this paper
• Cell migration: Rho GTPases lead the way.

  2004cited by this paper
• CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation

  2003cited by this paper
• Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer.

  2003influential reference
• Cyclosporine A regulate oxidative stress‐induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70

  2002cited by this paper
• Traditional Chinese medicine in the treatment of breast cancer.

  2002cited by this paper
• Inflammation and cancer

  2002cited by this paper
• Effects of tanshinone I isolated from Salvia miltiorrhiza Bunge on arachidonic acid metabolism and in vivo inflammatory responses

  2002cited by this paper
• Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation

  2002cited by this paper
• Global analysis of gene expression in invasion by a lung cancer model.

  2001influential reference
• Non-Small Cell Lung Cancer Cells Induce Monocytes to Increase Expression of Angiogenic Activity1

  2001cited by this paper
• Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza.

  2000cited by this paper
• The angiogenic factor interleukin 8 is induced in non-small cell lung cancer/pulmonary fibroblast cocultures.

  2000cited by this paper
• Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray.

  2000cited by this paper
• Nonsteroidal anti-inflammatory drugs and cancer prevention.

  2000cited by this paper
• Interleukin-8 messenger ribonucleic acid expression correlates with tumor progression, tumor angiogenesis, patient survival, and timing of relapse in non-small-cell lung cancer.

  2000cited by this paper
• Anti-inflammatory cytokines.

  2000cited by this paper
• Macrophages and microvessel density in tumors of the ovary.

  1999cited by this paper
• Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza Bunge.

  1999cited by this paper
• Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3

  1999cited by this paper
• Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas.

  1999cited by this paper
• Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast

  1999cited by this paper
• Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

  1999cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998cited by this paper
• Tumor induction of VEGF promoter activity in stromal cells.

  1998cited by this paper
• Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line.

  1997cited by this paper
• Mechanism of action of platelet-derived growth factor.

  1996cited by this paper
• Vascular endothelial grouth facter B, a novel growth facter for endothelial cells

  1996cited by this paper
• Nonsteroidal antiinflammatory drugs and breast cancer.

  1996cited by this paper
• Clinical applications of research on angiogenesis

  1996cited by this paper
• Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

  1996cited by this paper
• Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells.

  1996cited by this paper
• Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.

  1995cited by this paper
• Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

  1995cited by this paper
• IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells.

  1994cited by this paper
• Cytotoxic activities of tanshinones against human carcinoma cell lines.

  1991cited by this paper
• Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

  1990cited by this paper
• A new platelet aggregation inhibitor from Salvia miltiorrhiza.

  1989cited by this paper
• Human fibroblast-derived growth factor is a mitogen and chemoattractant for endothelial cells.

  1987cited by this paper
• [Inflammation and cancer].

  1974influential reference

• Clinically proven natural products against breast cancer, with mechanistic insights

  2025cites this paper
• New insights of advanced biotechnological engineering strategies for tanshinone biosynthesis in Salvia miltiorrhiza.

  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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• Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review

  2022cites this paper
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  2021cites this paper
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• Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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• Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective

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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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