According to Alzheimer's Disease International (ADI), nearly 50 million people worldwide live with dementia in 2017, and this number is expected to triple by 2050. Despite years of research in this field, the root cause and mechanisms responsible for Alzheimer's disease (AD) have not yet been fully elucidated. Moreover, promising preclinical results have repeatedly failed to translate into treatments for people. Until now, none of the molecules targeting AD has successfully passed the phase III trial. Although natural molecules have been the subject of many studies, they normally require high concentration to be effective or they are too large to cross the blood-brain barrier (BBB). In this review, we report the strategies for AD treatment, focusing almost exclusively on green chemistry (natural phenolic molecules) including therapeutic strategies for decreasing amyloid-β (Aβ) production, preventing and/or altering Aβ aggregation and reducing oligomers cytotoxicity, such as curcumin, (-)-epigallocatechin-3-gallate (EGCG), morin, resveratrol, tannic acid and other natural green molecules. We also show that potential candidate used outside of medicine and nutrition should be considered by discussing two intermediate-size green molecules having very similar molecular structures and key properties, hence being potential candidates for mitigating Alzheimer's disease (AD).
Mitigating Alzheimer's Disease by Natural Polyphenols : A Review.
Published 2019 in Current Alzheimer Research
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- Publication year
2019
- Venue
Current Alzheimer Research
- Publication date
2019-03-14
- Fields of study
Medicine, Chemistry, Environmental Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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