Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19).

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Immunobiology

• Publication date

  2014-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.imbio.2014.03.020PMID 24775271PMCID PMC4101182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis.

  2013cited by this paper
• Regulation of innate and adaptive immunity by Notch

  2013cited by this paper
• Mx1‐Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype

  2013cited by this paper
• HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

  2012cited by this paper
• Notch-RBP-J Signaling Regulates IRF8 to Promote Inflammatory Macrophage Polarization

  2012cited by this paper
• Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum

  2012cited by this paper
• Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.

  2011cited by this paper
• RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.

  2011cited by this paper
• Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response

  2011cited by this paper
• Direct regulation of interleukin-6 expression by Notch signaling in macrophages

  2011cited by this paper
• Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity*

  2011cited by this paper
• Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

  2010cited by this paper
• Effects of Regulator of G Protein Signaling 19 (RGS19) on Heart Development and Function*

  2010cited by this paper
• Down‐regulation of Notch‐1 and Jagged‐1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF‐κB signaling pathways

  2010cited by this paper
• Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J–Dependent Induction of Jagged1

  2010cited by this paper
• Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and γ-secretase inhibitors

  2010cited by this paper
• Regulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins.

  2009cited by this paper
• Regulators of G‐protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide

  2009cited by this paper
• Reciprocal regulation of Notch and PI3K/Akt signalling in T‐ALL cells In Vitro

  2008cited by this paper
• Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.

  2008cited by this paper
• Notch signaling is activated by TLR stimulation and regulates macrophage functions

  2008cited by this paper
• Regulation of interferon and Toll‐like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

  2008cited by this paper
• The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

  2008cited by this paper
• RGS19 regulates Wnt–β-catenin signaling through inactivation of Gαo

  2007cited by this paper
• Delta-Like 4 Induces Notch Signaling in Macrophages: Implications for Inflammation

  2007cited by this paper
• RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation.

  2007cited by this paper
• RGS19 regulates Wnt-beta-catenin signaling through inactivation of Galpha(o).

  2007cited by this paper
• NOTCH and PI3K-AKT pathways intertwined.

  2007cited by this paper
• Akt/Protein Kinase B Modulates Macrophage Inflammatory Response to Francisella Infection and Confers a Survival Advantage in Mice1

  2006cited by this paper
• Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity1

  2006cited by this paper
• In-gel digestion for mass spectrometric characterization of proteins and proteomes

  2006cited by this paper
• Toll-Like Receptor Signaling Alters the Expression of Regulator of G Protein Signaling Proteins in Dendritic Cells: Implications for G Protein-Coupled Receptor Signaling

  2004cited by this paper
• Notch and the immune system.

  2003cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.

  2000cited by this paper
• Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles.

  2000cited by this paper
• GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

  1995cited by this paper
• Molecular Systems Biology 6; Article number 371; doi:10.1038/msb.2010.29 Citation: Molecular Systems Biology 6:371

  year unknowncited by this paper

• Post-translational modifications of RGS protein family: pivotal switches in cellular signaling transduction and diseases.

  2025cites this paper
• Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3

  2025cites this paper
• Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat

  2023cites this paper
• Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease

  2023cites this paper
• Notch1 signaling contributes to TLR4-triggered NF-κB activation in macrophages.

  2022cites this paper
• Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

  2022cites this paper
• Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes

  2021cites this paper
• Notch1 Signaling Contributed To TLR4-Triggered NF-kB Activation In Macrophages

  2021cites this paper
• Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2

  2021cites this paper
• JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix

  2019cites this paper
• A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer

  2019cites this paper
• MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1

  2018cites this paper
• A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention

  2018cites this paper
• A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma

  2018cites this paper
• MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway

  2018cites this paper
• Caractérisation et généralisation de l’implication de la voie NOTCH cytoplasmique au cours des processus de transition épithélio-mésenchymateuse chez l’embryon de poulet

  2018cites this paper
• Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop

  2017cites this paper
• Notch 1 is a valuable therapeutic target against cell survival and proliferation in clear cell renal cell carcinoma

  2017cites this paper
• The Critical Role of Notch1–TLR 4 Signaling in the Inflammatory and Fungicidal Activity of Macrophages Against Paracoccidioides brasiliensis Strain Pb18

  2017cites this paper
• Notch and Myeloid Cells

  2017cites this paper
• Blockade of Notch signaling promotes acetaminophen-induced liver injury

  2017cites this paper
• Emerging Roles of Regulators of G Protein Signaling (RGS) Proteins in the Immune System.

  2017cites this paper
• Role of PACAP and VIP Signalling in Regulation of Chondrogenesis and Osteogenesis

  2016cites this paper
• Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization

  2016cites this paper
• The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity.

  2016cites this paper
• Regulators of G-protein-signaling proteins: negative modulators of G-protein-coupled receptor signaling.

  2015cites this paper
• Emerging roles of the γ-secretase-notch axis in inflammation.

  2015cites this paper
• Notch Pathway Inhibition Using PF-03084014, a γ-Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer

  2015influential citation
• Critical role of Rgs19 in mouse embryonic stem cell proliferation and differentiation.

  2015cites this paper
• PACAP and VIP signaling in chondrogenesis and osteogenesis.

  2015cites this paper