Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2006-04-06

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.3233/JAD-2006-9101PMID 16627930
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005influential reference
• Post-translational modifications of tau protein in Alzheimer’s disease

  2005cited by this paper
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  2005cited by this paper
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• Glucose transporter expression in the central nervous system: relationship to synaptic function.

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• Glucose metabolism and insulin receptor signal transduction in Alzheimer disease.

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• Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer’s disease

  2004cited by this paper
• ApoE genotype accounts for the vast majority of AD risk and AD pathology.

  2004cited by this paper
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  2004cited by this paper
• O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.

  2004influential reference
• Does Diabetes Protect or Provoke Alzheimer's Disease? Insights Into the Pathobiology and Future Treatment of Alzheimer's Disease

  2003cited by this paper
• Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization.

  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein.

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Amyloid beta-peptide decreases neuronal glucose uptake despite causing increase in GLUT3 mRNA transcription and GLUT3 translocation to the plasma membrane.

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein.

  2001cited by this paper
• Neurodegenerative tauopathies.

  2001cited by this paper
• Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Tau protein isoforms, phosphorylation and role in neurodegenerative disorders.

  2000cited by this paper
• Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Functional Expression of O-linked GlcNAc Transferase

  2000cited by this paper
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  2000cited by this paper
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• Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules

  1999cited by this paper
• O-linked N-acetylglucosamine levels in cerebellar neurons respond reciprocally to pertubations of phosphorylation.

  1999cited by this paper
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  1999cited by this paper
• Neurons may live for decades with neurofibrillary tangles.

  1999cited by this paper
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  1998cited by this paper
• Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins.

  1997cited by this paper
• GLUT-1 expression in the cerebra of patients with Alzheimer's disease.

  1997cited by this paper
• Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease

  1996cited by this paper
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  1996cited by this paper
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• Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

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  1994cited by this paper
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