IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Diabetes

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/db06-0436PMID 17259371PMCID PMC4295171
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: Evidence for tissue specificity of leptin resistance.

  2006cited by this paper
• The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro.

  2005cited by this paper
• The Peroxisome Proliferator-activated Receptor-γ Regulates Murine Pyruvate Carboxylase Gene Expression in Vivo and in Vitro*

  2005cited by this paper
• IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A

  2005cited by this paper
• Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor.

  2004cited by this paper
• Adipose tissue as an endocrine organ.

  2004cited by this paper
• Insulin-like growth factor binding protein-6 transgenic mice: postnatal growth, brain development, and reproduction abnormalities.

  2004cited by this paper
• Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice

  2004cited by this paper
• Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.

  2003influential reference
• Years of life lost due to obesity.

  2003cited by this paper
• IGF-binding protein-1 inhibits IGF effects on adipocyte function: implications for insulin-like actions at the adipocyte.

  2002cited by this paper
• Prevalence and trends in obesity among US adults, 1999-2000.

  2002cited by this paper
• Specifying the cellular responses to IGF signals: roles of IGF-binding proteins.

  2002cited by this paper
• Cellular actions of the insulin-like growth factor binding proteins.

  2002cited by this paper
• Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice.

  2002cited by this paper
• The role of circulating IGF-I

  2002cited by this paper
• Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice.

  2001cited by this paper
• Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.

  2001cited by this paper
• The biology of white adipocyte proliferation

  2001cited by this paper
• Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.

  2000cited by this paper
• Characterisation of receptor‐specific TNFα functions in adipocyte cell lines lacking type 1 and 2 TNF receptors

  2000cited by this paper
• Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance.

  2000influential reference
• Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain.

  1999cited by this paper
• Modulation of vasomotion in resistance arteries of JCR:LA-cp rats: a model of insulin resistance.

  1999cited by this paper
• Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice.

  1999cited by this paper
• Circulating levels of free insulin‐like growth factors in obese subjects: the impact of Type 2 diabetes

  1999cited by this paper
• Normal growth and development in the absence of hepatic insulin-like growth factor I.

  1999cited by this paper
• Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.

  1999cited by this paper
• Understanding adipocyte differentiation.

  1998cited by this paper
• Regulation of adipose cell number in man.

  1997cited by this paper
• Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics.

  1996cited by this paper
• Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis.

  1994cited by this paper
• Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).

  1993cited by this paper
• Differentiation of adipocyte precursors in a serum-free medium is influenced by glucocorticoids and endogenously produced insulin-like growth factor-I.

  1993cited by this paper
• Structure and localization of the human insulin-like growth factor-binding protein 2 gene.

  1991cited by this paper
• Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP.

  1990cited by this paper
• Insulin-like growth factor 1 induction of differentiation of porcine preadipocytes.

  1989cited by this paper
• Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes.

  1988cited by this paper
• Acute regulation of insulin‐like growth factor‐I gene expression by growth hormone during adipose cell differentiation.

  1987cited by this paper
• Development of a chemically defined serum-free medium for differentiation of rat adipose precursor cells.

  1987cited by this paper

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  2026cites this paper
• Aggregate Models, Not Explanations: Improving Feature Importance Estimation

  2026cites this paper
• Insulin-Like Growth Factors, Binding Proteins and Their Role in Pregnancy in Patients With Diabetes

  2025cites this paper
• Leveraging specificity for causal inference in observational studies

  2025cites this paper
• DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues

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• Insulin-like growth factor (IGF) and Insulin-like growth factor binding proteins (IGFBP) as predictors of type 2 diabetes risk in obese adults

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• Distinct alterations of adiponectin, FGF-21 and IGFBP-2 link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum

  2025cites this paper
• New insights into understanding obesity: from measures to mechanisms

  2024cites this paper
• IGFBP-2 in Critical Illness: A Prognostic Marker in the Growth Hormone/Insulin-like Growth Factor Axis

  2024cites this paper
• New Insights into IGF-1 Signaling in the Heart.

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• Prediction of gestational diabetes mellitus by multiple biomarkers at early gestation

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• Automating the Selection of Proxy Variables of Unmeasured Confounders

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• The Relationship between Birth Weight and the Risk of Overweight and Obesity among Chinese Children and Adolescents Aged 7–17 Years

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• Metabolic liability for weight gain in early adulthood

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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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• A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion

  2023cites this paper
• The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice

  2023cites this paper
• Associations between insulin-like growth factor binding protein-2 and insulin sensitivity, metformin, and mortality in persons with T2D.

  2023cites this paper
• FGF1 ameliorates obesity‐associated hepatic steatosis by reversing IGFBP2 hypermethylation

  2023cites this paper
• Brown adipose tissue-derived metabolites and their role in regulating metabolism.

  2023cites this paper
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  2023cites this paper
• The joint associations of high birth weight and not having siblings with metabolic obesity phenotype among school‐aged children and adolescents: A National Survey in China

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  2023cites this paper
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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
• Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines.

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