Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Development

• Publication date

  2007-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.001230PMID 17507400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• β-catenin, MAPK and Smad signaling during early Xenopus development

  2007cited by this paper
• Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas.

  2007cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006influential reference
• Maternal determinants of embryonic cell fate.

  2006cited by this paper
• Molecular control of liver development.

  2006cited by this paper
• Mesodermal Wnt2b signalling positively regulates liver specification

  2006cited by this paper
• Conditional deletion of beta-catenin reveals its role in liver growth and regeneration.

  2006cited by this paper
• FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo.

  2006cited by this paper
• Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal.

  2006influential reference
• Sfrp5 is not essential for axis formation in the mouse

  2006cited by this paper
• Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis.

  2005cited by this paper
• Embryonic development of the liver

  2005cited by this paper
• Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development

  2005cited by this paper
• Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.

  2005cited by this paper
• The initiation of liver development is dependent on Foxa transcription factors

  2005cited by this paper
• Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex.

  2005cited by this paper
• GATA6 Is Essential for Embryonic Development of the Liver but Dispensable for Early Heart Formation

  2005cited by this paper
• Interaction of Wnt and caudal-related genes in zebrafish posterior body formation.

  2005cited by this paper
• A conserved role for retinoid signaling in vertebrate pancreas development

  2004cited by this paper
• Cdx2 is essential for axial elongation in mouse development.

  2004cited by this paper
• Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus.

  2004cited by this paper
• Epithelio-mesenchymal relationships in the regional differentiation of the digestive tract in the amphibian embryo

  2004cited by this paper
• Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos

  2004cited by this paper
• Wnt impacts growth and differentiation in ex vivo liver development.

  2004cited by this paper
• Regulation of Hex gene expression and initial stages of avian hepatogenesis by Bmp and Fgf signaling.

  2004cited by this paper
• Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

  2004cited by this paper
• Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm

  2004cited by this paper
• Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox

  2004cited by this paper
• Sox17 and β-catenin cooperate to regulate the transcription of endodermal genes

  2004cited by this paper
• Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes.

  2004cited by this paper
• Secreted antagonists of the Wnt signalling pathway

  2003cited by this paper
• The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development.

  2003cited by this paper
• Novel gene expression domains reveal early patterning of the Xenopus endoderm.

  2003cited by this paper
• Tcf3: a transcriptional regulator of axis induction in the early embryo

  2003cited by this paper
• Beta-catenin, MAPK and Smad signaling during early Xenopus development.

  2002cited by this paper
• Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation

  2002cited by this paper
• FOR, a Novel Orphan Nuclear Receptor Related to Farnesoid X Receptor*

  2002influential reference
• Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm.

  2002influential reference
• Xhex-expressing endodermal tissues are essential for anterior patterning in Xenopus.

  2002influential reference
• Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus.

  2002cited by this paper
• Regulatory phases of early liver development: paradigms of organogenesis

  2002influential reference
• Cooperative Interaction of Xvent-2 and GATA-2 in the Activation of the Ventral Homeobox Gene Xvent-1B*

  2002influential reference
• BMP signalling regulates anteroposterior endoderm patterning in zebrafish.

  2002cited by this paper
• Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma.

  2001cited by this paper
• Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.

  2001cited by this paper
• A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus.

  2001cited by this paper
• Axis induction by wnt signaling: Target promoter responsiveness regulates competence.

  2001cited by this paper
• Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.

  2001cited by this paper
• The Wnt/beta-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism requiring FGF signalling.

  2001cited by this paper
• Gene expression in the embryonic Xenopus liver.

  2001cited by this paper
• Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.

  2001cited by this paper
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

  2001cited by this paper
• Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.

  2001cited by this paper
• Endoderm specification and differentiation in Xenopus embryos.

  2001cited by this paper
• A bipotential precursor population for pancreas and liver within the embryonic endoderm.

  2001cited by this paper
• Early mouse endoderm is patterned by soluble factors from adjacent germ layers.

  2000cited by this paper
• Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

  2000cited by this paper
• Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.

  2000cited by this paper
• Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.

  2000cited by this paper
• The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.

  2000cited by this paper
• Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.

  2000cited by this paper
• Anterior Endomesoderm Specification in Xenopusby Wnt/-catenin and TGF- Signalling Pathways

  1999influential reference
• T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.

  1999cited by this paper
• Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.

  1999influential reference
• Initiation of mammalian liver development from endoderm by fibroblast growth factors.

  1999cited by this paper
• The neural induction process; its morphogenetic aspects.

  1999cited by this paper
• Transcriptional regulation of Xvent homeobox genes.

  1999cited by this paper
• DNA-binding specificity and embryological function of Xom (Xvent-2).

  1999influential reference
• Requirement for Wnt3 in vertebrate axis formation

  1999cited by this paper
• Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

  1998cited by this paper
• Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm.

  1998influential reference
• The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis.

  1998cited by this paper
• Xvent‐1 mediates BMP‐4‐induced suppression of the dorsal‐lip‐specific early response gene XFD‐1′ in Xenopus embryos

  1998cited by this paper
• Development of the gut in Xenopus laevis

  1998cited by this paper
• Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors.

  1998cited by this paper
• Ectodermal patterning in vertebrate embryos.

  1997cited by this paper
• The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number.

  1997cited by this paper
• Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.

  1997cited by this paper
• Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

  1997cited by this paper
• A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos.

  1996influential reference
• Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox.

  1996influential reference
• Differentiation potencies of isolated parts of the urodele gastrula, by J. Holtfreter

  1996cited by this paper
• A Xenopus gene, Xbr-1, defines a novel class of homeobox genes and is expressed in the dorsal ciliary margin of the eye.

  1996influential reference
• Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.

  1996cited by this paper
• The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

  1996influential reference
• Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

  1996cited by this paper
• XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.

  1996cited by this paper
• TGF-beta signals and a pattern in Xenopus laevis endodermal development.

  1996cited by this paper
• Specification of the anteroposterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin.

  1995cited by this paper
• Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8.

  1995cited by this paper
• Wnt-3a regulates somite and tailbud formation in the mouse embryo.

  1994cited by this paper
• The Einsteck-method: position and structure of projections formed by implants of a ventral character.

  1994cited by this paper
• In pursuit of the functions of the Wnt family of developmental regulators: Insights from Xenopus laevis

  1993influential reference
• Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

  1993influential reference
• Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development.

  1991cited by this paper
• XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm.

  1989cited by this paper
• Fate map for the 32-cell stage of Xenopus laevis.

  1987influential reference
• Fates of the blastomeres of the 32-cell-stage Xenopus embryo.

  1987cited by this paper
• Hepatic induction in the avian embryo: specificity of reactive endoderm and inductive mesoderm.

  1981cited by this paper
• An experimental analysis of liver development.

  1975cited by this paper

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