Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Antimicrobial Chemotherapy

• Publication date

  2014-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/jac/dkt444PMID 24214905
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prevalence of obesity in the United States.

  2014cited by this paper
• Clinical practice guidelines for antimicrobial prophylaxis in surgery.

  2013cited by this paper
• Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery

  2013cited by this paper
• Subcutaneous adipose tissue blood flow and vasomotion in morbidly obese patients: Long term effect of gastric bypass surgery

  2012cited by this paper
• Prevalence of obesity in the United States, 2009-2010.

  2012cited by this paper
• Clinical pharmacokinetics and pharmacodynamics

  2011cited by this paper
• Pharmacokinetics and Tissue Penetration of Cefoxitin in Obesity: Implications for Risk of Surgical Site Infection

  2011cited by this paper
• Pharmacokinetics and protein binding of cefazolin in morbidly obese patients

  2011cited by this paper
• NONMEM User’s Guides. (1989–2009)

  2009cited by this paper
• Clinical Microdialysis in Skin and Soft Tissues: An Update

  2008cited by this paper
• Obesity prevalence from a European perspective: a systematic review

  2008cited by this paper
• Tissue concentrations: do we ever learn?

  2007cited by this paper
• Tissue penetration of antibacterial agents: how should this be incorporated into pharmacodynamic analyses?

  2007cited by this paper
• Protein binding of cefazolin is saturable in vivo both between and within patients.

  2007cited by this paper
• Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis.

  2006cited by this paper
• Metrics for External Model Evaluation with an Application to the Population Pharmacokinetics of Gliclazide

  2006cited by this paper
• Obesity and infection.

  2006cited by this paper
• Quantification of Lean Bodyweight

  2005cited by this paper
• Increase of Microcirculatory Blood Flow Enhances Penetration of Ciprofloxacin into Soft Tissue

  2005cited by this paper
• Perioperative antibiotic prophylaxis in the gastric bypass patient: do we achieve therapeutic levels?

  2004cited by this paper
• Obesity in general elective surgery.

  2003cited by this paper
• Obesity in general elective surgery.

  2003cited by this paper
• Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing

  2001cited by this paper
• Methodological issues in microdialysis sampling for pharmacokinetic studies.

  2000cited by this paper
• Guideline for the prevention of surgical site infection, 1999

  1999cited by this paper
• Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee.

  1999cited by this paper
• HPLC determination of cefazolin in plasma, urine and dialysis fluid

  1998cited by this paper
• Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity.

  1996cited by this paper
• Drug distribution studies with microdialysis. III: Extracellular concentration of caffeine in adipose tissue in man.

  1991cited by this paper
• Antibiotic prophylaxis for surgery in morbidly obese patients.

  1989cited by this paper
• Cefazolin serum protein binding and its inhibition by bilirubin, fatty acids and other drugs.

  1988cited by this paper
• Study of the interaction between human serum albumin and some cephalosporins.

  1982cited by this paper
• Pharmacokinetics and clinical use of cephalosporin antibiotics.

  1975cited by this paper
• Procedures for Detecting Outlying Observations in Samples

  1969cited by this paper
• Quantification of lean body weight

  year unknowncited by this paper
• Infection Control and Hospital Epidemiology Guideline for Prevention of Surgical Site Infection, 1999 Surgical Site Infection Guideline Sponsor

  year unknowncited by this paper

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  2020cites this paper
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