14-3-3 proteins—an update

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cell Research

• Publication date

  2005-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.cr.7290291PMID 15857577
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

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• The role of epigenetic inactivation of 14-3-3σ in human cancer

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• DNA methylation and cancer therapy: new developments and expectations

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• A Structural Basis for 14-3-3σ Functional Specificity*♦

  2005cited by this paper
• [DNA methylation and cancer].

  2005cited by this paper
• Phosphorylation of Grb10 Regulates Its Interaction with 14-3-3*

  2005cited by this paper
• Targeted Proteomic Analysis of 14-3-3ς, a p53 Effector Commonly Silenced in Cancer*S

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• Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts.

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• 14‐3‐3 regulation of cell spreading and migration requires a functional amphipathic groove

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• The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

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• Immunohistochemical expression of 14‐3‐3 sigma protein in human urological and gynecological tumors using a multi‐tumor microarray analysis

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• Isoform‐specific expression of 14‐3‐3 proteins in human lung cancer tissues

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• The role of epigenetic inactivation of 14-3-3sigma in human cancer.

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• Prostate cancer is characterized by epigenetic silencing of 14-3-3sigma expression.

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• 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

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• When the Checkpoints Have Gone: Insights into Cdc25 Functional Activation

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• The Clinical Application of Targeting Cancer through Histone Acetylation and Hypomethylation

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• 14‐3‐3 suppresses the nuclear localization of threonine 157‐phosphorylated p27Kip1

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• Expression of the Tumor Suppressor Protein 14-3-3σ Is Down-regulated in Invasive Transitional Cell Carcinomas of the Urinary Bladder Undergoing Epithelial-to-Mesenchymal Transition*

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• 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).

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• DNA methylation and cancer.

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• 14-3-3β Binds to Big Mitogen-activated Protein Kinase 1 (BMK1/ERK5) and Regulates BMK1 Function*

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• Binding of 14-3-3β but not 14-3-3σ controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B

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• Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

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• Loss of 14-3-3σ in Prostate Cancer and Its Precursors

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• Inhibition of Calcium/Calmodulin-dependent Protein Kinase Kinase by Protein 14-3-3*

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• Prostate cancer is characterized by epigenetic silencing of 14-3-3σ expression

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• 14-3-3 Family Members Act Coordinately to Regulate Mitotic Progression

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• Loss of 14-3-3sigma in prostate cancer and its precursors.

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• Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3 sigma and 14-3-3 zeta.

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• Continuous Zebularine Treatment Effectively Sustains Demethylation in Human Bladder Cancer Cells

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• G2 checkpoint abrogators as anticancer drugs.

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• Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3σ and 14-3-3ζ

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• Immunohistochemical demonstration of 14‐3‐3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage

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• Organization and evolution of multifunctional Ca(2+)/CaM-dependent protein kinase genes.

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• Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer.

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• Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains*

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• The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells.

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• Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras*

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• Reduction of 14-3-3 Proteins Correlates with Increased Sensitivity to Killing of Human Lung Cancer Cells by Ionizing Radiation

  2003cited by this paper
• Tuberous sclerosis genes regulate cellular 14-3-3 protein levels.

  2003cited by this paper
• Analysis of 14-3-3σ expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma

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• Short Communication The Tumor Suppressor Gene 14-3-3 Is Commonly Methylated in Normal and Malignant Lymphoid Cells

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• 14-3-3 Interacts Directly with and Negatively Regulates Pro-apoptotic Bax*

  2003cited by this paper
• Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization*

  2002cited by this paper
• Decreased expression of 14-3-3σ in neuroendocrine tumors is independent of origin and malignant potential

  2002cited by this paper
• Efp targets 14-3-3σ for proteolysis and promotes breast tumour growth

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• A unified view of the DNA-damage checkpoint.

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• Coincident inactivation of 14-3-3σ and p16INK4a is an early event in vulval squamous neoplasia

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• Frequent and histological type-specific inactivation of 14-3-3σ in human lung cancers

  2002cited by this paper
• Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.

  2002cited by this paper
• 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

  2002cited by this paper
• Regulation of TSC2 by 14-3-3 Binding*

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• The 14-3-3s

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• EphB1 Associates with Grb7 and Regulates Cell Migration*

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• How do 14‐3‐3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis

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• Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.

  2001cited by this paper
• Proteomic analysis reveals that 14-3-3σ is down-regulated in human breast cancer cells

  2001cited by this paper
• The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.

  2001cited by this paper
• Hypermethylation of 14-3-3 σ (stratifin) is an early event in breast cancer

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• Cdc25B activity is regulated by 14-3-3

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• Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

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• The G2/M Regulator 14-3-3ς Prevents Apoptosis through Sequestration of Bax*

  2001cited by this paper
• Proteomic analysis reveals that 14-3-3sigma is down-regulated in human breast cancer cells.

  2001cited by this paper
• Regulation of the G2/M transition by p53

  2001cited by this paper
• Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.

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• Positive regulation of Wee1 by Chk1 and 14-3-3 proteins.

  2001cited by this paper
• Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma

  2000cited by this paper
• Big Mitogen-activated Kinase Regulates Multiple Members of the MEF2 Protein Family*

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• Regulation of the Cdk inhibitor p27 and its deregulation in cancer

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• Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.

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• Inactivation of 14-3-3ς Influences Telomere Behavior and Ionizing Radiation-Induced Chromosomal Instability

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• High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.

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• BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival*

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• 14-3-3 proteins: structure, function, and regulation.

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• 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.

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• 14-3-3sigma is a p53-regulated inhibitor of G2/M progression.

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• The structural basis for 14-3-3:phosphopeptide binding specificity.

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• Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.

  1996cited by this paper
• The MAPK signaling cascade

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• CHROMATOGRAPHIC AND ELECTROPHORETIC FRACTIONATION OF SOLUBLE PROTEINS OF BRAIN AND LIVER.

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• Inhibition of 14-3-3 Protein Enhances Steroid Hormone Production and Oxidative Stress in Mouse Ovary: Implications for Apoptosis Regulation.

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