TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular and Cellular Biology

• Publication date

  2009-08-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00637-09PMID 19667075PMCID PMC2756882
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.

  2009influential reference
• Stalled Hox promoters as chromosomal boundaries.

  2009cited by this paper
• RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes

  2008cited by this paper
• NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.

  2008cited by this paper
• Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.

  2008cited by this paper
• Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

  2008cited by this paper
• The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

  2008cited by this paper
• Cracking the RNA polymerase II CTD code.

  2008cited by this paper
• Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.

  2007cited by this paper
• Chemical genetics: where genetics and pharmacology meet.

  2007cited by this paper
• The role of chromatin during transcription.

  2007cited by this paper
• Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis

  2007cited by this paper
• Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment

  2007influential reference
• A chromatin landmark and transcription initiation at most promoters in human cells.

  2007cited by this paper
• Serine-7 of the RNA Polymerase II CTD Is Specifically Required for snRNA Gene Expression

  2007influential reference
• Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7

  2007influential reference
• Phosphorylation and functions of the RNA polymerase II CTD.

  2006cited by this paper
• Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

  2006cited by this paper
• Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics

  2006cited by this paper
• Controlling the elongation phase of transcription with P-TEFb.

  2006cited by this paper
• Pause Sites Promote Transcriptional Termination of Mammalian RNA Polymerase II

  2006cited by this paper
• Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.

  2006cited by this paper
• Breaking barriers to transcription elongation

  2006cited by this paper
• Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors.

  2005cited by this paper
• Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.

  2005cited by this paper
• Altered nucleosome occupancy and histone H3K4 methylation in response to ‘transcriptional stress’

  2005cited by this paper
• RNA Polymerase II Carboxy-Terminal Domain Phosphorylation Is Required for Cotranscriptional Pre-mRNA Splicing and 3′-End Formation

  2004cited by this paper
• Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing.

  2004cited by this paper
• Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.

  2004cited by this paper
• NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.

  2003cited by this paper
• Cdk7 Is Required for Full Activation of Drosophila Heat Shock Genes and RNA Polymerase II Phosphorylation In Vivo

  2003cited by this paper
• Dynamic association of capping enzymes with transcribing RNA polymerase II.

  2000cited by this paper
• Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription.

  2000cited by this paper
• NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

  1999cited by this paper
• Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme.

  1999cited by this paper
• Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

  1999influential reference
• Evidence that P‐TEFb alleviates the negative effect of DSIF on RNA polymerase II‐dependent transcription in vitro

  1998cited by this paper
• Regulation of CDK7 substrate specificity by MAT1 and TFIIH

  1997cited by this paper
• Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase*

  1996cited by this paper
• Cdk-activating kinase complex is a component of human transcription factor TFIIH

  1995cited by this paper
• A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.

  1995cited by this paper
• Requirement for TFIIH kinase activity in transcription by RNA polymerase II

  1995cited by this paper
• Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation.

  1995cited by this paper
• The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor.

  1994cited by this paper
• The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.

  1994cited by this paper
• Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription

  1993cited by this paper

• Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR Inhibition

  2026cites this paper
• Targeting CDK12/CYCLIN K induces HIV gene activation and latency reversal which is mediated by P-TEFb

  2026cites this paper
• Sensitizing tumor response to topoisomerase I antibody drug conjugate by selective CDK7 inhibition

  2025cites this paper
• CDK7–CDK11 axis in spliceosome regulation and pre-mRNA splicing

  2025cites this paper
• Recent advances in development of CDK7 inhibitors and their clinical trials: a narrative review

  2025cites this paper
• Transcriptional Activation Mechanisms and Target Genes of the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1

  2025cites this paper
• Rtr1 and RPAP2: versatile players in transcription and more

  2025cites this paper
• Single-molecule microscopy reveals that TFIIE subunits dynamically interact with preinitiation complexes in a manner controlled by TFIIH

  2025cites this paper
• Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5′- and 3′ ends

  2025influential citation
• Direct targeting and regulation of RNA polymerase II by cell signaling kinases.

  2025cites this paper
• Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review

  2025cites this paper
• Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis

  2025cites this paper
• CTDP1 and RPB7 stabilize Pol II and permit reinitiation

  2025cites this paper
• Functional insight into cyclin-dependent kinase (CDK)7 via chemical inhibition of the priority fungal pathogen Cryptococcus neoformans

  2025cites this paper
• Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5′- and 3′-ends

  2025cites this paper
• Nucleotide Excision Repair: Insights into Canonical and Emerging Functions of the Transcription/DNA Repair Factor TFIIH

  2025cites this paper
• Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2− Breast Cancer

  2025cites this paper
• Cyclin-dependent kinases as mediators of aberrant transcription in prostate cancer

  2025cites this paper
• Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II.

  2025cites this paper
• SAGE: A Segment-Anchor-Guided Exploration Framework for the Optimization of CDK7 Inhibitors as Promising Cancer Therapy.

  2025cites this paper
• Single-molecule microscopy reveals that TFIIE subunits dynamically interact with preinitiation complexes in a manner impacted by TFIIH.

  2025cites this paper
• The general transcription factors (GTFs) of RNA polymerase II and their roles in plant development and stress responses

  2024influential citation
• Discovery of a Novel Macrocyclic Noncovalent CDK7 Inhibitor for Cancer Therapy.

  2024cites this paper
• Histone H2B monoubiquitylation regulates elongation-to-termination transition in RNA polymerase II transcription

  2024cites this paper
• Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment.

  2024cites this paper
• Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1

  2024cites this paper
• Emerging roles of cyclin-dependent kinase 7 in health and diseases.

  2024cites this paper
• The HIV-1 Transcriptional Program: From Initiation to Elongation Control.

  2024cites this paper
• CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.

  2024cites this paper
• The involvement of cyclin-dependent kinase 7 (CDK7) and 9 (CDK9) in coordinating transcription and cell cycle checkpoint regulation

  2024cites this paper
• Mechanisms and Functions of the RNA Polymerase II General Transcription Machinery during the Transcription Cycle

  2024cites this paper
• Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors.

  2024cites this paper
• The role of O-GlcNAcylation in RNA polymerase II transcription

  2024influential citation
• CDK2-based CDK7 mimic as a tool for structural analysis: Biochemical validation and crystal structure with SY5609.

  2024cites this paper
• Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7).

  2024cites this paper
• HDAC6 modulates the cognitive behavioral function and hippocampal tissue pathological changes of APP/PS1 transgenic mice through HSP90-HSF1 pathway

  2024cites this paper
• Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

  2024cites this paper
• Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel therapeutic strategy for different molecular types of breast cancer

  2024cites this paper
• Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors.

  2024cites this paper
• CDK7 in breast cancer: mechanisms of action and therapeutic potential

  2024cites this paper
• Pause Patrol: Negative Elongation Factor's role in Promoter-Proximal Pausing and beyond.

  2024cites this paper
• Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis.

  2024cites this paper
• Collaborators or competitors: the communication between RNA polymerase II and the nucleosome during eukaryotic transcription

  2024cites this paper
• Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7.

  2023cites this paper
• The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation

  2023cites this paper
• Enitociclib, a Selective CDK9 Inhibitor, Induces Complete Regression of MYC+ Lymphoma by Downregulation of RNA Polymerase II Mediated Transcription

  2023cites this paper
• The suppressive efficacy of THZ1 depends on KRAS mutation subtype and is associated with super‐enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis‐generating study

  2023cites this paper
• Cyclin‐dependent kinases: Masters of the eukaryotic universe

  2023cites this paper
• CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties

  2023cites this paper
• Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

  2023cites this paper
• A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors

  2023cites this paper
• Cyclin-dependent kinase-9 in B-cell malignancies: pathogenic role and therapeutic implications

  2023cites this paper
• Unveiling the noncanonical activation mechanism of CDKs: insights from recent structural studies

  2023cites this paper
• Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells

  2023cites this paper
• Never a dull enzyme, RNA polymerase II

  2023cites this paper
• CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma

  2023cites this paper
• Fine tuning of the transcription juggernaut: A sweet and sour saga of acetylation and ubiquitination.

  2023cites this paper
• Uncoupling the TFIIH Core and Kinase Modules Leads To Misregulated RNA Polymerase II CTD Serine 5 Phosphorylation

  2023cites this paper
• MED26‐containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies

  2023cites this paper
• The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics

  2023cites this paper
• The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma

  2023cites this paper
• Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration

  2022cites this paper
• Antileukemic activity of YPN-005, a CDK7 inhibitor, inducing apoptosis through c-MYC and FLT3 suppression in acute myeloid leukemia

  2022cites this paper
• THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours

  2022influential citation
• CDK12 regulates co-transcriptional splicing and RNA turnover in human cells

  2022cites this paper
• Anti‐hsa‐miR‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice

  2022cites this paper
• CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors

  2022cites this paper
• Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells.

  2022cites this paper
• SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters

  2022cites this paper
• Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells

  2022cites this paper
• Cyclin-dependent kinase inhibition and its intersection with immunotherapy in breast cancer: more than CDK4/6 inhibition

  2022cites this paper
• Targeting Cyclin-Dependent Kinase 7 - Association between CDK7 and pMED1 Expression in Prostate Cancer Tissue.

  2022cites this paper
• Control of non-productive RNA polymerase II transcription via its early termination in metazoans.

  2022cites this paper
• Super enhancers as master gene regulators in the pathogenesis of hematologic malignancies.

  2022cites this paper
• Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology

  2022cites this paper
• Control of Expression of Key Cell Cycle Enzymes Drives Cell Line-Specific Functions of CDK7 in Human PDAC Cells

  2022cites this paper
• Lysosomes: multifunctional compartments ruled by a complex regulatory network

  2022cites this paper
• Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

  2022cites this paper
• Targeting CDK4 and CDK6 in cancer

  2022cites this paper
• Evaluation of novel CDK-inhibitors in combination with apoptosis-modulating agents for the treatment of colorectal cancer

  2022cites this paper
• Distinct transcription kinetics of pluripotent cell states

  2022cites this paper
• A ubiquitous disordered protein interaction module orchestrates transcription elongation

  2021cites this paper
• HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform

  2021cites this paper
• The TFIIH complex is required to establish and maintain mitotic chromosome structure

  2021cites this paper
• Targeting transcription cycles in cancer

  2021cites this paper
• A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

  2021cites this paper
• Identification of CDK7 Inhibitors from Natural Sources Using Pharmacoinformatics and Molecular Dynamics Simulations

  2021cites this paper
• CDK9 keeps RNA polymerase II on track

  2021cites this paper
• Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer

  2021cites this paper
• MYC protein interactors in gene transcription and cancer

  2021cites this paper
• Transcriptional cyclin-dependent kinases: Potential drug targets in cancer therapy.

  2021cites this paper
• Evaluating Spatiotemporal Dynamics of Phosphorylation of RNA Polymerase II Carboxy-Terminal Domain by Ultraviolet Photodissociation Mass Spectrometry.

  2021cites this paper
• Nuclear RNA concentration coordinates RNA production with cell size in human cells

  2021cites this paper
• CDK12 is Necessary to Promote Epidermal Differentiation through Transcription Elongation

  2021cites this paper
• Newly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent States

  2021cites this paper
• CDK7 blockade suppresses super‐enhancer‐associated oncogenes in bladder cancer

  2021cites this paper
• Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription.

  2021cites this paper
• Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer.

  2021cites this paper
• Simplicity is the Ultimate Sophistication - Crosstalk of Post-translational Modifications on the RNA Polymerase II.

  2021cites this paper
• Low complexity domains, condensates, and stem cell pluripotency

  2021cites this paper