The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current Biology

• Publication date

  2007-07-03

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/J.CUB.2007.05.074PMID 17600714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.

  2007cited by this paper
• Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

  2007cited by this paper
• Cryopyrin activates the inflammasome in response to toxins and ATP

  2006cited by this paper
• Cryopyrin: in from the cold.

  2006cited by this paper
• The estrogen-responsive B box protein: a novel enhancer of interleukin-1β secretion

  2006cited by this paper
• Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents

  2006cited by this paper
• Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival.

  2006cited by this paper
• Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.

  2006cited by this paper
• The inflammasome: first line of the immune response to cell stress.

  2006cited by this paper
• Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

  2004cited by this paper
• Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes.

  2004cited by this paper
• The Estrogen-responsive B Box Protein

  2002cited by this paper
• The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

  2002cited by this paper
• Human keratinocytes constitutively produce but do not process interleukin‐18

  2000cited by this paper
• Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme a

  1998cited by this paper
• Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme.

  1998cited by this paper
• Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes by inflammatory and immunologic stimuli.

  1997cited by this paper
• Differential modulation of interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) in human epidermal keratinocytes by UVB.

  1994cited by this paper
• Differential modulation of interleukin‐1α (IL‐1α) and interleukin‐1β(IL‐1β in human epidermal keratinocytes by UVB

  1994cited by this paper
• Early molecular events in the induction phase of contact sensitivity.

  1992cited by this paper
• Keratinocytes as initiators of inflammation.

  1991cited by this paper
• Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.

  1991cited by this paper
• Ultraviolet action spectrum for intracellular free Ca2+ increase in human epidermal keratinocytes.

  1990cited by this paper
• The expression and modulation of IL-1 alpha in murine keratinocytes.

  1988cited by this paper
• Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation.

  1987cited by this paper
• Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1

  1986cited by this paper
• The effect of in vitro and in vivo UV irradiation on the production of ETAF activity by human and murine keratinocytes.

  1983cited by this paper

• Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

  2025cites this paper
• Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin

  2025cites this paper
• New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis

  2025cites this paper
• Suberythemal Sun and the Skin.

  2025cites this paper
• Primary Keratinocyte Model of Actinic Keratosis Reveals UV-Induced DNA Damage Accumulation and Persistent Interferon Signaling.

  2025cites this paper
• NLRP3 inflammasome in health and disease (Review)

  2025cites this paper
• Vias do inflamassoma na dermatite atópica: perspectivas sobre os mecanismos inflamatórios e alvos terapêuticos

  2025cites this paper
• Photoaging: UV radiation-induced cGAS-STING signaling promotes the aging process in skin by remodeling the immune network

  2025cites this paper
• NLRP1 inflammasome activation in skin equivalents reveals mechanistic insights into the roles of keratinocytes in psoriasis

  2025cites this paper
• Dual role of pyroptosis in liver diseases: mechanisms, implications, and therapeutic perspectives

  2025cites this paper
• Effects of Space Flight on Inflammasome Activation in the Brain of Mice

  2025influential citation
• Optimizing photopollution assessment: Insights from a reconstructed human epidermis model.

  2025cites this paper
• NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes

  2025cites this paper
• Targeting innate immune sensors for therapeutic strategies in infectious diseases.

  2025cites this paper
• p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p

  2025cites this paper
• Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies.

  2025cites this paper
• NLRP3 Inflammasome in Gynecologic Inflammatory Diseases: Mechanisms, Pathophysiology, and Therapeutic Strategies

  2025cites this paper
• Inflammasome pathways in atopic dermatitis: insights into inflammatory mechanisms and therapeutic targets

  2025cites this paper
• Exploring the correlation between innate immune activation of inflammasome and regulation of pyroptosis after intracerebral hemorrhage: From mechanism to treatment.

  2024cites this paper
• Advances in the Role of NLRP3 Inflammasome in Cardiovascular Diseases

  2024cites this paper
• Research progress on NLRP3 inflammasomes in male reproductive immunity

  2024cites this paper
• Comparison of Different Keratinocyte Cell Line Models for Analysis of NLRP1 Inflammasome Activation

  2024cites this paper
• CARD8: A Novel Inflammasome Sensor with Well-Known Anti-Inflammatory and Anti-Apoptotic Activity

  2024cites this paper
• Anti-inflammatory, immuno-modulatory, and anti-proliferative effects of 5-mer Oligogalacturonides (OG DP5) from citrus pectin on different types of human cells. Perspectives for treatment of dermal diseases such as atopic dermatitis and psoriasis

  2024cites this paper
• Poly-D,L-Lactic Acid Filler Attenuates Ultraviolet B-Induced Skin Pigmentation by Reducing Destruction of the Basement Membrane

  2024cites this paper
• Targeting IL-1 controls refractory pityriasis rubra pilaris

  2024cites this paper
• The Road Well Traveled: From Inflammasomes to Collagen Export During Fibrosis

  2024cites this paper
• Serum Levels of Interleukin-1 Beta are Decreased in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at the Time of Hospitalization

  2024cites this paper
• Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions

  2024cites this paper
• Inflammasome activation in response to aberrations of cellular homeostasis in epithelial cells from human cornea and retina

  2024cites this paper
• The gasdermin family: emerging therapeutic targets in diseases

  2024cites this paper
• Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes

  2024cites this paper
• Role of mitochondria in pathogenesis and therapy of renal fibrosis.

  2024cites this paper
• Death by ribosome.

  2024cites this paper
• Deciphering the links: Fragmented polystyrene as a driver of skin inflammation.

  2024cites this paper
• Inflammasomes in epithelial innate immunity: front line warriors

  2024cites this paper
• The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

  2024cites this paper
• Molecular evidence sterile tissue damage during pathogenesis of pododermatitis aseptica hemorrhagica circumscripta is associated with disturbed epidermal-dermal homeostasis.

  2024cites this paper
• Aberrant inflammasome activation as a driving force of human autoimmune skin disease

  2023influential citation
• NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise

  2023cites this paper
• Canonical Inflammasomes.

  2023cites this paper
• The gasdermins: a pore-forming protein family expressed in the epidermis

  2023cites this paper
• Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

  2023cites this paper
• Cell type-specific roles of NLRP3, inflammasome-dependent and -independent, in host defense, sterile necroinflammation, tissue repair, and fibrosis

  2023cites this paper
• Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome

  2023cites this paper
• The CARD8 inflammasome in HIV infection.

  2023cites this paper
• Human epidermis organotypic cultures, a reproducible system recapitulating the epidermis in vitro

  2023cites this paper
• Why traditional herbal medicine promotes wound healing: research from immune response, wound microbiome to controlled delivery.

  2023cites this paper
• Identification of potential immune-related ceRNA Regulatory Network in UVB-irradiated human skin

  2023cites this paper
• Epigenetic control of skin immunity

  2023cites this paper
• The NLRP1 inflammasome in skin diseases

  2023influential citation
• Skin colonization with S. aureus can lead to increased NLRP1 inflammasome activation in patients with atopic dermatitis.

  2023cites this paper
• Taurodeoxycholate, a GPCR19 agonist, ameliorates atopic dermatitis in Balb/c mice

  2023cites this paper
• The emerging role of pyroptosis in neuropathic pain.

  2023cites this paper
• NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics

  2022influential citation
• Interplay between epithelial and mesenchymal cells unveils essential proinflammatory and pro‐resolutive mediators modulated by photobiomodulation therapy at 660 nm

  2022cites this paper
• The Mechanism and Regulation of the NLRP3 Inflammasome during Fibrosis

  2022cites this paper
• The role of inflammasomes in cutaneous pathology

  2022cites this paper
• P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

  2022cites this paper
• Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus

  2022cites this paper
• Human NLRP1 is activated by ZAKɑ-driven ribotoxic stress response

  2022cites this paper
• High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells

  2022cites this paper
• SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1

  2022cites this paper
• Extracellular Vesicles as Biomarkers and Therapeutics for Inflammatory Eye Diseases.

  2022cites this paper
• Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer’s Disease: a Review of Mechanism of Activation, Regulation, and Inhibition

  2022cites this paper
• Application of a Reflectance Confocal Microscopy Imaging Analysis Score for the Evaluation of Non‐Melanogenic Changes in Male Photoaged Skin

  2022cites this paper
• Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes

  2022cites this paper
• Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice

  2022cites this paper
• Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets

  2022cites this paper
• Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

  2022cites this paper
• ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

  2022cites this paper
• AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis

  2022cites this paper
• NLRP1 Inflammasome Activation in Keratinocytes: Increasing Evidence of Important Roles in Inflammatory Skin Diseases and Immunity.

  2022cites this paper
• NLRP1 in Cutaneous SCCs: An Example of the Complex Roles of Inflammasomes in Cancer Development

  2022cites this paper
• Spleen tyrosine kinase regulates keratinocyte inflammasome activation and skin inflammation induced by UVB irradiation.

  2022cites this paper
• Cell death in skin function, inflammation, and disease

  2022cites this paper
• In vitro Evaluation of Programmed Cell Death in the Immune System of Pacific Oyster Crassostrea gigas by the Effect of Marine Toxins

  2021cites this paper
• Acid-electrolyzed functional water-induces Interleukin-1α release from Intracellular Storage Sites in Oral Squamous Cell Carcinoma

  2021cites this paper
• Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses

  2021cites this paper
• PARP‐1 involves in UVB‐induced inflammatory response in keratinocytes and skin injury via regulation of ROS‐dependent EGFR transactivation and p38 signaling

  2021cites this paper
• Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway

  2021cites this paper
• Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

  2021cites this paper
• Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier

  2021cites this paper
• Activation mechanisms of inflammasomes by bacterial toxins

  2021cites this paper
• Epidermal TRPV4 ion channels regulate UVB induced sunburn by triggering inflammmasome activation and MAPK signaling

  2021cites this paper
• The translational values of TRIM family in pan-cancers: from functions and mechanisms to clinics.

  2021cites this paper
• Dendrobium nobile protects retinal cells from UV-induced oxidative stress damage via Nrf2/HO-1 and MAPK pathways.

  2021cites this paper
• Critical roles of irradiance in the regulation of UVB-induced inflammasome activation and skin inflammation in human skin keratinocytes.

  2021cites this paper
• 1,25-Dihydroxyvitamin D3 attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes

  2021cites this paper
• Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation

  2021cites this paper
• Human NLRP1: From the shadows to center stage

  2021cites this paper
• Walking down Skeletal Muscle Lane: From Inflammasome to Disease

  2021cites this paper
• Polylysine for skin regeneration: A review of recent advances and future perspectives

  2021cites this paper
• Approaching neutrophil pyroptosis.

  2021cites this paper
• ASC Speck Formation after Inflammasome Activation in Primary Human Keratinocytes

  2021cites this paper
• Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure

  2021cites this paper
• Effect of 1-MHz ultrasound on the proinflammatory interleukin-6 secretion in human keratinocytes

  2021cites this paper
• Epithelial pyroptosis in host defense.

  2021cites this paper
• Purinergic Signaling and Inflammasome Activation in Psoriasis Pathogenesis

  2021cites this paper
• Novel Chemically Modified Curcumin (CMC) Analogs Exhibit Anti-Melanogenic Activity in Primary Human Melanocytes

  2021cites this paper