Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Biochemical Journal

• Publication date

  1982-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BJ2080053PMID 7159398PMCID PMC1153928
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation.

  1982cited by this paper
• Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo. Relation to proportion of inactive complex and rate of re-activation by phosphatase.

  1982cited by this paper
• Carnitine acyltransferase activities in rat liver and heart measured with palmitoyl-CoA and octanoyl-CoA. Latency, effects of K+, bivalent metal ions and malonyl-CoA.

  1982cited by this paper
• Occupancy of sites of phosphorylation in inactive rat heart pyruvate dehydrogenase phosphate in vivo.

  1981cited by this paper
• Thermolabile factor accelerates pyruvate dehydrogenase kinase reaction in heart mitochondria of starved or alloxan‐diabetic rats

  1981cited by this paper
• Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex.

  1979cited by this paper
• Action of the oral hypoglycemic agent 2-tetradecylglycidic acid on hepatic fatty acid oxidation and gluconeogenesis.

  1979cited by this paper
• Methyl 2-Tetradecylglycidate, An Orally Effective Hypoglycemic Agent that Inhibits Long Chain Fatty Acid Oxidation Selectively

  1979cited by this paper
• Inhibition of fatty acid oxidation and in normal and hypoxic perfused rat hearts by 2-tetradecylglycidic acid.

  1979cited by this paper
• Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan‐diabetes or starvation

  1978cited by this paper
• The effect of insulin on pyruvate dehydrogenase interconversion in heart muscle of alloxan-diabetic rats

  1978cited by this paper
• Regulation of pyruvate oxidation and the conservation of glucose.

  1978cited by this paper
• Coenzyme A and carnitine distribution in normal and ischemic hearts.

  1978cited by this paper
• Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent.

  1978cited by this paper
• Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.

  1978cited by this paper
• Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

  1977cited by this paper
• Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise.

  1976cited by this paper
• Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet.

  1976cited by this paper
• Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

  1975cited by this paper
• Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell

  1975cited by this paper
• Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.

  1975cited by this paper
• Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis.

  1975cited by this paper
• The metabolic effects of sodium dichloroacetate in the starved rat.

  1974cited by this paper
• Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.

  1974cited by this paper
• Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

  1974cited by this paper
• Regulation of the mammalian pyruvate dehydrogenase complex by covalent modification.

  1973cited by this paper
• Active and inactive forms of pyruvate dehydrogenase in rat liver. Effect of starvation and refeeding and of insulin treatment on pyruvate-dehydrogenase interconversion.

  1972cited by this paper
• The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart.

  1972cited by this paper
• Control of pyruvate dehydrogenase interconversion in adipose tissue by insulin

  1971cited by this paper
• Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies

  1971cited by this paper
• Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.

  1971cited by this paper
• Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones.

  1971cited by this paper
• Hormonal regulation of pyruvate dehydrogenase.

  1971cited by this paper
• Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart.

  1970cited by this paper
• Binding of long-chain fatty acids to bovine serum albumin.

  1969cited by this paper
• pH-dependence of carnitine acetyltransferase activity.

  1967cited by this paper
• Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion.

  1967cited by this paper
• Measurement of flow of carbon atoms from glucose and glycogen glucose to glyceride glycerol and glycerol in rat heart and epididymal adipose tissue. Effects of insulin, adrenaline and alloxan-diabetes.

  1967cited by this paper
• Removal of fatty acids from serum albumin by charcoal treatment.

  1967cited by this paper
• Interactions of metabolism and the physiological role of insulin.

  1966cited by this paper
• Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycl

  1964cited by this paper
• Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl-coenzyme A.

  1964cited by this paper

• Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics.

  2019cites this paper
• No Correlation Between Changes in Fatty Acid-binding Protein Content and Fatty Acid Oxidation Capacity of Rat Tissues in Experimental Diabetes

  2017cites this paper
• Metabolic shifts during aging and pathology.

  2015cites this paper
• Gene expression of sternohyoid and diaphragm muscles in type 2 diabetic rats

  2013cites this paper
• General Introduction: Reminiscences and Reflections on Fifty Years of the Endocrine Pancreas

  2011cites this paper
• Myocardial fatty acid metabolism in health and disease.

  2010cites this paper
• Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4

  2010cites this paper
• The effect of glucose on cardiac AMP-activated protein kinase

  2009cites this paper
• Gene Expression Profiling in the Type 1 Diabetes Rat Diaphragm

  2009cites this paper
• Regulation of Pyruvate and Amino Acid Metabolism

  2007cites this paper
• Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.

  2004cites this paper
• Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids.

  2004cites this paper
• Cellular mechanism of contractile dysfunction in the diabetic heart

  2003cites this paper
• Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver.

  2003cites this paper
• Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.

  2003cites this paper
• Effect of Dietary Fish Oil on Insulin Sensitivity and Metabolic Fate of Glucose in the Skeletal Muscle of Normal Rats

  2002cites this paper
• Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).

  2002cites this paper
• Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.

  2002cites this paper
• Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet.

  2001cites this paper
• Regulation of Glucose Metabolism in Skeletal Muscle

  2001cites this paper
• Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.

  2001cites this paper
• Selective modification of the pyruvate dehydrogenase kinase isoform profile in skeletal muscle in hyperthyroidism: implications for the regulatory impact of glucose on fatty acid oxidation.

  2000cites this paper
• Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.

  2000cites this paper
• The effect of insulin on the uptake and metabolic fate of glucose in isolated perfused hearts of dyslipemic rats.

  2000cites this paper
• Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression.

  2000cites this paper
• Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

  2000cites this paper
• Pyruvate dehydrogenase kinase 4 mRNA is increased in the hypertrophied ventricles of carnitine‐deficient juvenile visceral steatosis (JVS) mice

  1999cites this paper
• The impact of increased dietary lipid on the regulation of glucose uptake and oxidation by insulin in brown- and a range of white-adipose-tissue depots in vivo

  1999cites this paper
• Metabolism of [3-13C]alanine in liver of mice infected with cysticerci of Taenia crassiceps

  1999cites this paper
• Substrate interactions in the short- and long-term regulation of renal glucose oxidation.

  1999cites this paper
• Down Regulation of Pyruvate Dehydrogenase Complex in Skeletal Muscle during Sepsis: Implications for Sepsis-Induced Hyperlactatemia

  1999cites this paper
• Insulin activation of pyruvate dehydrogenase complex is enhanced by exercise training.

  1999cites this paper
• Chronic infusion of interleukin 1 induces hyperlactatemia and altered regulation of lactate metabolism in skeletal muscle.

  1999cites this paper
• Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase.

  1998cites this paper
• Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

  1998cites this paper
• Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart.

  1997cites this paper
• Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

  1997cites this paper
• Hepatic gluconeogenesis and the activity of PDH in individual tissues of GTG-obese mice following adrenalectomy.

  1996cites this paper
• SEPSIS‐INDUCED ALTERATIONS IN PYRUVATE DEHYDROGENASE COMPLEX ACTIVITY IN RAT SKELETAL MUSCLE: EFFECTS ON PLASMA LACTATE

  1996cites this paper
• Hormonal and nutritional modulation of PDHC activity status

  1996cites this paper
• No correlation between changes in fatty acid-binding protein content and fatty acid oxidation capacity of rat tissues in experimental diabetes.

  1996cites this paper
• Regulation of hepatic pyruvate dehydrogenase kinase by insulin and dietary manipulation in vivo. Studies with the euglycaemic-hyperinsulinaemic clamp.

  1996cites this paper
• Pyruvate inhibition of pyruvate dehydrogenase kinase

  1996cites this paper
• Interactive effects of insulin and triiodothyronine on pyruvate dehydrogenase kinase activity in cardiac myocytes.

  1995cites this paper
• Diversity of the Pyruvate Dehydrogenase Kinase Gene Family in Humans *

  1995cites this paper
• Mechanisms underlying suppression of glucose oxidation in insulin-resistant states.

  1995cites this paper
• The pyruvate dehydrogenase complex: nutrient control and the pathogenesis of insulin resistance.

  1995cites this paper
• Gluconeogenesis and effect of nutritional status on TCA cycle activity in the insect Manduca sexta.

  1995cites this paper
• The long-term regulation of skeletal muscle pyruvate dehydrogenase kinase by dietary lipid is dependent on fatty acid composition.

  1995cites this paper
• The role of the glucose/fatty acid cycle in the selective modulation of non-oxidative and oxidative glucose disposal by oxidative muscle in late pregnancy.

  1994cites this paper
• Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system

  1994cites this paper
• Glucose fatty acid interactions and the regulation of glucose disposal

  1994cites this paper
• Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase.

  1994cites this paper
• Site-selective modulation of enzymes of cardiac fuel utilization by a diet rich in fat.

  1994cites this paper
• Mechanisms modifying glucose oxidation in diabetes mellitus

  1994cites this paper
• In vivo insulin sensitivity of the pyruvate dehydrogenase complex in tissues of the rat.

  1993cites this paper
• Physiological modulation of the uptake and fate of glucose in brown adipose tissue.

  1993cites this paper
• Control of muscle pyruvate oxidation during late pregnancy

  1993cites this paper
• Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation.

  1993cites this paper
• Mechanisms involved in the coordinate regulation of strategic enzymes of glucose metabolism.

  1993cites this paper
• Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.

  1993cites this paper
• Long‐term regulation of pyruvate dehydrogenase kinase by high‐fat feeding

  1993cites this paper
• Changes in rates of glucose utilization and regulation of glucose disposal by fast-twitch skeletal muscles in late pregnancy.

  1993cites this paper
• Metabolic fate of alanine in an insect Manduca sexta: effects of starvation and parasitism.

  1993cites this paper
• The regulation of hepatic carbon flux by pyruvate dehydrogenase and pyruvate dehydrogenase kinase during long-term food restriction.

  1993cites this paper
• “In Vitro” Effects of Insulin on the PDH Complex of the Isolated Perfused Heart of Rats Fed a Sucrose-Rich Diet

  1992cites this paper
• An improved assay for pyruvate dehydrogenase in liver and heart.

  1992cites this paper
• Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle.

  1992cites this paper
• "In vitro" effects of insulin on the PDH complex of the isolated perfused heart of rats fed a sucrose-rich diet.

  1992cites this paper
• Adaptive changes in total pyruvate dehydrogenase activity in lipogenic tissues of rats fed high-sucrose or high-fat diets.

  1992cites this paper
• Hepatic pyruvate dehydrogenase kinase activities during the starved-to-fed transition.

  1992cites this paper
• An improved assay for pyruvate dehydrogenase in liver and heart.

  1991cites this paper
• Increased pyruvate dehydrogenase kinase activity in response to sepsis.

  1991cites this paper
• Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

  1991cites this paper
• Regulation of fatty acid synthesis in lactating rat mammary gland in the fed to starved transition: asynchronous control of pyruvate dehydrogenase, phosphofructokinase and acetyl-CoA carboxylase.

  1991cites this paper
• Glucose utilization by skeletal muscles in vivo in experimental hyperthyroidism in the rat.

  1990cites this paper
• Pyruvate dehydrogenase activities and rates of lipogenesis during the fed-to-starved transition in liver and brown adipose tissue of the rat.

  1990cites this paper
• Glucose utilization in heart, diaphragm and skeletal muscle during the fed-to-starved transition.

  1990cites this paper
• Brown-fat pyruvate dehydrogenase activities during the fed-to-starved transition.

  1990cites this paper
• Effects of non-esterified fatty acid availability on insulin stimulated glucose utilisation and tissue pyruvate dehydrogenase activity in the rat

  1990cites this paper
• Cardiac glucose utilization during the fed-to-starved transition.

  1990cites this paper
• Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation.

  1989cites this paper
• Fuel selection and carbon flux during the starved-to-fed transition.

  1989cites this paper
• Comparison of tissue pyruvate dehydrogenase activities on re-feeding rats fed ad libitum or meal-fed rats with a chow-diet meal.

  1989cites this paper
• Effects of re-feeding after prolonged starvation on pyruvate dehydrogenase activities in heart, diaphragm and selected skeletal muscles of the rat.

  1989cites this paper
• Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal muscles

  1989cites this paper
• The Role of Regulation of Tissue Pyruvate Dehydrogenase Complex Activity during the Starved‐to‐Fed Transition a

  1989cites this paper
• Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats.

  1989cites this paper
• Time courses of the responses of pyruvate dehydrogenase activities to short-term starvation in diaphragm and selected skeletal muscles of the rat.

  1989cites this paper
• Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase.

  1988cites this paper
• Role of anaerobic bacteria in intra-abdominal septic abscesses in mediating septic control of skeletal muscle glucose oxidation and lactic acidemia.

  1988cites this paper
• The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition.

  1988cites this paper
• Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones.

  1988cites this paper
• Effects of fasting and training on pyruvate dehydrogenase activation during exercise.

  1988cites this paper
• Impaired insulin action in adipocytes of New Zealand obese mice: a role for postbinding defects in pyruvate dehydrogenase and insulin mediator activity.

  1988cites this paper
• Acute effects of surgery on carbohydrate production and utilization in the fed rat.

  1988cites this paper
• The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state.

  1988cites this paper
• Effects of nutritional status and acute variation in substrate supply on cardiac and skeletal-muscle fructose 2,6-bisphosphate concentrations.

  1988cites this paper
• 13C NMR study of effects of fasting and diabetes on the metabolism of pyruvate in the tricarboxylic acid cycle and the utilization of pyruvate and ethanol in lipogenesis in perfused rat liver.

  1987cites this paper
• Effects of acute acid-base changes on rat renal pyruvate dehydrogenase. Renal pyruvate dehydrogenase during acid-base alterations.

  1987cites this paper