Diminished tyrosine protein kinase activity in T cells unresponsive to TCR stimulation

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of Leukocyte Biology

• Publication date

  1994-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jlb.55.3.289PMID 8120446
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction.

  1993cited by this paper
• Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.

  1993cited by this paper
• Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells

  1992cited by this paper
• Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation.

  1992cited by this paper
• The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation

  1992cited by this paper
• pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells.

  1992cited by this paper
• Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.

  1992influential reference
• The src family of tyrosine protein kinases in hemopoietic signal transduction

  1992cited by this paper
• The Src family of tyrosine protein kinases in hemopoietic signal transduction

  1992cited by this paper
• ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.

  1992influential reference
• CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.

  1992cited by this paper
• Phospholipase C-gamma 1 association with CD3 structure in T cells

  1992cited by this paper
• CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

  1992cited by this paper
• p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.

  1992cited by this paper
• Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.

  1992cited by this paper
• CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

  1992cited by this paper
• Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.

  1992cited by this paper
• CD28-stimulated IL-2 gene expression in Jurkat T cells occurs in part transcriptionally and is cyclosporine-A sensitive.

  1992cited by this paper
• Inhibition of the anti-CD3-induced T cell proliferation by crosslinking of stimulatory antibodies in the presence of PMA and interleukin-2.

  1992cited by this paper
• Protein tyrosine kinase p59fyn is associated with the T cell receptor‐CD3 complex in functional human lymphocytes

  1992cited by this paper
• Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes.

  1992cited by this paper
• CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

  1992cited by this paper
• Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.

  1992cited by this paper
• The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

  1992cited by this paper
• Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

  1992cited by this paper
• ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

  1992cited by this paper
• T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1.

  1991cited by this paper
• Multiple signal transduction pathways activated through the T cell receptor for antigen.

  1991cited by this paper
• The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

  1991influential reference
• Delayed thymocyte development induced by augmented expression of p56lck

  1991cited by this paper
• Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells.

  1991cited by this paper
• CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

  1991cited by this paper
• Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production.

  1991cited by this paper
• T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways

  1991cited by this paper
• Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

  1991cited by this paper
• T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck.

  1991cited by this paper
• CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

  1991cited by this paper
• Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

  1991cited by this paper
• Signal transduction by the T cell antigen receptor.

  1991cited by this paper
• Signal transduction by the SRC family of tyrosine protein kinases in hemopoietic cells.

  1991cited by this paper
• Protein phosphatases: recent progress.

  1991cited by this paper
• T cell antigen receptor activation pathways: the tyrosine kinase connection.

  1991cited by this paper
• Activation of Human T Lymphocytes by Phorbol‐12,13‐Dibutyrate and Ionomycin

  1990cited by this paper
• Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

  1990cited by this paper
• Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

  1990cited by this paper
• Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

  1990cited by this paper
• A novel model for antigen-dependent activation of normal human T cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor- alpha/beta complex with the cluster determinant 2 antigen

  1990cited by this paper
• Inability of CD8α′polypeptides to associate with p56 lck correlates with impaired function in vitro and lack of expression in vivo

  1989cited by this paper
• Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

  1989cited by this paper
• Calcium and T lymphocyte activation.

  1989cited by this paper
• Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes

  1989cited by this paper
• Kinases and phosphatases in T-cell activation.

  1989cited by this paper
• T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates.

  1989cited by this paper
• The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.

  1988cited by this paper
• Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation

  1988cited by this paper
• Coordination and reversibility of signals for proliferative activation and interleukin-2 mRNA production in resting human T lymphocytes by phorbol ester and calcium ionophore.

  1988cited by this paper
• Early signal transduction by the antigen receptor without commitment to T cell activation.

  1988cited by this paper
• Analysis of pp60c‐src tyrosine kinase activity and phosphotyrosyl phosphatase activity in human colon carcinoma and normal human colon mucosal cells

  1987cited by this paper
• Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

  1986cited by this paper

• Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets

  2023cites this paper
• Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells.

  2017cites this paper
• TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk*

  2016cites this paper
• TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

  2004cites this paper
• Src: regulation, role in human carcinogenesis and pharmacological inhibitors.

  2004cites this paper
• TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

  2004cites this paper
• Non-receptor protein tyrosine kinases.

  2003cites this paper
• Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells*

  1998cites this paper
• Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells*

  1996cites this paper
• Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils (*)

  1996cites this paper
• Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

  1995cites this paper
• Multiple kinases mediate T-cell-receptor signaling.

  1995cites this paper
• T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present.

  1995cites this paper
• Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri

  1995cites this paper
• Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes.

  1994cites this paper
• Transfection of an Fc gamma receptor cDNA induces T cells to become phagocytic.

  1994cites this paper