Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Virology

• Publication date

  1995-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.69.12.7814-7822.1995PMID 7494293PMCID PMC189725
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of Lck-binding Elements in Tip of Herpesvirus Saimiri (*)

  1995cited by this paper
• Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

  1995influential reference
• The Product of the Herpesvirus saimiri Open Reading Frame 1 (Tip) Interacts with T Cell-specific Kinase p56lck in Transformed Cells (*)

  1995cited by this paper
• Association of the viral oncoprotein STP-C488 with cellular ras

  1995cited by this paper
• p56lck interacts via its src homology 2 domain with the ZAP-70 kinase

  1994cited by this paper
• An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.

  1994cited by this paper
• Diminished tyrosine protein kinase activity in T cells unresponsive to TCR stimulation

  1994cited by this paper
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

  1994cited by this paper
• Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation

  1994influential reference
• The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

  1994cited by this paper
• Structural basis for the binding of proline-rich peptides to SH3 domains.

  1994cited by this paper
• Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.

  1994cited by this paper
• The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.

  1994cited by this paper
• LFA-1-mediated antigen-independent T cell adhesion is regulated by CD4 and p56lck tyrosine kinase.

  1994cited by this paper
• Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

  1994cited by this paper
• Myristylation and palmitylation of Src family members: The fats of the matter

  1994cited by this paper
• Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

  1994cited by this paper
• Myristylation and palmitylation of Src family members: the fats of the matter.

  1994cited by this paper
• Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.

  1993cited by this paper
• SH3 domains direct cellular localization of signaling molecules.

  1993cited by this paper
• The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes

  1993cited by this paper
• Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins

  1993cited by this paper
• Identification of a ten-amino acid proline-rich SH3 binding site.

  1993cited by this paper
• IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus.

  1993cited by this paper
• T cell activation by clustered tyrosine kinases.

  1993cited by this paper
• The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

  1993cited by this paper
• T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases.

  1993influential reference
• Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

  1993cited by this paper
• Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

  1992cited by this paper
• Profound block in thymocyte development in mice lacking p56lck

  1992cited by this paper
• Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.

  1992influential reference
• Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho.

  1992cited by this paper
• Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases

  1992cited by this paper
• Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck.

  1992cited by this paper
• Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells

  1992cited by this paper
• Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

  1992cited by this paper
• A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells

  1992cited by this paper
• Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

  1991cited by this paper
• The lymphocyte-specific tyrosine protein kinase p56lck.

  1991cited by this paper
• Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

  1991cited by this paper
• GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.

  1991cited by this paper
• T cell antigen receptor activation pathways: the tyrosine kinase connection.

  1991cited by this paper
• SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.

  1991cited by this paper
• Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri.

  1991cited by this paper
• The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype.

  1990cited by this paper
• Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

  1990cited by this paper
• Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

  1990cited by this paper
• Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

  1989cited by this paper
• The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain.

  1989cited by this paper
• The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

  1988cited by this paper
• Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

  1988cited by this paper
• In vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri

  1987cited by this paper
• Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization

  1986cited by this paper
• Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required for oncogenicity

  1984cited by this paper
• Herpesvirus saimiri strain variability

  1982cited by this paper

• Masters of manipulation: Viral modulation of the immunological synapse

  2018cites this paper
• T cell polarization and immunological synapses : from antigen recognition to virus spread

  2018cites this paper
• Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri

  2015cites this paper
• Characterisation of the Legionella pneumophila effector RidL

  2014cites this paper
• Saimiri.subgroup C strains of herpesvirus alphabeta and gammadelta T cells determined Functional phenotype of transformed human

  2013cites this paper
• Molecular Mimicry by γ-2 Herpesviruses to Modulate Host Cell Signaling Pathways

  2013cites this paper
• Species restriction of Herpesvirus saimiri and Herpesvirus ateles: human lymphocyte transformation correlates with distinct signaling properties of viral oncoproteins.

  2012cites this paper
• Herpes Simplex Virus Requires VP11/12 To Activate Src Family Kinase-Phosphoinositide 3-Kinase-Akt Signaling

  2011cites this paper
• Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses.

  2010cites this paper
• Primate Models for Gammaherpesvirus-Associated Malignancies

  2009cites this paper
• Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities

  2008cites this paper
• Systematic Mutagenesis of the Murine Gammaherpesvirus 68 M2 Protein Identifies Domains Important for Chronic Infection

  2008cites this paper
• Viral Modulation of T-Cell Receptor Signaling

  2008cites this paper
• T Cell Polarization and the Formation of Immunological Synapses: From Antigen Recognition to Virus Spread

  2007cites this paper
• Association of Herpesvirus Saimiri Tip with Lipid Raft Is Essential for Downregulation of T-Cell Receptor and CD4 Coreceptor

  2006cites this paper
• The Intersection Between Viral Transforming Proteins and Cellular Signal Transduction Pathways

  2006cites this paper
• Growth Transformation of Human T Cells by Herpesvirus Saimiri Requires Multiple Tip-Lck Interaction Motifs

  2006influential citation
• Herpesvirus saimiri-based gene delivery vectors.

  2006cites this paper
• Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.

  2006influential citation
• Cell transformation by Herpesvirus saimiri

  2005cites this paper
• T-Cell Growth Transformation by Herpesvirus Saimiri Is Independent of STAT3 Activation

  2005cites this paper
• T-cell transformation and oncogenesis by gamma2-herpesviruses.

  2005cites this paper
• Tyrosine Phosphorylation of the Tio Oncoprotein Is Essential for Transformation of Primary Human T Cells

  2005cites this paper
• Ingrid STAT 3 Activation Herpesvirus Saimiri Is Independent of T-Cell Growth Transformation

  2005cites this paper
• Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesis.

  2004cites this paper
• Oncogenic γ-herpesviruses: comparison of viral proteins involved in tumorigenesis

  2004cites this paper
• Development of herpesvirus-based episomally maintained gene delivery vectors

  2004cites this paper
• Tip, an Lck-interacting protein of Herpesvirus saimiri, causes Fas- and Lck-dependent apoptosis of T lymphocytes.

  2004cites this paper
• Molecular Mechanisms of the Effect of Herpesvirus saimiri Protein StpC on the Signaling Pathway Leading to NF-κB Activation*

  2004cites this paper
• The genome of herpesvirus saimiri C488 which is capable of transforming human T cells.

  2003cites this paper
• Semidominant Effect of the l(1)ts403 (sbr10) Mutation on Sex Chromosome Nondsjunction in Meiosis in Drosophila melanogaster Females Exposed to Heat

  2003cites this paper
• Activation of Mitogen-Activated Protein Kinase and NF-κB Pathways by a Kaposi's Sarcoma-Associated Herpesvirus K15 Membrane Protein

  2003cites this paper
• Herpesvirus saimiri: a potential gene delivery vector (review).

  2003cites this paper
• Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck.

  2002cites this paper
• Protein tyrosine phosphorylation in T cell signaling.

  2002influential citation
• The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro.

  2002cites this paper
• T Cell Activation and Lymphokine Induction in Herpesvirus saimiri Immortalized Cells

  2002cites this paper
• Suppression of Tetradecanoyl Phorbol Acetate-Induced Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus by K1 Signal Transduction

  2002cites this paper
• Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: tumor cell lines reveal subgroup-specific differences.

  2002cites this paper
• Viral immune evasion: a masterpiece of evolution

  2002cites this paper
• Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression.

  2002cites this paper
• Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-kappaB activity and interleukin-2 gene expression.

  2001cites this paper
• Herpesvirus saimiri.

  2001cites this paper
• Herpesvirus saimiri Tip Gene Causes T-Cell Lymphomas in Transgenic Mice

  2001cites this paper
• Downregulation of p56lck Tyrosine Kinase Activity in T Cells of Squirrel Monkeys (Saimiri sciureus) Correlates with the Nontransforming and Apathogenic Properties of Herpesvirus Saimiri in Its Natural Host

  2001cites this paper
• Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and Herpesvirus saimiri.

  2001cites this paper
• Herpesvirus saimiri Replaces ZAP-70 for CD3- and CD2-mediated T Cell Activation*

  2001cites this paper
• The sbrGene Product in Drosophila melanogasterand Its Orthologs in Yeast (Mex67p) and Human (TAP)

  2001cites this paper
• Simian homologues of human herpesvirus 8.

  2001cites this paper
• Primary Structure of the Herpesvirus Ateles Genome

  2000cites this paper
• Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.

  2000cites this paper
• MINIREVIEW Signaling Activities of Gammaherpesvirus Membrane Proteins

  2000cites this paper
• Analysis of Gene Expression in a Human Cell Line Stably Transduced with Herpesvirus Saimiri

  2000cites this paper
• Membrane Proteins Signaling Activities of Gammaherpesvirus

  2000cites this paper
• Evolutionary aspects of oncogenic herpesviruses

  2000cites this paper
• Identification of the Novel K15 Gene at the Rightmost End of the Kaposi's Sarcoma-Associated Herpesvirus Genome

  2000cites this paper
• Signaling Activities of Gammaherpesvirus Membrane Proteins

  2000cites this paper
• The Collagen Repeat Sequence Is a Determinant of the Degree of Herpesvirus Saimiri STP Transforming Activity

  2000cites this paper
• Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions.

  2000cites this paper
• The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells

  1999cites this paper
• Herpesvirus saimiri strategies for T cell stimulation and transformation

  1999cites this paper
• Herpesvirus Ateles Gene Product Tio Interacts with Nonreceptor Protein Tyrosine Kinases

  1999influential citation
• Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus saimiri proteins StpC and/or Tip.

  1999cites this paper
• Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis.

  1999cites this paper
• Mechanisms of cell transformation by Herpesvirus saimiri.

  1999cites this paper
• -Transformed T Cells Herpesvirus saimiri Signaling Molecules in IL-2-Independent Cutting Edge: Constitutive Activation of TCR

  1998cites this paper
• Viral proteins that regulate cellular signalling.

  1998influential citation
• The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.

  1998cites this paper
• STP and Tip Are Essential for Herpesvirus Saimiri Oncogenicity

  1998cites this paper
• Constitutive activation of TCR signaling molecules in IL-2-independent Herpesvirus saimiri-transformed T cells.

  1998cites this paper
• Human T cells transduced by a retroviral vector to express Herpesvirus saimiri proteins TIP and STPC.

  1998cites this paper
• GROWTH TRANSFORMATION OF HUMAN T CELLS

  1998cites this paper
• Mutation of the Lck-Binding Motif of Tip Enhances Lymphoid Cell Activation by Herpesvirus Saimiri

  1998cites this paper
• Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.

  1998cites this paper
• Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri

  1997cites this paper
• Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.

  1997cites this paper
• Functional Phenotype of Transformed Human aband gdT Cells Determined by Different Subgroup C Strains of Herpesvirus Saimiri

  1997cites this paper
• Non-receptor protein tyrosine kinases as immune targets of viruses.

  1997cites this paper
• Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip

  1997cites this paper
• DNA tumor viruses and Src family tyrosine kinases, an intimate relationship.

  1997influential citation
• Signalling by Src family kinases: lessons learnt from DNA tumour viruses.

  1997cites this paper
• The superantigen-homologous viral immediate-early gene ie14/vsag in herpesvirus saimiri-transformed human T cells

  1997cites this paper
• Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells

  1997cites this paper
• Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes

  1996cites this paper
• Contradictory concepts in the etiology and regression of kaposi’s sarcoma

  1996cites this paper
• Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses.

  1996cites this paper
• Association of the viral oncoprotein STP-C488 with cellular ras

  1995cites this paper