Regulatory T-cells: immunomodulators in health and disease.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Current Topics in Medicinal Chemistry

• Publication date

  2006-07-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2174/156802606778194262PMID 17017955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD.

  2005cited by this paper
• Skin cancer's ranks rise: immunosuppression to blame.

  2005cited by this paper
• Both Regulatory T Cells and Antitumor Effector T Cells Are Primed in the Same Draining Lymph Nodes during Tumor Progression1

  2005cited by this paper
• The renal‐sparing efficacy of basiliximab in adult living donor liver transplantation

  2005cited by this paper
• Is there a rationale to using leflunomide in early rheumatoid arthritis?

  2005cited by this paper
• Induction of transplantation tolerance-the potential of regulatory T cells.

  2005cited by this paper
• Anti-lymphoma effect of gammadelta T cells.

  2005cited by this paper
• Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

  2004cited by this paper
• Regulating the immune system: the induction of regulatory T cells in the periphery

  2004cited by this paper
• Antigen Nonspecific Suppression of T Cell Responses by Activated Stimulation-Refractory CD4+ T Cells 1

  2004cited by this paper
• CD4+CD25+ regulatory T cells: II. Origin, disease models and clinical aspects

  2004cited by this paper
• Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity.

  2004cited by this paper
• Revival of the regulatory T cell: new targets for drug development.

  2004cited by this paper
• Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function.

  2004cited by this paper
• Back to central tolerance.

  2004cited by this paper
• Regulatory T cells: potential in organ transplantation.1

  2004cited by this paper
• Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA‐4 expression

  2004cited by this paper
• Good riddance: Thymocyte clonal deletion prevents autoimmunity.

  2004cited by this paper
• Gene-based vaccines and immunotherapeutics

  2004cited by this paper
• An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection

  2004cited by this paper
• IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1

  2004cited by this paper
• Regulatory/suppressor T cells in health and disease.

  2004cited by this paper
• Antigen-specific regulatory T cells--their induction and role in infection.

  2004cited by this paper
• Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells1

  2004cited by this paper
• Twenty-first century Foxp3

  2003cited by this paper
• Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B‐cell chronic lymphocytic leukemia

  2003cited by this paper
• Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells

  2003cited by this paper
• Foxp3 and natural regulatory T cells: key to a cell lineage?

  2003cited by this paper
• Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo 1

  2003cited by this paper
• Natural killer T cells: natural or unnatural regulators of autoimmunity?

  2003cited by this paper
• Helicobacterpylori-Specific CD4+ CD25high Regulatory T Cells Suppress Memory T-Cell Responses to H. pylori in Infected Individuals

  2003cited by this paper
• CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

  2003cited by this paper
• TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression.

  2003cited by this paper
• T cell anergy.

  2003cited by this paper
• Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

  2003cited by this paper
• CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4.

  2003cited by this paper
• CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity.

  2002cited by this paper
• Contrasting Impacts of Immunosuppressive Agents (Rapamycin, FK506, Cyclosporin A, and Dexamethasone) on Bidirectional Dendritic Cell-T Cell Interaction During Antigen Presentation1

  2002cited by this paper
• Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

  2002cited by this paper
• Transforming growth factor-beta in T-cell biology.

  2002cited by this paper
• Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

  2002cited by this paper
• The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

  2002cited by this paper
• CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

  2002cited by this paper
• Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients.

  2001cited by this paper
• Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells.

  2001cited by this paper
• Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

  2001cited by this paper
• Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

  2001cited by this paper
• Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

  2001cited by this paper
• Control of T‐cell activation by CD4+ CD25+ suppressor T cells

  2001cited by this paper
• Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo

  2001cited by this paper
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

  2001cited by this paper
• Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

  2001cited by this paper
• CD38 expression and functional activities are up‐regulated by IFN‐γ on human monocytes and monocytic cell lines

  2001cited by this paper
• Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

  2001cited by this paper
• Impairment of CD8+ T Suppressor Cell Function in Patients with Active Systemic Lupus Erythematosus1

  2001cited by this paper
• Type 1 T regulatory cells

  2001cited by this paper
• Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

  2001cited by this paper
• Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

  2001cited by this paper
• Natural CD4+ CD25+ regulatory T cells. Their role in the control of superantigen responses

  2001cited by this paper
• Interleukin-10 and the interleukin-10 receptor.

  2001cited by this paper
• B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

  2000cited by this paper
• CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells

  2000cited by this paper
• Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

  2000cited by this paper
• Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

  2000cited by this paper
• Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model.

  2000cited by this paper
• NKT cells: facts, functions and fallacies.

  2000cited by this paper
• The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases.

  2000cited by this paper
• Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor

  2000cited by this paper
• Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

  2000cited by this paper
• Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation.

  2000cited by this paper
• Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.

  1999cited by this paper
• Cellular and molecular characterization of the scurfy mouse mutant.

  1999cited by this paper
• A role for CD45RBlow CD38+ T cells and costimulatory pathways of T‐cell activation in protection of non‐obese diabetic (NOD) mice from diabetes

  1999cited by this paper
• Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

  1999cited by this paper
• Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cells.

  1998cited by this paper
• α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

  1998cited by this paper
• Regulation of immune responses by TGF-beta.

  1998cited by this paper
• Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

  1998cited by this paper
• CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro

  1998cited by this paper
• Human CD38 is an authentic NAD(P)+ glycohydrolase.

  1998cited by this paper
• Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.

  1998cited by this paper
• CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

  1998cited by this paper
• Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T cells.

  1998cited by this paper
• Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

  1997cited by this paper
• A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

  1997cited by this paper
• Flow cytometric study of T cell development in NOD mice reveals a deficiency in alphabetaTCR+CDR-CD8- thymocytes.

  1997cited by this paper
• Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells

  1996cited by this paper
• Diabetes‐prone NOD mice are resistant to Mycobacterium avium and the infection prevents autoimmune disease

  1996cited by this paper
• Human CD38, a cell‐surface protein with multiple functions

  1996cited by this paper
• Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.

  1996cited by this paper
• Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

  1996cited by this paper
• Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

  1996cited by this paper
• Early quantitative and functional deficiency of NK1+‐like thymocytes in the NOD mouse

  1996cited by this paper
• Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

  1995cited by this paper
• Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.

  1995cited by this paper
• Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.

  1995cited by this paper
• Human CD38: a glycoprotein in search of a function.

  1994cited by this paper
• Gamma/delta cells.

  1993cited by this paper
• Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.

  1993cited by this paper
• Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

  1993cited by this paper

• Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes

  2017cites this paper
• Chemische Biologie der Glycosylphosphatidylinosit‐Anker

  2012cites this paper
• Chemical biology of glycosylphosphatidylinositol anchors.

  2012cites this paper
• Helicobacter pylori immunoproteomics in gastric cancer and gastritis of the carcinoma phenotype

  2010cites this paper
• Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease.

  2008cites this paper
• Conventional, Regulatory, and Unconventional T Cells in the Immunologic Response to Helicobacter pylori

  2008cites this paper